Clinical trials: Nasolabial Fold
Wrinkles
Injectable Filler for Facial Soft Tissue Augmentation
The purpose of this study is to assess the safety and performance of Hydroxytite in all subjects who have received sub dermal or deep dermal injections.
- Trial name
- NCT02218788
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Panaxia Ltd
Dermal Fillers, Cheek Augmentation
Evaluation of Performance and Safety of Injectable KIO017 Device Range for Facial Tissue Filling
The goal of this clinical trial is to primarily evaluate the performance of KIO017 in filling/volumizing after injection in different areas in healthy women or men, older than 18 years and seeking an improvement of her/his face…
- Conditions
- Dermal Fillers, Cheek Augmentation, Lip Augmentation, Perioral Rhytids
- Trial name
- LITCHEE (NCT06872359)
- Testing
- KIO017-1, KIO017-2, KIO017-3
- Where
- 3 sites in France, Poland
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Kiomed Pharma
Nasolabial Folds
To Evaluate the Efficacy and Safety of 'BRDE33-100' for the Temporary Correction of Moderate to Severe Nasolabial Folds
This study aims to demonstrate the non-inferiority of BRDE33-100 to Soonsoofill in temporarily improving moderate to severe nasolabial folds.
- Trial name
- NCT07069920
- Testing
- BRDE33-100, Soonsoofill
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- BRPharm Co., Ltd.
Wrinkles, Folds
A Clinical Investigation Comparing the Safety and Performance of RefillHA Solid With Hydryalix Ultra Deep Lidocaine for the Correction of Moderate-to-severe Nasolabial Folds
Prospective, controlled, randomized, monocentric, double-blind, split-face non-inferiority clinical study to evaluate the safety and performance of injectable implant based on hyaluronic acid hydrogel with lidocaine for…
- Trial name
- NCT07736703
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Glyance
Bilateral Nasolabial Fold Wrinkles
Safety and Efficacy Study of Isolagen Therapy in the Treatment of Nasolabial Fold Wrinkles
The purpose of this study is to evaluate the safety profile and the treatment effect of Isolagen TherapyTM compared with placebo when administered to bilateral nasolabial fold wrinkles.
- Trial name
- NCT00655356
- Testing
- Autologous Human Fibroblasts (azficel-T)
- Where
- 6 sites in United States
- Volunteers
- 218 people
- Sponsor
- Castle Creek Biosciences, LLC.
Correction of the Moderate to Severe Nasolabial Folds
Evaluation of the Effectiveness and Safety of Radiesse for the Correction of Nasolabial Folds in China
The objectives of this study are to evaluate the effectiveness and safety of Radiesse for the correction of nasolabial folds (NLFs).
- Trial name
- NCT03282357
- Testing
- Radiesse injectable implant (dermal filler), Restylane injectable implant (dermal filler)
- Where
- 4 sites in China
- Volunteers
- 181 people
- Sponsor
- Merz North America, Inc.
Nasolabial Folds
Phase 2 Study of TAT4 Gel for Reduction of Nasolabial Folds
This is a Phase 2, randomized, double-blind, placebo-controlled study of TAT4 Gel for the reduction of moderate to severe nasolabial folds.
- Trial name
- NCT02607670
- Testing
- TAT4 Gel
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Topokine Therapeutics, Inc.
Nasolabial Folds
Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections
Pliaglis® Cream versus compounded topical anesthetic for pain management during Restylane® injections for the correction of nasolabial folds.
- Trial name
- NCT00716443
- Testing
- tetracaine 7% / lidocaine 7% cream (Pliaglis® Cream), benzocaine 20% / lidocaine 6% / tetracaine 4% ointment
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- Galderma R&D
Nasolabial Fold, Hypoplastic
Princess® VOLUME Lidocaine for the Correction of Nasolabial Folds
In this study, eligible subjects with moderate to severe nasolabial folds will be treated with Princess® VOLUME Lidocaine and will return for follow-up assessments 2, 4, 24 and 36 weeks after the treatment.
