Clinical trials: Nasal High Flow Therapy
Obstructive Sleep Apnea
High Flow Nasal Cannula for Obstructive Sleep Apnea
This study compare the efficacy of high flow nasal cannula with nasal continuous positive airway pressure. All of participants will be randomized to receive one night high flow nasal cannula therapy and another night for nasal…
- Trial name
- NCT03843372
- Testing
- High flow nasal cannula
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- Chung-Chieh, Yu
Chronic Obstructive Pulmonary Disease, Nasal High Flow
Investigating the Effect of Nasal High Flow Oxygen Therapy on Regional Lung Function
This study aims to assess the effect of nasal high flow oxygen therapy on regional function measured by volumetric computed tomography, in patients with chronic obstructive pulmonary disease.
- Conditions
- Chronic Obstructive Pulmonary Disease, Nasal High Flow, Dynamic Volumetric Computed Tomography
- Trial name
- INVENT (NCT03821311)
- Testing
- Computed tomography
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Grenoble
Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure
Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study
This study targets adult patients treated with high flow nasal cannula (HFNC) at emergency department (ED) of Severance hospital, Yonsei university.
- Conditions
- Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure, Acute Hypoxemic Respiratory Failure, Hypercapnic Acute
- Trial name
- NCT06064409
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency
High Flow Therapy (HFT) to Treat Respiratory Insufficiency in Chronic Obstructive Pulmonary Disease (COPD)
The aim of this study is to see if the Vapotherm High Flow Therapy (HFT) device is effective to provide breathing support to patients with Chronic Obstructive Pulmonary Disease or COPD.
- Trial name
- NCT00990119
- Testing
- Vapotherm High Flow Therapy, Non-invasive positive pressure ventilation
- Where
- United States
- Sponsor
- Vapotherm, Inc.
Sedation Complication
Comparison of High-Flow Nasal Cannula Oxygen Application and Classic Nasal Cannula Oxygen Application
Recently, sedation practices have increased for diagnostic and interventional procedures for children in non-operating rooms. On the other hand, the rate of respiratory complications especially in non-operating room sedation…
- Trial name
- NCT04472273
- Testing
- high-flow nasal cannula / classic nasal cannula
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Kocaeli Derince Education and Research Hospital
Hypoxic Respiratory Failure
Diaphragmatic Ultrasound to Predict the Therapeutic Effect of High-flow Nasal Cannula Oxygen Therapy
Follow-up was conducted for every patient requiring high-flow nasal cannula oxygen therapy in district 1 of the Intensive Care Department of Chenzhou NO.1 People's Hospital.
- Trial name
- NCT06336265
- Testing
- Diaphragm ultrasound
- Volunteers
- 269 people
- Sponsor
- Xingui Dai
Oxygen Therapy; Heart Surgery
High-Flow Aerosol Generation Study
The study will be measuring aerosol generated from the point of tracheal extubation after cardiac surgery in patients who then receive either high-flow nasal oxygen therapy (HFNT) or standard low-flow oxygen therapy, who have…
- Trial name
- NCT05384275
- Testing
- High Flow Nasal Therapy
- Where
- United Kingdom
- Volunteers
- 61 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Acute Respiratory Distress Syndrome
High Flow Nasal Canula Oxygen Helps Preoxygenate ARDS Patients
Tracheal intubation in the ICU is associated with significant complications and morbidity. Desaturation is among the most frequent and hazardous complication, occurring in almost one out of four intubations, that may in some…
- Trial name
- HIGHER (NCT02214576)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hôpital Louis Mourier
Respiratory Distress Syndrome
Effects of Flow Magnitude on Cardiorespiratory Stability During Nasal High Flow Therapy in Preterm Infants
Premature babies often need help breathing for a longer period of time. Traditionally, this is done with a breathing aid called NCPAP (nasal continuous positive airway pressure).
- Trial name
- MASTER (NCT05908227)
- Testing
- NHF high, NHF low, NCPAP
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 150 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
High Flow Nasal Cannula, Oxygen Therapy
Closed-loop Oxygen Control for High Flow Nasal Therapy
In patients with acute hypoxemic respiratory failure (AHRF), High Flow Nasal Therapy (HFNT) improves oxygenation, tolerance, and decrease work of breathing as compared to standard oxygen therapy by facemask.
