Clinical trials: Myofascial Pain Dysfunction Syndrome
Temporomandibular Joint Disorders, Orofacial Pain
Occlusal Adjustment as Treatment for Chronic Orofacial Pain
The purpose of this study is to determine whether occlusal adjustment by selective grinding and/or occlusal addition is an effective treatment of chronic temporomandibular joint disorders.
- Trial name
- NCT00899717
- Testing
- Occlusal adjustment
- Where
- 2 sites in Spain
- Volunteers
- 21 people
- Sponsor
- University of Santiago de Compostela
Fibromyalgia
Repetitive Transcranial Magnetic Stimulation (rTMS) in Fibromyalgia
This study aims to evaluate the effectiveness of 10 Hz neuronavigated repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (DLPFC) on pain, stiffness, fatigue, depression/anxiety, quality…
- Trial name
- NCT03909009
- Testing
- rTMS + Neuronavigation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Izmir Katip Celebi University
Pain, Fibromyalgia
An Efficacy Study of Combination of Tramadol and Acetaminophen Tablets in the Treatment of Participants With Fibromyalgia Pain
The purpose of this study is to evaluate the analgesic effect of combination of tramadol hydrochloride and acetaminophen in participants for treatment of fibromyalgia pain (chronic widespread pain and presence of tender points).
- Trial name
- NCT00766675
- Testing
- Tramadol hydrochloride, Acetaminophen
- Volunteers
- 80 people
- Sponsor
- Johnson & Johnson Taiwan Ltd
Sleep Disorders, Fibromyalgia
The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia
Fibromyalgia is a condition of chronic widespread pain, sleep disturbance and fatigue. Most of the patients with fibromyalgia complain of either non-restorative sleep or complaints of disturbed sleep due to pain.
- Conditions
- Sleep Disorders, Fibromyalgia, Sleep
- Trial name
- NCT01234675
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mansoor Ahmed M.D.
Fibromyalgia
Evaluation of Smell and Taste in Fibromyalgia
Patients diagnosed with fibromyalgia syndrome according to 2016 ACR criteria and 18-70 years old healthy subjects will be included in the study. Their smell and taste will be assessed with sniffin sticks and taste strips.
- Trial name
- NCT03823937
- Testing
- Sniffin' Sticks test and Taste strips
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Fibromyalgia
The Effect of Minocycline and N-acetylcysteine for the Treatment of Fibromyalgia
Evaluation of the effect of combinatorial treatment of fibromyalgia patients (standard of care + minocycline + N-acetylcysteine (NAC) relative to standard of care on subjective pain measurement Revised Fibromyalgia Impact…
- Trial name
- NCT04594733
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Fibromyalgia
Randomized, Double-Blind, Placebo-Controlled Trial Of Pregabalin In Patients With Fibromyalgia.
This study, will compare pregabalin with placebo for the duration of 14 weeks to evaluate the efficacy and safety of pregabalin in patients with fibromyalgia.
- Trial name
- NCT00333866
- Testing
- pregabalin
- Where
- 74 sites in Australia, Canada and 14 more
- Volunteers
- 747 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Fibromyalgia
Safety and Efficacy of AGN 203818 for Pain Associated With Fibromyalgia Syndrome
This study will explore the safety and effectiveness of different doses of AGN 203818 in treating the pain associated with fibromyalgia syndrome. The study is being conducted in 2 parts.
- Trial name
- NCT00445705
- Testing
- AGN 203818
- Where
- 3 sites in United States, Switzerland and 1 more
- Volunteers
- 211 people
- Sponsor
- Allergan
Major Depression, Fibromyalgia
A Pilot Study of TMS Effects on Pain and Depression in Patients With Fibromyalgia
In this pilot study, the PI proposes to include 20 African American participants with Fibromyalgia to explore the effect of r TMS on pain and depressive symptoms.
- Trial name
- TMS (NCT00523302)
- Testing
- Active TMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Fibromyalgia
Dextromethorphan in Fibromyalgia
The objective of this protocol is to evaluate if Dextromethorphan (DXM) reduces Fibromyalgia (FM) pain. DXM is a drug found in several over-the-counter products, including cough suppressants.
- Trial name
- NCT03538054
- Testing
- Dextromethorphan
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Alabama at Birmingham
Primary Fibromyalgia
BEdtime Sublingual TNX-102 SL as Fibromyalgia Intervention Therapy (BESTFIT)
TNX-102 capsules [formerly known as very low dose (VLD) cyclobenzaprine] at bedtime have shown promise as a treatment of fibromyalgia, but the drug required new formulation technology for bedtime use.
