Clinical trials: Nasal High Flow Therapy
Idiopathic Pulmonary Fibrosis
High-flow Oxygen Therapy During Exercise in Idiopathic Pulmonary Fibrosis
Objectives: 1. To evaluate endurance time during cardiopulmonary exercise test (CPET) performance comparing standard oxygen therapy to high-flow nasal cannula (HFNC) oxygen therapy in subjects with idiopathic pulmonary fibrosis…
- Trial name
- NCT04564664
- Testing
- Oxygen
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Parc de Salut Mar
Respiratory Disease, Lung Diseases
Nasal High Flow Therapy in the Paediatric Home Setting
High flow nasal cannula (HFNC) therapy is non-invasive respiratory support designed to deliver a high flow of heated humidified air, with or without entrained oxygen, via specifically designed nasal prongs.
- Trial name
- HFNC (NCT04037839)
- Testing
- Questionnaire
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Acute Respiratory Failure
A Randomised Controlled Trial of High-Flow Nasal Oxygen Versus Standard Oxygen Therapy in Critically Ill Immunocompromised Patients
Acute respiratory failure (ARF) is the leading reason for ICU admission in immunocompromised patients. Usual oxygen therapy involves administering low-to-medium oxygen flows through a nasal cannula or mask [with or without a bag…
- Trial name
- HIGH (NCT02739451)
- Testing
- standard oxygen, HFNO
- Where
- France
- Volunteers
- 776 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
High-flow Nasal Cannula, Electrical Impedance Tomography
Effects of High-Flow Nasal Cannula Therapy Assessed by Electrical Impedance Tomography
This study aimed to determine the effects of HFNC therapy on lung recruitment and lung strain change assessed by electrical impedance tomography (EIT)
- Trial name
- NCT04245241
- Testing
- High-flow nasal cannula (HFNC)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Chronic Obstructive Pulmonary Disease, Hypercapnia
Physiological and Clinical Changes in NHF Therapy
The study explores the changes in pressure, volume and in hypercapnia in patients with COPD and ILD. The investigators will use different application forms.
- Conditions
- Chronic Obstructive Pulmonary Disease, Hypercapnia, Interstitital Lung Disease
- Trial name
- ATMOFLOW (NCT02504814)
- Testing
- Nasal Highflow (NHF)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- University of Leipzig
Acute Respiratory Failure, Bronchoscopy
HFNC During Bronchoscopy for Bronchoalveolar Lavage
The execution of diagnostic-therapeutic investigations by bronchial endoscopy can expose the patient to acute respiratory failure (ARF). In particular, the risk of hypoxemia is greater during broncho-alveolar lavage (BAL).
- Conditions
- Acute Respiratory Failure, Bronchoscopy, Bronchoalveolar Lavage
- Trial name
- NCT04016480
- Testing
- High Flow Nasal Cannula, Conventional Oxygen Therapy
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University Magna Graecia
Bronchiolitis
High Flow in Infants With Bronchiolitis
In this multi-centre randomized controlled trial the investigators compare the effect on dyspnoea severity of oxgen delivery through High Flow Nasal cannula with Low Flow Nasal Prongs in children < 2 years of age hospitalised for…
- Trial name
- NCT02913040
- Testing
- High Flow Nasal Cannula, Low Flow Nasal Prongs
- Where
- 7 sites in Netherlands
- Volunteers
- 111 people
- Sponsor
- Princess Amalia Children's Clinic
Adult Patients Ventilated More Than 48 h
Treatment Strategy in Patients With High-risk of Postextubation Distress in ICU Based on a Lung Ultrasound Score Versus Standard Strategy
Prospective, randomized clinical multicentric study in ICU during weaning from mechanical ventilation.
- Trial name
- WIN IN WEAN (NCT02123940)
- Testing
- lung ultrasound score
- Where
- France
- Volunteers
- 483 people
- Sponsor
- University Hospital, Clermont-Ferrand
Upper Gastrointestinal Bleeding
HFNC Versus Conventional Oxygen Therapy in Prolonged Upper Gastrointestinal Endoscopy in the ICU
Conventional supplemental oxygen therapy (COT) during upper gastrointestinal (UGI) endoscopy via nasal catheter is considered the standard practice in maintenance of oxygenation and prevention of hypoxia.
- Trial name
- NCT06350864
- Testing
- High-flow nasal cannula (HFNC), Conventional nasal oxygen therapy (COT), Upper gastrointestinal endoscopy (UGE) including gastroscopy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Chest Injuries, Respiratory Failure
Early Non-invasive Ventilation and High-flow Nasal Oxygen Therapy for Preventing Delayed Respiratory Failure in Hypoxemic Blunt Chest Trauma Patients.
