Clinical trials: Nasolabial Fold Wrinkles
Wrinkle Severity Rating Scale(WSRS) Grade 3 (Moderate) or 4 (Severe) of Nasolabial Folds
Clinical Trial of YYD701-2 for Treatment of Nasolabial Folds
A multicenter, active-controlled, randomized, evaluator and subject blinded, split-face, comparative, non-inferiority, Medical device Clinical trial.
- Trial name
- NCT03170050
- Testing
- YYD701-2, Restylane Perlane Lidocaine
- Where
- 2 sites in South Korea
- Volunteers
- 107 people
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Aging, Skin Wrinkling
Safety and Effectiveness of STYLAGE® L for Correction of Moderate and Severe Nasolabial Folds in Chinese Adults
This is a safety and efficacy study of STYLAGE® Lin Chinese adults with Nasolabial Folds.
- Trial name
- NCT04861766
- Testing
- STYLAGE® L, Active Comparator
- Where
- 8 sites in China
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Aging, Premature
Safety and Performance of DKL Crosslinked Sodium Hyaluronate 23 Dermal Filler for Improvement of NLF Appearance
This is a pivotal, prospective active-controlled, randomized, double blinded (blinded evaluator and subject), intra-individual split-face comparison, non-inferiority study of DKL crosslinked sodium hyaluronate 23 versus Juvederm…
- Trial name
- NCT05021913
- Testing
- DKL crosslinked sodium hyaluronate 23, Juvéderm Volift™ with lidocaine (Allergan, Inc)
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr. Korman Laboratories Ltd.
Facial Wrinkles (Nasolabial Folds)
A Study to Determine Safety & Efficacy of Autologous Human Platelet Lysate (HPL) in Facial Wrinkles(Nasolabial Folds)
This is a multicentre, open label, pilot study to evaluate safety and efficacy of Autologous Human Platelet Lysate (HPL) in subjects with Facial Wrinkles (Nasolabial Folds). The study is being conducted at 2 centers in India.
- Trial name
- NCT01644461
- Testing
- Autologous Human Platelet Lysate
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Kasiak Research Pvt. Ltd.
Nasolabial Folds
Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler
To assess pain during nasolabial fold treatment using Radiesse® Injectable Dermal Filler mixed with lidocaine.
- Trial name
- NCT01012661
- Testing
- Radiesse® Injectable Dermal Filler Mixed with Lidocaine, Radiesse® Injectable Dermal Filler without Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Wrinkle
Clinical Study for the Evaluation of the Safety and Effectiveness of Use of a Poly-L Lactic Acid Injectable Filler for the Aesthetic Treatment of Nasolabial Folds
The purpose of this study is to assess the effectiveness and safety of Gana V, a Poly L-lactic acid filler for the aesthetic treatment of nasolabial folds, in comparison with Sculptra.
- Trial name
- PLLA (NCT05215054)
- Testing
- Gana V®, Sculptra®
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- GCS Co., Ltd
Wrinkles
A Clinical Study to Evaluate the Efficacy and Safety of YVOIRE Classic Plus Versus YVOIRE Classic in Nasolabial Fold Injection
The objective of this study was to evaluate the efficacy and safety of HA IDF plus (with lidocaine) injected in the nasolabial fold compared to HA IDF (without lidocaine).
- Trial name
- NCT02340091
- Testing
- HA IDF plus, HA IDF
- Volunteers
- 62 people
- Sponsor
- LG Life Sciences
Facial Wrinkles
Safety and Effectiveness of Belotero® in Subjects With Fitzpatrick Phototypes IV Through VI
This is a study to assess how safe and effective an investigational product, Belotero® is in people with all skin types with facial wrinkles, such as nasolabial folds.
- Trial name
- NCT00922623
- Testing
- Belotero®
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Merz North America, Inc.
Facial Wrinkles
Evaluation of the Safety and Efficacy of CosmetaLife™ for the Correction of Nasolabial Folds
This is a randomized, double-blind pivotal study to evaluate the safety and effectiveness of CosmetaLife injectable dermal filler for the correction of wrinkles and folds, such as nasolabial folds (i.e., smile lines).
- Trial name
- NCT00414544
- Testing
- CosmetaLife, Restylane
- Where
- 5 sites in United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Cosmeta
Wrinkles Such as Nasolabial Folds
Post Market Study of Safety and Performance of RefillHA Volume+ for Facial Soft Tissue Augmentation and Correction of Wrinkles and Folds
This post market study was designed to collect clinical data regarding the safety and performance of RefillHA Volume+ upon its launch, from patients treated with the product in a routine clinical setting of treatments.