- Trial name
- VINO (NCT03050710)
- Testing
- Princess® VOLUME Lidocaine
- Where
- 3 sites in Austria
- Volunteers
- 62 people
- Sponsor
- Croma-Pharma GmbH
Nasolabial Fold Wrinkles
Randomized Masked Trial of Injectable Cross-Linked Hyaluronic Acid for Moderate-to-Severe Nasolabial Folds
The objective of this clinical trial is to evaluate the efficacy and safety of injectable cross - linked hyaluronic acid gel for correcting moderate to severe nasolabial fold wrinkles, on the premise of ensuring the safety of…
- Trial name
- NCT07367204
- Testing
- Intense, Restylane
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Chongqing Jinsaixing Medical Technology Co., Ltd
Nasolabial Fold
Post Market Clinical Follow up Evaluating the Performance and Safety of Juläine(TM) on Nasolabial Fold Wrinkles
The goal of this post marketing study is to verify clincal performance and safety of CE-marked device Juläine. The main objective is to evaluate device performance when used as intended for augmentation of shallow to deep…
- Trial name
- NCT06471933
- Testing
- Juläine
- Where
- 2 sites in Spain, Sweden
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Nordberg Medical AB
Nasolabial Fold
Pain and Safety of Restylane Perlane With and Without Lidocaine for Correction of Moderate and Severe Nasolabial Folds
The purpose of this study is to evaluate the pain and safety in associated with injection of Restylane Perlane Lidocaine compared to Restylane Perlane using VAS scale
- Trial name
- NCT03174132
- Testing
- Restylane Perlane Lidocaine, Restylane Perlane
- Where
- 3 sites in Taiwan
- Volunteers
- 70 people
- Sponsor
- Galderma R&D
Nasolabial Folds
Neuramis® Deep Lidocaine Compared to YVOIRE® Volume Plus for Correction of Nasolabial Folds
This clinical investigation is a randomized, evaluator-blind, active controlled, noninferiority study to evaluate the effectiveness and safety of Neuramis® Deep Lidocaine when compared with YVOIRE® Volume Plus.
- Trial name
- NCT03753152
- Testing
- experimental, comparator
- Where
- China
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Medy-Tox
Wrinkle
A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction
This is a randomized, split-face, subject-blinded, comparative study. Subjects will receive initial treatment with Defyne on one of the NLFs and with RHA3 on the other based on the pre-determined randomization.
- Trial name
- NCT06351293
- Testing
- Defyne Treatment in Nasolabial Fold, RHA3 Treatment in Nasolabial Fold
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Correction of Nasolabial Folds and Lip Augmentation
PREVELLE Shape (CX002) Dermal Filler Protocol
The purpose of this study was to assess PREVELLE Shape (CX002), with respect to safety and efficacy for one year following treatment, for correction of facial nasolabial folds and when applied as an intradermal implant for lip…
- Trial name
- NCT00764257
- Testing
- PREVELLE Shape, Restylane
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mentor Worldwide, LLC
Moderate or Severe Nasolabial Folds
Effectiveness and Safety Comparison of Lunaphil Ultra (Hyaluronic Acid, by Espad Pharmed Co.) Versus Juvederm Ultra 4® (Hyaluronic Acid, by Allergan Co.) in Nasolabial Folds (NLFs) Management
Rationale and background: Skin aging is a complex process that results in various changes in the skin, including wrinkles, sun spots, and sagging skin.
- Trial name
- NCT06509477
- Testing
- Hyaluronic acid Lunaphil Ultra (by Espad Pharmed Co.), Hyaluronic acid Juvederm Ultra 4® (by Allergan Co.)
- Where
- Iran
- Volunteers
- 104 people
- Sponsor
- Espad Pharmed
Nasolabial Fold
Pain and Safety of Restylane With and Without Lidocaine for Correction of Moderate and Severe Nasolabial Folds
The purpose of this study is to evaluate the pain and safety associated with injections of Restylane Lidocaine compared to Restylane using a visual analogue scale.
- Trial name
- NCT02918721
- Testing
- Restylane Lidocaine, Restylane
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Galderma R&D
Temporary Correction of Wrinkles
Clinical Study to Evaluate the Correction of Facial Wrinkles and Folds and Safety of YVOIRE Volume Versus Perlane in Nasolabial Fold Injection
This study was purposed to evaluate the non-inferiority of YVOIRE volume, a hyaluronic acid product, in terms of correction of wrinkles and safety in nasolabial fold deep-dermal injection, compared to Perlane, the control…
- Trial name
- NCT03738007
- Testing
- HA IDF II, Perlane
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Nasolabial Fold Wrinkles
Prospective, Multicentre, Randomized, Blind, Parallel-controlled Clinical Trial Evaluating the Efficacy and Safety of Recombinant Collagen Gel for Correcting Moderate to Severe Nasolabial Wrinkles
Trial name: Prospective, multicentre, randomized, blind, parallel-controlled clinical trial to evaluate the efficacy and safety of recombinant collagen gel for correcting moderate to severe nasolabial wrinkles Sponsor: Shaanxi…
- Trial name
- NCT06854796
- Testing
- Recombinant collagen gel, collagen implant agent
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Shaanxi Giant Biotechnology Co., Ltd
Correction of Nasolabial Folds
A Randomized, Multicenter, Evaluator-Blinded, Active-Controlled, Parallel-Group Investigation to Evaluate the Performance and Safety of YVOIRE® Classic Plus Versus Comparator for Temporary Correction of Nasolabial Folds
A Study to Evaluate the Performance and Safety of YVOIRE Classic plus on NLF.
- Trial name
- NCT05106751
- Testing
- Hyaluronic acid dermal filler
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- LG Chem