Clinical trials: NEUROLYSIS
Osteo Arthritis Knee, Knee Pain Chronic
RFA or Chemical Neurolysis of the Genicular Nerves Compared to Conservative Treatment for Knee Pain Caused by OA
A randomised controlled triall (RCT) with three parallel arms comparing the functional outcome of chemical ablation with phenol and radiofrequency ablation (RFA) of the genicular nerves with conservative treatment in patients…
- Trial name
- RADIOPHENOL (NCT06094660)
- Testing
- Diagnostic genicular nerve block, Genicular nerve block with Radiofrequency Ablation (RFA), Genicular nerve block with Phenol 6%
- Where
- 2 sites in Netherlands
- Volunteers
- 192 people
- Sponsor
- Dijklander Ziekenhuis
Intractable Pelvic Cancer Pain
Fluoroscopic &Ultrasonographic Guidance of Superior Hypogastric Plexus Neurolysis in Intractable Pelvic Pain
fluoroscopic group \& includes 30 patients where SHPB will be done Fluoroscopic-guided (the posterior oblique trajectory technique.the double modality group \& includes 30 patients where SHPB will be done using our described new…
- Trial name
- NCT03606811
- Testing
- fluroscopic guided block, double modality (ultrasound and fluroscopic) guided block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pancreatic Cancer
EUS-guided Celiac Plexus Neurolysis for the Treatment of Abdominal Pain in Pancreatic Cancer
Studies have shown that injecting local anesthetics in areas rich in blood vessels increases the risk of drug injection into blood vessels by mistake and increases the systemic absorption of drugs, which may increase the…
- Trial name
- NCT03940027
- Testing
- EUS-guided celiac plexus neurolysis
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changhai Hospital
Intractable Abdominal Pain Secondary to Inoperable Malignancy
EUS-guided CGN for Inoperable Cancer
Patients suffering from pancreatic cancer are associated with a poor prognosis and survival of less than one year is expected in inoperable tumours. Management of these patients would be towards palliation of symptoms.
- Trial name
- NCT02356640
- Testing
- EUS-guided celiac ganglion neurolysis, Percutaneous celiac plexus neurolysis, Olympus UM 2000
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Chinese University of Hong Kong
Radiofrequency, Alcohol
Radiofrequency Applications and Alcoholic Neurolysis of Genicular Nerve for the Treatment of Knee Osteoarthritic Pain
This study aims to investigate the efficacy of radiofrequency ablation and alcoholic neurolysis of genicular nerve on alleviating pain and improving the function of advanced knee osteoarthritis patients.
- Conditions
- Radiofrequency, Alcohol, Genicular Nerve, Knee Osteoarthritis
- Trial name
- NCT06520384
- Testing
- Radiofrequency, Alcohol 30%, Alcohol 50%
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Pancreatic Cancer
Intraoperative Celiac Plexus Neurolysis for Patients With Operable Pancreatic and Periampullary Cancer
Determine if the addition of an intraoperative ethanol celiac plexus neurolysis (alcohol block) in patients undergoing surgical intervention for pancreatic cancer will result in a decrease in cancer associated pain
- Trial name
- NCT00806611
- Testing
- Alcohol Block
- Where
- United States
- Volunteers
- 438 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Abdominal Cancer
Radiofrequency and Chemical Neurolysis of Thoracic Splanchnic Nerve for Abdominal Cancer Pain
The study compares between the efficacy, safety and impact on the quality of life of radiofrequency thermocoagulation and chemical neurolysis of bilateral thoracic splanchnic nerves in the management of refractory pain which…
- Trial name
- RF (NCT03063112)
- Testing
- Radiofrequency generator device, Lidocaine, C arm fluoroscopic device
- Where
- Egypt
- Volunteers
- 79 people
- Sponsor
- South Egypt Cancer Institute
Pain, Pancreatic Cancer
Endoscopic Ultrasound (EUS) Guided-Celiac Plexus Neurolysis (CPN) in Unresectable Pancreatic Cancer
The purpose of this study is to examine endoscopic ultrasound guided celiac plexus neurolysis (CPN) with analgesic therapy in patients with unresectable pancreatic cancer as it applies to decreasing the severity of abdominal pain…
- Trial name
- NCT00968175
- Testing
- Ultrasound guided celiac plexus neurolysis (CPN)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Dexmedetomidine
Dexmedetomidine in Splanchnic Nerve Neurolysis
Malignancy related abdominal and pelvic pain can be debilitating and affects survival as well as quality of life. Pain from cancer and its treatments can result in anxiety, depression, fear, anger, helplessness, and hopelessness…
- Trial name
- NCT05291364
- Testing
- Group 1, Group 2
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Assessment of Pain Intensity Using 10-point Numerical Rating Scale (NRS-10)(9)Immediately After Intervention , 1 Week,1month,3 Months,6months and One Year, Assessment of Knee Function Using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
Comparison of the Efficacy of Chemical Genicular Nerve Neurolysis Using Alcohol or Phenol Versus Radiofrequency Ablation Under Ultrasound Guidance for Pain Management in Patients With Knee Osteoarthritis
Chronic knee pain is a common condition that affects many people, particularly those with knee osteoarthritis. It can limit mobility, reduce the quality of life, and increase the risk of falling .
