Clinical trials: Nail Diseases
Osteogenesis Imperfecta
Tranexamic Acid During Telescoping Nail Application In Osteogenesis Imperfecta
The aim of this study is to assess the effective of intraoperative use of tranexamic acid in reducing blood loss during telescoping nail application in cases of osteogenesis imperfecta.
- Trial name
- NCT05321199
- Testing
- Tranexamic acid
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Anxiety, Literacy
Effect of an Educational Nail Biopsy Video on Pre-operative Anxiety, Health Literacy, and Patient Satisfaction
The investigators are interested in studying the effect of an animated video depicting a nail biopsy procedure on the anxiety, health literacy, and satisfaction of participants recommended to undergo a nail biopsy procedure.
- Conditions
- Anxiety, Literacy, Satisfaction, Patient
- Trial name
- NCT06274775
- Testing
- Educational Video
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Pachyonychia Congenita
A Multicenter, Phase 3 Randomized, Double-Blind, Vehicle-Controlled Study Evaluating the Safety and Efficacy of QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Pachyonychia Congenita
This study evaluates the safety and efficacy of QTORIN 3.9% rapamycin anhydrous gel in the treatment of adults with Pachyonychia Congenita. This study includes a screening period, baseline period and 6-month treatment period.
- Trial name
- VAPAUS (NCT05180708)
- Testing
- QTORIN 3.9% rapamycin anhydrous gel, Vehicle
- Where
- 8 sites in United States, United Kingdom
- Volunteers
- 87 people
- Sponsor
- Palvella Therapeutics, Inc.
Onychomycosis
Topical Penlac Nail Lacquer for Onychomycosis in Children
Five months of therapy is sufficient to treat onychomycosis in children. Topical therapy of onychomycosis in children with Penlac nail lacquer has comparable efficacy and a superior cost and safety profile compared to systemic…
- Trial name
- NCT01419847
- Testing
- Ciclopirox
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rady Children's Hospital, San Diego
Onychomycosis
A Study of ATB1651 in Adults With Mild to Moderate Onchomycosis
The study is designed to evaluate the Safety, Tolerability and Pharmacokinetics of ATB1651 in participants with mild to moderate onychomycosis
- Trial name
- NCT06327295
- Testing
- ATB1651-102- Cohort 1, ATB1651-102- Cohort 2, ATB1651-102- Cohort 3
- Where
- New Zealand
- Volunteers
- 120 people
- Sponsor
- AmtixBio Co., Ltd.
Onychomycosis
Effectiveness of Podiatry Care on Onychomycosis (EPOCAON)
Onychomycosis occurs in more than 50% of all pathologies unguinal, affecting the health and quality of life of the patient. Although the investigators have a wide therapeutic arsenal, there is still a disparity when carrying out…
- Trial name
- EPOCAON (NCT00938925)
- Testing
- Nail lacquer plus aggressive debridement, Nail lacquer alone
- Where
- 3 sites in Spain
- Sponsor
- University of Malaga
Onychomycosis
Comparative Efficacy of Bifonazole Cream vs Placebo After Nail Ablation With Urea Paste
The study is focused to prove that the efficacy of a 1% Bifonazole cream is superior to a placebo cream after non-surgical nail ablation with a 40% urea paste.
- Trial name
- NCT00781820
- Testing
- Bifonazole cream 1%
- Where
- 51 sites in Czechia, Germany and 1 more
- Volunteers
- 693 people
- Sponsor
- Bayer
Onychomycosis
A Study of the Systemic Absorption of MOB015B
A Study of the Systemic Absorption of Once Daily MOB015B when Applied for 28 Days in Subjects with Moderate to Severe Onychomycosis of the Toenails.
- Trial name
- NCT03244280
- Testing
- MOB015B
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Moberg Pharma AB
Onychomycosis
Efficacy Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail
This study is designed to assess the efficacy, safety and tolerability of a topical formulation of terbinafine solution applied daily in patients with toenail fungus.
- Trial name
- NCT00443820
- Testing
- terbinafine
- Where
- 23 sites in United States, France and 1 more
- Volunteers
- 526 people
- Sponsor
- Novartis Pharmaceuticals
Onychomycosis
Erbium-doped Yttrium Aluminium Garnet Laser(Er:Yag)Associated With Amorolfine Lacquer in the Treatment of Onychomycosis
The study aims to investigate the effectiveness of a single application of Er:YAG laser to the nail plate in increasing the efficacy of the amorolfine lacquer used in the treatment of onychomycosis (fungal infection of nails)…
- Trial name
- NCT01528813
- Testing
- Er:YAG laser + amorolfine lacquer, Amorolfine lacquer
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Brasilia University Hospital
Exostosis
Utility of High-resolution Ultrasound to Evaluate Dorsal Osteophyte
This study will evaluate the usefulness of ultrasonography in detecting dorsal osteophytes associated with claw nails compared to radiographs.
- Trial name
- NCT06266208
- Testing
- Exostectomy, Cut fingernail
- Where
- 4 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Nails, Ingrown
Nonrandomized Assessment of Ingrown ToenaiLs Treated by Excision of Skinfold Rather Than Toenail
Ingrown toenails occur when the nail grows into the surrounding skin, resulting in pain and infection. The most common procedure to treat this problem is a wedge excision (removal of part of the toenail) and matricectomy…
- Trial name
- NAILTEST (NCT02067897)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Michael Livingston
Psoriasis, Cardiovascular Diseases
Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis
In a prospective cohort study (n = 1.000), the investigators aim to investigate the correlation between cardiac biomarkers and advanced echocardiography and determine whether these are prognostic markers of heart disease in…
- Conditions
- Psoriasis, Cardiovascular Diseases, Cardiovascular Risk Factor, Cardiovascular Pathology
- Trial name
- PSOCADIA (NCT04950218)
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Herlev and Gentofte Hospital
Ingrown Toenail (Onychocryptosis)
Comparison of Two Surgical Methods (Winograd vs. Sleeve Method) in the Treatment of Ingrown Toenail.
This randomized clinical trial aims to compare the recurrence rates of two surgical techniques-Winograd procedure and sleeve (gutter) method-in the treatment of ingrown toenails (onychocryptosis).
- Trial name
- NCT07547241
- Testing
- Winograd Technique, Sleeve (Gutter) Method
- Where
- Pakistan
- Volunteers
- 312 people
- Sponsor
- Pakistan Institute of Medical Sciences
Punctate Palmoplantar Keratoderma Type 1, Pachyonychia Congenita
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases
In this phase 1 open label study for patients with type I punctate palmoplantar keratoderma or pachyonychia congenital, 2 arms will be recruited to be treated twice daily, with 1% topical KM-001.
- Trial name
- NCT05435638
- Testing
- Serum chemistry, Hematology, Urinalysis
- Where
- 3 sites in Israel
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Orvida Pharma (formerly Kamari Pharma)
Psoriasis, Psoriatic Arthritis
Discovery of Arthritis in Psoriasis Patients for Early Rheumatological Referral
Rationale: Psoriasis (PsO) is a common inflammatory skin disease. Besides the skin, it is recognized that this disease can affect multiple domains such as nails, joints and entheses.
- Conditions
- Psoriasis, Psoriatic Arthritis, Psoriasis Vulgaris, Psoriatic Nail
- Trial name
- DAPPER (NCT03816917)
- Testing
- cutaneous parameters of psoriasis (exposure), comorbidity (exposure), family history (exposure)
- Where
- Netherlands
- Volunteers
- 304 people
- Sponsor
- Radboud University Medical Center
Osteogenesis Imperfecta
Post-market Observational Study on JTIN Telescopic Nail in Osteogenesis Imperfecta Pediatric Patients
This study has been planned as part of the Orthofix Srl post-market active surveillance plan for the collection of data on both the clinical performance and the safety profile of the JTIN.
- Trial name
- JTIN (NCT05612139)
- Testing
- JTIN implantation surgery
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Orthofix s.r.l.
Onychomycosis
Efficacy and Safety Study of 4 Dose Regimens of Oral Albaconazole in Subjects With Distal Subungual Onychomycosis
Phase 2 study to examine how the study drug works and its side effects in subjects with toenail fungus.
- Trial name
- NCT00730405
- Testing
- Albaconazole 100mg, Albaconazole 200mg, Albaconazole 400mg
- Where
- 33 sites in United States, Canada and 1 more
- Volunteers
- 582 people
- Sponsor
- Stiefel, a GSK Company
Osteopenia, Osteoporosis
Periprosthetic Plate Over Humeral Nail
use of plate over humeral nail in deformity correction of femur in adult osteoporotic bone
- Trial name
- osteoporosis (NCT06812195)
- Testing
- Plate and nail
- Volunteers
- 3 people
- Sponsor
- Assiut University
Cryotherapy Effect, Peripheral Neuropathy
The Use of Cryotherapy to Prevent Paclitaxel-induced Peripheral Neuropathy and Nail Changes in Women With Breast Cancer
This study will determine the efficacy of cryotherapy to prevent paclitaxel-induced peripheral neuropathy and nail changes in women with breast cancer.
- Conditions
- Cryotherapy Effect, Peripheral Neuropathy, Nail Toxicity
- Trial name
- NCT04558034
- Testing
- cryotherapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Parkview Health