Clinical trials: Natural History
Recurrent Bacterial Infection, Autoimmune Disorder
A Natural History Study to Assess the Clinical Outcomes of Patients With Complement Factor I Deficiency-Mediated Disease
This study will follow participants with a disease which is associated with an absence or deficiency in Complement Factor I (CFI) as confirmed in the CFI-001 screening study.
- Trial name
- NCT05095623
- Testing
- Natural History Observation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Catalyst Biosciences
Hiv Infection
Human Papillomavirus Infection and Related Anal Lesions in HIV-positive Men Who Have Sex With Men
Multicentric epidemiological non-comparative study in France characterising evolution of anal Human papillomavirus (HPV) infection and related lesions and evaluating markers associated with the observed evolution.
- Trial name
- APACHES (NCT02287961)
- Testing
- Standard proctologic examination, High resolution anoscopy, Biopsy(ies) during High Resolution Anoscopy
- Where
- France
- Volunteers
- 516 people
- Sponsor
- ANRS, Emerging Infectious Diseases
WHIM Syndrome
A Retrospective and Prospective Natural History Study of Patients With WHIM Syndrome
This natural history study is a prospective and retrospective, observational study of WHIM patients. WHIM syndrome is a rare, genetic, primary immunodeficiency disorder (a disorder in which the body's immune system does not…
- Trial name
- NCT03087370
- Testing
- No intervention
- Sponsor
- X4 Pharmaceuticals
Graft vs Host Disease, Healthy Volunteer
Collection of Saliva and/ or Peripheral Blood From Healthy Volunteers for Research
Background: Researchers often collect samples from healthy volunteers to further their research. These samples can help better understand serious side effects and complications of transplant treatments in patients.
- Conditions
- Graft vs Host Disease, Healthy Volunteer, Graft-Versus-Host Disease
- Trial name
- NCT01851382
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Cancer Institute (NCI)
Coronary Arteriosclerosis
Identifying Vulnerable Plaques in Blood Vessels of the Heart Using a New Imaging Technique
Atherosclerosis, a condition in which fatty deposits of plaque build up along the inner walls of arteries, is a condition that may increase the risk of having a heart attack.
- Trial name
- NCT00540761
- Testing
- OFDI imaging
- Where
- 3 sites in United States
- Volunteers
- 320 people
- Sponsor
- Massachusetts General Hospital
Frontotemporal Lobar Degeneration
Natural History Characterization in Symptomatic and Asymptomatic Progranuline Gene Mutation Carriers
The purpose of this study is to investigate whether cognitive deficits, structural and functional changes can be detected before symptom onset in presymptomatic progranuline mutation carriers.
- Trial name
- Predict-PGRN (NCT04014673)
- Testing
- Behavioral : Characterization
- Where
- 2 sites in France
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy Volunteer
Collection of Data and Samples From Healthy Donors for Use in Translational Research
Increased numbers of white blood cells called eosinophils can cause disease. To investigate this disease, researchers need blood, urine, sputum, stool, cerebrospinal fluid, skin and/or bone marrow samples to compare to samples…
- Trial name
- NCT00090662
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Herpes Virus-Related Illnesses
Herpesviruses Reactivation In Hiv-Infected Women Initiating ART (HERA)
Background: Herpes virus can cause sores on the body. It can cause flu-like symptoms like fever and muscle aches, and even a type of cancer. Many people with HIV also have infections with herpes virus.
- Trial name
- NCT03092505
- Where
- 2 sites in United States, Uganda
- Volunteers
- 190 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma, Parkinson's Disease
Agricultural Health Study Follow-up
Background: The Agricultural Health Study (AHS) is looking at the long-term health effects of farming exposures including pesticides, crops, and animals.
- Trial name
- NCT01399411
- Where
- 3 sites in United States
- Volunteers
- 89,656 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Breast Cancer, Healthy Volunteer
An Exploratory Evaluation of Biomarkers in Blister Fluid in Healthy Volunteers and Irradiated Skin
Background: Blister fluid contains many of the same biomarkers (substances that can be used to determine the effects of certain kinds of treatments) as blood and urine samples, particularly regarding changes in the skin.