- Conditions
- High Flow Nasal Cannula, Oxygen Therapy, Hypoxemia, Hyperoxemia
- Trial name
- HILOOP (NCT04965844)
- Testing
- Oxygen close-loop, No intervention
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Gynecologic Surgery, High-flow Nasal Cannula
A RCT on the Preventive Effect of HFNC on Postoperative Pulmonary Complications in Patients With Gynecologic Neoplasms
Patients at high risk of post-operative pulmonary complications (PPC) will be screened out from gynecological tumor patients undergoing surgical treatment, and randomly assigned into the HFNC group and control group, which uses…
- Conditions
- Gynecologic Surgery, High-flow Nasal Cannula, Post-operative Pulmonary Complications
- Trial name
- NCT05526534
- Testing
- heated humidified high flow nasal cannula oxygen therapy, HFNC, Nasal cannula oxygen
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Evaluation of Prone Position Effect During NIV and HFNC on Acute Hypoxemic Respiratory Failure
Prone Position in Non-Invasive Ventilation and High-Flow Oxygen Therapy
The aim of this trial is to study the effect of prone position during NIV and HFNC on acute hypoxemic respiratory patients.
- Trial name
- ProPNIVFlow (NCT04306107)
- Testing
- Prone position during non-invasive respiratory support
- Volunteers
- 100 people
- Sponsor
- Hospital General Universitario Morales Meseguer
High Flow Nasal Cannula, Respiratory Insufficiency
Weaning Protocol for High Flow Nasal Cannula Oxygen Therapy
High flow nasal cannula oxygen therapy has been widely used in critically ill patients. Despite effectiveness of high flow nasal cannula as a treatment, optimal methods to withdrawal high flow nasal cannula after recovery from…
- Trial name
- SLOWH (NCT03845244)
- Testing
- Flow reduction first, FiO2 reduction first, Simultaneous (flow and FiO2) reduction
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Burn Injury, Hypoxia
Comparison of High Flow Nasal Oxygen and Nasal Cannula in Burn Patients Under Sedation
Burn-related pain is severe and often difficult to manage. Burn patients often require high doses of opioids and anxiolytics. Anesthetic agents used during sedation such as benzodiazepines, propofol and opioids can cause…
- Conditions
- Burn Injury, Hypoxia, Sedation
- Trial name
- NCT06756906
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ankara City Hospital Bilkent
Hypoxemia During Surgery
High-Flow Nasal Oxygen vs. Face Mask During Sedoanalgesia in Non-Intubated Thoracoscopic Pericardial Window Surgery
This is a prospective, randomized, parallel-group clinical trial designed to evaluate the effects of high-flow nasal oxygen therapy (HFNOT) versus conventional oxygen mask (COM) on perioperative hypoxia in patients undergoing…
- Trial name
- HIFI-NIVATS (NCT07432607)
- Testing
- High-Flow Nasal Oxygen Therapy (HFNOT), Conventional Oxygen Mask (COM)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ebru Girgin Dinc
Acute Respiratory Failure
High Flow Therapy for the Treatment of Respiratory Failure in the ED
The overall objective of this study is to determine if Vapotherm high flow nasal cannula therapy (HFT), when used to treat respiratory failure in the ED, is at least equivalent to the current standard of care for non-invasive…
- Trial name
- NCT02236559
- Testing
- Noninvasive positive pressure ventilation (NIPPV), Vapotherm
- Where
- 5 sites in United States
- Volunteers
- 204 people
- Sponsor
- Vapotherm, Inc.
Mild-Moderate Obstructive Sleep Disordered Breathing
Non-Inferiority Trial of Acute HFT Versus nCPAP
Order randomized crossover non-inferiority study evaluating the acute efficacy of High Flow Therapy (HFT) as compared to nasal Continuous Positive Airway Pressure therapy (CPAP) in the management of apnea / hypopnea index (AHI).
- Trial name
- NCT01860560
- Testing
- High-Flow Therapy, Continuous Positive Airway Pressure
- Where
- United States
- Sponsor
- Vapotherm, Inc.
Cardiac Surgery
High Flow Nasal Oxygen Therapy (Optiflow™) in High-risk Cardiac Surgical Patients
Background: High risk patients with lung disease who undergo cardiac surgery are at significant risk of postoperative complications leading to prolonged hospital stay.
- Trial name
- NCT02496923
- Testing
- High flow nasal oxygen therapy (Optiflow™), Standard oxygen therapy (Hudson Type face mask or nasal prongs)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Chronic Obstructive Pulmonary Disease (COPD)
High-flow Nasal Cannula Therapy for Stable Chronic Obstructive Pulmonary Disease (COPD)
This is a prospective, randomized crossover study for evaluation of the efficacy and safety of long-term nocturnal high-flow nasal cannula therapy with the myAIRVO2® in stable COPD patients with stage 2-4 of the Global Initiative…
- Trial name
- NCT02545855
- Testing
- High-flow nasal cannula therapy, Home oxygen therapy (HOT)
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Moderate Respiratory Distress, Severe Respiratory Distress
High Flow Nasal Oxygen Therapy an Implementation Study in Pediatric Wards
The purpose of this study is to prospectively evaluate the process of implementing HFNO in several MSF projects, varying according to geographical and programmatic contexts, population, health structures, human resources, and…
- Trial name
- HFNO (NCT06715423)
- Where
- Afghanistan
- Volunteers
- 960 people
- Sponsor
- Epicentre