Clinical trials: Nail Diseases
Onychomycosis
Efficacy and Safety of RV4104A Ointment in Onychomycosis
The purpose of the study is to evaluate the efficacy of RV4104A ointment versus bifonazole-urea ointment for the complete removal of the clinically infected nail plate area in patients with toenail onychomycosis.
- Trial name
- NCT00808366
- Testing
- Keratolytic/Antifungal
- Where
- France
- Volunteers
- 228 people
- Sponsor
- Pierre Fabre Dermo Cosmetique
Ingrown Nail
Clinical Efficacy of Nail Brace for Treatment of Ingrown Toenails
Background: Ingrown toenails are one of the most frequent nail disorders and can be treated with conservative or surgical approaches.
- Trial name
- NCT03008629
- Testing
- Podofix nail brace, Combiped nail brace, Podofix and then Combiped nail brace
- Volunteers
- 40 people
- Sponsor
- Taipei Medical University WanFang Hospital
Foot Dermatoses
Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish
The main objective is to compare efficacy, in terms of antifungal activity of Loceryl Nail Lacquer associated with a Cosmetic Varnish and Loceryl Nail Lacquer alone, in the treatment of mild to moderate toenail Distal Subungual…
- Trial name
- COOL (NCT02321098)
- Testing
- Loceryl NL + Cosmetic varnish, Loceryl NL 12 weeks, Loceryl NL 15 months
- Where
- Iceland
- Volunteers
- 50 people
- Sponsor
- Galderma R&D
Onychomycosis
Safety & Efficacy of NAB001 in the Treatment of Mild to Moderate Onychomycosis of the Toenails
The objectives of this study are to assess the safety of NAB001 for topical treatment of mild to moderate distal onychomycosis of the toenails over 52 weeks and to compare the efficacy of NAB001 to vehicle alone at the end of the…
- Trial name
- NCT01208168
- Testing
- NAB001, Vehicle alone
- Where
- 24 sites in United States, Dominican Republic
- Volunteers
- 468 people
- Sponsor
- Promius Pharma, LLC
Nails, Ingrown, Hyaluronic Acid
Hyaluronic Acid in Postoperative Cures in the Phenol/Alcohol Technique
The purpose of this study is to compare the efficacy of a postoperative treatment protocol with hyaluronic acid-based ointment compared to the standard protocol (betadine gel) in partial chemical matricectomies with phenol…
- Trial name
- EHAPAT (NCT04812457)
- Testing
- Hialucic, Betadine gel
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Onychomycosis of Toenail, Onychomycosis
Early Feasibility Study to Evaluate the Efficacy of the RenewalNail™ Plasma Treatment System in Patients With Onychomycosis (Fungal Nail)
A study to determine if a three-treatment protocol with the RenewalNail™ plasma treatment system over a week will result in mycological cure and/or clear nail growth on the treated hallux toe.
- Trial name
- NCT03216200
- Testing
- plasma treatment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- DeviceFarm, Inc.
Onychomycosis
Iontophoretic Application of Terbinafine Gel to the Large Toe Nail
Terbinafine is recognized as one of the most effective drugs for the treatment of toe nail fungus (onychomycosis). This trial will be the first test of a new device to improve the delivery of terbinafine directly to the toe nail.
- Trial name
- NCT00768768
- Testing
- Electrokinetic Transungual System (ETS) - Terbinafine Gel, ETS-Terbinafine Gel
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Transport Pharmaceuticals
Diabetes Mellitus, Type 2, Onychomycosis
Laser Treatment for Onychomycosis in Diabetes
Fungal infections of the toe affect one in three people with diabetes. Current treatments for fungal toe infections include oral medications, but these drugs often interact with other common medications.
- Trial name
- NCT02019446
- Testing
- Laser Treatment YAG laser, Standard Treatment (control group) terbinafine hydrochloride tablets
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- BCDiabetes.Ca
Chemotherapeutic Agent Toxicity, Pain
Cryotherapy in Preventing Peripheral Neuropathy and Nail Toxicity in Patients With Breast Cancer Who Are Receiving Paclitaxel
RATIONALE: Cryotherapy may help prevent peripheral neuropathy or nail toxicity in patients receiving chemotherapy. PURPOSE: This clinical trial studies cryotherapy in preventing peripheral neuropathy and nail toxicity in patients…
- Conditions
- Chemotherapeutic Agent Toxicity, Pain, Peripheral Neuropathy, Recurrent Breast Cancer
- Trial name
- NCT01243541
- Testing
- cryotherapy, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Northwestern University
Ingrown Toenail, Virtual Reality
Virtual Reality in Ingrown Toenail Surgery
Ingrown toenail is a common condition that may cause significant pain, functional impairment, and recurrent disease. Although conservative management is appropriate for mild cases, moderate-to-severe or recurrent ingrown toenails…
- Trial name
- NCT07707726
- Testing
- Virtual Reality (VR)
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ankara City Hospital Bilkent
Onychomycosis
Evaluation of the Efficacy of CURE-EX Treatment in Onychomycosis
Open label study to evaluate the efficacy of CURE-EX device in the treatment of onychomycosis.
- Trial name
- NCT02436291
- Testing
- CURE-EX device
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- MB Mazor Ltd.
Breast Carcinoma
Efficacy of Evonail® Solution in the Prevention of Nail Damage Induced by Docetaxel in Patients With Breast Cancer.
Docetaxel is widely used in oncology for the treatment of many solid tumors. The side effects of docetaxel are many and sometimes serious. The primary toxicity of docetaxel is neutropenia.
- Trial name
- EVONAIL (NCT02870699)
- Testing
- Evonail
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut de Cancérologie de Lorraine
Habits, Bruxism
Prevalence Of Deleterious Oral Habits Among a Group of School Children in Cairo, Egypt: Cross-Sectional Study
This study aims to detect the prevalence of practicing oral habits among a group of school children in Cairo, Egypt.
- Conditions
- Habits, Bruxism, Sucking Behavior, Nail Biting
- Trial name
- ACU333 (NCT05769166)
- Testing
- thired domain of nordic orofcial test-screen
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Ahram Canadian University
Psoriasis Palmaris, Psoriasis Genital
Efficacy of Tildrakizumab in Difficult-to-treat Areas in Psoriasis
Psoriasis is a chronic inflammatory disease that affects between 2% and 4% of the French population.Some specific localizations are more difficult to manage, such as the scalp, nails, genital region and palmoplantar…
- Conditions
- Psoriasis Palmaris, Psoriasis Genital, Psoriasis of Scalp, Psoriasis Plantaris
- Trial name
- ZODIPSO (NCT05938361)
- Testing
- Psoriasis clinical assessments, Quality of life evaluation, Satisfaction assessment
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Clin4all
Onychomycosis
A Trial to Evaluate the Safety and Efficacy of DBI-001 Gel, DBI-002 Gel, and Aqueous Gel in Subjects With Onychomycosis
This is a randomized, observer-blinded, Aqueous Gel-controlled trial examining the safety and efficacy of daily application of DBI-001 Gel vs. DBI-002 Gel vs. Aqueous Gel for 24 consecutive weeks in subjects with onychomycosis.
- Trial name
- NCT05491603
- Testing
- DBI-001, DBI-002, Aqueous Gel
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- DermBiont, Inc.
Onychomycosis of Toenail
Comparison of Efficacy and Safety Between Methylene Blue-mediated Photodynamic Therapy and 5% Amorolfine Nail Lacquer for Toenail Onychomycosis Treatment
Study centre and address King Chulalongkorn Memorial Hospital Primary objective To compare the efficacy and the safety of methylene blue-mediated photodynamic therapy and 5% amorolfine nail lacquer for toenail onychomycosis in…
- Trial name
- NCT03098342
- Testing
- Methylene blue-mediated photodynamic therapy, Amorolfine 5% Nail Lacquer
- Where
- Thailand
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Onychomycosis
Topical Gel Anti-Fungal Agent for Tinea Unguium
The purpose of this study is to compare, in a controlled fashion, the response to two anti-fungal agents, naftifine or terbinafine, with vehicle in novel topical gel formulations in the treatment of subjects with distal subungual…
- Trial name
- NCT00253305
- Testing
- Organogel of naftifine, 2%, Organogel of terbinafine, 2%, Organogel of naftifine, 6%
- Where
- 5 sites in United States
- Volunteers
- 75 people
- Sponsor
- MediQuest Therapeutics
Paronychia, Epidermal Growth Factor Receptor Inhibitor
Efficacy and Safety of Kinesiology Tape Wrapping for Paronychia Induced by Epidermal Growth Factor Receptor Inhibitors
Epidermal growth factor receptor inhibitors(EGFRIs) have been applied in several common malignancies including advanced non-small cell lung cancer.
- Trial name
- NCT06411093
- Testing
- Kinesiology tape wrapping, Conventional treatment including silver nitrate cauterization
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Chang Gung Memorial Hospital
Nails, Ingrown
Nonrandomized Assessment of Ingrown ToenaiLs Treated by Excision of Skinfold Rather Than Toenail
Ingrown toenails occur when the nail grows into the surrounding skin, resulting in pain and infection. The most common procedure to treat this problem is a wedge excision (removal of part of the toenail) and matricectomy…
- Trial name
- NAILTEST (NCT02067897)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Michael Livingston
Nail Diseases
The Evaluation of External Thermomechanical Stimulation for Pain Reduction in Patients Undergoing Nail Injection
The purpose of this study is to assess the efficacy and safety of a thermomechanical device delivering vibration and cold stimuli in lowering pain during intramatricial nail injections
- Trial name
- NCT04422795
- Testing
- External thermomechanical device delivering cold and vibration stimuli, External thermomechanical device without delivering cold and vibration stimuli, Ethyl chloride skin refrigerant spray
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University