Clinical trials: Myocarditis
Cardiac Transplant, Cardiac Sarcoid
DEtection of Cellular Inflammation With FERumoxytol in the HEART
To non-invasively image myocardial accumulation of ultrasmall superparamagnetic particles of iron oxide (USPIOs) by an increase in R2* values (compared to controls) within the myocardium of patients with: i.
- Conditions
- Cardiac Transplant, Cardiac Sarcoid, Myocarditis, Healthy Volunteers
- Trial name
- DECIFER (NCT02319278)
- Testing
- Ferumoxytol
- Where
- 3 sites in United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Rheumatoid Arthritis, Myocardial Inflammation
Effects of Abatacept on Myocarditis in Rheumatoid Arthritis
This study aims to evaluate the effects of abatacept, a CTLA4-Ig fusion protein that binds cluster of differentiation antigen 80 (CD80)/86 (B7-1/B7-2), on subclinical myocarditis in rheumatoid arthritis (RA) through its effect on…
- Trial name
- AMiRA (NCT03619876)
- Testing
- Abatacept, Adalimumab
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Columbia University
Myocarditis Acute
MCE Molecular Imaging for Myocarditis
Inflammation of the heart (myocarditis) is a serious condition that can cause heart failure, abnormal heart rhythms, cardiac arrest, and death. Rapid diagnosis of this condition is key to reversing it.
- Trial name
- NCT07538544
- Testing
- Myocardial contrast echocardiography molecular imaging for inflammation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Non-ischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM)
Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study.
Non-ischemic cardiomyopathies (NICM) represent a heterogeneous group of pathologies characterized by absence of obstructive disease of the epicardial coronary vessels and distinct structural and functional changes of the…
- Conditions
- Non-ischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM), Hypertrophic Cardiomyopathy (HCM), Restrictive Cardiomyopathy
- Trial name
- AINICM (NCT06607471)
- Testing
- Support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation, Support treatment, cardiac medical treatment, aetiology-specific treatment
- Where
- Italy
- Volunteers
- 15,000 people
- Sponsor
- Scientific Institute San Raffaele
Myocarditis Acute, Ventricular Arrythmia
Evaluation of Long-term Incidence of Ventricular Arrhythmias in Patients With Acute Myocarditis
Myocarditis is an inflammatory disease of the heart muscle which is mostly caused by viruses, bacteria, parasites, toxic substances/drugs or by primary autoimmune mechanisms.
- Trial name
- AIM-ICD (NCT04264455)
- Testing
- Biomonitor, Life Vest, Implantable Cardioverter-Defibrillator (ICD)
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Wuerzburg University Hospital
Myocarditis
Efficacy of a Myocardial Panel in the Management and Treatment of Pediatric Myocarditis
The goal of this observational study is to determine the efficacy a of combined management and treatment driven by the systematic determination of viral genome, bacterial serology, and markers of inflammation in pediatric…
- Trial name
- NCT07086144
- Testing
- Determination of viral genome, bacterial serology, and markers of inflammation in pediatrics diagnosed with myocarditis
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliero, Universitaria Ospedali Riuniti
Myocarditis Acute, Ventricular Arrythmia
Ventricular Arrhythmia After Myocarditis in Sportsman
The study aims to assess the prevalence of ventricular rhythmic disorder after an acute myocarditis in sportsmen. 50 patients with acute myocarditis, confirmed by MRI, will be assessed by ECG Holter and Treadmill stress test…
- Trial name
- ARYMYS (NCT03842592)
- Testing
- Treadmill Stress test
- Where
- 4 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Myocarditis
Prognostic Impact of Cardiac Imaging During Suspected Immune Checkpoint Inhibitor Myocarditis
It consists of evaluating the advantage of routine detection of phIGFBP-1 to reduce the total duration of hospitalization for patients with a risk of preterm labor before 32 weeks of gestation without increasing the number of…
- Trial name
- IMMUNOIMAGING (NCT05086146)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Myocarditis
Hospital Registry of Acute Myocarditis: Evolution of the Proportion of Positive SARS-COV-2 (COVID19) Cases
To date, the effects of SARS-Cov-2 (Covid-19) on the myocardium and the role it plays in the evolution towards an acute myocarditis are badly understood.
