Clinical trials: NERVES
Melanoma (Skin)
Biological Therapy in Treating Patients With Metastatic Melanoma
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. PURPOSE: Phase I/II trial to study the effectiveness of biological therapy in treating patients who have…
- Trial name
- NCT00002786
- Testing
- aldesleukin, therapeutic tumor infiltrating lymphocytes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Fred Hutchinson Cancer Center
Neuroendocrine Tumours
Efficacy and Safety of Lanreotide Autogel in Tumour Stabilization of Patients With Progressive Neuroendocrine Tumours
To evaluate, in patients with progressive neuroendocrine tumours who are not eligible to be treated with either surgery or chemotherapy at the moment of study inclusion, the efficacy of lanreotide Autogel in tumour growth…
- Trial name
- NCT00326469
- Testing
- lanreotide (Autogel formulation)
- Where
- 27 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Ipsen
Melanoma Stage III or IV
Dendritic Cell Vaccination in Melanoma Patients Scheduled for Regional Lymph Node Dissection
Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. As such they are currently used in clinical vaccination protocols in cancer patients, and both immunological and clinical responses have…
- Trial name
- NCT00243594
- Testing
- Peptide-pulsed dendritic cells
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Immunotherapy
Treatment of Metastatic Melanoma With Autologous Melan-A/MART-1 Specific CTL Clones
Most of HLA-A2 melanomas express Melan-A/MART-1 antigen and are recognized by tumor reactive Melan-A specific T lymphocytes. By using blood samples from HLA-A2 melanoma patients (stage III and IV), our goal is to produce a tumor…
- Trial name
- NCT00720031
- Testing
- autologous Melan-A/MART-1 specific CTL clones
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Nantes University Hospital
Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Study of Tumor Samples From Patients With Ewing Sarcoma
This laboratory study is looking at tumor samples from patients with Ewing sarcoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and…
- Trial name
- NCT00898053
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Oncology Group
Pain, Postoperative, Lung Cancer
Postoperative Pain Control With Lipossomic Extended Release Bupivacaine
Randomized trial of intraoperative intercostal block with bupivacaine with epinephrine compared to lipossomal extended release bupivacaine.
- Trial name
- NCT03560362
- Testing
- Bupivacaine liposome, Bupivacaine / Epinephrine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Tennessee
Glioblastoma, Recurrent Glioblastoma
Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma
This phase I trial studies the side effects and best dose of adavosertib when given together with radiation therapy and temozolomide in treating patients with glioblastoma that is newly diagnosed or has come back.
- Trial name
- NCT01849146
- Testing
- Adavosertib, Radiation Therapy, Temozolomide
- Where
- 12 sites in United States
- Volunteers
- 74 people
- Sponsor
- National Cancer Institute (NCI)
Melanoma (Skin)
Patient-led Surveillance Compared to Clinician-led Surveillance in People Treated for Localised Melanoma.
The purpose of this pilot study is to evaluate digitally supported skin self-examination compared to usual care in people treated for localised melanoma.
- Trial name
- MEL-SELF (NCT03581188)
- Testing
- Patient-led surveillance, Clinician-led surveillance
- Where
- 3 sites in Australia
- Volunteers
- 100 people
- Sponsor
- University of Sydney
Chronic Dizziness, Persistent Postural Perceptual Dizziness
A Study Of Auricular Transcutaneous Vagus Nerve Stimulation In Chronic Dizziness
The purpose of this study is to measure the change in dizziness, as measured by change in Dizziness Handicap Inventory (DHI) score, following a 4-week treatment period with auricular transcutaneous vagus nerve stimulation (aTVNS).
- Trial name
- NCT07420803
- Testing
- Auricular transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Metastatic Uveal Melanoma, Metastatic Cutaneous Melanoma
Hepatic Arterial Infusion of Autologous Tumor Infiltrating Lymphocytes in Patients With Melanoma and Liver Metastases
The purpose of this study is to evaluate the feasibility, safety and tolerability of treatment with autologous tumor infiltrating lymphocytes (TIL) administered via hepatic arterial infusion in patients with liver metastases…
- Trial name
- HAITILS (NCT04812470)
- Testing
- Autologous Tumor Infiltrating Lymphocytes, Melphalan, Interleukin-2
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Vastra Gotaland Region
Glaucoma, Electrical Stimulation
Treatment of Patients With Optic Nerve Damage Patients Using Electrostimulation
The aim of the present study is to investigate the possibilities of visual field enhancement with electrical stimulation (ES) as a home stimulation method, in a total of 50 patients with optical neuropathy, who have already been…
- Conditions
- Glaucoma, Electrical Stimulation, Home Treatment
- Trial name
- HomeStim (NCT04010994)
- Testing
- Transorbital electrical stimulation
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Magdeburg
Melanoma
A Phase II Study of Pegylated Interferon Alfa-2b for the Adjuvant Treatment of Melanoma Subjects in Russia (MK-4031-400)
This study will assess the safety of Pegylated Interferon Alfa-2b (PEG-IFN) as an adjuvant treatment for melanoma.