- Conditions
- Breast Cancer, Healthy Volunteer, Prostate Cancer
- Trial name
- NCT00923104
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- National Cancer Institute (NCI)
Hypertension
Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0
Background: High blood pressure is a common problem. It can cause heart attacks, strokes, and kidney failure. It affects African Americans more than other racial groups.
- Trial name
- NCT02290392
- Where
- United States
- Volunteers
- 1,692 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Rheumatoid Arthritis
Genetic and Social Network Correlates of Rheumatoid Arthritis Outcomes in Hispanic Populations: A Prospective Study
Background: Rheumatoid arthritis (RA) is more severe in Hispanic people. Genetics plays a role. But social issues may also lead to more severe RA in Hispanics. Some Hispanics may not seek help for early symptoms.
- Trial name
- NCT05457816
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Iron-deficiency, Iron Deficiency Anemia
Iron Fish for Dominican Republic (DR) Infants
This study evaluates the feasibility of cooking with an iron ingot, Lucky Iron Fish™ (LIF), and evaluate the natural history of hemoglobins and iron status among infants of families using this iron ingot in a population with a…
- Trial name
- NCT03606993
- Testing
- Lucky Iron Fish (TM) - An iron ingot that is a Cooking supplement
- Where
- Dominican Republic
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
COVID-19
Transmissibility and Viral Load of SARS-CoV-2 in Oral Secretions
Background: COVID-19 is a worldwide pandemic and currently there is no effective therapy or vaccine. SARS-CoV-2, the virus that causes the COVID-19 respiratory infection, appears to be very contagious however all the modes of…
- Trial name
- NCT04348240
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Neuroaxonal Dystrophy, Infantile
A Natural History Study of Infantile Neuroaxonal Dystrophy
This study is a longitudinal and prospective study of the natural history of infantile neuroaxonal dystrophy (INAD).
- Trial name
- NCT04027816
- Where
- 5 sites in China, Egypt and 3 more
- Volunteers
- 43 people
- Sponsor
- Biojiva LLC
Heart Transplantation
Study of Heart Transplant Rejection
This study will investigate the causes of acute and chronic rejection of transplanted hearts. To find better ways to detect, treat and possibly prevent heart transplant rejection, more information about the cause is needed.
- Trial name
- NCT00042614
- Where
- 2 sites in United States
- Volunteers
- 188 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Parathyroid Cancer, Primary Hyperparathyroidism
Natural History Study of Parathyroid Disorders
Background: Parathyroid disorders are very common in the general population and include disorders of parathyroid excess, deficiency, or defects in parathyroid hormone (PTH) signaling.
- Conditions
- Parathyroid Cancer, Primary Hyperparathyroidism, Pseudohypoparathyroidism, Inheritable Bone Diseases
- Trial name
- NCT04969926
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Macrophage Activation Syndrome, Primary Hemophagocytic Lymphohistiocytosis
Retrospective Study of Immunotherapy Related Toxicities and Factors Impacting Outcomes in Children and Adults With Cancer
Immunotherapy is changing the landscape of cancer therapy. Particularly unique to immunotherapy is the toxicity profile, which differs from chemotherapy-based strategies and can be associated with inflammatory responses and/or…
- Trial name
- NCT03827343
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Cancer Institute (NCI)
Sickle Cell
Stem Cell Collection for Adult Volunteers
This study will examine the development of stem cells (very immature cells produced by the bone marrow) and their potential to change into cells of other organ types.
- Trial name
- NCT00033774
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Systemic Capillary Leak Syndrome
Studies in the Pathogenesis of Systemic Capillary Leak Syndrome
Background: Systemic Capillary Leak Syndrome (SCLS) is a disorder of unknown cause characterized by episodes of life-threatening drop in blood pressure and leakage of fluids into tissues.
- Trial name
- NCT00936325
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.