Clinical trials: Narcotic-Related Disorders
Heroin Dependence, Opioid-Related Disorders
Studies of Opioid Seeking Behavior: Yohimbine and Hydrocortisone Effects
This research deals with behaviors that are part of opioid dependence. The purpose is to study the extent to which stress and other factors, including money and amount of work effort, affect opioid choice.
- Trial name
- YHO (NCT01536925)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Wayne State University
Opioid Use Disorder, Alcohol Intoxication
Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals With Opioid Use Disorder
The goal of this clinical trial is to examine whether individuals with co-occurring opioid use disorder and alcohol use (OUD+ALC) experience heightened pain sensitivity, pain-related negative affect, and greater alcohol…
- Conditions
- Opioid Use Disorder, Alcohol Intoxication, Pain
- Trial name
- NCT07894276
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University
Opioid-Related Disorders
Suboxone: (Buprenorphine/Naloxone) Comparison of Two Taper Schedules - 1
The purpose of this protocol is to to compare the clinical utility of two dosage tapering regimens in Buprenorphine/Naloxone stabilized subjects for opiate detoxification.
- Trial name
- NCT00078117
- Testing
- Buprenorphine
- Where
- 11 sites in United States
- Volunteers
- 516 people
- Sponsor
- University of California, Los Angeles
Opioid Use Disorder (OUD), Chronic Pain
Opioid Adherence and Support Through Innovative Texting Strategies
The goal of this clinical trial is to examine the effects of reminder and mindfulness text messages on medication adherence and managing craving, pain, and withdrawal symptoms in people taking medications for opioid use disorder…
- Trial name
- OASIS (NCT07350148)
- Testing
- Mindfulness text messages
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of New Mexico
Opioid Use Disorder, Posttraumatic Stress Disorder (PTSD)
Integrated Treatment for Opioid Use Disorder and PTSD
This study will test a therapy intervention, HOPE, for individuals with opioid use disorder and posttraumatic stress disorder. Interested individuals will need to be taking medications for opioid use disorder (e.g., suboxone…
- Trial name
- NCT06641115
- Testing
- HOPE Therapy
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical University of South Carolina
Substance-Related Disorders, Opioid-Related Disorders
Fatal Overdose Review Teams - Research to Enhance Surveillance Systems
This project seeks to address the overdose epidemic by working with overdose fatality review (OFR) teams. Current OFR practices rely on a case review model where OFR teams assess one or two overdose cases to make policy and…
- Trial name
- FORTRESS (NCT06084221)
- Testing
- Data-Driven Decision Making (DDDM), Overdose-prevention strategies inventory
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Indiana University
Opioid Use Disorder, Pregnancy Related
Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD
The primary objective of this study is to evaluate the ability of TOME to increase Medication for Opioid Use Disorder (MOUD) and opioid-overdose knowledge in pregnant and postpartum persons.
- Conditions
- Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse
- Trial name
- TOME (NCT06262347)
- Testing
- Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control
- Where
- 6 sites in United States
- Volunteers
- 131 people
- Sponsor
- T. John Winhusen, PhD
Opioid Use Disorder
Behavioral Activation for Opioid Use Disorder
The overall purpose of this pilot study is to evaluate the feasibility and acceptability of values-based behavioral activation (BA) as an adjunct intervention for patients receiving medications for opioid use disorder (OUD) in…
- Trial name
- NCT05262725
- Testing
- Values-based Behavioral Activation
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Minnesota
Substance Use Disorders, Overdose
Project POINT: Effectiveness and Scalability of an Overdose Survivor Intervention
The investigators seek to assess the effectiveness of Project POINT (Planned Outreach, Intervention, Naloxone, and Treatment). As originated in Indianapolis, Project POINT is a collaboration between Indianapolis Emergency Medical…
- Trial name
- POINT (NCT03336268)
- Testing
- POINT
- Where
- 2 sites in United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Indiana University
Opioid-use Disorder, Substance Use Disorders
Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)
The purpose of this clinical trial is to investigate Low Intensity Focused Ultrasound (LIFU) using the Exablate® Model 4000 Type 2.0/2.1 as an adjunctive neuromodulatory treatment for OUD (Opioid Use Disorder) and/or other…
- Trial name
- NCT04197921
- Testing
- Exablate Model 4000 Type 2.0/2.1
- Where
- 4 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- InSightec
Opioid-Related Disorders
Improving Health and Employment Outcomes Through Workplace Opioid Policies
Evaluate the feasibility of implementing workplace opioid guidelines in the construction trades; define and collect measures of implementation and efficacy.
- Trial name
- NCT05387408
- Testing
- Best Practice Health and Employment Opioid-related Policies
- Where
- United States
- Volunteers
- 4,939 people
- Sponsor
- Washington University School of Medicine
Opioid Use Disorder
Screening in Trauma for Opioid Misuse Prevention
The current study seeks to begin the crucial work of creating effective protocols to prevent opioid misuse, addiction, and related complications by developing and pilot testing an opioid risk screening protocol at Wisconsin…
- Trial name
- STOMP (NCT02861976)
- Testing
- Opioid risk screen development & implementation
- Where
- United States
- Volunteers
- 346 people
- Sponsor
- University of Wisconsin, Madison
Heroin Dependence
Pharmacogenomics Study of Sleep Disturbance and Neurocognitive Impairments in the Opioid Addicts
Opioid abuse is a complex problem, which not only impacts on addicts' physical and psychological health individually, but also threats the society.
- Trial name
- NCT01668706
- Where
- 5 sites in Taiwan
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Opiate Dependence
Extended-Release Naltrexone for Opioid Relapse Prevention Following Release From Jail
This pilot study's primary aim is to compare rates of sustained opioid relapse, defined as self-reported opioid use >50% (>15 of 30) of days during the first 30 days following release from jail, among persons treated with XR-NTX…
- Trial name
- NCT01180647
- Testing
- Extended-Release Naltrexone, Motivational Enhancement Counseling
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- NYU Langone Health
Opioid Dependence
Community Studies of Long Acting Buprenorphine (CoLAB)
Despite research demonstrating the efficacy of buprenorphine (BPN), effectiveness in real-world settings has been limited by shorter retention than for methadone, and the need for daily or near-daily dosing (frequently supervised…
- Trial name
- CoLAB (NCT03809143)
- Testing
- RBP-6000
- Where
- 6 sites in Australia
- Volunteers
- 100 people
- Sponsor
- The University of New South Wales
Opioid Use Disorder
Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder
This preliminary study is designed to evaluate mechanisms by which excitatory dorsolateral prefrontal cortex (dlPFC) repetitive transcranial magnetic stimulation (rTMS) (vs. sham) and pharmacological stress (vs.
- Trial name
- NCT04231708
- Testing
- Yohimbine + Hydrocortisone, Active rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wayne State University
Opioid Abuse (Disorder), Stimulant Use Disorders
Optimizing Pregnancy and Treatment Interventions for Moms 3.0
We want to learn if Patient Navigation helps pregnant Medicaid members with opioid use disorder, with or without stimulant use disorder, stay in care, use medications for opioid use disorder, reduce substance use, and connect…
- Trial name
- OPTI-Mom (NCT07586917)
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 429 people
- Sponsor
- University of Utah
Opioid Use Disorder
Following Outcomes Remotely Within Addiction Recovery Domains
The aim of this study is to describe outcome of people with opioid use disorder over the long-term by collecting monthly and yearly data on their recovery.
- Trial name
- FORWARD (NCT06001437)
- Where
- United States
- Volunteers
- 369 people
- Sponsor
- Mclean Hospital
Opioid Related Disorders, Opiate Addiction
Monitoring Patterns of Prescribing to Identify Changes in Access to ER/LA Opioid Analgesics
Changes in prescribing will be compared in prescribers from specialties whose prescribing is hypothesized to be relatively unaffected by the REMS (such as oncologists and hospice providers) versus those for whom the REMS could…
- Conditions
- Opioid Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02920775
- Testing
- Non-interventional study - retrospective database review
- Volunteers
- 360,000 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Opioid Use Disorder, Substance Use Disorders
Implementing a Pharmacist-Integrated Collaborative Model of Medication Treatment for Opioid Use Disorder
This project will provide novel empirical information about how to optimally engage pharmacists and pharmacies as key partners in collaborative integrated care models designed to expand access to evidence-based medication…
- Trial name
- PharmICO (NCT05310786)
- Testing
- Pharmacist-integrated Medication Treatment for Opioid Use Disorder (PrIMO)
- Where
- 4 sites in United States
- Volunteers
- 149 people
- Sponsor
- Trustees of Dartmouth College