Clinical trials: NEURON SPECIFIC ENOLASE
Congenital Heart Disease (CHD), Hypoxic Encephalopathy
Early Detection of Brain Injury After Congenital Heart Surgery in Infants
Infants with congenital heart disease undergoing cardiac surgery with extracorporeal circulation are at risk for perioperative hypoxic-ischaemic brain injury.
- Trial name
- NCT07424976
- Testing
- Observational study: blood analisys, EEG, MRI
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Out-of-hospital Cardiac Arrest (OHCA), Post-Cardiac Arrest Syndrome
Pulse Pressure and Outcomes After Out-of-Hospital Cardiac Arrest
STEP-PRESS is a predefined exploratory observational substudy nested within the STEPCARE trial. The study will evaluate whether early low pulse-pressure burden after out-of-hospital cardiac arrest is associated with early…
- Trial name
- STEP-PRESS (NCT07586878)
- Where
- Sweden
- Volunteers
- 3,500 people
- Sponsor
- Region Skane
Advanced Non Small Cell Lung Cancer (NSCLC)
Clinical Effects of Alpha-Lipoic Acid in Advanced NSCLC
Non-small cell lung cancer (NSCLC) is a common and aggressive type of lung cancer often diagnosed at advanced stages, with limited treatment options and poor prognosis.
- Trial name
- ALA /NSCLC (NCT07574684)
- Testing
- Alpha Lipoic Acid 600mg
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Heart; Surgery, Heart, Functional Disturbance as Result
The Use of Cooling Helmet for Neuroprotection Management in Open Heart Surgery
To know the relationship between the use of cooling helmet with the changes of NSE level and postoperative delirium event in open heart surgery
- Trial name
- NCT05264766
- Testing
- Cooling helmet on, Cooling helmet off
- Where
- Indonesia
- Volunteers
- 26 people
- Sponsor
- Universitas Indonesia
Out-Of-Hospital Cardiac Arrest, Postcardiac Arrest Syndrome
Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors
The mortality and neurological outcomes among out-of-hospital cardiac arrest survivors have not improved despite the medical advances. The whole body ischemia/reperfusion injuries after cardiac arrest mainly damaged the brain.
- Trial name
- NCT04921189
- Testing
- The combined supplement of Ascorbic acid, Thiamine, and Cortisol
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Asan Medical Center
Liver Transplantation
S100β and Neuron Specific Enolase Levels in Liver Transplantation
Several neurological problems which include both central nervous system and peripheral nervous system can occur as a result of acute liver failure or severe chronic liver failure.
- Trial name
- NCT03453047
- Testing
- S100β and Neuron specific enolase (NSE)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bora Dinc
Spinal Cord Injury
S-100B and Neuron-specific Enolase (NSE) in Spinal Trauma
The investigators are studying the clinical worth of the serum markers S-100B and NSE in patients with spinal cord injuries e.g. in patients with vertebral fractures.
- Trial name
- WBS (NCT00980434)
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Postoperative Cognitive Dysfunction, NEURON SPECIFIC ENOLASE
EFFECT OF ANESTHESİA TECHNIQUES ON POSTOPERATİVE COGNİTİVE DYSFUNCTION FOR MMSE AND NSE LEVEL
The aim of this study is to compare the effects of total intravenous anesthesia and inhalation anesthesia methods on postoperative cognitive dysfunction according to Mini Mental State Examination scores and Neuron Specific…
- Conditions
- Postoperative Cognitive Dysfunction, NEURON SPECIFIC ENOLASE, MINI MENTAL STATE EXAMINATION TEST
- Trial name
- NCT04279132
- Testing
- POSTOPERATIVE COGNITIVE DYSFUNCTION
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Erzincan University
Silent Stroke, Coronary Disease
Evaluation of Brain Damage Due to Coronary Angioplasty in Percutaneous Intervention Patients
This study examines the formation mechanism and patient-related factors of silent cerebral infarcts, whose importance has become increasingly recognized in patients undergoing percutaneous coronary intervention.
- Trial name
- NCT04734587
- Testing
- Blood serum Neuron-specific Enolase measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ondokuz Mayıs University
Brain Damage, Postoperative Cognitive Dysfunction
Liver Transplant Does it Affect the Brain
Neuronal damage caused by neuroinflammation in patients undergoing major surgery is the most determinant factor of postoperative cognitive disfunction (POCD).
- Conditions
- Brain Damage, Postoperative Cognitive Dysfunction, Neuron Specific Enolase, Glial Fibrillary Acidic Protein
- Trial name
- NCT04368052
- Testing
- Mini Mental Test (MMT), S-100 beta, Neuron specific enolase and Glial fibrillary acidic protein
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Ege University
Craniosynostosis, Anesthesia
Influence of General Anesthesia on the Dynamic Changes in Brain Damage Markers During and After Craniosynostosis Operations in Infancy
The issue of anesthetics neurotoxicity is one of the most discussed topics in pediatric anesthesiology, thus it opens the question of the safety of commonly used anesthetics in the pediatric patient.
- Trial name
- TAnBrainDam (NCT05911139)
- Where
- Slovakia
- Volunteers
- 45 people
- Sponsor
- Comenius University
Donor Site Complication, Delirium
s100β, NSE n GFAP in Living Donor Hepatectomy and Delirium
The post-operative delirium picture is a serious and common complication seen after any major surgery, including hepatic resection.
- Conditions
- Donor Site Complication, Delirium, Uremic Encephalopathy, Neurologic Manifestations
- Trial name
- NCT04422925
- Testing
- Living Donor Hepatectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Cardiac Arrest
Identification of Neurological Prognostic Markers of Cardiac Arrest Patients Alive on 3rd Day
The aim of the study is to identify prognostication predictors of 6-months neurological outcome in survivors at day 3 after cardiac arrest (CA) treated with therapeutic hypothermia (TH).
- Trial name
- NCT02888184
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Advanced Heart Failure, Left Ventrucular Assist Device
Neuron Specific Enolase in Ventricular Assist Device Recipients
An observational study of neuron specific enolase, as a marker of reperfusion injury, in LVAD recipients before and following VAD implantation.
- Trial name
- NSE-LVAD (NCT01643551)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Cardiac Surgery, Postoperative Cognitive Dysfunction
The Effects of Dexmedetomidine on Postoperative Cognitive Function in Open Heart Surgery
To assess the impact of Dexmedetomidine on postoperative cognitive function and serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgery
- Conditions
- Cardiac Surgery, Postoperative Cognitive Dysfunction, Neurologic Manifestations
- Trial name
- NCT06655025
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sohag University
Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury
Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest
Most patients resuscitated from out-of-hospital cardiac arrest (OHCA) remain comatose on hospital admission and are routinely managed with continuous sedation.
- Conditions
- Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury, Post-Cardiac Arrest Syndrome
- Trial name
- NCT07895771
- Testing
- Minimal sedation, Standard continuous sedation
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Magnesium Sulfate, Remifentanil
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus…
- Conditions
- Magnesium Sulfate, Remifentanil, S 100beta, S100 Beta Protein, Human
- Trial name
- NCT07181564
- Testing
- Propofol / Remifentanil, Ketamine + Magnesium sulfate (drug combination), Sevoflurane and Remifentanil
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University General Hospital of Patras
Hydrocephalus, Normal Pressure, Biochemical Lesions Head Region
Role of Brain Specific Biomarkers in Hydrocephalus
Normal pressure hydrocephalus (NPH) is a neurodegenerative disease of unclear etiology characterized by a clinical trias named after the neurosurgeon Hakim.
- Conditions
- Hydrocephalus, Normal Pressure, Biochemical Lesions Head Region, Brain Damage
- Trial name
- NCT06083233
- Testing
- Lumbar puncture, External lumbar drainage, Ventriculo-peritoneal shunt placement
- Where
- Czechia
- Volunteers
- 32 people
- Sponsor
- University Hospital Hradec Kralove
Trauma, Brain
Impact of Amantadine on Traumatic Brain Injury
The aim of this study is to evaluate whether the addition of amantadine to the management regimen of traumatic brain injury patients would have a favorable effect on recovery and neurological complications in association with…
- Trial name
- NCT04527289
- Testing
- Amantadine (100mg) as add on therapy.
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Damanhour University