Clinical trials: Myocardium; Injury
Cardiac Surgery
Risk of Oxygen During Cardiac Surgery Trial
The investigators will recruit and randomize 200 elective cardiac surgery patients to receive physiologic oxygenation (normoxia) or hyper-oxygenation (hyperoxia) during surgery to test the hypothesis that intraoperative…
- Trial name
- ROCS (NCT02361944)
- Testing
- Oxygen - normoxia, Oxygen - hyperoxia
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Vanderbilt University
Covid19
Patterns of Arrhythmias and Conduction Block in COVID-19 Patients and Its Relation to Myocardial Injury Detected by Cardiac Magnetic Resonance
Detection of the incidence and types of arrhythmia and conduction block in COVID - 19 patients Detection and description of CMR patterns of myocardial injury in COVID-19 patients with arrhythmias.
- Trial name
- NCT04584411
- Testing
- Cardiac Magnetic resonance imaging
- Volunteers
- 50 people
- Sponsor
- Assiut University
Coronary Artery Bypass Grafting (CABG) Surgery, Myocardial Protection
Impact of Different Cardioplegia Solutions on Indicators of Myocardial Injury During Coronary Surgery
The aim of the present study is to investigate intra-operative changes in markers of myocardial injury during ischemia and reperfusion, comparing three methods of myocardial protection; St.
- Trial name
- Cardioplegia2 (NCT07358221)
- Testing
- The intervention is the use of a specific cardioplegia solution for myocardial protection
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Damascus University
Atrial Fibrillation, Myocardium; Injury
Statin Therapy In Cardiac Surgery
The purpose of STICS trial (Statin Therapy In Cardiac Surgery) is to test whether perioperative treatment with Rosuvastatin 20 mg once daily prevents post-operative atrial fibrillation and reduces perioperative irreversible…
- Trial name
- STICS (NCT01573143)
- Testing
- Rosuvastatin
- Where
- China
- Volunteers
- 1,922 people
- Sponsor
- University of Oxford
Coronary Syndrome, Acute, Coronary Artery Disease
A Study of Population and Sex-specific Troponin Cutoffs for Ruling Out Acute Myocardial Infarction
Acute myocardial infarction (MI) is defined as a rise and/or fall in cardiac troponins (cTn) with at least one value above the 99th percentile upper reference limit (URL) in the context of symptoms or clinical evidence of…
- Conditions
- Coronary Syndrome, Acute, Coronary Artery Disease, Myocardial Infarction
- Trial name
- DANSPOT (NCT05336435)
- Testing
- Implementation of the new population and sex-specific 99th percentile URL for cardiac troponin
- Where
- 22 sites in Denmark
- Volunteers
- 5,175 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
COVID-19, Myocardial Injury
Myocardial Injury and Quality of Life After COVID-19
In this observational study follow-up and dynamic observation will be conducted on the participants recovered from pneumonia caused by COVID-19.
- Conditions
- COVID-19, Myocardial Injury, Myocarditis Post Infection
- Trial name
- NCT04794062
- Where
- Russia
- Volunteers
- 119 people
- Sponsor
- Voronezh Regional Clinical Consultative and Diagnostic Center
Coronary Artery Disease
Aroxxen® Inhalation for Cardioprotection After Elective PCI With Stent Implantation
This is an open-label, randomized, multicenter Phase II clinical study designed to evaluate the cardioprotective effect, to determine the optimal dosages and duration of inhalation, and to assess the clinical safety of the…
- Trial name
- NCT07397351
- Testing
- Aroxxen
- Where
- Russia
- Volunteers
- 180 people
- Sponsor
- Research Institute of Geroprotective Technologies
Chronic Stable Angina, PTCA
Myocardial Damage and Music Study
MYDA-MUSIC study is a randomized, double blind (operator and analyst) study performed in San Filippo Neri Hospital, Roma, Italy and in Di Venere Hospital, Bari, Italy. The planned study duration is 12 months.
- Trial name
- MYDA-MUSIC (NCT03507361)
- Testing
- HRV-BASED MUSIC
- Where
- Italy
- Volunteers
- 443 people
- Sponsor
- San Filippo Neri General Hospital
Risk
Remembering Risk: Using Visual Risk Display of MINS to Obtain Informed Consent to Undergo Elective Surgery
Disclosure of anticipated risks to individuals considering undergoing an operative procedure is an important aspect of informed consent process.
- Trial name
- NCT04247841
- Testing
- Visual Aid, Scripted Risk Discussion
- Where
- Canada
- Volunteers
- 456 people
- Sponsor
- Dr. Michael McMullen
Perioperative Care
Validation of B-type Natriuretic Peptide With N-terminal Pro B-type Natriuretic Peptide in Perioperative Risk Assessment
This is a single-centre, prospective study to determine the correlation and comparative thresholds between N-terminal pro-brain natriuretic peptide (NT ProBNP, Roche) and brain natriuretic peptide (BNP, Abbott) tests.
