Clinical trials: Nasal Bleeding
Epistaxis
Assessment of Performance and Safety of an Asymmetric Balloon in the Treatment of Intranasal Bleeding Managed in an Emergency Setting
Between 10 and 12% of the general population suffers from epistaxis, out of which 10% would need to be medically managed. Most of patients treated for epistaxis are managed through emergency departments.
- Trial name
- BATSI (NCT03912051)
- Testing
- asymmetric balloon
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Dianosic
Hereditary Hemorrhagic Telangiectasia, Epistaxis
Pazopanib for the Treatment of Epistaxis in Hereditary Hemorrhagic Telangiectasia
Investigators will test the value of very low dose Pazopanib administered to patients with hereditary hemorrhagic telangiectasia for the reduction in the severity of nose bleeds in those with frequent and long duration bleeding…
- Trial name
- NCT03850730
- Testing
- Pazopanib
- Volunteers
- 30 people
- Sponsor
- Cure HHT
Epistaxis, Analgesia
The Effect of Local Anesthesia With Lidocaine During Insertion and Removal of Nasal Packing
This study aims to investigate the effect of local nasal anesthesia with lidocaine spray on the insertion of nasal tampons during active nasal bleeding.
- Trial name
- NCT04519463
- Testing
- Xylocaine Mucosal Product
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Muhamed Masalha
Epistaxis
Usage of Orange Peel Extract in Management of Epistaxis
Efficacy of orange peel extract in treatment of epistaxis in children
- Trial name
- NCT06836102
- Testing
- Orange
- Volunteers
- 60 people
- Sponsor
- Minia University
Telangiectasia, Hereditary Hemorrhagic, Epistaxis
North American Study of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)
The purpose of the NOSE Study is to carefully examine the efficacy and safety of 3 nasal sprays (bevacizumab, estriol, and tranexamic acid), compared to placebo, for the treatment of HHT related nosebleeds.
- Trial name
- NOSE (NCT01408030)
- Testing
- Sterile saline, Bevacizumab, Estriol
- Where
- 6 sites in United States
- Volunteers
- 123 people
- Sponsor
- James Gossage
Trauma-related Wound, Head Injury
Teaching First Aid and Trauma Management to School Students
This proposal aims to describe research that will utilize first aid in primary education students and will attempt to identify the frequency with which the training should be repeated and the type of trainer who will carry out…
- Conditions
- Trauma-related Wound, Head Injury, Choking, Nose Bleed
- Trial name
- NCT05563129
- Testing
- First aid lessons
- Where
- Greece
- Volunteers
- 192 people
- Sponsor
- University of Ioannina
Hereditary Hemorrhagic Telangiectasia (HHT)
A Trial of TER-1754 in Patients With Hereditary Hemorrhagic Telangiectasia
This is a Phase 1a/1b, multicenter study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and clinical activity of TER-1754 (a novel AKT1 inhibitor) in patients with HHT.
- Trial name
- NCT07255846
- Testing
- TER-1754
- Where
- United States
- Sponsor
- Terremoto Biosciences Inc.
Telangiectasia, Hereditary Hemorrhagic
Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose
Epistaxis are present in over 90 % of patients with Rendu - Osler . They involve no significant difference 2 sexes. They often appear in childhood and adolescence and are present in three-quarters of patients at the age of 20…
- Trial name
- EROSB (NCT02157987)
- Testing
- bevacuzimab spray
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Epistaxis
Microporous Polysaccharide Hemospheres Epistaxis
The purpose of this study is to compare a new treatment for nosebleeds to the treatment that has been used for many years.
- Trial name
- NCT02466464
- Testing
- Microporous Polysaccharide Hemospheres, Nasal Tampon
- Where
- United States
- Sponsor
- Emory University
Endoscopic Sinus Surgery, Nasal Polyps
Comparing Blood Loss and Visualization After the Preoperative Use of Topical 0.05% Oxymetazoline Versus 1:1000 Epinephrine Prior to Endoscopic Sinus Surgery
The purpose of this study is to compare the effects of Oxymetazoline and Epinephrine (which are 2 different nasal decongestants both of which are routinely used before sinus surgery) on blood loss and the surgeon's view of the…
- Trial name
- NCT03228914
- Testing
- Oxymetazoline, Epinephrine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Epistaxis Nosebleed
Tranexamic Acid Versus Blood Stopper Treatments in Epistaxis Management
In this randonmized controlled trial, aim to compare the effectiveness of local administration of tranexamic acid and blood stopper (Ankaferd®) on cessation of bleeding in epistaxis patients.
