Clinical trials: NERVES
Solid Tumor, Adult Central Nervous System Germ Cell Tumor
Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor
RATIONALE: Giving high-dose chemotherapy before an autologous stem cell transplant stops the growth of tumor cells by stopping them from dividing or killing them.
- Conditions
- Solid Tumor, Adult Central Nervous System Germ Cell Tumor, Adult Rhabdomyosarcoma, Childhood Central Nervous System Germ Cell Tumor
- Trial name
- NCT00638898
- Testing
- busulfan, melphalan, topotecan hydrochloride
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- City of Hope Medical Center
Intracranial Hypertension, Endotracheal Intubation
Lidocaine, Dexmedetomidine, Esmolol and Magnesium Effect on Optic Nerve Sheath Diameter After Laryngoscopy
This clinical trial aims to compare the effects of lidocaine, dexmedetomidine, esmolol, and magnesium on optic nerve sheath diameter and hemodynamic response to laryngoscopy.
- Conditions
- Intracranial Hypertension, Endotracheal Intubation, Optic Nerve Sheath Diameter, General Anesthesia
- Trial name
- NCT06254534
- Testing
- optic nerve ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Haseki Training and Research Hospital
Coronary Artery Disease, Peripheral Nerve Blocks
Recto-intercostal Block for Coronary Artery Bypass Grafting
This interventional study aims to learn about the postoperative analgesic efficacy of a new fascial plane block, recto-intercostal fascial plane block, at coronary artery bypass grafting with sternotomy.
- Conditions
- Coronary Artery Disease, Peripheral Nerve Blocks, Sternotomy
- Trial name
- NCT06418100
- Testing
- The recto intercostal fascial plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Haseki Training and Research Hospital
Hip Fracture, Pericapsular Nerve Group Block (PENG Block)
COmparison of PENG Block and SIFICB in Hip Fracture Surgeries
The aim of this study is to compare the effectiveness of the PENG block and SIFIB in facilitating the positioning for neuroaxial anesthesia and their impact on the quality of postoperative analgesia.
- Conditions
- Hip Fracture, Pericapsular Nerve Group Block (PENG Block), Suprainguinal Fasya Iliaca Block
- Trial name
- NCT06878963
- Testing
- PENG Block, SIFICB Block
- Volunteers
- 150 people
- Sponsor
- Adiyaman University Research Hospital
Endotracheal Intubation During Surgery, Optic Nerve Sheath Diameter
Oropharyngeal Vs Intravenous Lidocaine Effects on Optic Nerve Sheath Diameter After Intubation
This study aims to evaluate the effects of pre-intubation oropharyngeal topical lidocaine on optic nerve sheath diameter (ONSD) post-endotracheal intubation.
- Trial name
- NCT06874179
- Testing
- Optic nerve sheath diameter measurement 0, optic nerve sheath diameter measurement 1, optic nerve sheath diameter measurement 2
- Where
- Turkey (Türkiye)
- Volunteers
- 190 people
- Sponsor
- Ankara City Hospital Bilkent
Anesthetics Complications, Anesthetic Toxicity
PK/PD Levobupivacaine with and Without Epinephrine After Ultrasound Guided ESP Block
Currently there is no standardized management or single technique to manage postoperative pain after Video-assisted thoracic surgery (VATS), there are many options available ranging from intravenous opioids, morphine or fentanyl…
- Conditions
- Anesthetics Complications, Anesthetic Toxicity, Bupivacaine Overdose, Nerve Block
- Trial name
- NCT04799184
- Testing
- Levobupivacaine 0.25% with epinephrine 5 ug/ml, Levobupivacaine 0.25% without epinephrine 5 ug/ml
- Where
- Chile
- Volunteers
- 38 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Dry Eye Disease (DED), Dry Eye
Role of Corneal Nerves in Dry Eye Disease
This study aims to determine whether corneal nerve function and morphology are affected by tear film instability and ocular surface homeostasis loss.
- Conditions
- Dry Eye Disease (DED), Dry Eye, Dry Eye Sensation, Corneal Nerve
- Trial name
- NCT06841471
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Daniela Nosch
Parkinson Disease, Physical Activity
Neuroplasticity in Parkinson´s Disease After Training
This project aims to determine the effects of the HiBalance program on neuroplastic changes in people with mild to moderate Parkinson´s disease.
- Conditions
- Parkinson Disease, Physical Activity, Gait Disorders, Neurologic, Neural Degeneration
- Trial name
- BETA-PD (NCT03213873)
- Testing
- HiBalance, Speech and communication therapy
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Karolinska Institutet
Nerve Block, Regional Anaesthesia
A Comparative Study of Combined Adductor Canal and Interspace Between Popliteal Artery and Knee Capsule Versus Combined Adductor Canal and Genicular Nerve in Total Knee Arthroplasty
The aim of this study is to investigate the effectiveness of combined adductor canal block (ACB) with interspace between popliteal artery and the knee capsule (IPACK) versus combined ACB with genicular nerve block (GNB) for…
- Trial name
- NCT06864663
- Testing
- nerve block with bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Peripheral Nerve Block, Post Operative Analgesia
Transversus Abdominis Plane Lock Versus Quadratus Lumborum Block in Children
Although abdominal wall surgeries are also as routinely performed on pediatric patients, postoperative pain in children has remained under-researched compared to adults.