- Trial name
- NCT02155322
- Testing
- Pegylated Interferon Alfa-2b
- Volunteers
- 33 people
- Sponsor
- Merck Sharp & Dohme LLC
Meningioma, Artificial Intelligence
Automated Segmentation and Volumetry for Meningioma Using Deep Learning
U-Net-based architectures will be applied to 500 contrast-enhanced axial MR images of different patients from a single institution after manual segmentation of meningioma, of which 50 were used for testing.
- Trial name
- NCT05093751
- Testing
- Observation
- Volunteers
- 600 people
- Sponsor
- Seoul National University Hospital
Skin Cancer
DermaSensor Study of Primary Care Physician Use of Elastic-Scattering Spectroscopy (ESS) on Skin Lesions Suggestive of Skin Cancer
The purpose of this study is to evaluate the clinical validity of the proprietary DermaSensor Elastic Scattering Spectroscopy (ESS) device and classifier algorithm to support assessment of skin lesions suggestive of melanoma…
- Trial name
- DERM-SUCCESS (NCT06690086)
- Testing
- Lesion biopsy, DermaSensor Device Use
- Where
- United States
- Volunteers
- 1,028 people
- Sponsor
- DermaSensor, Inc.
Healthy
The Effects of Hamstring Stretching With and Without Neural Load on Flexibility, Maximum Isometric Strength and Tibial Nerve Pressure Pain Threshold
The study will be carried out at the Faculty of Nursing and Physiotherapy of the University of Alcala. The study has been approved by the Animal Research and Experimentation Ethics Committee of the University of Alcalá.
- Trial name
- NCT05344586
- Testing
- Hamstring stretching program with neural load, Hamstring stretching program without neural load
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Jaén
Neuroendocrine Tumors
Biomarker Identification of Radionuclide Therapy-induced Radiation Responses
Peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-[Tyr3]octreotate (177Lu-DOTATATE) is a form of internal radiation treatment for patients with neuroendocrine tumors (NET) to reduce tumor growth and stabilize…
- Trial name
- Radio-Marker (NCT05513469)
- Testing
- Lutathera
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Erasmus Medical Center
Glioblastoma, Medulloblastoma
Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG
Indoximod was developed to inhibit the IDO (indoleamine 2,3-dioxygenase) enzymatic pathway, which is important in the natural regulation of immune responses.
- Conditions
- Glioblastoma, Medulloblastoma, Ependymoma, Diffuse Intrinsic Pontine Glioma
- Trial name
- NCT04049669
- Testing
- Indoximod, Partial Radiation, Full-dose Radiation
- Where
- 5 sites in United States
- Volunteers
- 130 people
- Sponsor
- Theodore S. Johnson
Malignant Glioma, Neoplasms
Antisense102: Pilot Immunotherapy for Newly Diagnosed Malignant Glioma
This human Phase 1 trial is a continuation of a Phase 1 trial which enrolled patients with recurrent gliomas (#TJU-14379-101) and which was designed after a previously conducted Phase 1 human trial at our institution.
- Trial name
- NCT02507583
- Testing
- IGF-1R/AS ODN; Surgery with tissue harvest and implantation 20 diffusion chambers in the rectus sheath with IGF-1R/AS ODN within 24 hours of craniotomy, implanted for 48 hours.
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- david andrews
Bell's Palsy
Mirror Therapy vs Mime Therapy in Bell's Palsy
This randomized controlled trial aims to compare the effectiveness of mirror book therapy and mime therapy in patients with Bell's palsy.
- Trial name
- NCT07716683
- Testing
- Mirror Book Therapy, Mime Therapy
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- University of Lahore
Cutaneous Melanoma, Stage III, Cutaneous Melanoma, Stage IV
pDNA Intralesional Cancer Vaccine for Cutaneous Melanoma
Six patients will receive IFx-Hu2.0 on an outpatient basis at a single time point in a single lesion, two lesions, or three lesions, as a monotherapy (a maximum of three lesions could be injected).
- Trial name
- NCT03655756
- Testing
- IFx-Hu2.0
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- TuHURA Biosciences, Inc.
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