Clinical trials: NAS
Neonatal Abstinence Syndrome
Clonidine Versus Phenobarbital as Adjunctive Therapy for Neonatal Abstinence Syndrome
The purpose of this study is to compare clonidine versus phenobarbital as adjunctive therapy in those infants who have failed monotherapy with morphine sulfate for neonatal abstinence syndrome (NAS).
- Trial name
- NCT03670160
- Testing
- Phenobarbital, Clonidine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Tennessee Medical Center
Hepatitis B
A Study of GC1102(Recombinant Hepatitis B Immunoglobulin) in Chronic Hepatitis B Patients
The purpose of this study is to evaluate the efficacy and safety of GC1102 in combination of Nucleo(t)ide analogues (NAs) in patients with chronic hepatitis B
- Trial name
- NCT03801798
- Testing
- GC1102
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Green Cross Corporation
Postnatal Adaptation and Stress in Healthy Newborns Born by Cesarean Section
Effect of Amniotic Fluid Odor on Newborn Adaptation and Stress (AFO-NAS)
This study aims to determine whether exposure to the odor of a newborn's own amniotic fluid affects postnatal adaptation and stress in healthy newborns born by cesarean section.
- Trial name
- AFO-NAS (NCT07736235)
- Testing
- Amniotic Fluid Odor Sterile Distilled Water Odor
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Drug; Withdrawal Symptoms, Neonatal, Withdrawal
Sublingual Buprenorphine Treatment for Neonatal Abstinence Syndrome - Pilot Study
Summary: There have been two published RCTs showing efficacy of buprenorphine treatment for NAS. However these trials excluded an estimated 22-47% of infants requiring pharmacologic treatment; those infants born to mothers with…
- Conditions
- Drug; Withdrawal Symptoms, Neonatal, Withdrawal, Fetus and Newborn Affected by Other Maternal Medication
- Trial name
- NCT02249026
- Testing
- BZDs + opiate exposure treated with BPN, Opiates exposure treated with BPN
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Gauda, Estelle B., M.D.
Neonatal Abstinence Syndrome
Treatment of Neonatal Abstinence Syndrome
This study compares treatment of Neonatal Abstinence Syndrome (NAS) with two different drugs for the difference in the length of treatment.
- Trial name
- HOMENOW (NCT01723722)
- Testing
- Methadone, Diluted Deodorized Tincture of Opium
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Eastern Maine Medical Center
Substance Addiction
Maternal Acupuncture for Substance Abuse
To determine the efficacy of daily maternal acupuncture treatments in reducing the frequency and severity of neonatal abstinence syndrome among infants born to substance-using women..
- Trial name
- NCT00225316
- Testing
- Acupuncture
- Where
- Canada
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Neonatal Abstinence Syndrome
Clonidine to Treat Iatrogenic-induced Opioid Dependence in Infants
Thousands of critically ill infants (and children) are exposed to opioids and benzodiazepines to achieve sedation and analgesia as part of routine care in neonatal and pediatric intensive care units.
- Trial name
- NCT01360450
- Testing
- Clonidine HCL, saline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Neonatal Abstinence Syndrome
Assessing the Effects of Auricular Acupressure on Newborns With NAS
This study will determine the feasibility of using auricular acupressure as an intervention in newborns with neonatal abstinence syndrome(NAS).
- Trial name
- NCT03890562
- Testing
- Auricular acupressure
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Neonatal Abstinence Syndrome, Vagal Tone
Vagal Tone and Neonatal Abstinence Syndrome
Symptoms of Neonatal Abstinence Syndrome (NAS) can be attributed largely to dysfunction of the autonomic nervous system in opiate exposed neonates.
- Trial name
- NAS (NCT00496951)
- Testing
- Vagal tone assessment
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Johns Hopkins University
Neonatal Opioid Withdrawal Syndrome, Neonatal Abstinence Syndrome
MicroRNA Biomarkers for Neonatal Opioid Withdrawal Syndrome
Infants with neonatal abstinence syndrome (NAS) experience prolonged hospital stays and poor neurodevelopmental outcomes, in-part because of the lack of accurate, individualized, biologic assessments available to manage this…
- Trial name
- NCT05937594
- Testing
- Buccal swab saliva for further genetic testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Milton S. Hershey Medical Center
Neonatal Abstinence Syndrome
Methadone Demonstration Project With Neonatal Intensive Care Unit Infants Diagnosed With Neonatal Abstinence Syndrome
This is a non-randomized, un-blinded feasibility study project comparing the Length of Stay (LOS) of Neonatal Intensive Care Unit (NICU) infants diagnosed with Neonatal Abstinence Syndrome (NAS) treated with methadone with…
- Trial name
- NCT03134703
- Testing
- Methadone, Morphine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Johns Hopkins All Children's Hospital
Neonatal Abstinence Syndrome
The Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome
The chronic use of opiate medications during pregnancy is a major public health challenge. Prolonged exposure to opiates in utero may result in withdrawal symptoms in infants commonly referred to as neonatal abstinence syndrome…
- Trial name
- NCT01754324
- Testing
- Methadone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Nurse's Role
Nursing Activity Score (Nursing Activities Score-NAS) Verification of Turkish Version
Various tools for measuring nursing workload have been described in the national and international literature. For this purpose, Cullen et al. The Therapeutic Intervention Scoring System (TISS)-28, created by Miranda et al.
- Trial name
- NCT06206889
- Testing
- NAS
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Samsun University
Neonatal Abstinence Syndrome
Buprenorphine for the Treatment of Neonatal Abstinence Syndrome
Neonatal abstinence syndrome is a disease that affects children who were exposed to opioid drugs prior to birth. Commonly used treatments at present include morphine or tincture of opium.
- Trial name
- NCT00521248
- Testing
- buprenorphine, Oral morphine solution
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Thomas Jefferson University
Chronic Hepatitis B
A Multicenter Study of AHB-137 Injection Combined With Other Hepatitis B Drugs
This is a randomized, open-label, multicenter phase II study to evaluate the efficacy and safety of AHB-137 injection in combination with other hepatitis B drugs in participants with HBeAg-negative CHB treated with NAs.
- Trial name
- NCT07069569
- Testing
- AHB-137, Peg-IFN, Hepatitis B Vaccine
- Where
- 14 sites in China
- Volunteers
- 200 people
- Sponsor
- Ausper Biopharma Co., Ltd.
Neonatal Opioid Withdrawal Syndrome
Randomized Control Trial of Buprenorphine vs. Morphine for the Treatment of Neonatal Opioid Withdrawal Syndrome (NOWS)
This randomized control trial will compare buprenorphine and morphine, two currently used medications for the treatment of neonatal opioid withdrawal syndrome (NOWS), in newborns to determine which medication will reduce the…
- Trial name
- NCT04455802
- Where
- United States
- Sponsor
- Women and Infants Hospital of Rhode Island
Neonatal Abstinence Syndrome
Comparison Between Methadone and Morphine for Neonatal Opiate Withdrawal
Hypothesis is that the effectiveness of opiate treatment with morphine will result in shorter duration of opiate medication treatment and fewer infants treated with a second drug.
- Trial name
- NAS (NCT01804075)
- Testing
- Methadone, Morphine
- Volunteers
- 31 people
- Sponsor
- Eastern Maine Medical Center
Opiate Dependence, Pregnancy
The Effects of Methadone and Buprenorphine on Fetal Neurobehavior and Infant Neonatal Abstinence Syndrome - 1
The purpose of this study is to evaluate the effects of drugs used by treatment providers on the fetuses and infants of opiate dependent women.
- Trial name
- NCT00218621
- Testing
- Buprenorphine / methadone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Stroke, Acute
Optimized C-arm Cone Beam CT for the Endovascular Treatment (EVT) of Acute Stroke
When it comes to acute stroke, everyone deserves the best care. Today, more patients can benefit from endovascular treatment (EVT) in a comprehensive stroke center.
- Trial name
- ASO-AVC (NCT04774510)
- Testing
- Diagnostic Test: optimized C-Arm Cone Beam Computed Tomography
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neonatal Abstinence Syndrome
NAS Treatment - Opiate Versus Non-Opiate
The purpose of this study is to compare two different medicines to treat babies with opiate withdrawal. The treatment medicines are morphine, which is an opiate, and clonidine, a non-opiate.
- Trial name
- NAS (NCT01734551)
- Testing
- Morphine, Clonidine
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Henrietta Bada