Clinical trials: NGAL
Acute Kidney Injury
ProNephro NGAL Test for Early Detection of Acute Kidney Injury in Adult ICU Patients (ALPACA)
The purpose of this study is to evaluate the performance of the ProNephro AKI™ (NGAL) test for identifying critically ill adults at risk of developing moderate to severe acute kidney injury (KDIGO Stage 2/3) within 48 to 72 hours…
- Trial name
- ALPACA (NCT07751913)
- Testing
- ProNephro AKI™ (NGAL)
- Volunteers
- 800 people
- Sponsor
- BioPorto Diagnostics
Pyelonephritis
Plasma NGAL in APN Patients
In recent years, novel biomarkers of renal dysfunction have attracted attention for the diagnosis of UTIs. NGAL is a 25 kDa protein that belongs to the lipocalin.
- Trial name
- NCT06802796
- Testing
- Plasma NGAL test
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Kafrelsheikh University
Early Acute Kidney Injury
Neutrophil Gelatinase-Associated Lipocalin: Biomarker of Acute Kidney Injury After Cardiac Surgery
The following objectives were used for comparison: 1)primary objective: Evaluate the urinary excretion of NGAL as a marker of early development of acute kidney injury in patients undergoing cardiac surgery.
- Trial name
- NCT00594919
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital de Base
Hypotension During Surgery, NGAL
Controlled Hypotension and Renal Injury During Septoplasty
This prospective randomized single-blind study investigated the effects of two different mean arterial pressure (MAP) targets during controlled hypotension on renal injury in patients undergoing septoplasty.
- Conditions
- Hypotension During Surgery, NGAL, Kidney Injury
- Trial name
- NCT07662577
- Testing
- Controlled Hypotension (MAP 50-57 mmHg), Controlled Hypotension (MAP 58-65 mmHg)
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Chronic Kidney Disease
Usefulness of Neutrophil Gelatinase-associated Lipocalin(NGAL) to Confirm Acute Kidney Function Decrease of the Patients Who Had Non-cardiac Surgery
Although post-op renal function decrease is determined by serum creatinine, serum creatinine has disadvantages that it increases a long time after renal function decrease and it has various increasing time based on the level of…
- Trial name
- NCT02233010
- Testing
- The level of NGAL after pre op,post op 4hr, post op 12hr
- Volunteers
- 43 people
- Sponsor
- Inje University
Kidney Injury
The NGAL Test™ As An Aid in the Risk Assessment for AKI Stage II and III in an Intensive Care Population
The NGAL TestTM is a particle-enhanced turbidimetric immunoassay for the quantitative determination of neutrophil gelatinase-associated lipocalin (NGAL) in human EDTA plasma for testing on automated clinical chemistry analyzer.
- Trial name
- NCT03057457
- Testing
- NGAL Test
- Where
- 2 sites in United States
- Volunteers
- 530 people
- Sponsor
- BioPorto Diagnostics
Acute Renal Failure, Acute Kidney Injury
Early Diagnosis of Postoperative Acute Renal Failure-using Biomarker to Predict Outcome of Cardiac Surgery Associated Acute Kidney Injury
The purpose of this study is to determine soluble HJV could be an early diagnosis urinary biomarker of ischemia/reperfusion injury in post CPB-patients.
- Trial name
- NSARF (NCT01503710)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Remote Ischemic Preconditioning, Contrast Induced - Acute Kidney Injury
Remote Ischemic Preconditioning and Contrast Induced - Acute Kidney Injury in Patients Undergoing Elective PCI
Prospective, randomized, sham-controlled clinical study was conducted to assess whether RIPC reduces the incidence of CI-AKI measured standard way of using SCr concentration but also with the use of serum NGAL as a new potential…
- Trial name
- NCT03761368
- Testing
- Remote Ischemic Preconditioning
- Where
- Poland
- Volunteers
- 101 people
- Sponsor
- Medical University of Lodz
Acute Kidney Injury
Combining CAF, L-FABP and NGAL as a Potentially Diagnostic Model for Acute Kidney Injury.
Acute kidney injury was a common clinical complication, and many diseases were associated with a high risk of occurrence of AKI.
- Trial name
- NCT04555382
- Testing
- Blood and Urine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease, Atherosclerosis
Neutrophil Gelatinase-associated Lipocalin Concentration in Coronary Artery Disease
Serum NGAL has been described as a biomarker of neutrophil activation and an inflammatory marker which correlates to obesity and its metabolic complications.
- Trial name
- NCT00749281
- Where
- Greece
- Volunteers
- 73 people
- Sponsor
- Cardiovascular Research Society, Greece
Acute Kidney Injury (Nontraumatic)
Biomarkers of Acute Kidney Injury in Cardiac Surgery
Acute kidney injury (AKI) is the most common complication in patients after cardiac surgery. An usual estimation of risk for AKI is estimation of serum creatinine, which is unreliable indicator of AKI risk.