- Trial name
- NCT07109635
- Where
- Israel
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Glyance
Nasolabial Fold, Facial Wrinkles
Histology Study of Biostimulatory Activity of Injectable Poly-L-Lactic Acid (Sculptra Aesthetic)
The study device, Sculptra, is an injectable implant formulation of poly-L-lactic acid microbeads, approved by the FDA for treatment of facial fat loss (lipoatrophy of HIV disease).
- Trial name
- NCT04957446
- Testing
- Sculptra Aesthetic
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sadick Research Group
Bilateral Nasolabial Fold Wrinkles
Safety and Efficacy Study of Isolagen TherapyTM in the Treatment of Nasolabial Fold Wrinkles
The purpose of this study is to evaluate the safety profile and the treatment effect of Isolagen TherapyTM compared with placebo when administered to bilateral nasolabial fold wrinkles.
- Trial name
- NCT00649428
- Testing
- Autologous Human Fibroblast (azficel-T)
- Where
- 7 sites in United States
- Volunteers
- 203 people
- Sponsor
- Castle Creek Biosciences, LLC.
Wrinkle, Nasolabial Fold
RHA® 4 NLF Cannula
This is a randomized, controlled, single-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA®4 injected in NLFs with a cannula is non-inferior to RHA®4 injected in NLFs with a sharp…
- Conditions
- Wrinkle, Nasolabial Fold, Aging
- Trial name
- NCT04754646
- Testing
- Split-face injection of RHA® 4 with a cannula into a single NLF., Split-face injection of RHA® 4 with a needle (TSK 27G x ½") into the contralateral NLF.
- Where
- 4 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Face; Atrophy
DA-13-007 Versus Sculptra for the Treatment of Nasolabial Folds Wrinkles
Study DA-13-007 is a randomized, evaluator-blinded, within subject (split face) multicenter clinical study of DA-13-007l (Injectable poly-l-lactic acid) compared to SCULPTRA in the treatment of nasolabial fold wrinkles.
- Trial name
- NCT02310490
- Testing
- DA-13-007 right with left side Sculptra left side, DA-13-007 left with left side Sculptra right side
- Where
- 4 sites in United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- DermAvance
Nasolabial Folds, Wrinkles
TEOSYAL® RHA Ultra Deep and Perlane-L® for the Correction of Nasolabial Folds
The purpose of this study is to compare the effectiveness and safety of TEOSYAL® RHA Ultra Deep versus Perlane-L® in the treatment of moderate to severe nasolabial folds.
- Trial name
- NCT02253147
- Testing
- TEOSYAL® RHA Ultra Deep
- Where
- 4 sites in United States
- Volunteers
- 140 people
- Sponsor
- Teoxane SA
Skin Manifestations
Study to Evaluate the Safety and Effectiveness of GP0116
This is a prospective, randomized, evaluator-blinded, comparator-controlled, parallel group, multicenter study in the U.S. for correction of moderate to severe dynamic facial wrinkles and folds, such as nasolabial folds (NLFs).
- Trial name
- NLF (NCT05987163)
- Testing
- GP0116, Active Comparator: FDA approved dermal filler device (RHA 3)
- Where
- 19 sites in United States, Puerto Rico
- Volunteers
- 186 people
- Sponsor
- Galderma R&D
Correction of Nasolabial Folds and Lip Augmentation
PREVELLE Shape (CX002) Dermal Filler Protocol
The purpose of this study was to assess PREVELLE Shape (CX002), with respect to safety and efficacy for one year following treatment, for correction of facial nasolabial folds and when applied as an intradermal implant for lip…
- Trial name
- NCT00764257
- Testing
- PREVELLE Shape, Restylane
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mentor Worldwide, LLC
Aging Problems, Wrinkle
Comparing Polydioxanone Thread Embedding Acupuncture and Manual Acupuncture for Nasolabial Fold Reduction
This study was aimed to compare the effectiveness of polydioxanone thread embedding acupuncture and manual acupuncture on the reduction of the nasolabial fold.
- Trial name
- NCT05098912
- Testing
- Manual acupuncture, Thread embedding acupuncture
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Nasolabial Folds, Wrinkles
Non-comparative Evaluation of Facial Expressions Following Lower Face Correction Using Emervel Classic and Emervel Deep
Study is designed to characterize subject and treating investigator reported outcomes in the early post-treatment period, following bilateral correction of nasolabial folds using Emervel Classic and Emervel Deep. 1.
- Trial name
- NCT02672644
- Testing
- Emervel Classic, Emervel Deep
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Physiological Stress, Disorder of Aging
Non-inferiority of Belotero® Basic Versus Juvéderm® Ultra 3
This study will investigate the non-inferiority of Belotero® Basic versus Juvéderm® Ultra 3 in the treatment of nasolabial folds
- Conditions
- Physiological Stress, Disorder of Aging, Skin Diseases, Wrinkles
- Trial name
- NCT01305187
- Testing
- Hyaluronic Acid Filler
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH