Clinical trials: Myopia; Refractive Error
Myopia
Comparison of Femto LDV Z8 Corneal Lenticule Extraction for Advanced Refractive Correction (CLEAR) and Visumax Small Incision Lenticule Extraction (SMILE)
This observational study aims to compare two laser corrective procedures for treating myopia and myopic astigmatism: a novel refractive technique, the CLEAR procedure, and the established SMILE procedure.
- Trial name
- NCT06774651
- Testing
- Procedure: Corneal lenticule extraction for advanced refractive correction (CLEAR), Procedure: Small Incision Lenticule Extraction (SMILE)
- Where
- Singapore
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Singapore Eye Research Institute
Myopia, Astigmatism
Randomized, Non-inferiority Trial Comparing SMILE and LASIK
Background: Small Incision Lenticule Extraction or SMILE is a novel form of 'flapless' corneal refractive surgery that was adapted from Refractive Lenticule Extraction (ReLEx).
- Conditions
- Myopia, Astigmatism, Hypermetropia
- Trial name
- NCT01216475
- Testing
- Femtosecond LASIK, Small incision lenticule extraction (SMILE)
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Keratitis, Myopia
Safety of Overnight Corneal Reshaping Lenses
This retrospective chart review study compares the incidence of corneal inflammation due to infection in children vs. adult patients wearing overnight corneal reshaping lenses.
- Trial name
- NCT01272271
- Volunteers
- 1,317 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Myopia, Refractive Errors
Peripheral Defocus Profile of Multifocal Minus Contact Lenses
Purpose: Numerous studies have proven that emmetropization in young animals including humans is regulated by visual input. It has long been hypothesized that peripheral myopic defocus may act as a stop signal to reduce myopia…
- Conditions
- Myopia, Refractive Errors, Contact Lens
- Trial name
- NCT06335212
- Testing
- Single vision and multifocal contact lenses
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- State University of New York College of Optometry
Myopia, Refractive Errors
PiXL as a Treatment for Low Grade Myopia
To assess the improvement in myopia with phototherapeutic intrastromal corneal collagen cross-linking (PiXL) without epithelial debridement (epi-on) in high oxygen environment for low grade myopia.
- Trial name
- NCT04663048
- Testing
- PiXL
- Where
- Sweden
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Umeå University
Myopia
Evaluating the Initial Lens Handling Experience of Neophyte Contact Lens Wearers Fitted With Precision1 and 1-Day Acuvue Moist Contact Lenses
The initial subjecting handling experience of neophyte contact lens wearers with Precision1 will be compared to that with a daily disposable lens which mas been on the market for numerous years (1-Day ACUVUE Moist).
- Trial name
- SALUKI (NCT04205162)
- Testing
- Verafilcon A, Etafilcon A
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Myopia Progressing, Myopia
Effect of Branched-Chain Amino Acid Supplementation on Myopia Progression
This study is a randomized controlled trial designed to evaluate whether branched-chain amino acid (BCAA) supplementation can help slow the progression of myopia in young adults.
- Trial name
- NCT07585877
- Testing
- Branched-Chain Amino Acids (BCAA) Supplementation
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Zhongda Hospital
Presbyopia
Investigation of the Presbia Flexivue Microlens™
The Presbia Flexivue Microlens is a corneal inlay.
- Trial name
- NCT02110472
- Testing
- Corneal inlay
- Where
- 11 sites in United States
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- PresbiBio, LLC
Obesity, Myopia
Beijing (Peking)---Myopia and Obesity Comorbidity Intervention (BMOCI)
Based on the RE-AIM framework, this project intends to integrate the prevention and control measures of myopia and obesity, and establish a set of key suitable technical packages and guarantee systems for the…
- Trial name
- NCT05275959
- Testing
- A cluster randomized trial of a comprehensive intervention nesting family and clinic into school centered implementation to reduce myopia and obesity among children and adolescents in Beijing, China
- Where
- 3 sites in China
- Volunteers
- 3,963 people, healthy volunteers welcome
- Sponsor
- Peking University
no Obvious Abnormalities, Diabetic Retinopathy (DR)
Retinal Clinical Assessment With AI-derived Quantitative Information
This randomized controlled trial evaluates whether providing clinicians with AI-derived quantitative retinal information improves the quality and efficiency of retinal clinical assessment.