In blunt chest trauma patients without immediate life-threatening conditions, delayed respiratory failure and need for mechanical ventilation may still occur in 12 to 40% of patients, depending on the severity of the trauma, the…
- Trial name
- OptiTHO (NCT03943914)
- Testing
- Preventive strategy, Standard of care
- Where
- 14 sites in France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Bordeaux
Oxygen Deficiency
Incidence of Use of High-Flow Nasal Cannula Oxygen Therapy in Intensive Care Units Patients
Patients with one or more organ failure (heart, lung) require hospitalization in intensive care where these failures can be managed.
- Trial name
- OHE-REA (NCT04141956)
- Testing
- High-Flow Nasal Cannula
- Where
- 10 sites in France
- Volunteers
- 257 people
- Sponsor
- Nantes University Hospital
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in…
- Trial name
- WINDSURFER (NCT07558265)
- Testing
- Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
- Where
- 6 sites in United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Hypoxia, Obesity
Nasopharyngeal Airway Combined With Nasal High-flow Oxygen Therapy During Painless Gastroscopy in Obesity Patients
Gastroscopy is a commonly used, direct, and reliable method for screening and diagnosing digestive tract diseases. However, as an invasive examination, it can cause adverse reactions such as pain, nausea, vomiting, and choking…
- Conditions
- Hypoxia, Obesity, Gastrostomy
- Trial name
- NCT06966934
- Testing
- NPA
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Acute Respiratory Failure, Treatment With Noninvasive Positive Pressure Ventilation
Pilot Study of High-flow Humidified Nasal Oxygen During Breaks From Noninvasive Ventilation
The purpose of this study is to assess whether Optiflow, a high-flow humidified oxygen delivery system, is superior to standard oxygen therapy during breaks off noninvasive ventilation in patients affected by acute respiratory…
- Trial name
- OPTINIV (NCT01925534)
- Testing
- High-flow humidified nasal oxygen delivery system, Standard oxygen therapy
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Tufts Medical Center
Respiratory Failure
ROX Index Versus MROX Index to Predict Treatment Outcome for High Flow Nasal Cannula And/or Noninvasive Ventilation in Patients with Respiratory Failure
One of managing steps in respiratory failure is high flow nasal cannula (HFNC), but the exact time to turn to invasive machine ventilation (IMV) is necessarily being determined.
- Trial name
- NCT06715644
- Volunteers
- 120 people
- Sponsor
- Assiut University
Hypoxemia During Surgery
High-flow Nasal Oxygen Therapy for Advanced Endoscopy in High-risk Patients.
Anesthesia is crucial during upper GI endoscopy in order to improve the procedural conditions for the interventionist, increase the quality of examination and alleviate patient discomfort.
- Trial name
- NCT06610461
- Testing
- HFNO-Treatment
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Beth Israel Deaconess Medical Center
Respiratory Failure With Hypercapnia, Therapeutic Bronchofiberoscopy
To Assess the Types of Mechanical Ventilation in Enabling Therapeutic Bronchofiberoscopy in Patients With Decompensated Respiratory Acidosis (Complete Respiratory Failure).
Background: Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes.
- Trial name
- NCT06970041
- Testing
- Use of NIV during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure, Use of HFNC during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure
- Volunteers
- 315 people
- Sponsor
- Medical University of Silesia
COVID-19
Interest in the Use of Nasal High-Flow Oxygen Therapy (OptiFlow™) in Secondary Transport of COVID-19 Positive Patients
Since the beginning of COVID-19 pandemic situation, several modes of ventilation have been tried to correct the hypoxaemia induced by SARS-CoV-2 virus.
- Trial name
- SAMU83 (NCT05289141)
- Testing
- Use of high flow nasal oxygen therapy, Use of other non-invasive ventilation or high concentration oxygen masks
- Where
- France
- Volunteers
- 229 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Infant, Premature, Neonatal Respiratory Distress
Maintaining Optimal HVNI Delivery Using Automatic Titration of Oxygen in Preterm Infants
Oxygen treatment is common in management of preterm babies requiring intensive care. Delivery of too much or too little oxygen increase the risk of damage to eyes and lungs, and contributes to death and disability.
- Conditions
- Infant, Premature, Neonatal Respiratory Distress, Oxygen Saturation, Bronchopulmonary Dysplasia
- Trial name
- MODERATION Neo (NCT05030012)
- Testing
- Automated Control, Manual Control
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Vapotherm, Inc.
Respiratory Failure, Heart Rate Variability (HRV)
Heart Rate VAriability as a MaRker for tItrATing hIgh flOw Nasal Cannula Therapy
High-flow nasal cannula is a type of non-invasive respiratory support that helps patients breathe more comfortably. Because the flow is high, it can deliver more oxygen to the lungs and make breathing easier by reducing the…
- Conditions
- Respiratory Failure, Heart Rate Variability (HRV), High Flow Nasal Cannula
- Trial name
- VARIATION (NCT07518862)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto