Clinical trials: NAD, open to volunteers
NAD+ Metabolism, Pharmacokinetics
Effects of Trigonelline Monohydrate on NAD+ Metabolism, Pharmacokinetics, Safety, and Tolerability in Healthy Adults
This Phase 1 study is designed to evaluate the pharmacokinetic, pharmacodynamic, bioavailability, safety, and tolerability effects of trigonelline monohydrate in generally healthy adults aged 40 to 70 years.
- Conditions
- NAD+ Metabolism, Pharmacokinetics, Bioavailability, Healthy Adults
- Trial name
- NCT07880925
- Testing
- Nicotinamide Mononucleotide (NMN), Trigonelline Monohydrate
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Cardiac Dysfunction
PEDIatric Cardiac Dysfunction Treated With Injectable Nicotinamide Adenine Dinucleotide
Brief Summary This study is a multicenter, randomized, double-blind, placebo-controlled trial designed to evaluate whether an injectable form of Coenzyme I (also known as nicotinamide adenine dinucleotide, or NAD⁺) is safe and…
- Trial name
- PEDI-NAD (NCT07839130)
- Testing
- Nicotinamide Adenine Dinucleotide
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Beijing Children's Hospital
Pulmonary Hypertension
Mechanistic Study of Nicotinamide Riboside on NAD+ Biology in Individuals With Combined Pulmonary Hypertension
Pulmonary hypertension (PH) is a serious condition that puts strain on the heart and lungs and often leads to frequent hospital stays and shortened life expectancy.
- Trial name
- NCT07563322
- Testing
- Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Glaucoma, Open-angle, Primary Open Angle Glaucoma (POAG)
Nicotinamide for Retinal Protection in Primary Open-Angle Glaucoma (NADIR Trial)
The goal of this clinical trial is to learn whether a high-dose vitamin B3 supplement called nicotinamide can protect retinal nerve cells in adults with primary open-angle glaucoma (POAG) who are already receiving standard…
- Trial name
- NADIR (NCT07808333)
- Testing
- Nicotinamide, Standard Glaucoma Therapy
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Chicago
Healthy Adults
Validation of NAD+ Measurements for Human Clinical Studies
The purpose of this study is to determine nicotinamide adenine dinucleotide (NAD) levels in healthy adult subjects before and after supplementing with over-the counter nicotinamide riboside (NR) using magnetic resonance…
- Trial name
- NCT07416786
- Testing
- Oral NR Supplementation
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Type2diabetes, Diabetic Kidney Disease
NAD Augmentation in Diabetes Kidney Disease
A phase 2a trial randomized, double-blind, placebo-controlled, parallel group trial to determine whether NMN administration improves DKD, as indicated by a significantly greater reduction in UACR compared with placebo…
- Trial name
- DKD (NCT05759468)
- Testing
- Investigational Product - MIB 626
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Brigham and Women's Hospital
Stage IV Ovarian Cancer, Testis Cancer, Refractory
CLDN6/GPC3/Mesothelin/AXL-CAR-NK Cell Therapy for Advanced Solid Tumors
This study is an open, exploratory clinical study to evaluate the safety and preliminary efficacy of Claudin6, GPC3, Mesothelin, or AXL targeting CAR-NK cells in patients with Claudin6, GPC3, Mesothelin, or AXL-positive advanced…
- Conditions
- Stage IV Ovarian Cancer, Testis Cancer, Refractory, Endometrial Cancer Recurrent, CAR NK
- Trial name
- NCT05410717
- Testing
- Claudin6, GPC3, Mesothelin, or AXL targeting CAR-NK cells
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Healthy Adults
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors
We are doing this research to learn how healthy younger and older adults use two forms of vitamin B3-called nicotinamide mononucleotide (NMN) and nicotinamide (NAM)-to make NAD+.
- Trial name
- NCT06882096
- Testing
- Nicotinamide Mononucleotide (NMN), Nicotinamide (NAM)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Metro International Biotech, LLC
Systemic Lupus Erythematosus (Sle)
Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus
Study Description: Systemic lupus erythematosus (SLE) occurs predominantly in women and is driven by type I interferon dysregulation and neutrophil hyperresponsiveness.
- Trial name
- NCT06032923
- Testing
- Nicotinamide Riboside
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Progressive Supranuclear Palsy, Multiple System Atrophy
The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism
Progressive supranuclear palsy (PSP), Multiple system atrophy (MSA) and corticobasal syndrome (CBS) are severe neurodegenerative diseases with rapid progression and no effective treatment.
