Clinical trials: NEUROLYSIS
Pancreatic Cancer
EUS Guided Neurolysis Celiac Block w/wo Bupivacaine in Patient Being Treated Palliatively for Pancreatic Cancer
The goal of this project is to determine if EUS-CPN without Bupivacaine (versus EUS-CPN with Bupivacaine) can reduce pain scores and improve quality of life in patients with inoperable pancreatic cancer by reducing the morbidity…
- Trial name
- EUS-CPN (NCT02682082)
- Testing
- Endoscopic ultrasound-guided celiax plexus neurolysis, Bupivacaine
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Joint Pain
Genicular Nerve Phenol Neurolysis Versus Radiofrequency Ablation for Pain Relief in Grade 4 Knee Osteoarthritis
The goal of this clinical trial is to compare the efficiency and efficacy of genicular nerves blockade by chemical phenol neurolysis versus radiofrequency ablation in managing pain in patients suffering from grade IV KOA in term…
- Trial name
- NCT06864390
- Testing
- genicular nerve neurolysis
- Volunteers
- 114 people
- Sponsor
- Ain Shams University
Knee Pain Chronic
Efficacy of Genicular Nerve Alcohol Neurolysis in Knee Osteoarthritis Pain
This study aimed to evaluate the efficacy of genicular nerve alcohol neurolysis in the treatment of pain caused by chronic knee osteoarthritis.
- Trial name
- NCT06060678
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Diskapi Teaching and Research Hospital
Knee Osteoarthritis, Chronic Knee Pain
Selective Nerve Ablation for Chronic Knee Pain: A Retrospective Study
SAVE-KNEE is a single-center retrospective observational cohort study evaluating outcomes of ultrasound-guided cryoneurolysis, radiofrequency ablation and chemical neurolysis for chronic knee pain in routine clinical care.
- Trial name
- SAVE-KNEE (NCT07835672)
- Testing
- Ultrasound-Guided Cryoneurolysis, Ultrasound-Guided Radiofrequency Ablation, Ultrasound-Guided Chemical Neurolysis
- Where
- Poland
- Volunteers
- 746 people
- Sponsor
- Michał Bartoszewicz
Pain, Chronic
Phenol Neurolysis of Genicular Nerves for Chronic Knee Pain
Chronic knee pain from osteoarthritis (OA) is commonly treated with total knee arthroplasty (TKA) when conservative therapies fail to provide pain relief. More than 600,000 TKAs are performed in the U.S.
- Trial name
- NCT03973177
- Testing
- Phenol Injection, Methylprednisolone Injection
- Sponsor
- Northwestern University
Pudendal Neuralgia
Decompression of Pudendal and Inferior Cluneal Nerves Using Robot-assisted Laparoscopy for Entrapment Neuralgias : the X-DECO Study
The objective of our study is to evaluate the efficacy of the laparoscopic robot-assited approach after 1 year of follow-up, on pain experience, and anxiety, depression, post-traumatic stress syndrome and quality of life.
- Trial name
- X-DECO (NCT06578767)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- UBOSGA
Osteoarthritis, Osteoarthritis, Hip
Pericapsular Nerve Group Block Chemical Neurolysis in Advanced Hip Osteoarthritis
PENG neurolysis in advanced osteoarthritis of the hip joint.
- Trial name
- PENG (NCT06087588)
- Testing
- 0.9%sodium chloride, 95% ethanol
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Medical Sciences
Postamputation Pain
Alcohol Neurolysis and Capsaicin for Postamputation Pain (PAP)
Postamputation pain is a complex condition that includes phantom limb pain (PLP), stump pain and residual limb pain (RLP), the latter of which may be referred from joints, the spine and inflamed bursa and tendons.
- Trial name
- NCT07443553
- Testing
- Injection of alcohol near neuroma, Lidocaine 2% injection, Injection of capsaicin 150 mcg per mL if relief with lidocaine 2%
- Where
- Ukraine
- Volunteers
- 120 people
- Sponsor
- Northwestern University
Pain Cancer
Fluoroscopic Anterior Approach Versus Ultrasound Guided Superior Hypogastric Plexus Neurolysis in Cancer Pelvic Pain
Cancer related pelvic pain can be debilitating and difficult to treat. Superior hypogastric plexus neurolysis (SHPN) is considered to be an option for adequately relieving pain, with fewer side effects and improving the quality…
- Trial name
- NCT05299047
- Testing
- Group US-guided, Group fluoroscopy-guided
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Mansoura University
Inoperable, Painful Pancreatic Cancer
Trial of Endoscopic Ultrasound (EUS) - Guided Celiac Plexus Neurolysis
Pancreatic cancer presents with pain in the majority of cases. Destruction of the celiac ganglia by ultrasound guided injection of sclerosing agents such as alcohol is sometimes used for pain that no longer responds to treatment…
- Trial name
- NCT00974948
- Testing
- EUS-guided celiac plexus neurolysis
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Sacroiliitis
Use of the Neurolyser XR for the Treatment of Low Back Pain Related to Sacroiliitis
The Neurolyser XR is a device used to deliver high-intensity focused ultrasound for the ablation of the lateral sacral branch nerve in patients with Sacroiliitis.