- Conditions
- Assessment of Pain Intensity Using 10-point Numerical Rating Scale (NRS-10)(9)Immediately After Intervention , 1 Week,1month,3 Months,6months and One Year, Assessment of Knee Function Using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee Osteoarthritis
- Trial name
- NCT06798038
- Testing
- radiofrequency ablation, phenol neurolysis, alcohol neurolysis
- Volunteers
- 105 people
- Sponsor
- Tanta University
Neurotmesis of Peripheral Nerve (Disorder)
Intraoperative ADSC Administration During Nerve Release
The goal of the investigator's observational, nonrandomized, open label study is to investigate the safety and efficacy of autologous adipose derived mesenchymal cells (ADSC) transplantation into the individuals with faiure in…
- Trial name
- NEUROASC (NCT04346680)
- Testing
- ADSC administration
- Volunteers
- 6 people
- Sponsor
- Mossakowski Medical Research Centre Polish Academy of Sciences
Pancreatic Cancer Non-resectable, Tumor Pancreas
Upfront EUS CGN/CPN vs Conventional Step up Approach for Inoperable Painful Pancreatic Cancer
Patients with unresectable pancreatic cancer are often demoralized by intractable, persistent and incapacitating pain. It must be managed aggressively and strong opioids are recommended as the mainstay of treatment.
- Conditions
- Pancreatic Cancer Non-resectable, Tumor Pancreas, Pain Cancer
- Trial name
- NCT06160323
- Testing
- EUS-guided coeliac ganglion neurolysis / celiac plexus neurolysis
- Where
- Hong Kong
- Volunteers
- 94 people
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthritis
Comparison of the Efficacy of Phenol Block and Corticosteroid-Local Anesthetic Block Applied to the Genicular Nerve
There are different neurolysis methods. Aim of this study is to compare two different methods, phenol block and corticosteroid local anesthetic block.
- Trial name
- NCT06265675
- Testing
- Phenol, Celestone, Lidocain
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Hypertension
The Peregrine Study: A Safety and Performance Study of Renal Denervation
The Ablative Solutions, Inc. Peregrine System Infusion Catheter is a catheter-based device which is intended to be used to ablate the afferent and efferent sympathetic nerves serving the kidneys.
- Trial name
- NCT02155790
- Testing
- The Peregrine System Infusion Catheter
- Where
- 3 sites in Czechia, Poland
- Volunteers
- 10 people
- Sponsor
- Ablative Solutions, Inc.
Ulnar Nerve Compression, Cubital Tunnel
Sonographic Examination Cubital Tunnel Release
The investigators want to compare changes in cross-sectional area (CSA) of the ulnar nerve at the elbow after open release or endoscopic release.
- Trial name
- SPECTRE (NCT02739945)
- Testing
- Cubital tunnel release
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Osteo Arthritis Knee, Osteoarthritis
The Impact of Genicular Nerves Chemical Neurolysis on the Quality of Life of Patients with Advanced Knee Osteoarthritis.
Genicular nerves chemical neurolysis in advanced osteoarthritis of the knee joint.
- Trial name
- NCT06087601
- Testing
- 0.9% Sodium chloride, 95% ethanol
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Medical Sciences
Osteoarthritis Knee, Chronic Pain
Comparison of Denervation Techniques for the Treatment of Knee Osteoarthritis: Continuous Ablative Radiofrequency Vs. Chemical Denervation with Absolute Alcohol
This randomized clinical trial compares two minimally invasive treatments for knee osteoarthritis pain that has not responded to conventional therapies.
- Trial name
- NCT06858228
- Testing
- Continuous Ablative Radiofrequency, Chemical Denervation with Absolute Alcohol
- Where
- Brazil
- Volunteers
- 288 people
- Sponsor
- Federal University of São Paulo
Spasticity as Sequela of Stroke
Phenol and Botulinum Toxin vs Botulinum Toxin Alone for Post-Stroke Upper-Limb Spasticity
This study aims to evaluate the efficacy of a combined treatment approach for post-stroke upper limb spasticity using phenol neurolysis and botulinum toxin (BoNT).
- Trial name
- NCT07440173
- Testing
- phenol neurolysis, Botulinum Toxin - A injections
- Volunteers
- 60 people
- Sponsor
- Assiut University
Efficacy of Adding Lidocaine 10% to Phenol in Superior Hypogastric Plexus Neurolysis
Efficacy of Adding Lidocaine 10% to Phenol in Ultrasound Guided Superior Hypogastric Plexus Neurolysis in The Management of Pelvic Cancer Pain
The superior hypogastric plexus (SHP) is a complex nervous collection located at the lumbosacral region below the level of the aortic bifurcation at the level of the lower third of the fifth lumbar vertebral body and upper third…
- Trial name
- NCT05145972
- Testing
- Ultrasound Guided Superior Hypogastric Plexus
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Knee Osteoarthritis, Genicular Nerve Block
Phenol Neurolysis Versus Local Anesthetic Plus Steroid Genicular Nerve Block in Knee Osteoarthritis
This study aims to evaluate two different ultrasound-guided procedures for patients with knee osteoarthritis (gonarthrosis) who did not benefit from conservative treatments.
- Trial name
- NCT07267039
- Testing
- Phenol Injection, Bupivacaine + Triamcinolone Acetonide Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Salim Sencar