- Trial name
- MYOCOVID (NCT04375748)
- Testing
- Performing routine care (clinical and paraclinical tests), Examinations for the research:
- Where
- 65 sites in France, Martinique and 2 more
- Volunteers
- 756 people
- Sponsor
- University Hospital, Toulouse
Heart Transplantation, Dilated Cardiomyopathy (DCM)
Multimodal Analysis of Endomyocardial Biopsies
The goal of this observational study is to pursue a multimodal approach to identify the molecular signatures and immune signalling molecules of various myocardial diseases and thereby contribute to improving diagnosis and…
- Conditions
- Heart Transplantation, Dilated Cardiomyopathy (DCM), Hypertrophic Cardiomyopathy (HCM), Myocarditis, Pericarditis
- Trial name
- NCT07359690
- Where
- Germany
- Volunteers
- 216 people
- Sponsor
- University Hospital, Essen
Myocarditis
Cardiac Magnetic Resonance in Acute Myocarditis
Cardiac magnetic resonance (MR) is an established noninvasive diagnostic tool for detection of acute myocarditis. Diagnosis of myocarditis at 1.5T is currently made with the help of the Lake Louise Criteria (two of three criteria…
- Trial name
- NCT02299856
- Testing
- Cardiac magnetic resonance scan
- Where
- Germany
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Myocarditis
Myocarditis Registry for Children and Adolescents - MYKKE
MYKKE is a prospective multi-center registry for children and adolescents with myocarditis. The aim is to generate prospective multi-center data on epidemiology, diagnostics, and therapy of pediatric patients with myocarditis in…
- Trial name
- MYKKE (NCT02590341)
- Where
- 13 sites in Germany
- Volunteers
- 1,500 people
- Sponsor
- German Heart Institute
Glucocorticoid Resistant ICIs-related Myocarditis
The Efficacy and Safety of Tofacitinib in Patients With Glucocorticoid Resistant ICIs-related Myocarditis
The efficacy and safety of Tofacitinib in patients with glucocorticoid resistant ICIs-related myocarditis: a single-arm, prospective, phase 2 trial
- Trial name
- NCT06393972
- Testing
- Tofacitinib 5 MG BID
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Shanghai Zhongshan Hospital
Myocarditis, Premature Ventricular Contractions
Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry
To assess potential link between unrecognized myocardial inflammation (myocarditis) and premature ventricular contractions (PVCs) associated with and without reduced Left ventricular ejection fraction (LVEF) through comprehensive…
- Conditions
- Myocarditis, Premature Ventricular Contractions, Ventricular Tachycardia (VT)
- Trial name
- MAVERIC (NCT05158751)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Myocarditis Acute
Positron Emission Tomography for the Diagnosis of Immune Checkpoint Inhibitor-Related Myocarditis
This study evaluates positron emission tomography for the diagnosis of immune checkpoint inhibitor-related myocarditis. Immune checkpoint inhibitors have shown promising results in various malignancies however, several immune…
- Trial name
- NCT05062395
- Testing
- Computed Tomography, Fludeoxyglucose F-18, Low Carbohydrate High Fat Diet
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- M.D. Anderson Cancer Center
Cardiac Failure, Coronary Artery Disease
Evaluation of MyoStrain™ in Clinical Practice
Evaluate MyoStrain cardiac MRI pulse sequence in Clinical practice
- Conditions
- Cardiac Failure, Coronary Artery Disease, Sarcoidosis, Amyloidosis
- Trial name
- NCT03825224
- Testing
- Diagnostic Test: Myostrain
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Kansas Medical Center
COVID-19
Descriptive and Retrospective Analysis of Acute Myocarditis Associated With Pandemic COVID-19 in Children
The study objectives are to descript clinical, biological and echocardiographic features of an acute myocarditis in children in the context of COVID-19 and to identify the underlying mechanism : direct viral damage and/or…
- Trial name
- HEART-COVID (NCT04420468)
- Where
- 4 sites in France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19 Infection
Cardiac and Thoracic Imaging in Pediatric Patients With Evidence of Systemic Inflammation COVID19 Linked
To perform comprehensive cardiac and thoracic non invasive imaging assessment by MRI and/or CT scan including cardiac functional evaluation and myocardial tissue characterization of COVID_19 related disease in pediatric patients…
- Trial name
- CARDOVID (NCT04455347)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Imagine Institute
COVID-19, Myocarditis
Clinical Significance of Subclinical Myocardial Involvement in Recovered COVID-19 Patients Using Cardiovascular Magnetic Resonance
Introduction: Coronavirus disease 2019 (COVID-19) remains a major health issue resulting in >800,000 deaths as of 30th August 2020. A concerning discovery of COVID-19 is the involvement of the myocardium.
- Trial name
- R-COVID-CMR (NCT05184114)
- Testing
- Cardiac Magnetic Resonance, Blood Tests
- Where
- Hong Kong
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Myocarditis
Role of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in Children With Myocarditis
Children can have or develop certain problems with their heart function, specifically with the heart muscle or myocardium. This problem can be caused by many things specifically by infection resulting in myocarditis (inflammation…
- Trial name
- NCT00693134
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center