Clinical trials: Nasal High Flow Therapy
High-flow Nasal Cannula, Respiratory Distress
The Factors Causing Treatment Failure in Children Receiving Oxygen Therapy With High-flow Nasal Cannula
The goal of this observational study is to identify the variables that predict treatment failure in order to identify the patients in which HFNC treatment may fail and not delay the transition to advanced respiratory support…
- Conditions
- High-flow Nasal Cannula, Respiratory Distress, Treatment Failure
- Trial name
- NCT06146439
- Where
- Turkey (Türkiye)
- Volunteers
- 201 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Oxygen Therapy
Initial Temperature of High Flow Nasal Cannula
In the literature there are no indication on which is the best setting of the humidification temperature at the start of treatment with high flow nasal cannula (HFNC) in intensive care unit (ICU).
- Trial name
- BEST/2022 (NCT05688189)
- Testing
- different starting temperature setting of HFNC
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Chronic Obstructive Pulmonary Disease (COPD)
Time Course of Respiratory Oscillometry Parameters During Nasal High-Flow Therapy in Stable Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) can affect the small airways and alter respiratory mechanics. Nasal high-flow therapy delivers warmed and humidified gas through nasal cannulas and may change airway resistance.
- Trial name
- NHFlOscillo (NCT07750613)
- Testing
- Heated Humidified Nasal High-Flow Therapy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- ADIR Association
Dyspnea, Lung Diseases
Effects of Automated Oxygen Titration Alone or With High Flow Nasal Therapy on Dyspnea and Exercise Tolerance
The main purpose of this study is to evaluate the effects of automated oxygen administration (FreeO2 system) alone or with high-flow oxygen on dyspnea and exercise tolerance in people with desaturating chronic lung disease…
- Conditions
- Dyspnea, Lung Diseases, Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05267418
- Testing
- Automated nasal O2 titration with FreeO2
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Chronic Respiratory Acidosis
Respiratory Stabilization in Chronic Acidosis Before Bronchofiberoscopy & Non-Invasive Ventilation Effectivenes
Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes. FOB frequently impairs respiratory function, which may lead to possible exacerbation of respiratory failure.
- Trial name
- NCT06970002
- Testing
- Use of NIV during FOB as a respiratory support method, Use of HFNC during FOB as a respiratory support method
- Volunteers
- 210 people
- Sponsor
- Medical University of Silesia
Pulmonary Diseases, Oxygen Therapy
Effects of High-Flow Nasal Cannula on Exercise Outcomes in Lung Transplant Candidates: A Pilot Study
The study evaluated patients on the national lung transplant waiting list. It was pioneering in assessing high-complexity patients with severe pulmonary diseases subjected to a cardiopulmonary rehabilitation protocol using a…
- Conditions
- Pulmonary Diseases, Oxygen Therapy, High-flow Nasal Cannula, Exercise Tolerance
- Trial name
- NCT06620081
- Testing
- Performance Tests, Functional Tests
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital Israelita Albert Einstein
Otorhinolaryngologic Surgical Procedures, Laser Therapy
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Laser Laryngeal Surgery
The purpose of this study is to investigate whether laser laryngeal surgery can be safely and potentially more effectively performed without the use of tracheal intubation or jet ventilation, under completely tubeless conditions.
- Trial name
- NCT03086265
- Testing
- THRIVE, Endotracheal tube
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Bronchiolitis
HFNC Versus NCPAP/ NPPV in Infants With Severe Bronchiolitis
The purpose of the study was to test the null hypothesis that there is no difference between nasal continuous positive airway pressure / nasal positive pressure ventilation (NCPAP/NPPV) and high flow nasal cannula (HFNC) devices…
- Trial name
- NCT04650230
- Testing
- nasal continuous positive airway pressure / nasal positive pressure ventilation (NCPAP/NPPV) and high flow nasal cannula (HFNC) devices
- Volunteers
- 268 people
- Sponsor
- Children's Hospital of Tunis
ARDS, Hypoxemia
Almitrine in COVID-19 Patients With ARDS Treated by HFNO
The purpose of this study is to determine the effects of Almitrine administration on oxygenation in COVID-19 patients with acute respiratory distress syndrome treated by high-flow nasal canula oxygen therapy as first-line…
- Trial name
- NCT05216575
- Testing
- Administration of Almitrine
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acute Respiratory Failure, Immunosuppression
HFNC Alone or Associated With NIV for Immunocompromised Patients Admitted to ICU for Acute Respiratory Failure
Acute respiratory failure is the leading cause of ICU admission of immunocompromized patients. In this subgroup of patients, the need for intubation and invasive mechanical ventilation occurs in about 50% of cases and is…
- Trial name
- FLORALI-IM (NCT02978300)
- Testing
- NIV/HFNC, HFNC
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Poitiers University Hospital
Acute Hypoxemic Respiratory Distress
HFNO or Conventional Oxygen Therapy for Patients With Acute Hypoxemic Respiratory Distress
A quarter of the patients admitted to the Shock Room or Resuscitation Room of an Emergency Department (ED) are admitted for severe hypoxemia resulting from acute respiratory distress.
