Clinical trials: Natriuretic Peptide, Brain
Acute Kidney Failure
BNP (Nesiritide) vs. Placebo to Protect Kidney Function in Patients Undergoing Heart Bypass Surgery.
Use of BNP (nesiritide) vs placebo to help protect kidney function in patients undergoing heart bypass surgery.
- Trial name
- NCT00252200
- Testing
- Neseritide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Acute Myocardial Infarction
Nesiritide Therapy to Preserve Function of the Left Ventricle After Myocardial Infarction
The purpose of this study is to determine the efficacy of intravenous human beta natriuretic peptide (BNP, Nesiritide) as compared to placebo to prevent adverse post acute myocardial infarction left ventricular remodeling.
- Trial name
- Believe II (NCT00573144)
- Testing
- Nesiritide
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Mayo Clinic
Growth Hormone Deficiency, Cardiac Function
Cardiac Function and Morphology Evaluated by Magnetic Resonance Imaging in Growth Hormone Deficiency and Acromegaly
To test the hypothesis that both lack and excess of growth hormone (GH) is associated with cardiac abnormalities. Cardiac function and morphology will be evaluated by MRI before and after treatment.
- Trial name
- NCT00970463
- Volunteers
- 22 people
- Sponsor
- Herlev Hospital
Heart Failure
Nesiritide in Chronic Heart Failure
The purpose of this study is to look at the safety and effectiveness of longer term intravenous (IV) infusion of the study drug, nesiritide in patients with acutely decompensated chronic heart failure.
- Trial name
- NCT00145873
- Testing
- nesiritide, continuous infusion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Congestive Heart Failure
STARBRITE: A Randomized Pilot Trial of BNP-Guided Therapy in Patients With Advanced Heart Failure
The primary hypothesis is that, in patients with advanced heart failure, an outpatient fluid management strategy guided by BNP levels and clinical targets will lead to fewer days hospitalized or dead over a 3-month period…
- Trial name
- STARBRITE (NCT00484770)
- Testing
- Brain Natriuretic Peptide Levels -- Diagnostic testing, clinical assessment
- Volunteers
- 135 people
- Sponsor
- Duke University
Surgery, Cardiovascular Complications
B-type Natriuretic Peptide Guided Therapy to Improve Clinical Outcomes for Patients Undergoing Non-cardiac Surgery
The primary hypothesis of the BETTER pilot trial is that B-type natriuretic peptide (BNP) directed medical therapy prior to noncardiac surgery will be associated with improved cardiovascular outcomes, when compared to standard of…
- Conditions
- Surgery, Cardiovascular Complications, Risk Assessment
- Trial name
- BETTER pilot (NCT02679859)
- Testing
- BNP guided medical therapy optimisation
- Volunteers
- 100 people
- Sponsor
- University of KwaZulu
Acute Kidney Injury (Nontraumatic)
Exploring the Relationship Among BNP, Fluid Status and Acute Kidney Injury in Critically Ill Patients
B-type natriuretic peptide (BNP) is rapidly released by the ventricles of the heart in response to myocardial stretch. This cardiac neurohormone is mostly elevated in patients with fluid overload or myocardium dysfunction.
- Trial name
- NCT02095275
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Heart Decompensation, Congestive Heart Failure
An Open-label, One-arm, Study to Evaluate the Hemodynamic Changes and Safety of Nesiritide for Acute Decompensated Heart Failure
The present study was an open-label, uncontrolled, and multi-centered phase III clinical trial for evaluation of the efficacy (clinical efficacy and hemodynamics) and safety of nesiritide.
- Trial name
- NCT00813202
- Testing
- Nesiritide
- Where
- 4 sites in China
- Volunteers
- 41 people
- Sponsor
- Xian-Janssen Pharmaceutical Ltd.
Heart Failure, Liver Cirrhosis
B-type Natriuretic Peptide in the Diagnosis of Heart Failure Related Ascites
The serum albumin ascites gradient (SAAG) is a recommended tool for ascites diagnosis since values ≥1.1 g/dl are found in nearly 97% of patients with portal hypertension.
