Clinical trials: Myopathies
Myotonic Dystrophy Type 2, Myotonic Dystrophy Type 1
Brain Structure and Clinical Endpoints in Myotonic Dystrophy Type 2
Nearly two-third of patients with myotonic dystrophy type 2 (DM2) report that impaired cognition is among the most disabling symptoms and deeply affects their quality of life.
- Trial name
- BraCE-DM2 (NCT05854433)
- Testing
- Non-interventional study
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pain, Trigger Point Pain, Myofascial
Subthreshold Stimulation Versus Suprathreshold Stimulation in People With Chronic Low Neck Pain
this trial will involve three groups. Group 1 will receive subthreshold stimulation. Group 2 will receive suprathreshold stimulation. Group 3 will receive shame treatment.
- Trial name
- NCT06559358
- Testing
- electrical stimulation
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Strain of Fascia of Intrinsic Muscle of Foot (Disorder), Elastography
Integrated Exercise Therapy Interventions on the Performance and Injury Prevention in Competitive Sports
Football is an increasingly popular exercise and common practice among adolescent and elite athletes. However, these athletes tend to have injuries involving the lower extremity and foot.
- Conditions
- Strain of Fascia of Intrinsic Muscle of Foot (Disorder), Elastography, Muscle Weakness
- Trial name
- NCT04384003
- Testing
- Shear Wave Ultrasound Elastography, The 3-D Motion Analysis, Electromyographic
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
Cleft Palate
Comparison of Different Feeding Appliances for Cleft Palate Babies
This study will compare flexible , rigid feeding plates and a special feeding bottle for children with cleft palate.
- Trial name
- NCT06103162
- Testing
- flexible feeding plate
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University
Abdominal Compartment Syndrome
Abdominal Compartment Syndrome and Ruptured Aortic Aneurysm : Validation of a Predictive Test
It is an observational study on ruptured abdominal aortic aneurysm and abdominal compartment syndrome. the aim of this study is to assess the qualities of a predictive score on the occurence of this syndrome after surgery of…
- Trial name
- SCA-AAR (NCT02859662)
- Testing
- ruptured aortic aneurysm
- Where
- 10 sites in France
- Volunteers
- 165 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Temporomandibular Joint Disorders, Myofascial Pain Syndromes
Post-Isometric Relaxation in Temporomandibular Disorders
This planned randomized, single-blind clinical trial will investigate the effects of adding the Post-Isometric Relaxation (PIR) technique to a standard postural exercise program in individuals with moderate to severe…
- Conditions
- Temporomandibular Joint Disorders, Myofascial Pain Syndromes, Mandibular Dysfunction
- Trial name
- PIR-TMD (NCT07130279)
- Testing
- Postural Exercises + Post-Isometric Relaxation (PIR) Technique, Postural Exercises
- Volunteers
- 40 people
- Sponsor
- Sanem ŞENER
Polymyalgia Rheumatica
Lymphocyte and Cytokine Disturbances in Polymyalgia Rheumatica
Pathophysiology of polymyalgia rheumatica (PMR) is ill defined. This study aims at characterizing immunological abnormalities in PMR patients, and to assess the effects of tocilizumab therapy on this abnormalities.
- Trial name
- TENOR-IMMUNO (NCT02888496)
- Testing
- tocilizumab
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Multiple Sclerosis
Evaluating the Effects of the EXOPULSE Suit on Mobility, Walking Ability, and Balance in People With Multiple Sclerosis
This clinical research study is investigating whether the EXOPULSE Suit, a wearable device that delivers electrical stimulation, can help improve movement difficulties caused by spasticity in adults with multiple sclerosis (MS).
- Trial name
- EXO-MS (NCT07897760)
- Testing
- Electrostimulation suit
- Where
- 2 sites in United States, Germany
- Volunteers
- 100 people
- Sponsor
- Otto Bock Healthcare Products GmbH
LIPIN1 Deficiency
Acute Rhabdomyolysis and Muscle Pain Associated With Mutations in the LPIN1 Gene - A Retrospective Study Describing the Safety and Efficacy of Hydroxychloroquine Sulfate Given on a Compassionate Basis to Patients Suffering From Lipin-1 Deficiency
Lipin-1 deficiencies are responsible for severe rhabdomyolysis and muscle pain in childhood. A specific treatment does not exist.