- Trial name
- HIFLOWED (NCT04607967)
- Testing
- High Flow Nasal Oxygen
- Where
- 10 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Oxygen Inhalation Therapy Endoscopy
Comparison of Two Ventilation Methods During Endoscopy of the Pharynx, Larynx and Oesophagus
Around 15,000 ENT cancers are diagnosed each year in France. The majority of these cancers will at one time or another require an Endoscopy of the Pharynx, Larynx and Esophagus (Endo-PLE or suspension laryngoscopy).
- Trial name
- OPTIGO (NCT07004699)
- Testing
- Laryngoscopy, High-flow oxygen therapy
- Where
- 3 sites in France
- Volunteers
- 610 people
- Sponsor
- Poitiers University Hospital
Adherence, Treatment
High-Flow in Hypercapnic Stable COPD Patients
Monocentric, prospective, open, randomized 1:1, controlled study to evaluate the impact of nasal high-flow (NHF) on nocturnal transcutaneous PCO2 (PtCO2) compared to non-invasive ventilation ± Long-Term Oxygen Therapy (LTOT) in…
- Trial name
- HIGH-FLOW (NCT04281316)
- Testing
- Nasal High Flow installation, Non Invasive Ventilation, Training session
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Grenoble
Pulmonary Disease, Chronic Obstructive
Efficacy and Physiology of Nasal High Flow Therapy
The effects of a nasal high-flow (NHF) therapy in patients with chronic obstructive hypercapnic respiratory failure are still not sufficiently known yet.
- Trial name
- NCT02083120
- Testing
- NHF therapy, Long term Oxygen Therapy (LOT)
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV
Acute Respiratory Failure Requiring Reintubation
High-flow Nasal Cannula Oxygen Therapy With or Without NIV During the Weaning Period
Prospective multicenter randomized controlled open-label trial comparing 2 strategies of oxygenation during the post-extubation period in ICU patients at high risk of extubation failure.
- Trial name
- HIGH-WEAN (NCT03121482)
- Testing
- HFNC, NIV
- Where
- France
- Volunteers
- 650 people
- Sponsor
- Poitiers University Hospital
Apnea, Hypoxia
High Flow Nasal Oxygen Therapy Undergoing Colonoscopy
Investigation of the Clinical Efficacy of High Flow Nasal Oxygen in Patients Over 60 Years of Age Undergoing Colonoscopy
- Trial name
- NCT05396274
- Testing
- High Flow Nasal Cannula
- Volunteers
- 70 people
- Sponsor
- Turkish Society of Anesthesiology and Reanimation
Respiratory Failure With Hypoxia, Respiratory Failure, ICU
Weaning From High Flow Nasal Oxygen in Acute Respiratory Failure : a Target Trial Emulation
Acute respiratory failure is a frequent reason for admission to the intensive care unit (ICU). It is associated with high healthcare consumption and mortality.
- Conditions
- Respiratory Failure With Hypoxia, Respiratory Failure, ICU, High-Flow Nasal Oxygen Therapy
- Trial name
- HFNO-Weaning (NCT07030413)
- Where
- 3 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Poitiers University Hospital
Respiratory Failure
Noninvasive Technique and High Flow Nasal Oxygen in Respiratory Failure
After obtaining Institutional Ethical Committee approval of Faculty of Medicine, Minia University and written informed consent from patients or first- degree relatives, this prospective randomized non-blind comparative study will…
- Trial name
- NCT07521254
- Testing
- HFNC, NIV
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Minia University
Bronchiolitis
High-flow Nasal Oxygen Therapy in Hospitalized Infant With Moderate-to-severe Bronchiolitis
Over the last decade, high-flow nasal oxygen therapy (HFN) has emerged as a new method to provide respiratory support in children with moderate to severe bronchiolitis.
- Trial name
- BRONCHOPTI (NCT02856165)
- Testing
- High-flow nasal canula oxygen therapy, Low-flow oxygen therapy with standard nasal canula
- Where
- France
- Volunteers
- 268 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adult Patients 20 Years of Age or Older Who Are Planning to Undergo Surgery Under General Anesthesia
Comparison of the Efficacy of High-flow Nasal Oxygen Therapy and Facial Mask Ventilation on the Increase of the Oxygen Reserve Index During Anesthetic Induction
The purpose of this study is to compare the ability of oxygenation with high-flow nasal oxygen therapy and mask ventilation technique for induction of anesthesia in adult patients who are planning to undergo surgery under general…
- Trial name
- NCT04291339
- Testing
- High-flow nasal oxygen technique, Mask ventilation technique
- Where
- South Korea
- Volunteers
- 198 people
- Sponsor
- Yonsei University