- Conditions
- Heart Failure, Liver Cirrhosis, Ascites, Carcinomatosis
- Trial name
- NCT01150916
- Testing
- BNP, SAAG, ascites total protein, echocardiography
- Where
- 2 sites in Brazil
- Volunteers
- 278 people
- Sponsor
- University of Sao Paulo
General Anesthesia, Vascular Surgery
BNP and Vascular Surgery
Background and rationale of the study: Patients undergoing non-cardiac major surgery show a perioperative cardiac risk and postoperative complications, that can be stratified based on parameters linked to patient's conditions and…
- Conditions
- General Anesthesia, Vascular Surgery, Abdominal Aortic Aneurysm, Natriuretic Peptide, Brain
- Trial name
- BNPinVasc (NCT03926104)
- Where
- Italy
- Volunteers
- 165 people
- Sponsor
- University of Parma
Respiratory Insufficiency
Brain Natriuretic Peptide (BNP) Levels in Patients in Non Invasive Mechanical Ventilation
The purpose of the study is to evaluate variation of BNP in non invasive mechanical ventilated patients with severe acute respiratory failure.
- Trial name
- NCT00453726
- Testing
- Non invasive mechanical ventilation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale S. Giovanni Bosco
Arteriovenous Fistula, Arteriovenous Graft
Access Creation for Hemodialysis: Association With Structural Changes of the Heart
The purpose of this study is to determine if the creation of a fistula or a graft plays a role in the development of heart disease for patients undergoing hemodialysis
- Conditions
- Arteriovenous Fistula, Arteriovenous Graft, Left Ventricular Hypertrophy, Brain Natriuretic Peptide
- Trial name
- NCT00368147
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Ottawa Hospital Research Institute
Diastolic Heart Failure
Study of Nesiritide in Diastolic Heart Failure.
We hypothesize that nesiritide will have favorable effect in decreasing heart filling pressures and echocardiogram studies.
- Trial name
- NCT00309868
- Testing
- neseritide
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Hypertension, Congestive Heart Failure
The VALIDATE Study of Valsartan for Patients With Early Stage Heart Failure
This is a study to evaluate the response of patients with hypertension and early stage heart failure to valsartan.
- Trial name
- NCT00241098
- Testing
- valsartan
- Volunteers
- 37 people
- Sponsor
- Novartis
Heart Failure Congestive
Effect of omega3 on Congestive Heart Failure
In this double blinded study patients with resynchronization pacemaker- AICD were assigned to Omega3 and placebo randomly, results indicated that Omega3 had no more effect than placebo in mortality, BNP level and 6 minutes walk…
- Trial name
- NCT01227837
- Testing
- omga3
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Shiraz University of Medical Sciences
Cardiovascular Risk Factor
Effect Levosimendan Administration on Postoperative NT-proBNP in Cardiac Risk Patients
This is a prospective randomised trial investigating the effect of a preemptive administration of levosimendan on postoperative cardiac NT-proBNP concentrations.
- Trial name
- IMPROVE (NCT04329624)
- Testing
- Levosimendan
- Where
- Austria
- Volunteers
- 230 people
- Sponsor
- Medical University of Vienna
Diabetes
Effect of Nesiritide Infusion on Insulin Sensitivity in Healthy Obese Insulin Resistant Subjects
The purpose of the study is to compare the effects of nesiritide to placebo administered by a continuous IV infusion over 48 hours for the treatment of insulin resistance in healthy, obese, insulin resistant individuals.
- Trial name
- BNP3 (NCT03234751)
- Testing
- Continous IV infusion of Nesiritide, Hyperinsulinemic euglycemic clamp
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Chronic Obstructive Pulmonary Disease
Inhaled Iloprost, Dynamic Hyperinflation, and Oxidative Stress in COPD Patients
The purpose of this study is to investigate the role of the pulmonary vasculature in the development and progression of chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01941225
- Testing
- Inhaled iloprost 5.0 mcg
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Eclampsia
Point-of-care Ultrasound Abnormalities in Eclampsia
Preeclampsia (PE) and eclampsia remain leading causes of maternal morbidity and mortality, in both high-, low-and-middle-income countries.
- Trial name
- NCT05678062
- Testing
- Point-of-care ultrasound
- Where
- South Africa
- Volunteers
- 70 people
- Sponsor
- University of Cape Town
Acute Decompensated Heart Failure
Assessment of Biomarkers and Cardiorenal Syndrome in Acute Decompensated Heart Failure With Vasodilator Therapy
The purpose of this study is to determine whether Nesiritide is more effective than nitroglycerin in modifying inflammatory and neurohormonal biomarkers without renal toxicity when proper infusion duration is administered.
- Trial name
- ABC-HFT (NCT00842023)
- Testing
- Nesiritide, Nitroglycerin
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Western University of Health Sciences