Clinical trials: Myometrium; Contractility
Hyponatremia
Hyponatremia and Myometrium Contractility. An Invitro Study
Hyponatremia during labour has been associated with prolonged labour, and increased incidence of instrumental delivery and emergency caesarean section.
- Trial name
- NCT01708811
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska University Hospital
Postpartum Hemorrhage
Spontaneous and Oxytocin-induced Contractility After Exposure to Intravenous Anesthetic Agents: an In-vitro Study in Human Myometrium
Poor uterine tone after the birth of a baby may cause serious bleeding (called postpartum hemorrhage or PPH). This is a major cause of maternal death worldwide. In the developed world the cesarean section rate is increasing.
- Trial name
- NCT03852797
- Testing
- Oxytocin, Ketamine, Propofol
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
Effect of Magnesium Sulphate Pre-exposure on Oxytocin-induced Contractility in Desensitized Human Myometrium - an in Vitro Study
Postpartum hemorrhage (PPH) is the loss of more than 500ml of blood within 24 hours after delivery. It is a major cause of maternal morbidity and mortality across the globe.
- Trial name
- NCT02647268
- Testing
- Oxytocin, Magnesium Sulphate
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Pregnancy Complications
The ADRB3 Receptor in Pregnancy
The primary overall objective of this study is to characterize the levels of and compare levels of the ADRB3 receptor in human non-pregnant myometrium, pregnant myometrium at different time points in pregnancy, in normal and…
- Trial name
- NCT02381106
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Thyrothrophin Receptor in Myometrium Tissue
Detection of Thyrotrophin Receptor in Human Myometrium
It has been recognized for many decades that high thyrotrophin (TSH) levels in pregnant women are associated with poor obstetric outcome.
- Trial name
- NCT01348191
- Testing
- Myometrial biopsy
- Where
- 4 sites in Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Postpartum Hemorrhage (Primary)
Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium
Postpartum hemorrhage (PPH) continues to be an increasing problem globally. Uterotonics play an essential role in the pharmacological management of uterine atony.
- Trial name
- NCT06930391
- Testing
- Oxytocin, Carbetocin, Calcium
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Myometrium; Contractility, GDM
Adipokines Effect in Myometrial Contractility
Investigate the effect of two adipokines which are adiponectin and TNFa on the force of myometrial contractility in diabetic, non-obese pregnant women and obese, non-diabetic term pregnant women at the time of scheduled cesarean…
- Conditions
- Myometrium; Contractility, GDM, Obesity
- Trial name
- NCT03505541
- Testing
- Adiponectin and TNFa
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hypotension
Effects of Ephedrine, Phenylephrine, Norepinephrine and Vasopressin on Contractility of Human Myometrium and Umbilical Vessels: An In-vitro Study
Hypotension is one of the most common adverse effects of spinal anesthesia for cesarean deliveries, affecting as many as 55-90% of mothers.
- Trial name
- NCT04053478
- Testing
- Ephedrine, Phenylephrine, Norepinephrine
- Where
- Canada
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
The Relaxant Effect of Nitroglycerin on Oxytocin Desensitized Human Myometrium
Oxytocin causes myometrial contraction via the oxytocin receptor (OTR). Desensitization of the OTR after exposure to oxytocin has been demonstrated in previous studies.
- Trial name
- NCT03408054
- Testing
- Oxytocin, Nitroglycerin
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
In Vitro Evaluation of Spontaneous and Oxytocin-induced Contractility of Pregnant Human Myometrium During Exposure to Dexmedetomidine
Postpartum hemorrhage (PPH) remains to be one of the leading causes of maternal morbidity and mortality. It has been noted that an increasing number of PPH is attributed to the increased incidence of uterine atony.
- Trial name
- NCT05511415
- Testing
- Oxytocin, Dexmedetomidine
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital