Clinical trials: NAT2 Genotype
Tuberculosis, Hepatotoxicity
NAT2 in Re-challenge of INH in Patients With Hepatitis
Apply the information of NAT2 genotyping into the re-challenge protocol of INH titration in patients with anti-TB medication induced hepatitis.
- Trial name
- NCT00728546
- Testing
- Isoniazid (Rifinah)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Hepatotoxicity
NAT2 Genotyping in Re-challenge Protocol of INH Titration in Patients With Anti-TB Medications-induced Hepatitis
To improve the treatment outcome in patients with tuberculosis and integrate the pharmacogenetics into clinical practice, the information of NAT2 genotyping was used in re-challenge protocol for isoniazid (INH) titration in…
- Trial name
- NCT02076685
- Testing
- isoniazid
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
NAT2 Genotype
Isoniazid Dosage Prediction Model Development
Isoniazid (INH) is an essential component of first-line anti-tuberculosis (TB) treatment. However, treatment with INH is complicated by polymorphisms in the expression of the enzyme system primarily responsible for its…
- Trial name
- NCT02747654
- Testing
- genotype
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Tuberculous Meningitis
Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis
The genetically polymorphic N-acetyltransferase type 2 (NAT2) is responsible for isoniazid metabolism, and rapid acetylators were associated with low concentrations of isoniazid based on previous studies.
- Trial name
- NCT03787940
- Testing
- Isoniazid
- Where
- 4 sites in China
- Volunteers
- 676 people
- Sponsor
- Beijing Chest Hospital
Pulmonary Tuberculosis
Isoniazid Dose Adjustment According to NAT2 Genotype (IDANAT2)
The study is conducted to compare safety and efficacy of isoniazid administered as an adjusted dose based on NAT2 (arylamine N-acetyltransferase type 2)genotype and as a standard dose.
- Trial name
- NCT00571753
- Testing
- isoniazid
- Where
- 12 sites in Bulgaria, Germany and 1 more
- Volunteers
- 900 people
- Sponsor
- University of Cologne