Clinical trials: Natriuretic Peptide Brain
Electrolyte Disturbances, Subarachnoid Hemorrhage
Electrolyte and Fluid Disturbances in Subarachnoid Hemorrhage and Traumatic Brain Injury
During the course of their acute illness patients with subarachnoid hemorrhage and severe traumatic brain injury often develop disturbances in their fluid balance and electrolyte homeostasis.
- Conditions
- Electrolyte Disturbances, Subarachnoid Hemorrhage, Traumatic Brain Injury, Natriuretic Peptides
- Trial name
- NCT01313975
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiorenal Syndrome
Use of Nesiritide (BNP) in Kidney Function in Patients With Congestive Heart Failure (CHF) and Kidney Failure
The objective of this study is to determine the safety and effectiveness of intrarenal administration of brain natriuretic peptide (BNP) in improving renal function as measured by glomerular filtration rate (GFR) and sodium…
- Trial name
- NCT00348556
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Horng Chen
Diet, Sodium-Restricted, Heart Failure, Systolic
Effect of Sodium Intake on Brain Natriuretic Peptide Levels in Patients With Heart Failure
The SODA-HF trial is a randomized, double-blind, controlled trial to evaluate the effect of moderate to severe sodium restriction on brain natriuretic peptide in patients with heart failure and reduced ejection fraction (less…
- Conditions
- Diet, Sodium-Restricted, Heart Failure, Systolic, Natriuretic Peptide, Brain, Clinical Trial
- Trial name
- SODA-HF (NCT03351283)
- Testing
- Severe sodium restriction, Moderate sodium restriction
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Instituto Mexicano del Seguro Social
Patients Undergoing Cardiac Surgery
The Relation Between Preoperative ScO2 and the Postoperative Course of Humoral Organ Dysfunction Markers.
Cerebral oxygen saturation (ScO2) is a measure of cerebral and systemic oxygen delivery to demand ratio. An observational trial in a heterogeneous cohort of 1078 patients patients revealed that a ScO2 below 50% absolute during…
- Trial name
- NCT01409941
- Volunteers
- 765 people
- Sponsor
- University of Luebeck
Diabetes
Effect of Nesiritide Infusion on Insulin Sensitivity in Healthy Obese Insulin Resistant Subjects
The purpose of the study is to compare the effects of nesiritide to placebo administered by a continuous IV infusion over 48 hours for the treatment of insulin resistance in healthy, obese, insulin resistant individuals.
- Trial name
- BNP3 (NCT03234751)
- Testing
- Continous IV infusion of Nesiritide, Hyperinsulinemic euglycemic clamp
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Chronic Kidney Disease, Acute Heart Failure
Utility of Brain Natriuretic Peptide (BNP) in Patients With Type IV Cardio-renal Syndrome Admitted to the Intensive Care Unit (ICU)
Admission BNP was a useful marker for diagnosing and predicting type IV cardio-renal syndrome type IV in patients with chronic kidney disease admitted to the ICU for acute heart failure in a retrospective study.
- Trial name
- NCT01211886
- Volunteers
- 83 people
- Sponsor
- Hallym University Medical Center
Congestive Heart Failure
Utility of Serial BNP Levels in Emergency Department CHF
The purpose of the study is to determine if a series of BNP blood tests performed on patients who present to the Emergency Department with congestive heart failure (CHF) can predict which patients may have adverse outcomes.
- Trial name
- NCT00534066
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Ohio State University
Arthritis, Rheumatoid, Spondylitis, Ankylosing
Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker
The purpose of this study is to determine possible alterations in cardiac function in patients with Rheumatoid Arthritis and Ankylosing Spondylitis under anti-TNF therapy, without clinical heart disfunction at baseline, using…
- Trial name
- NCT01072058
- Testing
- TNF blockers (infliximab, adalimumab, etanercept)
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
End Stage Renal Disease on Dialysis
Intradialytic Kinetics of Cardiac Biomarkers During Hemodialysis and Hemodiafiltration
This randomized, crossover study aims to investigate the intradialytic kinetics of selected cardiac biomarkers in patients with end-stage renal disease treated with dialysis.
- Trial name
- NCT06526702
- Testing
- High-flux hemodialysis, Post-dilution hemodiafiltration
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Aalborg University Hospital
Aortic Stenosis, Disorder of Prosthetic Cardiac Valve
Biomarkers in Aortic Stenosis - B.A.S.S.