- Trial name
- NCT05352698
- Testing
- NT ProBNP (Roche)
- Where
- Canada
- Volunteers
- 466 people
- Sponsor
- Jordan Leitch
Myocardial Injury
Comparison of the Effects of Crystalloid Cardioplegia and HTK Solution for Postoperative Troponin-I and CK-MB Levels After Pediatric Cardiac Surgery
The purpose of this study is to compare two different cardioplegia solutions effect on postoperative Troponin-I and CK-MB levels after pediatric cardiac surgery.
- Trial name
- NCT01548872
- Testing
- HTK solution, crystalloid cardioplegia solution
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Baskent University
Perioperative Myocardial Injury, Autonomic Dysfunction
LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery
Limiting perioperative tachycardia (aiming for a heart rate <90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing…
- Conditions
- Perioperative Myocardial Injury, Autonomic Dysfunction, Cardiovascular (CV) Risk, Major Surgery
- Trial name
- LANTA-P (NCT07168421)
- Testing
- Landiolol
- Where
- Switzerland
- Volunteers
- 114 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Myocardial Injury, Myocardial Ischemia
PeRiOperaTivE CardioproTection With Ivabradine in Non-cardiac Surgery
Perioperative myocardial injury (PMI) after non-cardiac surgery (NCS), i.e. the elevation of postoperative troponin, occurs in nearly 20% of patients older than 45 years undergoing NCS and is independently and strongly associated…
- Trial name
- PROTECTIN (NCT04436016)
- Testing
- Ivabradine
- Where
- Switzerland
- Volunteers
- 78 people
- Sponsor
- University Hospital, Geneva
Type II Myocardial Infarction
Rivaroxaban in Type 2 Myocardial Infarctions
This trial is the pilot phase of a randomized controlled trial to test the feasibility of recruiting patients with a type 2 myocardial infarction and randomizing them to low-dose rivaroxaban to reduce the risk of major…
- Trial name
- R2MI (NCT04838808)
- Testing
- Rivaroxaban 2.5 MG [Xarelto]
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Myocardial Injury
Effects of Remimazolam on Postoperative Myocardial Injury
This study is designed as a prospective, double-blind, randomized controlled trial to investigate the effect of remimazolam on intraoperative cardiac output (CO) in elderly patients undergoing general anesthesia, and to evaluate…
- Trial name
- NCT07725185
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Atrial Fibrillation, Arrythmia
Comparison of Efficacy and Safety of Two Biphasic Defibrillators in Cardioversion of Atrial Fibrillation
Background: Biphasic truncated exponential (BTE) waveforms are standard for cardiac defibrillation and synchronized cardioversion up to date.
- Conditions
- Atrial Fibrillation, Arrythmia, Electric Countershock
- Trial name
- NCT04032678
- Testing
- Schiller Defigard Touch 7 - DGT7, Schiller Medical, France, LIFEPAK 15, Physio-Control Inc., Redmond, WA, USA
- Where
- Bulgaria
- Volunteers
- 75 people
- Sponsor
- University National Heart Hospital
Stable Angina Pectoris
Prevalence and Prognostic Value of Unrecognized Myocardial Injury in Stable Coronary Artery Disease (PUMI)
This study includes patients with stable coronary artery disease without previously known myocardial infarction, and investigates the prevalence of clinically unrecognized myocardial damage and its prognostic implication.
- Trial name
- PUMI (NCT01257282)
- Where
- 6 sites in Sweden
- Volunteers
- 275 people
- Sponsor
- Uppsala University
MYOCARD INFARCTUS, Non Cardiac Surgery
Myocardial Injury After Noncardiac Surgery (MINS) in Lumbar Surgery Patients
The aim of this study is to evaluate the incidence of myocardial injury after noncardiac surgery (MINS) in patients undergoing lumbar surgery, and to investigate the associated risk factors.
- Conditions
- MYOCARD INFARCTUS, Non Cardiac Surgery, Lumbar Surgery, Anesthesia
- Trial name
- NCT07081009
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Myocardial Injury After Non-cardiac Surgery, Abdomen, Acute
Troponin I Level and Mortality in Acute Abdominal Surgery
The goal of this prospective cohort study is to estimate the incidence of myocardial injury after non-cardiac surgery (MINS) in patients undergoing acute high-risk abdominal surgery.
- Trial name
- NCT05933837
- Testing
- Troponin I
- Where
- Denmark
- Volunteers
- 341 people
- Sponsor
- Nordsjaellands Hospital
Atrial Fibrillation, Atrial Flutter
Comparison of Oxygen Interventions and Defibrillator Efficiency
Background: Cardiac arrhythmias can be terminated by electrical current applied by an external defibrillator. This treatment, named cardioversion, has been used for decades in the treatment of atrial fibrillation.
- Trial name
- CODE (NCT02317029)
- Testing
- Cardioversion with a pulsed biphasic waveform, Normoxia during cardioversion, Cardioversion with a biphasic truncated exponential waveform
- Where
- Denmark
- Volunteers
- 134 people
- Sponsor
- Randers Regional Hospital