Clinical trials: Naevi
Acne, Actinic Keratosis
Potential Research Study Participant Registry
The purpose of the potential research study participant registry is to keep potential research subjects informed about any future research studies in which they may meet the criteria for enrollment.
- Conditions
- Acne, Actinic Keratosis, Dysplastic Nevi, Eczema
- Trial name
- NCT00710489
- Where
- United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Melanoma, Melanoma (Skin)
Atypical MOLes and Melanoma Early Detection Study (MoleMed)
This is a multicenter, ambispective, low-interventional clinical study evaluating molecular genetic markers for non-invasive differential diagnosis of benign and malignant pigmented skin and mucosal neoplasms.
- Conditions
- Melanoma, Melanoma (Skin), Moles, Nevus
- Trial name
- MoleMed (NCT04353050)
- Testing
- Non-invasive adhesive system (patch)
- Where
- 2 sites in Russia
- Volunteers
- 350 people
- Sponsor
- Russian Academy of Medical Sciences
Ocular Melanoma
Optical Coherence Tomography of Retinal Abnormalities Associated With Choroidal Nevus, Choroidal Melanoma and Choroidal Melanoma Treated With Iodine-125 Brachytherapy
During regularly scheduled appointments, Optical Coherence Tomography (OCT) is performed on consented subjects. The OCT is a new type of camera that takes very detailed pictures inside of the eye and deeper into eye tissues.
- Trial name
- NCT00346372
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Lymphatic Malformation, Generalized Lymphatic Anomaly (GLA)
Lymphatic Anomalies Registry for the Assessment of Outcome Data
Lymphatic anomalies are a rare subset of vascular anomalies that are poorly understood. the understanding of the natural history, long-term outcomes, risk factors for morbidity and mortality, and the relative benefit of medical…
- Conditions
- Lymphatic Malformation, Generalized Lymphatic Anomaly (GLA), Central Conducting Lymphatic Anomaly, CLOVES Syndrome
- Trial name
- NCT02399527
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Boston Children's Hospital
Pigmentation Disorder
Fractional Laser as Treatment Option for Various Pigment Disorders
The purpose of this study is to determine whether the use of ablative fractional laser is effective in the treatment of Becker's nevus.
- Trial name
- fractional-2 (NCT01083498)
- Testing
- Ablative fractional laser therapy
- Volunteers
- 11 people
- Sponsor
- Netherlands Institute for Pigment Disorders
Skin Lesion, Nevus
Genetic Risk Stratification of Pediatric Skin Lesions
A study to understand the clinical utility of noninvasive adhesive skin biopsies in pediatric patients by exploring whether DermTech Pigmented Lesion Assay (PLA) genetic risk analysis of suspicious lesions in children correlates…
- Trial name
- NCT05418959
- Testing
- DermTech PLA noninvasive adhesive biopsy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Malignant Pleural Mesothelioma (MPM), Choroidal Nevus
Clinical and Histopathologic Characteristics of BAP1 Mutations
The goal of this protocol is to determine the prevalence of somatic and germline mutations in BAP1 (BRCA associated protein-1) among patients with mesothelioma , choroidal nevus, primary uveal melanoma (UM), or metastatic UM seen…
- Conditions
- Malignant Pleural Mesothelioma (MPM), Choroidal Nevus, Primary Uveal Melanoma (UM), Metastatic Uveal Melanoma (UM)
- Trial name
- NCT01773655
- Testing
- tumor specimens
- Where
- 2 sites in United States
- Volunteers
- 196 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Melanoma (Skin)
Tretinoin With or Without Fenretinide in Treating Patients With Dysplastic Nevus Syndrome
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of tretinoin and/or fenretinide may be an effective way to prevent the recurrence or further…
- Trial name
- NCT00003601
- Testing
- fenretinide, tretinoin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Eastern Cooperative Oncology Group
Basal Cell Nevus Syndrome, Gorlin's Syndrome
Trial Comparing the Effects of Intermittent Vismodegib vs. PDT in Patients With Multiple Basal Cell Carcinomas
The purpose of this study is to evaluate and compare the safety and efficacy of intermittent vismodegib and of Photodynamic Therapy (PDT).
- Trial name
- Vismodegib (NCT01556009)
- Testing
- Vismodegib, Aminolevulinic acid %20 topical solution
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Skin Carcinoma
Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Chest and Back
RATIONALE: Drugs used in chemotherapy, such as tazarotene, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00783965
- Testing
- tazarotene
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Malignant Melanoma
International Melanoma Algorithm Training Study - IMATS
This is an international, multicenter, prospective, non controlled, non randomized, clinical study to collect electrical impedance data of potentially malignant pigmented nevi and histological diagnoses (International Melanoma…
- Trial name
- NCT00966173
- Testing
- SciBase III Electrical Impedance Spectrometer
- Where
- Sweden
- Volunteers
- 1,800 people
- Sponsor
- SciBase AB
Nevus, Cicatrix
A Trial to Investigate Scar Improvement Efficacy of RN1001 (Avotermin) After Head and Neck Naevi Excision
This trial will investigate whether four doses of RN1001 (20ng, 50ng, 100ng and 200ng) are efficacious in preventing or reducing the resultant scar, as compared to placebo, when applied intradermally to wound margins following…
- Trial name
- NCT00656227
- Testing
- Avotermin
- Where
- United Kingdom
- Volunteers
- 239 people
- Sponsor
- Renovo
Port-wine Birthmarks, Port-Wine Stain
A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin PDT
This is a multi-center, randomized, double-blind, vehicle-controlled, and sequential group Phase 2 study. Eligible subjects aged 18 to 75 years old with PWB will receive Hemoporfin PDT or vehicle PDT in 8-week cycles at fixed…
- Conditions
- Port-wine Birthmarks, Port-Wine Stain, Nevus Flammeus
- Trial name
- NCT05171894
- Testing
- Hemopfin+Green Light, Vehicle+Green Light
- Where
- 5 sites in United States
- Volunteers
- 84 people
- Sponsor
- Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
Nevus
In Vivo Confocal Scanning Laser Microscopy of Benign Nevi
In vivo confocal laser scanning microscopy (CLSM) offers the possibility to non-invasively investigate skin lesions at nearly histologic resolution.
- Trial name
- CSLM-nevi (NCT00487864)
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Basal Cell Carcinoma in Basal Cell Nevus Syndrome
Study of ASN-002 to Treat Basal Cell Carcinomas (BCCs) in Individuals With Basal Cell Nevus Syndrome (BCNS)
The primary objective is to confirm the safety of treating multiple BCCs once weekly x 3 weeks in individuals with Basal Cell Nevus Syndrome (BCNS).
- Trial name
- NCT03208296
- Testing
- ASN-002
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ascend Biopharmaceuticals Ltd
Melanoma
Effects of Anti-PD1 Adjuvant Checkpoint Blockade Immunotherapy on Atypical/Dysplastic Nevi
This study will examine the impact of anti-programmed cell death 1 (PD1) therapy given in the approved adjuvant therapeutic regimens upon the morphologic, histopathologic, molecular and immunologic as well as genomic features of…
- Trial name
- NCT06599619
- Testing
- Single agent, adjuvant anti-PD1 therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- John Kirkwood
Basal Cell Nevus Syndrome
Blue vs Red Light During Levulan Based Photodynamic Therapy in Patients With Basal Cell Nevus Syndrome
The investigators will be testing whether aminolevulinate-based (Levulan™) Photodynamic Therapy (PDT) shows effectiveness in the treatment and prevention of cutaneous basal cell carcinoma (BCC) in Basal Cell Nevus Syndrome (BCNS)…
- Trial name
- NCT02157623
- Testing
- Levulan, Red Light PDT, Blue Light PDT
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Edward Maytin, MD, PhD
Epidermal Nevi
A Pilot Study to Examine the Efficacy and Tolerability of Sirolimus on Epidermal Nevi Lesions in Patients 6 Years Old and Above.
We hypothesize that topical sirolimus could suppress the mTOR activation of linear verrucous epidermal nevi, particularly when the variants are involving genes upstream of mTOR and perhaps even those of the RAS pathway through…
- Trial name
- NCT07813533
- Testing
- sirolimus topical gel 0.2%
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Northwestern University
Solar Lentigo, Nevus Zygomaticus
Advanced Harmonic Generation Microscopy for Treatment Assessment of Cutaneous Pigmentary Disorder
In this study, the investigators demonstrated that in vivo THG microscopy can differentiate Solar lentigos (SL), Nevus zygomaticus(NZ) and normal skin based on the optical nature of melanin.
- Trial name
- NCT03578315
- Testing
- HGM
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Dysplastic Nevus Syndrome
Evaluation of 20% Betulinic Acid Ointment for Treatment of Dysplastic Nevi (Moderate to Severe Dysplasia)
The purpose of this study is to evaluate the safety and effectiveness of an experimental 20% betulinic acid ointment (BA ointment) as a treatment for dysplastic nevi with the potential to transform into melanoma.
- Trial name
- NCT00346502
- Testing
- 20% betulinic acid ointment, BA
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Illinois Chicago