- Trial name
- BESTFIT (NCT01903265)
- Testing
- TNX-102 SL 2.8mg
- Where
- 17 sites in United States
- Volunteers
- 205 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Fibromyalgia
Virtual Reality and Meditation for Fibromyalgia
Fibromyalgia (FM) is a particularly debilitating rheumatological syndrome which affects millions of adults in the United States.
- Trial name
- NCT05512650
- Testing
- Virtual Reality Meditation, Non-VR Meditation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Tufts University
Myofascial Pain Syndrome
Efficacy of Photobiomodulation Therapy Using 980nm Versus 635nm Diode Lasers for Treatment of Myofascial Pain
This randomized controlled clinical trial aims to evaluate the efficacy of low-level laser therapy (LLLT) using two different diode laser wavelengths (980 nm and 635 nm) in the treatment of myofascial pain associated with…
- Trial name
- LLLTsEMG (NCT07069764)
- Testing
- Doctor smile 635nm For Arm 1, Doctor smile 980 nm For Arm2
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- National Institute of Laser Enhanced Sciences
Temporomandibular Joint Dysfunction Syndrome
Immediate Effect of Ultrasound Therapy on Bilateral Masseter Myalgia: Randomized Single Blinded Investigational Trial
Introduction. Temporomandibular disorders (TMD) are a group of conditions that are multifactorial in nature, and it primarily presents with symptoms of pain and decreased functional capacity.
- Trial name
- NCT02295644
- Testing
- Ultrasound Sonicator 740
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- State University of New York at Buffalo
Primary Fibromyalgia
12-Month Open-Label Long-term Safety Study of TNX-102 SL Tablets in Fibromyalgia Patients
This was an open-label, extension trial designed to evaluate the long-term safety over 12 months of TNX-102 SL tablets taken daily at bedtime for the treatment of fibromyalgia.
- Trial name
- BESTFIT-OLE (NCT02015234)
- Testing
- TNX-102 SL
- Where
- 13 sites in United States
- Volunteers
- 158 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Fibromyalgia, Pain
Cyclobenzaprine Extended Release (ER) for Fibromyalgia
Amrix (Cyclobenzaprine hydrochloride Extended release capsules) is approved by the FDA as a muscle relaxant, indicated for the treatment of muscle spasm associated with acute, painful musculoskeletal conditions.
- Conditions
- Fibromyalgia, Pain, Sleep, Fatigue
- Trial name
- NCT01041495
- Testing
- cyclobenzaprine ER (AMRIX)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- State University of New York - Upstate Medical University
Fibromyalgia
The Clinical Effect of Low-Intensity Electromagnetic Field Neurostimulation in Fibromyalgia Syndrome Patients
The purpose of this study is to determine whether persons treated with a low-intensity, noninvasive form of cortical electrical stimulation experience a reduction in symptoms of fibromyalgia different than persons receiving a…
- Trial name
- NCT01180244
- Testing
- Noninvasive cortical electrical stimulation
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- McLaren Regional Medical Center
Fibromyalgia, Myofascial Pain Syndromes
A Study to Evaluate eFFIcacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With fibRoMyalgia
The use of low-dose CBP dosed nightly at bedtime for FM was supported by the results of Tonix' TNX-CY-F202 Phase 2b study (also referred to as the BESTFIT Study).
- Conditions
- Fibromyalgia, Myofascial Pain Syndromes, Muscular Diseases, Musculoskeletal Diseases
- Trial name
- AFFIRM (NCT02436096)
- Testing
- TNX-102 SL Tablet, 2.8mg
- Where
- 35 sites in United States
- Volunteers
- 519 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Fibromyalgia Syndrome
Assessing Efficacy and Safety of Lacosamide Compared to Placebo in Reducing Signs and Symptoms of Fibromyalgia Syndrome.
This trial investigated the efficacy and safety of 400mg/day of lacosamide as compared to placebo in reducing the signs and symptoms of fibromyalgia syndrome.
- Trial name
- NCT00401830
- Testing
- Lacosamide
- Where
- 25 sites in United States
- Volunteers
- 159 people
- Sponsor
- UCB Pharma
Epilepsy, Neuropathic Pain
Lyrica (Pregabalin) Korean Post Marketing Surveillance Study
This study collects post-marketing safety and efficacy surveillance data in real world clinical use of pregabalin for its approved indications in Korea.
- Conditions
- Epilepsy, Neuropathic Pain, Fibromyalgia, Post-market Surveillance
- Trial name
- NCT01220180
- Testing
- pregabalin (Lyrica)
- Volunteers
- 4,175 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.