- Conditions
- Peripheral Nerve Block, Post Operative Analgesia, Ultrasound-guided Regional Anesthesia
- Trial name
- NCT06861556
- Testing
- Ultrasound guided Transversus Abdominis Plane block with 0.2ml/kg bupivacaine 0.25%, Ultrasound-guided Quadratus Lumborum block with 0.2ml/kg bupivacaine 0.25%
- Where
- Tunisia
- Volunteers
- 90 people
- Sponsor
- Tunis University
Postoperative Cognitive Impairment, Optic Nerve Sheath Edema
Effect of Different Ventilation Modes on POCD in Elderly Patients with Abdominal Wall Hernia
The purpose of this clinical trial is to understand the effect of different ventilation patterns during surgery on postoperative cognitive impairment in elderly patients with abdominal wall hernias.
- Trial name
- NCT06764745
- Testing
- PC Ventilation Modes, VC Ventilation Modes, PRVC Ventilation Modes
- Where
- China
- Volunteers
- 471 people, healthy volunteers welcome
- Sponsor
- Inner Mongolia University of Science and Technology
Iliopsoas Nerve Block, Femoral Nerve Block
Iliopsoas Nerve Block and Femoral Nerve Block in Hip Fracture Surgeries
This study aims to compare iliopsoas nerve Block (IPB) to femoral nerve block (FNB) regarding pain control, patient satisfaction, and early ambulation in patients undergoing hip fracture surgeries
- Conditions
- Iliopsoas Nerve Block, Femoral Nerve Block, Hip Fracture Surgeries
- Trial name
- NCT06852378
- Testing
- Iliopsoas nerve block, Femoral nerve block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Adductor Magnus Plain Injection for Sciatic Nerve Block
Using the Adductor Magnus Plain Block as an Innovative Approach for Sciatic Nerve Block for Lower Limb Surgeries.
the goal of this clinical trial is to compare the efficacy of adductor magnus muscle plane injection as an approach for sciatic nerve block to sub-gluteal approach in combination with femoral nerve blocks as perioperative…
- Trial name
- NCT06852118
- Testing
- AMM Group: Adductor Magnus Muscle Plane approach + Femoral Nerve Blocks, SG Group: Sciatic nerve block by sub-gluteal approach + Femoral nerve blocks
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mohammed Gaber Saad
Peripheral Nerve Disease
The Development of Diagnosis and Prognosis Predictive Model for Peripheral Nerve Disease
This is a retrospective observational cohort study (MRN-PND), aiming to explore the utility of contrast-enhanced MRN (ceMRN) compared to plain MRN in diagnosing peripheral nerve diseases and predicting the prognosis of patients…
- Trial name
- NCT06843642
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
fMRI Research, Transcranial Magnetic Stimilation
The Relationships Between Neural Correlates of Effort Perception and Physical Activity Engagement
Objectives and research hypothesis Physical inactivity is a major health concern that has been linked to a variety of chronic diseases, including obesity, diabetes, cancer, cardiovascular diseases, and mental disorders.
- Conditions
- fMRI Research, Transcranial Magnetic Stimilation, EEG Brain Oscillations, Motor Task
- Trial name
- EffortLESS (NCT06691490)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Perfusion Index, Plethysmography
Evaluation of Caudal Block and Ilioinguinal-ilioohypogastric Nerve Block Efficacy with Perfusion Index (PI)
The study is a prospective, randomised, controlled double-blind clinical trial. The primary aim was to evaluate the efficacy of caudal block and ilioinguinal-iliohypogastric nerve block with PI and PVI in pediatric inguinal…
- Conditions
- Perfusion Index, Plethysmography, Anesthesia, Caudal, Nerve Block
- Trial name
- NCT06203743
- Testing
- caudal block group, ilioinguinal-iliohypogastric nerve block group
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Ischemic Stroke, Motor Deficits
Effect of Vagus Nerve Stimulation Via the Outer Ear on Motor and Cognitive Deficits After Ischemic Stroke
The goal of this clinical trial is to learn if transcutaneous auricular vagus nerve stimulation (taVNS) works to treat motor and neurocognitive deficits after ischemic stroke when applied within 30 days after onset of stroke.
- Conditions
- Ischemic Stroke, Motor Deficits, Cognitive Impairment, Vagus Nerve Stimulation
- Trial name
- EVAMOS (NCT06822140)
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- Switzerland
- Volunteers
- 144 people
- Sponsor
- Rheinburg-Klinik
Nerve Block, Anesthesia, Local
Combining Lidocaine and Ropivacaine for an Infraclavicular Brachial Plexus Nerve Block
The aim of the study is to investigate how the combination of ropivacaine (a slow onset, long duration local anesthetic) with lidocaine (a rapid onset, shorter duration local anesthetic) affects the onset and duration of a…
- Conditions
- Nerve Block, Anesthesia, Local, Forearm Fracture, Surgery
- Trial name
- NCT06381622
- Testing
- Ropivacaine 0.5% Injectable Solution, Lidocaine epinephrine, Ropivacaine 0.75% Injectable Solution
- Where
- Denmark
- Volunteers
- 78 people
- Sponsor
- Nordsjaellands Hospital
Healthy Females, Vagus Nerve Stimulation
Effects of tVNS on Visceral Pain
Transcutaneous auricular vagal nerve stimulation (taVNS) has shown promise in reducing chronic abdominal pain, such as in irritable bowel syndrome (IBS).
- Conditions
- Healthy Females, Vagus Nerve Stimulation, Abdominal Pain
- Trial name
- NCT06659172
- Testing
- taVNS
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cranial Nerve Diseases
: Association of Melatonin Levels and Light and Noise Isolation in ICU
Melatonin is secreted from the epiphyseal gland with a circadian rhythm and is known to be anti-inflammatory. In this study, it is planned to investigate the effect of sleep disruptions on melatonin levels and inflammation…
- Trial name
- NCT03659760
- Testing
- Group Isolated
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital