Clinical trials: Narcotic Abuse
Narcotic Abuse
Aprepitant Effects on Oxycodone Response
Addressing the issue of opioid dependence and tolerance has public health implications for the treatment of opioid abuse (both heroin as well as pharmaceutical opioids) and for the treatment of pain.
- Trial name
- NCT00999544
- Testing
- Aprepitant 0mg, Aprepitant 40mg, Aprepitant 200mg
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Sharon Walsh
Substance Abuse, Decision Making, Shared
Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention
Oregon's decision makers (e.g., community service providers, public health, justice, advocacy groups, payers) are calling for comprehensive, current, and trusted data to inform how they allocate resources to improve substance use…
- Conditions
- Substance Abuse, Decision Making, Shared, Implementation Science, Decision Making
- Trial name
- D2A Oregon (NCT06852170)
- Testing
- Co-Design Sessions (CDS), Data products
- Where
- United States
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Opioid-related Disorders
Abuse Liability of Suboxone Versus Subutex
The study is designed to compare the abuse liabilities of intravenous buprenorphine and buprenorphine/naloxone in individuals who are physically dependent on sublingual buprenorphine.
- Trial name
- NCT00710385
- Testing
- Heroin, Naloxone, Low Bup Dose
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opioid Related Disorders
Computer-based Prescription Opioid Abuse Prevention for Adolescents
The investigators are developing an interactive, web-based program for youth ages 12-17 focused on the prevention of prescription opioid abuse because to the investigators knowledge, no science-based, interactive program focused…
- Trial name
- NCT02737696
- Testing
- Web-based prescription opioid prevention for adolescents, JustThinkTwice.gov website (DEA)
- Where
- United States
- Volunteers
- 435 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Opiate Abuse, Marijuana Abuse
Detecting Drugs of Abuse Via Exhaled Breath Samples Using Differential Mobility Spectrometry
This Phase II STTR program consists of two major goals within the overarching goal of developing and validating a proprietary device (BID2) for marijuana and opioid detection in breath samples.
- Conditions
- Opiate Abuse, Marijuana Abuse, Diagnostic
- Trial name
- NCT05384470
- Testing
- Marihuana, BID2 Instrument - breathalyzer
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Opioid-use Disorder, Opioid Use
The Analgesic Efficacy of Continuous Sub-fascial Bupivacaine Infusion and Lidocaine Patches in Post-cesarean Patients With Opiate Use Disorder: A Comparative Efficacy Analysis
Pregnant women with a history of opioid use disorder, chronic opioid use or those who are on medication assisted treatment will be randomly assigned to receive either a sub-fascial continuous infusion of bupivacaine or…
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Dependence, Opioid Abuse
- Trial name
- NCT04033562
- Testing
- Lidocaine patch, Ambu ACTion pump, 0.125% bupivacaine at 8cc/hr
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- WellSpan Health
Motivation, Drug Effect
How Stress Alters Opioid Drug Effects
The main objective of the study is to test the hypothesis that opioid drug effects vary as a function of pre-drug affective state.
- Conditions
- Motivation, Drug Effect, Stress Reaction, Misuse, Opioid
- Trial name
- OPIOIDREWARD (NCT06485817)
- Testing
- Oxycodone, Stress State Induction, Control State Induction
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Opioid-Related Disorders, Stimulant-Related Disorder
Preventing Parental Opioid and/or Methamphetamine Addiction Within DHS-Involved Families: PRE-FAIR
Young parents aged 16 to 30, involved in the DHS system for child welfare or self-sufficiency needs are at risk for opioid use disorder and/or methamphetamine use disorder (OUD; MUD).
- Conditions
- Opioid-Related Disorders, Stimulant-Related Disorder, Child Neglect, Mental Health Impairment
- Trial name
- PRE-FAIR (NCT05380440)
- Testing
- Prevention Adaptation of Families Actively Improving Relationships (PRE-FAIR), Standard Case Management and Referral
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Heroin Dependence, Nicotine Dependence
Pioglitazone for Heroin and for Nicotine Dependence
The goal of the proposed research is to improve the effectiveness of treatments for opioid and for nicotine dependence by testing a novel pharmacological strategy.
- Trial name
- NCT01395797
- Testing
- PIO
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opioid Use, Opioid Dependence
Safe Return and Disposal of Unused Opioids
The opioid epidemic in the United States has become a clear health and safety concern for our children and families. Opioids given to our patients for the treatment of pain that go unused after the immediate post operative period…
- Conditions
- Opioid Use, Opioid Dependence, Opioid Abuse, Unspecified
- Trial name
- NCT03352479
- Testing
- Opioid Return
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Opioid Sensitivity, Individual Difference
A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans
Within-subject, double-blind, placebo-controlled examination of opioid abuse potential in healthy individuals as a function of A118G SNP on the OPRM1 gene.
- Conditions
- Opioid Sensitivity, Individual Difference, Abuse Opioids
- Trial name
- NCT02360371
- Testing
- Within-subject test of blinded study medication
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid Use Disorder
Cannabis and Opioid Use Disorder
This study plans to enroll participants with opioid use disorder who are not currently seeking treatment to assess the effects of cannabis on opioid withdrawal and other related outcomes.
- Trial name
- NCT05729932
- Testing
- Inhaled vaporized cannabis, Intransal opioid
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Shanna Babalonis, PhD
Opioid-Related Disorders
Abuse Potential of Buprenorphine and Naloxone in Non-Dependent Opioid Users
Buprenorphine is a medication used to treat opioid addiction, but individuals who use this drug are at risk of abusing it. A buprenorphine and naloxone combination may reduce the likelihood of buprenorphine addiction.
- Trial name
- NCT00158236
- Testing
- Buprenorphine, Buprenorphine and Naloxone, Hydromorphone
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Behavior Therapy, Cocaine
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1
Although LAAM, a derivative of methadone, has been successfully used as an alternative to methadone maintenance in opioid addicts, its effect on concurrent opioid and cocaine abuse has not been ascertained.
- Conditions
- Behavior Therapy, Cocaine, Contingency Management, Heroin Dependence
- Trial name
- NCT00158288
- Testing
- LAAM
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Abuse
Buprenorphine Induction and Naloxone Distribution Program-Combined With Warm Hand-Off Referral to Continued Treatment
This study is a collaboration between the University of Utah and Castleview Hospital in Price, Utah. Buprenorphine is a medication approved by the FDA to treat Opioid Use Disorder (OUD).
- Trial name
- BINDeR-TX (NCT06087991)
- Testing
- Implementation of the BINDeR-Tx service model
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Jerry Cochran
Opioid-Related Disorders, Pain, Acute
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults
This clinical trial is being conducted to compare concentrations of hydrocodone and acetaminophen in the blood after administration of a new and a marketed tablet formulation under fasted and fed conditions in healthy adults.
- Conditions
- Opioid-Related Disorders, Pain, Acute, Pain, Postoperative
- Trial name
- NCT03137017
- Testing
- Norco 5Mg-325Mg Tablet, GRT7014 - Abuse Deterrent Tablet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Opioid Abuse
A Multi-centre Survey on Tramadol Abuse in Singapore
The rampant prescription of opioid has in part contributed to the ongoing worldwide opioid crisis. In the United States of America, it is estimated that death from the use of opioids outnumber death from motor vehicle accident…
- Trial name
- NCT04813458
- Where
- 3 sites in Singapore
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Opioid Abuse, Prescription Opioid Abuse
Community Pharmacy-Based Prescription Drug Monitoring Program Opioid Risk Assessment Tool
This goal of this observational study is to develop and test the Opioid Risk Reduction Clinical Decision Support (ORRCDS) tool. The tool will be an opioid medication risk screener and decision support platform that will be used…
- Trial name
- PharmTool (NCT05706311)
- Testing
- Clinical Decision Support Tool (Moderate Risk), Clinical Decision Support Tool (High Risk), Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Utah
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Cancer Patients, Cancer-related Pain
A Consensus on Opioid Prescription for Oncologic Patients in Latin America - A DELPHI Study.
As seen worldwide, cancer incidence is increasing in Latin America achieving an amount of 1.3 million new cases annually.1 In addition, it is expected that up to 70% of patients with cancer will experience pain2, one of the most…
- Trial name
- NCT04844788
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto do Cancer do Estado de São Paulo