- Trial name
- NCT06490653
- Testing
- Blood Stopper (Ankaferd)
- Volunteers
- 186 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Epistaxis
Topical Intranasal Tranexamic Acid for Epistaxis in the Emergency Department
It is estimated that epistaxis results in 4.5 million emergency department visits per year throughout the United States. Due to the adverse effects of standard treatment options for epistaxis, tranexamic acid (TXA) may be…
- Trial name
- NCT02930941
- Testing
- Tranexamic Acid, 0.9% Sodium Chloride
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, Davis
Tranexamic Acid, Epistaxis
Comparing Effectiveness of Merocel and Packing With Tranexamic Acid in the Management of Anterior Epistaxis
Aim of this study is evaluate whether superior nasal compression with tranexamic acid to simple nasal compression and Merocel packing.
- Conditions
- Tranexamic Acid, Epistaxis, Nasal Packing
- Trial name
- NCT03360045
- Testing
- Tranexamic Acid, Normal saline, Merocel
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Kecioren Education and Training Hospital
Epistaxis, ENT Disorder
Correlation Between PT and INR to Factor 7
The purpose of our study: Given the large number of coagulability tests done before a number of surgeries, specially otolaryngology procedures, such as tonsillectomy and adenoidectomy, as well as a part of epistaxis workup…
- Trial name
- NCT03788460
- Testing
- no intervention
- Volunteers
- 60 people
- Sponsor
- Laniado Hospital
Epistaxis
Floseal Treatment for Posterior Epistaxis Study
Effectiveness of Floseal for the treatment of posterior epistaxis.
- Trial name
- NCT01098578
- Testing
- Floseal
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Oral Surgery
Epinephrine Nasal Drops for Epistaxis During Nasal Intubation
Epistaxis is the most common complication of nasotracheal intubation. Incidence of epistaxis during nasotracheal intubation ranges from 22% to 80%.
- Trial name
- NCT06789549
- Testing
- epinephrine nasal drops, oxymetazoline nasal drops
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Padjadjaran
Nasotracheal Intubation, Nasal Bleeding
Nasotracheal Intubation Over a Bougie
The purpose of this study is to determine whether nasal intubation over a bougie placed via a nasal trumpet will decrease nasal trauma when compared to the conventional technique of blind nasal endotracheal tube passage.
- Trial name
- NCT03003455
- Testing
- Nasotracheal intubation over a bougie, Conventional Nasotracheal Intubation
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Epistaxis
Management of Persistent Epistaxis Using Floseal Hemostatic Matrix
Nosebleeds that persist even after adequate traditional nasal packing may require aggressive treatment strategies to stop bleeding.
- Trial name
- NCT02488135
- Testing
- Floseal Hemostatic Matrix, Traditional Nasal Packing
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University of Alberta
Epistaxis, Intubation Complication
The Effect of Bevel Direction on the Pathway of the Nasotracheal Tube
In this study, the subjects are divided into two groups (group I: intervention group = the nasotracheal tube inserted with the bevel of the nasal tube facing the direction of the patient's head, and Group II: conventional group =…
- Trial name
- NCT03740620
- Testing
- Bevel facing the cephalad direction of the patient, Bevel facing leftward of the patient
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Nasal Sinus; Inflammation, Opioid Abuse
Pain Management Following Sinus Surgery
This Study evaluates the effect of adding Non-steroidal anti-inflammatories (NSAIDs) to the post-operative pain management of sinus surgery patients and wether or not this addition reduces or eliminates the need for narcotic pain…
- Conditions
- Nasal Sinus; Inflammation, Opioid Abuse, Pain, Postoperative
- Trial name
- NCT03822962
- Testing
- Ibuprofen 600Mg Tablet, Standard Regimen | Tylenol
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska