Clinical trials: Natriuretic Peptide Brain
Heart Failure
Effects of Aliskiren, Ramipril, and the Combination on Levels of Angiotensin II in Patients With Decompensated Systolic Heart Failure
In addition to the blood pressure lowering effects of aliskiren, it may have beneficial effects on blocking the so called RAAS (renin-angiotensin-aldosterone system) at the tissue level.
- Trial name
- ESCAPE-SHF (NCT00923156)
- Testing
- aliskiren, ramipril
- Where
- 16 sites in Germany, Poland and 1 more
- Volunteers
- 123 people
- Sponsor
- Novartis Pharmaceuticals
Heart Decompensation, Congestive Heart Failure
An Open-label, One-arm, Study to Evaluate the Hemodynamic Changes and Safety of Nesiritide for Acute Decompensated Heart Failure
The present study was an open-label, uncontrolled, and multi-centered phase III clinical trial for evaluation of the efficacy (clinical efficacy and hemodynamics) and safety of nesiritide.
- Trial name
- NCT00813202
- Testing
- Nesiritide
- Where
- 4 sites in China
- Volunteers
- 41 people
- Sponsor
- Xian-Janssen Pharmaceutical Ltd.
Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
Use of Beta-agonists in Stable Severe Congestive Heart Failure
The purpose of this study is to determine whether Salbutamol is effective in the treatment of severe heart failure due to ischemic and non- ischemic cardiomyopathy.
- Conditions
- Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy, Heart Failure
- Trial name
- NCT01447069
- Testing
- Salbutamol
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rabin Medical Center
Kidney Diseases, Congestive Heart Failure
Brain Natriuretic Peptide (BNP) to Preserve Renal Function in Hospitalized Patients With Heart Failure
Patients hospitalized for treatment of decompensated heart failure (CHF) are at risk for prolonged length of stay (LOS) and frequent readmissions.
- Conditions
- Kidney Diseases, Congestive Heart Failure, Cardiomyopathy
- Trial name
- NCT00170183
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Mayo Clinic
Sepsis, Septic Shock
Investigation of the Role of Brain Natriuretic Peptide and Lactate in Early Goal-directed Therapy for Patients With Severe Sepsis and Septic Shock
B-type natriuretic peptide (BNP) is a cardiac neurohormone which rapidly released by the ventricle in response to myocardial stretch.
- Trial name
- NCT01539551
- Testing
- check BNP and lactate
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Aortic Stenosis
A Comparison of Advanced Imaging Techniques in Aortic Stenosis
In patients with aortic stenosis the valve through which blood is pumped out of the main heart chamber is narrowed. This results in heart muscle working harder to open the valve so blood can circulate around the body.
- Trial name
- AIm-AS (NCT01775215)
- Testing
- Cardiac I123-MIBG Scintigraphy, Cardiac MRI, Stress and rest Echocardiogram
- Where
- United Kingdom
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Heart Failure, Congestive Cardiac Failure
B-type NAtriuretic Peptide In Critically Ill : A Multicentric Diagnostic Study (B-rAPID)
Difficulty in breathing or increased rate of breathing are common causes of admission to intensive care unit. This may be due to heart failure, or other causes such as infection in the lungs.
- Conditions
- Heart Failure, Congestive Cardiac Failure, Dyspnoea
- Trial name
- B-RAPID (NCT01685385)
- Testing
- Patients who will receive the BNP test
- Where
- 4 sites in India
- Volunteers
- 800 people
- Sponsor
- Mahatma Gandhi Institute of Medical Sciences
Congenital Heart Disease, Total Cavo-pulmonary Connection
Impact of Nesiritide on Early Postoperative Recovery After Total Cavo-Pulmonary Connection Surgery in Children
Nesiritide, a recombinant human B-type natriuretic peptide, has favorable effects on patient symptoms, hemodynamics, and the neurohumoral profile in adults with decompensated congestive heart failure and in those recovering from…
- Trial name
- NCT03207295
- Testing
- Nesiritide, Normal saline
- Where
- China
- Volunteers
- 108 people
- Sponsor
- China National Center for Cardiovascular Diseases
Heart Failure
Brain Natriuretic Peptide (BNP) Usefulness In Elderly Dyspneic Patients (BED)
The purpose of this study is to test the usefulness of measuring plasma brain natriuretic peptide (BNP) for diagnosis and prognosis in very elderly dyspneic patients.
- Trial name
- BED (NCT00658216)
- Where
- France
- Volunteers
- 390 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiomyopathy, Pregnancy
Plasma Brain Natriuretic Peptide Levels in Pregnancy
To evaluate the maternal blood concentrations of brain natriuretic peptide (BNP) during the second and third trimesters of a normal pregnancy.
- Trial name
- NCT00324402
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Congestive Heart Failure Exacerbation, Renal Insufficiency
BNP for Cardio-Renal Decompensation Syndrome (BNP-CARDS)
Many patients with exacerbations of heart failure have significant concomitant kidney dysfunction. The combination of these two conditions makes pharmacological management difficult.
- Trial name
- NCT00186329
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Pulmonary Hypertension
Acute Effects of rhBNP in Patients With PH Associated With Acute Exacerbation of Chronic Pulmonary Disease
To evaluate the acute effect of recombinant human brain natriuretic peptide(rhBNP) on pulmonary hypertension of acute exacerbations of chronic pulmonary disease.
- Trial name
- NCT02742909
- Testing
- rhBNP
- Where
- China
- Volunteers
- 9 people
- Sponsor
- LI ZHAO
Patent Ductus Arteriosus
Do Elevated BNP Levels Predict Hemodynamically Significant PDAs
The purpose of this study is to determine if B type natriuretic peptide (BNP) levels can be used to predict a hemodynamically significant patent ductus arteriosus (PDA).
- Trial name
- NCT01497054
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Pulmonary Hypertension
Serum Brain Natriuretic Peptide Levels and Pulmonary Hypertension in Pediatric Sickle Cell Patients
The purpose of this study is 1. To determine if Brain natriuretic peptide levels correlates with elevated tricuspid regurgitation flow velocity levels in pediatric patients with sickle cell disease 2.
- Trial name
- NCT01023451
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Akron Children's Hospital
Ischemic Stroke, Transient Ischemic Attack
Prognostic Value of Cardiac and Renal Markers in Ischemic Stroke and Transient Ischemic Attack
Patients with stroke or transient ischemic attack (TIA) are at high risk of poor outcome, recurrence of cardiovascular events or vascular death.Until now, no reliable predictive biological marker could be identified in the acute…
- Trial name
- ABC-AVC (NCT00479518)
- Where
- 3 sites in France
- Volunteers
- 159 people
- Sponsor
- University Hospital, Tours
Congestive Heart Failure
Use of NT-proBNP Testing to Guide Heart Failure Therapy in the Outpatient Setting.
Levels of amino-terminal pro-brain natriuretic peptide (NT-proBNP) a hormone released from the heart in patients with heart failure (HF) are strongly prognostic of adverse events, such as hospitalization or death from HF.
- Trial name
- PROTECT (NCT00351390)
- Testing
- Drug therapy for HF, NT-proBNP guided HF therapy
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Massachusetts General Hospital
COVID19 Pneumonia
N-terminal Pro B-type Natriuretic Peptide and Vitamin D Levels as Prognostic Markers in COVID-19 Pneumonia
This study is designed to assess the difference between level of NT-pro-BNP, and Vitmin D in moderate cases who progressed to severe or critically ill category compared to those who did not.
- Trial name
- NCT04487951
- Testing
- Pro BNP , Vitamin D
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Specimens With BNP Values of 5 to 5000 pg/ml, Triage
Alere Triage fs B-type Natriuretic Peptide (BNP) Method Comparison Evaluation
This study will evaluate method correlation and mean bias between six B-type natriuretic peptide (BNP) platforms.
- Trial name
- ABC (NCT01434433)
- Volunteers
- 360 people
- Sponsor
- Alere San Diego
Congestive Heart Failure, Chronic Heart Failure
Evaluation of Combined Action Between Natrecor and Furosemide on Kidney and Neurohormone Responses in Chronic Heart Failure: A Phase-IV study704.351 / DSS
This is a randomized, open-label, three-way crossover design study with 3 treatment groups:TREATMENT A: Furosemide;TREATMENT B: Nesiritide administered IV bolus, followed by an infusion for 6 hours;TREATMENT C: Treatment B for at…
- Trial name
- NCT00652652
- Testing
- nesiritide, furosemide
- Sponsor
- Scios, Inc.
Heart Failure
Provider Notification for High B-type Natriuretic Peptide Values
This proposal examines use of a clinical reminder to the primary provider of patient with a high B type natriuretic peptide but no prior imaging.
- Trial name
- NCT01734135
- Testing
- Clinical Reminder
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- VA Palo Alto Health Care System