- Trial name
- LIPIN-1-METAB (NCT04007562)
- Testing
- Hydroxychloroquine Sulfate
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myositis, Myasthenia Gravis
Rituximab for the Treatment of Refractory Inflammatory Myopathies and Refractory Myasthenia Gravis
The traditional treatment of inflammatory myopathies (IM) and generalized myasthenia gravis (MG) is immunosuppressive therapy, usually beginning with corticosteroids.
- Trial name
- FORCE (NCT00774462)
- Testing
- Rituximab
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Muscle Weakness, Metatarsal Fracture
Comparison Different Method Treatment in Tuberosity Fractures of the Proximal Fifth Metatarsal
Fracture of the base of the fifth metatarsal is one of the most common injuries in ankle trauma. There are many conservative treatment protocols for fifth metatarsal base fractures which have up to 99% success.
- Conditions
- Muscle Weakness, Metatarsal Fracture, Healing Fracture of Bone
- Trial name
- NCT04168411
- Testing
- Symptomatic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istanbul University
Chronic Pain, Fibromyalgia
Chronic Pain, Couples, & Physical Activity
Chronic pain affects more than 50 million adults in the United States and is estimated to cost the nation more than $560 billion dollars each year.
- Conditions
- Chronic Pain, Fibromyalgia, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- NCT04077164
- Testing
- No intervention, observational only.
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Illinois Institute of Technology
Psychoeducation, Parents
Psychoeducation Program for Parents of Children with Duchenne Muscular Dystrophy
Having and caring for a child with disabilities brings emotional, social and economic difficulties for many families. Families may experience many physiological and psychological problems due to the stress and anxiety they…
- Conditions
- Psychoeducation, Parents, Psychological Wellness, Duchenne Muscular Dystrophy
- Trial name
- NCT06412328
- Testing
- Psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Lokman Hekim University
Musculoskeletal Pain
Investigation of Popular Recovery Techniques for Ultramarathon Recovery
The study is a randomized clinical trial examining the effectiveness of massage and intermittent pneumatic compression on recovery from a 161-km ultramarathon.
- Trial name
- NCT02530190
- Testing
- intermittent pneumatic compression, massage
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Western States Endurance Run Research Foundation
Delayed Onset Muscle Soreness (DOMS), Inflammation
Effects of Immediate and Delayed Repeated Cold Exposure After Physical Exertion
The goal of this clinical trial is to learn if applying cold therapy can reduce swelling, inflammation, and pain after physical activity in adults who experience muscle soreness (Delayed Onset Muscle Soreness, or DOMS).
- Conditions
- Delayed Onset Muscle Soreness (DOMS), Inflammation, Muscle Pain, Muscle Damage
- Trial name
- NCT06813690
- Testing
- Cold Therapy with Axanova Cold Hot Pearls Maxi Pack
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Cerebral Palsy, Spastic
Effects of Botulinum Toxin Injection Combined with RESWT in Lower Extremity Spasticity in Children with Cerebral Palsy
This study aimed to check and compare the effects of botulinum toxin injection combined with shock wave therapy versus botulinum toxin injection only for lower extremity spasticity in children with cerebral palsy
- Trial name
- NCT06494618
- Testing
- Radial Extracorporeal Shockwave Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul Medeniyet University
Fibromyalgia
Virtual Reality and Meditation for Fibromyalgia
Fibromyalgia (FM) is a particularly debilitating rheumatological syndrome which affects millions of adults in the United States.
- Trial name
- NCT05512650
- Testing
- Virtual Reality Meditation, Non-VR Meditation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Tufts University
Healthy, Musculoskeletal Pain
Pain Modulatory Profiles in Massage for Healthy Participants
One in ten adults experience widespread pain. Neck pain, for example, is a prevalent condition with a high rate of recurrence that affects between 10.4% and 21.3% of the population annually.
- Trial name
- NCT03490474
- Testing
- Pain Inducing Massage, Pain Free Massage, Coldpressor
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Florida
Muscle Weakness
The Effect of GI Biome #7 on Gut Microbiome and Health of the Elderly
This study aims to investigate the effects of probiotics named GI Biome #7 on the gut microbiome and muscle strength in older adults aged 60 years or older.
- Trial name
- NCT05735418
- Testing
- GI Biome #7
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Sjogren-Larsson Syndrome
ADX-629 Therapy for Sjogren-Larsson Syndrome
This research study will determine whether orally administered ADX-629 is safe and has biochemical efficacy in participants with Sjögren-Larsson syndrome (SLS), a rare inherited disorder of fatty aldehyde metabolism The disease…
- Trial name
- NCT05443685
- Testing
- ADX-629
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Nebraska
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