Clinical trials: Nanopore Sequencing
Endophthalmitis
Nanopore Sequencing in Ophthalmology
In this pilot study, the feasibility of the Oxford Nanopore MinION to identify pathogens from vitrectomy samples in eyes with endophthalmitis shall be assessed.
- Trial name
- NCT05372861
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Blood Stream Infection, Gut Microbiota
Application of Nanopore Sequencing in Newly Diagnosed Acute Myeloid Leukemia Patients With Bloodstream Infection
Acute myeloid leukemia (AML) patients are prone to blood stream infection (BSI) due to bone marrow suppression, oral and gastrointestinal mucositis, endovascular tubes, and the application of a large number of broad-spectrum…
- Conditions
- Blood Stream Infection, Gut Microbiota, Acute Myeloid Leukemia
- Trial name
- NCT05016752
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Liver Transplant Infection
Application of Nanopore Adaptive Sequencing
Infection post liver transplantation is an important factor in the death in patients. The traditional method of diagnosing infection post liver transplantation is laboratory tests.
- Trial name
- NCT06542042
- Testing
- NAS, NGS and Laboratory tests
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Third People's Hospital
Post-operative Pain
Genetics of Cytochrome CYP2D6 and Effects of Codeine and Tramadol on Postoperative Pain Management
Codeine is one of the most commonly prescribed opioids in the world. The speed at which our liver metabolizes codeine into morphine depends on an important protein called cytochrome P450 2D6 (CYP2D6).
- Trial name
- CYP2D6 (NCT06723379)
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Fraser Health
Infection, Fracture
Metagenomic Next-Generation Sequencing for the Diagnosis of Fracture-related Infection
The value of next-generation sequencing (NGS) using Nanopore technology has been demonstrated in the case of diabetic patients' wounds or in prosthetic joint infections.
- Conditions
- Infection, Fracture, Bone
- Trial name
- METADIAG 2 (NCT07256405)
- Testing
- Metagenomic sequencing
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Benign Pancreatic Neoplasm, Malignant Pancreatic Neoplasm
"Answers in Hours" A Randomized Controlled Trial Using Microbiome Metagenomics for Bile Duct Cultures
This trial evaluates whether testing of bile with nanopore sequencing results in earlier detection of bacteriobilia (bacteria in bile) that may lead to surgical site infections in patients undergoing surgery for benign or…
- Trial name
- NCT05523154
- Testing
- Biospecimen Collection, Laboratory Procedure, Nanopore Sequencing
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Ischemic Heart Disease, Coronary Artery Disease
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN)
Despite advancements in medical care, ischemic heart disease (IHD) remains the leading global cause of death. IHD develops through lipid accumulation into the coronary arteries with subsequent formation of larger atherogenic…
- Conditions
- Ischemic Heart Disease, Coronary Artery Disease, Aortic Valve Stenosis, Acute Myocardial Infarction
- Trial name
- IHD-EPITRAN (NCT04533282)
- Testing
- Blood samples., Collection of right atrial appendage tissue sample., Health Survey, Clinical symptom scaling
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Hospital District of Helsinki and Uusimaa
Fractures, Bone, Infections
Clinical Metagenomic of Post-traumatic Infections
Treatment of fracture related infection is challenging and often lead to failure in such situation that carry a high health cost burden.
- Trial name
- METADIAG (NCT05770856)
- Testing
- Metagenomic sequencing
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Neuro-Degenerative Disease
Contribution of New Generation Oxford Nanopore-type High-throughput Sequencing in the Diagnostic Strategy of Neurogenetic Diseases.
Since 2012, NGS sequencing of long fragments or long reads has developed in various fields of research and today presents itself as a very promising alternative solution in the analysis of repeat amplifications.
- Trial name
- NEURONGS3 (NCT04621422)
- Testing
- Subject carrying an amplification of nucleotide repeats in one of the following 9 genes FMR1, DMPK, ZNF9, SCA2, JPH3, HD, FXN, C9ORF72, RFC1
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Cervical Cancers, HPV Testing
Third-Generation Nanopore HPV Integration Site for Precise Prediction of Cervical Cancer Prognosis
Cervical cancer is a significant health threat to women, with over 500,000 new cases and approximately 342,000 deaths worldwide annually, and about 107,000 new cases in China with 51,000 fatalities.
- Conditions
- Cervical Cancers, HPV Testing, Nanopore Sequencing, HPV Integration Site Detection
- Trial name
- NCT06644677
- Testing
- HPV integration
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Irritable Bowel Syndrome
Effects of Vivatlac Synbiotic on Gut Micribiota of IBS Patients
Multi-center, randomized, double-blind, placebo-controlled, 12 weeks trial investigating the effects of a nine-strain synbiotic (Vivatlac Synbiotikum) on the gut microbiota of IBS patients
- Trial name
- ViIBS3 (NCT07235228)
- Testing
- Vivatlac Synbiotic
- Where
- 2 sites in Poland
- Volunteers
- 20 people
- Sponsor
- The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz
Bacterial Infections
Evaluation of a mNGS Workflow for Infection Diagnosis Using Oxford Nanopore Sequencing.
This is a laboratory evaluation of a new testing methodology for microbiological diagnosis, whereby participant samples received as part of routine care will be divided between the standard diagnostic pathway and this new…
- Trial name
- NCT04864873
- Testing
- Metagenomic next generation sequencing using Oxford Nanopore, Standard microbiological diagnostic pathway
- Where
- New Zealand
- Volunteers
- 400 people
- Sponsor
- Capital and Coast District Health board
Whole Genome Sequencing, Genetic Disease
N-Care Project: Enhancing Asian-Pacific Collaboration
Through Asian-Pacific multinational collaboration, we aim to utilize third-generation genome sequencing to rapidly diagnose genetic diseases in critically ill infants and young children, achieving the goal of early diagnosis for…
- Conditions
- Whole Genome Sequencing, Genetic Disease, Critical Care, Intensive Care, Nanopore Sequencing
- Trial name
- N-Care project (NCT06821386)
- Testing
- Genetic study with nanopore sequencing
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Breast Cancer Invasive
Fast and Accurate Breast Cancer Diagnosis Using Nanopore Sequencing in Tanzania (Fast-ABCD Sequencing)
This pilot study will test the feasibility of using nanopore sequencing for breast cancer diagnosis in Tanzania. It aims to show that nanopore sequencing is non-inferior to the current standard of care, with the potential for…
- Trial name
- NCT06633276
- Where
- Tanzania
- Volunteers
- 100 people
- Sponsor
- University of Bonn