Clinical trials: Nasolabial Fold
Dermatological Non-Disease
Effectiveness and Safety of Princess FILLER Lidocaine in Correction of Nasolabial Folds (NLF)
Clinical Investigation to demonstrate the effectiveness and safety of Princess Filler Lidocaine in the correction of moderate to severe nasolabial folds
- Trial name
- FILIDO (NCT03990883)
- Testing
- Princess Filler Lidocaine
- Where
- 11 sites in United States
- Volunteers
- 295 people
- Sponsor
- Croma-Pharma GmbH
Nasolabial Fold
Pain and Safety of Restylane Perlane With and Without Lidocaine for Correction of Moderate and Severe Nasolabial Folds
The purpose of this study is to evaluate the pain and safety in associated with injection of Restylane Perlane Lidocaine compared to Restylane Perlane using VAS scale
- Trial name
- NCT03174132
- Testing
- Restylane Perlane Lidocaine, Restylane Perlane
- Where
- 3 sites in Taiwan
- Volunteers
- 70 people
- Sponsor
- Galderma R&D
Nasolabial Folds
Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler
To assess pain during nasolabial fold treatment using Radiesse® Injectable Dermal Filler mixed with lidocaine.
- Trial name
- NCT01012661
- Testing
- Radiesse® Injectable Dermal Filler Mixed with Lidocaine, Radiesse® Injectable Dermal Filler without Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Nasolabial Folds
Safety and Effectiveness of JUVÉDERM™ Injectable Gel With Lidocaine
Safety and effectiveness of JUVÉDERM™ Injectable Gel with Lidocaine compared to JUVÉDERM™ without Lidocaine for procedural pain in the treatment of nasolabial folds.
- Trial name
- NCT00653861
- Testing
- JUVÉDERM™ Injectable Gel with Lidocaine, JUVÉDERM™ Injectable Gel
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Allergan Medical
Correction of Moderate to Severe Nasolabial Folds
Evaluation of Pain With Belotero® Balance With Integral Lidocaine for Correction of the Nasolabial Folds
Demonstrate the effectiveness of Belotero Balance with lidocaine (Test group) for the reduction of injection-related pain in comparison to Belotero Balance without lidocaine (Control group) for the correction of NLFs.
- Trial name
- NCT03319719
- Testing
- Belotero® Balance with integral lidocaine, Belotero® Balance
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- Merz North America, Inc.
Nasolabial Folds in Chinese Population
Efficacy and Safety of Restylane Perlane Compared to Restylane for Correction of Moderate and Severe Nasolabial Folds
The purpose of this study is to determine the safety and efficacy of using Restylane Perlane compared to Restylane for correction of moderate to severe nasolabial folds (NLF) in a Chinese population.
- Trial name
- NCT02432742
- Testing
- Restylane Perlane, Restylane
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Galderma R&D
Nasolabial Folds
Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds
Safety \& tolerability study that compares Restylane to Restylane with Lidocaine (Restylane-L) while correcting wrinkles in the area around your nose.
- Trial name
- NCT00797459
- Testing
- Restylane and Restylane-L
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medicis Global Service Corporation
Nasolabial Folds
Extension Study for 43USSA1705
To evaluate the long-term safety of Sculptra Aesthetic as a single regimen for correction of Nasolabial Fold (NLF) contour deficiencies after changes in reconstitution and injection procedures compared to the approved label.
- Trial name
- NCT04225273
- Testing
- Sculptra Aesthetic, Lidocaine HCL
- Where
- 4 sites in United States
- Volunteers
- 38 people
- Sponsor
- Galderma R&D
Correction of Moderate to Severe Nasolabial Folds (NLFs)
Evaluation of the Effectiveness and Safety of Radiesse for the Correction of Moderate to Severe Nasolabial Folds
Effectiveness: The purpose of this study is to demonstrate the non-inferiority of Radiesse (CaHA) to Restylane (HA) following subdermal implantation for the correction of moderate to severe facial wrinkles and folds, such as…
- Trial name
- NCT04647721
- Testing
- Radiesse injectable implant (dermal filler), Restylane injectable implant (dermal filler)
- Where
- 7 sites in China
- Volunteers
- 134 people
- Sponsor
- Merz North America, Inc.
Correction of Nasolabial Folds
Post Market Study Evaluating Princess Filler Lidocaine for the Correction of Nasolabial Folds
In this study, eligible subjects with moderate to severe nasolabial folds will be treated with Princess® FILLER Lidocaine and will return for follow-up assessments 2, 4, 24 and 36 weeks after the treatment.
- Trial name
- FINO (NCT03611491)
- Testing
- Princess FILLER Lidocaine
- Where
- 2 sites in Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Croma-Pharma GmbH
Temporary Correction of Wrinkles
Clinical Study to Evaluate the Correction of Wrinkles and Folds and Safety of YVOIRE Classic Versus Restylane in Nasolabial Fold Intradermal Injection
This study was purposed to evaluate the non-inferiority of HA IDF, a hyaluronic acid product, in terms of correction of wrinkles and safety in nasolabial fold intradermal injection, compared to Restylane, the control preparation.
- Trial name
- NCT03738020
- Testing
- HA IDF (YVOIRE classic), Restylane
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Moderate to Severe Nasolabial Folds
A Safety and Effectiveness Study of JUVÉDERM VOLIFT® XC Versus Control for Moderate to Severe Nasolabial Folds
A prospective, multicenter, within-subject controlled study of the safety and effectiveness of JUVÉDERM VOLIFT® XC versus Control for the correction of moderate to severe nasolabial folds (NLFs).
- Trial name
- NCT01976663
- Testing
- JUVEDERM VOLIFT® XC, Control
- Where
- 7 sites in United States
- Volunteers
- 126 people
- Sponsor
- Allergan
Facial Wrinkles
Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®.
This was a study to find out how an investigational product, Belotero, compares to a second product in people with facial wrinkles, such as nasolabial folds.
- Trial name
- NCT00876265
- Testing
- Belotero, Zyplast
- Where
- 6 sites in United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Nasolabial Folds
Safety and Effectiveness of Sculptra Aesthetic for Correction of Nasolabial Folds.
This study has been designed to evaluate the safety of Sculptra Aesthetic as a single regimen for correction of Nasolabial Fold (NLF) contour deficiencies after changes in reconstitution and injection procedures compared to the…
- Trial name
- NCT03780244
- Testing
- Sculptra Aesthetic 8ml, Sculptra Aesthetic 5ml
- Where
- 5 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Wrinkle
Clinical Study for the Evaluation of the Safety and Effectiveness of Use of a Poly-L Lactic Acid Injectable Filler for the Aesthetic Treatment of Nasolabial Folds
The purpose of this study is to assess the effectiveness and safety of Gana V, a Poly L-lactic acid filler for the aesthetic treatment of nasolabial folds, in comparison with Sculptra.
- Trial name
- PLLA (NCT05215054)
- Testing
- Gana V®, Sculptra®
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- GCS Co., Ltd
Nasolabial Fold Correction
Study to Evaluate Safety and Efficacy of Revanesse® Ultra + vs Revanesse® Ultra for Correction of NLF
A Multicenter, Double-Blind, Randomized, Split-Face Study to Evaluate the Safety and Efficacy of Revanesse® Ultra + (with Lidocaine) versus Revanesse® Ultra for the Correction of Nasolabial Folds to compare the safety and…
- Trial name
- NCT02991040
- Testing
- Revanesse Ultra+ (with lidocaine), Revanesse Ultra
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Prollenium Medical Technologies Inc.
Nasolabial Folds, Wrinkles
TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines, and Juvéderm® Ultra XC for the Correction of Nasolabial Folds
The purpose of this study is 1) to compare the effectiveness and safety of TEOSYAL® RHA Global Action versus Juvéderm® Ultra XC, and 2) to compare the effectiveness and safety of TEOSYAL® RHA Deep Lines versus Juvéderm® Ultra XC…
- Trial name
- NCT02195427
- Testing
- TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines
- Where
- 5 sites in United States
- Volunteers
- 148 people
- Sponsor
- Teoxane SA
Moderate to Severe Nasolabial Folds
Saypha® Volume LIdocaine in Nasolabial Folds
Comparison of saypha Volume Lidocaine from 2 different manufacturing locations in correcting moderate to sever nasolabial folds
- Trial name
- SAVINO (NCT04883632)
- Testing
- Saypha Volume Lidocaine
- Where
- 3 sites in Austria
- Volunteers
- 110 people
- Sponsor
- Croma-Pharma GmbH
Facial Wrinkles
Safety and Effectiveness of Belotero® in Subjects With Fitzpatrick Phototypes IV Through VI
This is a study to assess how safe and effective an investigational product, Belotero® is in people with all skin types with facial wrinkles, such as nasolabial folds.
- Trial name
- NCT00922623
- Testing
- Belotero®
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Merz North America, Inc.
Nasolabial Folds
Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections
Pliaglis® Cream versus compounded topical anesthetic for pain management during Restylane® injections for the correction of nasolabial folds.
- Trial name
- NCT00716443
- Testing
- tetracaine 7% / lidocaine 7% cream (Pliaglis® Cream), benzocaine 20% / lidocaine 6% / tetracaine 4% ointment
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- Galderma R&D