Clinical trials: NAD
Acute Renal Insufficiency, NAD
Evaluation of the Impact of an Alteration of NAD+ Metabolism on the Renal Prognosis of Patients Admitted to Intensive Care (NI-AKI)
Among all patients admitted to intensive care, it is estimated that more than half of them are exposed during their stay to acute renal failure (ARF).
- Trial name
- NI-AKI (NCT07203131)
- Testing
- Urine sample, Phone call at day 28
- Where
- France
- Volunteers
- 150 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Healthy
The Age-related Changes of Energy Metabolism in Physically Fit Adult Males
The influence of age and physical fitness level on the level of energy metabolism and antioxidant capacity in adult males.
- Trial name
- NCT05113914
- Testing
- Cardio-pulmonary exercise test
- Where
- Poland
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Stage IV Ovarian Cancer, Testis Cancer, Refractory
CLDN6/GPC3/Mesothelin/AXL-CAR-NK Cell Therapy for Advanced Solid Tumors
This study is an open, exploratory clinical study to evaluate the safety and preliminary efficacy of Claudin6, GPC3, Mesothelin, or AXL targeting CAR-NK cells in patients with Claudin6, GPC3, Mesothelin, or AXL-positive advanced…
- Conditions
- Stage IV Ovarian Cancer, Testis Cancer, Refractory, Endometrial Cancer Recurrent, CAR NK
- Trial name
- NCT05410717
- Testing
- Claudin6, GPC3, Mesothelin, or AXL targeting CAR-NK cells
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Sudden Sensorineural Hearing Loss
Small Sample，Unicentric，Randomized, Controlled Clinical Study of Coenzyme I for Injection in the Treatment of Sudden Sensorineural Hearing Loss
Sudden sensorineural hearing loss is one of the most common emergencies in otorhinolaryngology, and its incidence is increasing year by year and tends to be younger.
- Trial name
- NCT05849519
- Testing
- Coenzyme I for Injection + conventional treatment, Conventional treatment
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Idiopathic Pulmonary Fibrosis
GKT137831 in IPF Patients With Idiopathic Pulmonary Fibrosis
A placebo-controlled, multicenter, randomized trial to test GKT137831 in ambulatory patients with idiopathic pulmonary fibrosis.
- Trial name
- GKT137831 (NCT03865927)
- Testing
- GKT137831
- Where
- 4 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of Alabama at Birmingham
Enhance Immune Function
The Exploratory Study on the Nicotinamide Mononucleotide (Vital NAD ) to Promote the Rejuvenation of the Peripheral Blood Immune Cells of Adults.
The purpose of this study is to investigate the changes in adult peripheral blood immune cell subpopulations, subpopulations, and cell functional status before and after intervention with Nicotinamide Mononucleotide (Vital NAD )…
- Trial name
- NCT05984550
- Testing
- NMN
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Shanghai Cell Therapy Group Co.,Ltd
Parkinson Disease
A Randomized Controlled Trial of Nicotinamide Riboside Supplementation in Early Parkinson's Disease
NOPARK is a double-blinded randomized controlled phase II trial, with the aim to assess the efficacy of nicotinamide adenine dinucleotide (NAD)-replenishment therapy in the form of oral nicotinamide riboside (NR) in delaying the…
- Trial name
- NOPARK (NCT03568968)
- Testing
- Nicotinamide Riboside
- Where
- 11 sites in Norway
- Volunteers
- 410 people
- Sponsor
- Haukeland University Hospital
Acute Kidney Injury (AKI)
Mitochondrial Health and Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients
Renal replacement therapy is a life-saving treatment for patients who have sudden and severe kidney failure. However, some of these patients blood pressure who receive this treatment could become unstable, thus resulting in more…
- Trial name
- MitoHIRRT (NCT05264285)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Circadian Rhythm
Effect of Circadian Rhythm on Brain NAD Measured by Phosphorus Magnetic Resonance Spectroscopy at 7 Tesla
The Discovery of the circadian clock first established a genetic basis for behavior, and our understanding of circadian rhythm (CIR) has since expanded to provide molecular insights into physiology and disease.
- Trial name
- ChronoBrain (NCT05093088)
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Concussion, Mild
Use of 31P MRS to Assess Brain NAD+ in Healthy Current and Former Collegiate Athletes
Can nicotinamide riboside (750 mg/day for 12 weeks) affect the levels of NAD+ in the brain as measured by 31P MRS?