- Trial name
- NCT06053255
- Testing
- High-intensity focused ultrasound for Sacroiliitis using the Neurolyser XR
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- FUSMobile Inc.
Osteoarthritis (OA) of the Knee, Knee Pain Arthritis
Neurolysis for the Treatment of Medial Chronic Knee Pain Due to Osteoarthritis
This study involves the use of sound waves to block pain signals caused by osteoarthritis of the knee. The sound waves are tightly focused on a specific area of the nerve.
- Conditions
- Osteoarthritis (OA) of the Knee, Knee Pain Arthritis, Chronic Knee Pain
- Trial name
- NCT07178951
- Testing
- Neurotomy of the medial sensory articular branches
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- FUSMobile Inc.
Analgesia
Pulsed Radiofrequency of S2-4 Versus Ganglion Impar Neurolysis for Severe Perianal and Perineal Pain in Cancer Patients
Perineal pain resulting from malignancy is usually severe. Pain can be related to the malignancy or as a complication related to the treatment.
- Trial name
- NCT05591430
- Testing
- Ganglion Impar Neurolysis, Bilateral S2, S3 and S4 Pulsed radiofrequency
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute, Egypt
Cancer of Pancreas, Pancreatic Neoplasms
EUS-Coeliac Plexus Block Versus Radiofrequency Ablation in Pain Relief of Patients With Malignancy
Many cancer patients suffer from intractable pain and which is often suboptimally controlled by even strong opioid analgesics. Coeliac plexus neurolysis (CPN) is procedure which intended to permanently destroy the nociceptive…
- Conditions
- Cancer of Pancreas, Pancreatic Neoplasms, Pain, Cancer-Associated Pain
- Trial name
- NCT04809935
- Testing
- 98% dehydrated alcohol, 19G EUSRA needle, Taewoong Medical, Korea
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- The University of Hong Kong
Cancer, Malignant Tumors, Abdominal Cancer
Neurolytic Block Techniques In Abdominal Visceral Cancer Pain
The neurolytic blocks of sympathetic chains are commonly used for the treatment of cancer-related pain. This study aims to compare celiac plexus neurolysis and splanchnic nerve neurolysis for the treatment of abdominal visceral…
- Conditions
- Cancer, Malignant Tumors, Abdominal Cancer, Cancer Pain, Visceral Pain
- Trial name
- CONCERN (NCT06978673)
- Testing
- Splanchnic nerve neurolysis - 5 ml of absolute alcohol (100%), Celiac Plexus Neurolysis - 5 ml of absolute alcohol (100%)
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Whiplash Injuries
Is Chronic Whiplash-associated Pain of Neurogenic Origin?
The purpose of this study is to compare the effects of neurolysis with the effects of a exercise program on pain and other symptoms in individuals with chronic whiplash (WAD II-III).
- Trial name
- NCT02692937
- Testing
- Neurolysis, Traditional neck-specific exercise program
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Sacro Iliac Joint Pain, Low Back Pain
Effectiveness Of Alcohol Addition In Ultrasound-Guided Periarticular Sacroiliac Joint Injection
The aim of this work is to evaluate the efficacy of adding alcohol to local anesthetics and steroids to provide pain relief in patients with sacroiliac joint pain.
- Conditions
- Sacro Iliac Joint Pain, Low Back Pain, Alcohol Induced Neurolysis
- Trial name
- NCT07151027
- Testing
- sacroiliac joint injection
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Fayoum University
Pain, Cancer
Endoscopic Ultrasound-guided Celiac Plexus Neurolysis in the Management of Pain in Abdominal Non-pancreatic Malignancies
Celiac plexus neurolysis (CPN) has been performed for nearly 100 years to alleviate the abdominal pain associated with pancreatic malignancy and other conditions, and is usually undertaken at a late stage in the disease process…
- Trial name
- NCT01166529
- Testing
- EUS-guided Celiac Plexus Neurolysis
- Where
- United States
- Sponsor
- Northwestern University
Pancreatic Cancer Pain
EUS Guided Celiac Neurolysis
Hypothesis: Direct CGN enhances neurolytic drug delivery into celiac ganglia and increases the efficacy of neurolysis and subsequent pain control and survival in patients with pancreatic carcinoma.
- Trial name
- NCT01615653
- Testing
- EUS
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Mayo Clinic
Upper Abdominal Cancer Pain, Pancreatic Cancer
Outcomes of Fluoroscopy-Guided Transdiscal Splanchnic Nerve Neurolysis for Upper Abdominal Cancer Pain.
The goal of this prospective study is to learn whether fluoroscopy-guided transdiscal splanchnic nerve neurolysis can safely reduce severe upper abdominal cancer pain in adults with pancreatic, gastric, or hepatobiliary cancer.
- Conditions
- Upper Abdominal Cancer Pain, Pancreatic Cancer, Gastric Cancer, Hepatobiliary Cancer
- Trial name
- NCT07825870
- Testing
- Chemical Neurolysis
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Sahiwal medical college sahiwal