This study is being done to determine whether or not new blood test(s) can determine the severity of heart conditions. Aortic stenosis, hypertrophic cardiomyopathy, mitral regurgitation, aortic regurgitation, artificial heart…
- Conditions
- Aortic Stenosis, Disorder of Prosthetic Cardiac Valve, Aortic Valve Insufficiency, Mitral Valve Insufficiency
- Trial name
- BASS (NCT01334801)
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Heart Failure and Reduced Ejection Fraction (HFrEF)
Secondary Use of PARALLEL-HF Data
This study utilized the blood and first morning void (FMV) urine samples from the PARALLEL-HF study (core part). The PARALLEL-HF study (core part) was a multicenter, randomized, double-blind, double-dummy, parallel-group…
- Trial name
- NCT07527767
- Where
- Japan
- Volunteers
- 236 people
- Sponsor
- Novartis Pharmaceuticals
Heart Defects, Congenital, Cardiopulmonary Bypass
Nesiritide Use Following Cardiac Surgery in Infants
The purpose of this study is to determine the effects of nesiritide on urine output and hemodynamics following cardiopulmonary bypass in infants. Safety and pharmacokinetic data will also be obtained.
- Trial name
- NCT00281671
- Testing
- nesiritide
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Boston Children's Hospital
General Anesthesia, Vascular Surgery
BNP and Vascular Surgery
Background and rationale of the study: Patients undergoing non-cardiac major surgery show a perioperative cardiac risk and postoperative complications, that can be stratified based on parameters linked to patient's conditions and…
- Conditions
- General Anesthesia, Vascular Surgery, Abdominal Aortic Aneurysm, Natriuretic Peptide, Brain
- Trial name
- BNPinVasc (NCT03926104)
- Where
- Italy
- Volunteers
- 165 people
- Sponsor
- University of Parma
Acute Decompensated Heart Failure
Neutrophil Gelatinase-Associated Lipcalin (NGAL) Evaluation Along With B-Type Natriuretic Peptide in Acutely Decompensated HF
This is a multi-center prospective pilot clinical study to assess the utility of the Triage NGAL Test - alone and in conjunction with the Triage BNP test - as an aid in the early risk assessment for heart-failure-related adverse…
- Trial name
- GALLANT (NCT00693745)
- Where
- 5 sites in United States, Netherlands and 1 more
- Volunteers
- 231 people
- Sponsor
- Abbott RDx Cardiometabolic
Heart Failure
Nesiritide and Vo2 Max in Heart Failure Patients
This research study, funded by Scios, Inc., and conducted by the Cardiology Division of the Department of Medicine at the University of Rochester School of Medicine and Dentistry investigates the potential benefit of nesiritide…
- Trial name
- NCT00240084
- Testing
- nesiritide (Natrecor(TM))
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
Congestive Heart Failure
STARBRITE: A Randomized Pilot Trial of BNP-Guided Therapy in Patients With Advanced Heart Failure
The primary hypothesis is that, in patients with advanced heart failure, an outpatient fluid management strategy guided by BNP levels and clinical targets will lead to fewer days hospitalized or dead over a 3-month period…
- Trial name
- STARBRITE (NCT00484770)
- Testing
- Brain Natriuretic Peptide Levels -- Diagnostic testing, clinical assessment
- Volunteers
- 135 people
- Sponsor
- Duke University
Heart Failure, Congestive
Effect of NT-proBNP Guided Treatment of Chronic Heart Failure
The purpose of this study is to determine whether NT-proBNP guided treatment of chronic congestive heart failure will reduce heart failure related morbidity and mortality compared to therapy guided by standard clinical judgement.
- Trial name
- NCT00149422
- Testing
- NT-proBNP measurements
- Where
- Netherlands
- Sponsor
- Netherlands Heart Foundation
AKI - Acute Kidney Injury, Cardiac Surgical Procedures
rhBNP for Prevention of Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI)
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common and serious perioperative complication, independently associated with prolonged hospitalization, increased mortality, and progression to chronic kidney disease.
- Conditions
- AKI - Acute Kidney Injury, Cardiac Surgical Procedures, Cardiopulmonary Bypass
- Trial name
- PROTECT-CS (NCT07617675)
- Testing
- Recombinant Human Brain Natriuretic Peptide (rhBNP)
- Where
- China
- Volunteers
- 694 people
- Sponsor
- China National Center for Cardiovascular Diseases
Breast Cancer, Chemotherapeutic Toxicity
Alpha-Lipoic Acid in Breast Cancer Patients
Investigate the ability of alpha lipoic acid to counter act anthracycline associated cardiotoxicity and cumulative taxens-related PN in patients with breast cancer.
- Trial name
- NCT03908528
- Testing
- Alpha-lipoic acid Plus Chemotherapy (doxorubicin (also known as Adriamycin) plus cyclophosphamide followed by taxol)
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Damanhour University
Surgery
Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?
The investigators hypothesize that the level of perioperative natriuretic peptides is associated with in-hospital and long term major adverse cardiac events.
- Trial name
- NCT00942786
- Where
- Austria
- Volunteers
- 297 people
- Sponsor
- Medical University of Graz