- Trial name
- AKIrisk (NCT03830450)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nikola Bradic, MD
Renal Failure Chronic Requiring Hemodialysis
Serum NGAL Levels in Hemodialysis (HD) Patients; Relation to Iron Status, HD and Intravenous (IV) Iron Administration
The purpose of this study is to assess changes in serum levels of the siderophore binding protein NGAL by hemodialysis without and with intravenous iron administration
- Trial name
- NCT00560976
- Testing
- Iron Saccharate (Venofer)
- Where
- 3 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Urinary Tract Infections
Evaluation of the Plasmatic NGAL as a Predictive Marker of Renal Injury in Children With Urinary Infection. (Perf-NGAL-IU)
Urinary infections in children is very common. Delay in the diagnosis may be followed by complications. Pyelonephritis is a febrile urinary infection with a renal injury.
- Trial name
- Perf-NGAL-IU (NCT04191785)
- Testing
- plasmatic NGAl and MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Fondation Lenval
Periodontitis, Type 2 Diabetes Mellitus (T2DM)
Salivary Apelin, Chemerin, Ghrelin, and Lipocalin-2 Levels in Diabetic Patients With Periodontitis
This observational cross-sectional study will evaluate salivary apelin, chemerin, ghrelin, and lipocalin-2 levels in individuals with different periodontal and systemic conditions.
- Trial name
- NCT07703345
- Testing
- Salivary Biomarker Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
HEMORRHOIDS, Extracellular Matrix Alteration
Hemorrhoids and Metalloproteinases, Observational Study
An association between hemorrhoidal disease and matrix metalloproteinases (MMPs) has been described previously. MMPs regulate extracellular structural proteins and tissue remodeling.
- Trial name
- HeMe (NCT02358174)
- Testing
- Hemorrhoidectomy, blood sampling, tissue sampling
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
No-Reflow Phenomenon, STEMI - ST Elevation Myocardial Infarction
NGAL and Its Association With the No-reflow Phenomenon in ST-elevation Myocardial Infarction
The aim of this study is to investigate the association between NGAL plasma levels in ST-elevation myocardial infarction and the no-reflow phenomenon, adverse events during hospitalization and at 30-day follow-up.
- Trial name
- NCT03264859
- Testing
- NGAL levels early and post STEMI
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Acute Renal Failure, Acute Kidney Tubular Necrosis
Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery
Acute Renal Failure (ARF) is defined by a severe, and usually reversible, glomerular filtration rate decreasing. Acute Tubular Necrosis (ATN) remain the major cause of ARF involving distress and destruction of tubular cells.
- Conditions
- Acute Renal Failure, Acute Kidney Tubular Necrosis, Chronic Kidney Failure
- Trial name
- PIIINP-NGAL (NCT02889575)
- Where
- France
- Volunteers
- 287 people
- Sponsor
- Nantes University Hospital
Post Cardiac Arrest Patient Who Was Treated by Hypothermia Protocol
Plasma Neutrophil Gelatinase-associated Lipocalin (NGAL) as Early Biomarker for Renal Dysfunction and Good Neurologic Outcome in Out of Hospital Cardiac Arrest Patients
Postresuscitation disease is a constellation of disorders related to whole-body ischemia and reperfusion syndrome. It includes hypoxic damage in brain, liver, kidney, heart and other organ.
- Trial name
- NCT01987466
- Testing
- Serum NGAL level
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Yonsei University
Preoperative KIDNEY FAILURE, CHRONIC, Postoperative KIDNEY FAILURE, ACUTE
NGAL Predictive Value of Acute Kidney Failure After Cardiac Surgery in Patients With Preoperative Chronic Kidney Failure
Primary endpoint: To evaluate predictive value of plasmatic levels of Neutrophil Gelatinase Associated Lipocalin (NGAL) to reveal acute kidney failure after cardiac surgery in patients with preoperative chronic kidney failure…
- Conditions
- Preoperative KIDNEY FAILURE, CHRONIC, Postoperative KIDNEY FAILURE, ACUTE, Cardiac Surgical Procedures
- Trial name
- NGAL-CKF (NCT01227122)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hopital Jean Minjoz
Acute Kidney Injury, Anemia
Urinary NGAL Acute Kidney Injury After Stored Red Blood Cells Transfusion in Critically Ill Patients.
The study aims to explore the association of the novel urinary bio marker NGAL with the age of PRBCs(packed red blood cells) transfusion in critically ill patients.
- Trial name
- NCT03560921
- Testing
- urinary NGAL
- Where
- Egypt
- Volunteers
- 147 people
- Sponsor
- Kasr El Aini Hospital