- Trial name
- TRMC-004 (NCT02721537)
- Testing
- Nicotinamide Riboside
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Alzheimer's Disease (Incl Subtypes), Dementia
Sirtuin-NAD Activator in Alzheimer's Disease
The primary objectives are to: 1. To determine whether MIB-626, after its daily oral administration, penetrates the blood-brain barrier in humans by measuring the cerebrospinal fluid (CSF) concentrations of MIB-626 and its key…
- Trial name
- NCT05040321
- Testing
- MIB-626
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Brigham and Women's Hospital
Amyotrophic Lateral Sclerosis
31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis (REPAIR-ALS)
REPAIR-ALS is a single-center open label pilot, sequential group, investigator and patient blinded study to assess the CNS metabolic effects, safety, pharmacokinetics, and pharmacodynamics of CNM-Au8 in patients who have been…
- Trial name
- REPAIR-ALS (NCT03843710)
- Testing
- Gold Nanocrystals
- Where
- United States
- Sponsor
- Clene Nanomedicine
Systemic Lupus Erythematosus (Sle)
Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus
Study Description: Systemic lupus erythematosus (SLE) occurs predominantly in women and is driven by type I interferon dysregulation and neutrophil hyperresponsiveness.
- Trial name
- NCT06032923
- Testing
- Nicotinamide Riboside
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
NAD, NAD+ Levels in the Blood
Comparison of Three Qualia NAD⁺ Formulations on Intracellular NAD⁺ Levels
This is a double-blind, placebo-controlled, parallel-group study evaluating the effects of three distinct Qualia NAD⁺ formulations on intracellular NAD⁺ levels in healthy adults aged 35-75 years.
- Trial name
- NCT07132801
- Testing
- Qualia NAD⁺ version 1, Qualia NAD⁺ version 2, Qualia NAD⁺ version 3
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Qualia Life Sciences
Acute Kidney Injury
NAD Supplementation to Reduce the Incidence of Cardiac Surgery Associated Acute Kidney Injury
The purpose of this single-center, randomized, double-blinded placebo-controlled pilot trial is to demonstrate feasibility and help design a larger trial to assess the effectiveness of nicotinamide (NAM) supplementation in…
- Trial name
- NCT07739290
- Testing
- Nicotinamide (NAM)
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Immune Thrombocytopenia, Treatment
A Clinical Study of NAD in the Treatment of Immune Thrombocytopenia
To evaluate the safety and efficacy of nicotinamide adenine dinucleotide in the treatment of immune thrombocytopenia in patients who have not responded adequately or relapsed after first-line treatment and at least one…
- Trial name
- NCT06776510
- Testing
- nicotinamide adenine dinucleotid/nicotinamide mononucleotide
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
NAD
Nicotinamide Riboside Impact on Extracellular Nicotinamide Adenine Dinucleotide (NAD+)
The investigation is a clinical study in which the impact of taking the dietary supplement nicotinamide riboside (NR) on the concentration of extracellular nicotinamide adenine dinucleotide (eNAD+) in human plasma over time will…
- Trial name
- NICE (NCT06005350)
- Testing
- Niagen
- Where
- Germany
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Glaucoma
Comparisons of NAD Precursors for Neuroenhancement in Glaucoma Patients
The goal of this clinical trial is to determine whether oral supplementation with different nicotinamide adenine dinucleotide (NAD) precursors can improve visual function in adults with primary open-angle glaucoma.
- Trial name
- NCT06991712
- Testing
- Nicotinamide Riboside, Nicotinamide, Nicotinamide Mononucleotide
- Where
- Hong Kong
- Volunteers
- 138 people
- Sponsor
- Christopher Kai Shun Leung
Metabolic Syndrome, Premature Aging
The Safety and Efficacy Study of RiaGev in Healthy Adults
This current randomized, double-blind, comparator-controlled, cross over study investigates the efficacy and safety of RiaGev™ via evaluation of NAD+, ATP, glucose, insulin, glutathione, and cortisol levels in healthy adults of…
- Trial name
- NCT04483011
- Testing
- RiaGev
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bioenergy Life Science, Inc.
Heart Failure
The Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects
Background: People are living longer and are more likely to survive a heart attack if they have one. Longer life expectancy is good but it also means more people get chronic heart failure over time.
- Trial name
- NCT03565328
- Testing
- Nicotinamide Riboside
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)