- Conditions
- Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Syndrome
- Trial name
- NADAPT (NCT06162013)
- Testing
- Nicotinamide Riboside
- Where
- 3 sites in Norway
- Volunteers
- 330 people
- Sponsor
- Haukeland University Hospital
Down Syndrome (DS)
NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome
The aim of the study is to determine the safety and tolerability of different increasing doses of MIB-626 (a microcrystalline form of β nicotinamide mononucleotide; NMN) given daily for 28 consecutive days to adults with Down…
- Trial name
- NCT07278492
- Testing
- MIB-626
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Brigham and Women's Hospital
Immune Thrombocytopenia, Treatment
A Clinical Study of NAD in the Treatment of Immune Thrombocytopenia
To evaluate the safety and efficacy of nicotinamide adenine dinucleotide in the treatment of immune thrombocytopenia in patients who have not responded adequately or relapsed after first-line treatment and at least one…
- Trial name
- NCT06776510
- Testing
- nicotinamide adenine dinucleotid/nicotinamide mononucleotide
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Obesity, Abdominal
Nicotinamide Adenine Dinucleotide (NAD+) Metabolism in Human Brown Adipose Tissue
A fully functional brown fat helps maintain a healthy weight and decreases the risk of metabolic diseases such as type II diabetes (T2DM).
- Trial name
- BATNAD (NCT06627868)
- Testing
- NAD+ precursor
- Where
- Finland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Turku
Skin Aging on Face, Skin Care Dermocosmetics
Efficacy of Topical Niacinamide Riboside on the Signs of Facial Skin Aging
Niacinamide riboside (topical NR, also known as nicotinamide riboside) is an endogenous compound and a precursor (building block) to the essential cellular co-enzyme, nicotinamide adenine dinucleotide (NAD+).
- Conditions
- Skin Aging on Face, Skin Care Dermocosmetics, Skin Care, Fine Lines and Wrinkles
- Trial name
- NR-RADIANCE (NCT07774000)
- Testing
- Topical niacinamide riboside
- Where
- South Africa
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- ChromaDex, Inc.
Sleep
NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals
The purpose of this study is to evalue the effects of nicotinamide adenine dinucleotide (NAD) supplementation (nicotinamide riboside (NR) form) on sleep in healthy adults compared to a placebo.
- Trial name
- NADream (NCT06971224)
- Testing
- Nicotinamide Riboside (NR)
- Where
- Norway
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Heat Strain, Healthy Volunteer Study
The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers.
- Conditions
- Heat Strain, Healthy Volunteer Study, Kidney Dysfunction
- Trial name
- NCT06983730
- Testing
- Vitamin B3
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Frailty, Frail Elderly Syndrome
The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging
This clinical study, designed as a double-blind, randomized, placebo-controlled trial, aims to investigate the potential of nicotinamide riboside (NR) to decelerate functional decline in the elderly frail population.
- Conditions
- Frailty, Frail Elderly Syndrome, Frailty Syndrome, Aging
- Trial name
- NADage (NCT06208527)
- Testing
- Nicotinamide Riboside (NR)
- Where
- 2 sites in Norway
- Volunteers
- 100 people
- Sponsor
- Haukeland University Hospital
Healthy Aging, Lifestyle-related Condition
Nicotinamide Riboside Supplementation and Exercise Training to Promote Healthy Longevity
The prevalence of age-related chronic diseases (like obesity, type 2 diabetes and cardiovascular diseases) is mounting worldwide, reaching pandemic proportions.
- Conditions
- Healthy Aging, Lifestyle-related Condition, Metabolic Diseases
- Trial name
- RESTORENAD (NCT06425042)
- Testing
- Nicotinamide Riboside (NR)
- Where
- Chile
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Finis Terrae University
Acute Renal Insufficiency, NAD
Evaluation of the Impact of an Alteration of NAD+ Metabolism on the Renal Prognosis of Patients Admitted to Intensive Care (NI-AKI)
Among all patients admitted to intensive care, it is estimated that more than half of them are exposed during their stay to acute renal failure (ARF).
- Trial name
- NI-AKI (NCT07203131)
- Testing
- Urine sample, Phone call at day 28
- Where
- France
- Volunteers
- 150 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Healthy Aging
Absorption and Tolerability of Injectable Administration of Niagen®+, as Compared to NAD+
This study evaluates the subjective effects of injection administration of NR on healthy adult populations.
- Trial name
- NCT06919328
- Testing
- Niagen®, NAD+
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Nutraceuticals Research Institute