- Conditions
- no Obvious Abnormalities, Diabetic Retinopathy (DR), AMD, Cup-to-disc Ratio Bigger Than 0.5
- Trial name
- NCT07291960
- Testing
- AI-derived retinal quantitative information-assisted reporting
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Myopia
Myopia Control Efficacy of Second-generation DIMS Spectacle Lenses on Fast Progressing Myopes
The purpose of this study is to examine the efficacy and performance of the variant of Defocus Incorporated Spectacle lenses on controlling myopia progression in fast progressing myopic children.
- Trial name
- NCT05888792
- Testing
- Variant of Defocus Incorporated Spectacle lens (DG2)
- Where
- Hong Kong
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Refractive Errors, Astigmatism
Study of a Hand-held Device Plus Mobile App Versus Standard Eye Care Devices in Measuring Refractive Error of the Eye
Single-center, open-label, prospective study in healthy volunteers desiring refraction for correction of visual acuity to compare a handheld device supported by a mobile application with the phoropter and autorefractor.
- Trial name
- NCT03929588
- Testing
- Hand-held device supported by a mobile application, Phoropter, Autorefractor
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- EyeQue Corp.
Nearsightedness
Effect of Defocus in Soft Contact Lenses on Internal Retinal Vascularization
The purpose of this study is to gain a better understanding of the retinal vascular changes that occur in response to the optical effect of a myopic defocus daily disposable soft contact lens (MDSL) in a group of healthy young…
- Trial name
- NCT06527274
- Testing
- Experimental: Myopic defocus soft lens design (MDSL), Active Comparator: Single vision soft lens design (SVSL
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Myopia
Clinical Study of Approved Contact Lenses
Evaluation of Johnson \& Johnson Acuvue Vita (senofilcon C) soft contact lenses to the Bausch + Lomb Ultra (samfilcon A) soft contact lenses
- Trial name
- NCT03351101
- Testing
- Senofilcon C, Samfilcon A
- Where
- 11 sites in United States
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Myopia, Astigmatism
Wavefront-guided LASIK Surgery Compared to Ray Tracing-Guided LASIK Surgery
We are enrolling participants aged 22 and older to have LASIK surgery in both eyes. We will perform wavefront-guided LASIK in one eye and ray tracing-guided LASIK in the fellow eye of each participant.
- Trial name
- NCT07078799
- Testing
- LASIK
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stanford University
High Myopia
Wuhan High Myopia Study
The study aims to observe the long-term changes of ocular（especially fundus） structure and visual function in patients with high myopia, so as to provide evidence for the prevention, diagnosis and prognosis of high myopia.
- Trial name
- LOVE-WH (NCT06162234)
- Testing
- observational
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
Myopia Progressing
3D Designed Defocus Lenses on Myopia Control in Children and Adolescents
This study aims to evaluate the effectiveness of lenses with 3D Designed Defocus in controlling the progression of myopia in children and adolescents, and to explore the feasibility of effective design, and apply personalized…
- Trial name
- NCT07284147
- Testing
- Defocus Lenses
- Where
- China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Presbyopia
Comparison of a Compound With Pilocarpine and Brimonidine to Improve Near Vision in Healthy Presbyopic Patients
Safety and Efficacy of Pilocarpine, Brimonidine, Oxymetazoline, Hyaluronic acid, Bromfenac (PBOHB) ophthalmic compound compared to Pilocarpine and Brimonidine to improve uncorrected near vision in healthy presbyopic patients one…
- Trial name
- PBOHB (NCT05001243)
- Testing
- Compound Pilocarpine, Brimonidine, Oxymetazoline, Hyaluronic acid, Bromfenac, Pilocarpine Hydrochloride, Brimonidine Tartrate
- Where
- Mexico
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Optall Vision
Myopia, Myopia; Astigmatism
Assessment of IOP After Corneal Refractive Surgery Based on AI
Significance, Background, and Current Status Studies show the global average prevalence of myopia is 22%, with hyperopia incidence being similar.
- Conditions
- Myopia, Myopia; Astigmatism, Refractive Surgery, Intraocular Pressure Changes
- Trial name
- AIOP-CRS-AI (NCT07544615)
- Where
- China
- Volunteers
- 10,030 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Myopia, Small-incision Lenticule Extraction (SMILE) Surgery
Factor Analysis of Unintended Initial Dissection of the Posterior Plane
To explore the potential factors for unintended initial dissection of the posterior plane in a large sample retrospective analysis and surgeons of different levels.
- Trial name
- NCT05367154
- Testing
- Small incision lenticule extraction
- Where
- China
- Volunteers
- 3,003 people, healthy volunteers welcome
- Sponsor
- Yifeng Yu