Clinical trials: Natural History
Wide Spectrum of Diseases, Hematologic Diseases
Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors
Background: Researchers seek ways to study people s medical problems in order to teach and further general knowledge. The ability to assess and treat people with a wide range of diseases is critical to training people to be good…
- Trial name
- NCT04450927
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Glanzmann Thrombasthenia
Multinational Glanzmann Study
Glanzmann thrombasthenia is a rare autosomal recessive platelet disorder characterized by a lack of functional integrins alfaIIb or beta3 (glycoproteins IIb/IIIa).
- Trial name
- Glanzmann-NHS (NCT06204042)
- Volunteers
- 200 people
- Sponsor
- UMC Utrecht
Intellectual Disabilities, Congenital Anomaly
Genome Medical Sequencing for Gene Discovery
Background: A number of rare inherited diseases affect only a few patients, and the genetic causes of these conditions remain unknown.
- Conditions
- Intellectual Disabilities, Congenital Anomaly, Rare Disorders
- Trial name
- NCT01087320
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Neurodegenerative Disease, Hereditary, Mitochondrial Diseases
Natural History Study of FDXR Mutation-related Mitochondriopathy
The purpose of the study is to systematically characterize the clinical course of the progressive neuropathy and optic atrophy observe in pediatric and adult patients with biallelic mutations in the ferredoxin reductase gene.
- Conditions
- Neurodegenerative Disease, Hereditary, Mitochondrial Diseases, Optic Atrophy
- Trial name
- NCT04580979
- Testing
- Mutation analysis
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- State University of New York at Buffalo
High Grade Meningioma, Ependymoma
Rare CNS Tumors Outcomes &Risk
Background: Primary tumors of the brain and spine are those that start in the brain or spine. These tumors are rare, accounting for <2% of all cancers diagnosed in the United States.
- Conditions
- High Grade Meningioma, Ependymoma, Medulloblastoma, PNET
- Trial name
- NCT03251989
- Where
- United States
- Volunteers
- 326 people
- Sponsor
- National Cancer Institute (NCI)
Healthy Subjects, Schizophrenia
Studies of Frontal Lobe Brain Functioning in Schizophrenia
The purpose of this study is to use brain imaging technology to investigate the role of the frontal lobe of the brain in the thinking of individuals with schizophrenia and other neuropsychiatric disorders and healthy volunteers.
- Conditions
- Healthy Subjects, Schizophrenia, Parkinson Disease
- Trial name
- NCT00001258
- Testing
- Oxygen-15 Water
- Where
- United States
- Volunteers
- 1,039 people
- Sponsor
- National Institute of Mental Health (NIMH)
T-cell Lymphoma, B-Cell Lymphoma
Investigation of the Human Immune Response in Normal Subjects and Patients With Disorders of the Immune System and Cancer
This protocol is being submitted to consolidate, update, and expand two previously approved protocols (77-C-0066 and 82-C-0044) into a single protocol.
- Conditions
- T-cell Lymphoma, B-Cell Lymphoma, ATL, Myeloma
- Trial name
- NCT00001582
- Where
- United States
- Volunteers
- 902 people
- Sponsor
- National Cancer Institute (NCI)
Prostatic Neoplasms
Evaluation of Atherosclerotic Plaques in Abdominal CT Studies
Background: Fat and calcium can build up as plaque in artery walls. The Agatston score measures plaque using computed tomography (CT) that does not use an injected contrast agent.
- Trial name
- NCT04652973
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Scoliosis Idiopathic
Development and Internal Validation of Predicting Models of Idiopathic Scoliosis Natural History and Treatment Outcomes Through the Use of Artificial Intelligence in a Large Clinical Database
Scoliosis is a three-dimensional deformity of the spine. In its most common form (about 70% of cases), the causes are unknown, therefore it is called idiopathic scoliosis.
- Trial name
- PREPARE (NCT06408896)
- Where
- Italy
- Volunteers
- 9,651 people
- Sponsor
- Istituto Scientifico Italiano Colonna Vertebrale
Age Related Macular Degeneration (AMD), Age Related Macular Degeneration
Evaluating the Relationship Between Function and Structure Using Data From a GA Natural History Cohort
Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration that leads to progressive and irreversible vision loss.
- Conditions
- Age Related Macular Degeneration (AMD), Age Related Macular Degeneration, AMD, Geographic Atrophy
- Trial name
- ARCHERY (NCT07424235)
- Volunteers
- 60 people
- Sponsor
- IRCCS Ospedale San Raffaele
Proteus Syndrome, PIK3CA Related Overgrowth Spectrum
Study of Proteus Syndrome and Related Congenital Disorders
This study will examine rare congenital disorders that involve malformations and abnormal growth. It will focus on patients with Proteus syndrome, whose physical features are characterized by overgrowth, benign tumors of fatty…
- Trial name
- NCT00001403
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
LCAT Deficiency
LCAT (Lecithin Cholesterol Acyl Transferase) Natural History Study
The purpose of the LCAT (Lecithin cholesterol acyl transferase) Natural History Study (LCAT NHS) is to help identify people with a mutation in a gene called LCAT, collect and store information about their medical history and…
- Trial name
- LCAT NHS (NCT06217588)
- Testing
- Demographics, diagnosis type, genotype, lipid profile, renal function profile, treatment allocation, ophthalmology exam, country of residence.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Lyme Disease, Tick-Borne Disease
Evaluation and Follow-up of People With Tick-borne Diseases
Background: Lyme disease is the most common tick-borne disease in the United States, but other diseases transmitted by ticks have also been on the rise in recent years.
- Trial name
- NCT04318925
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sleep Circadian Rhythms, Chronodisruption
Assessing Sleep and Circadian Rhythms in Primary Brain Tumors Patients
Background: Sleep disturbances are among the most common and severe symptoms reported by people with primary brain tumors (PBT).
- Trial name
- NCT04669574
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- National Cancer Institute (NCI)
Healthy Volunteer, Neurodegenerative Diseases
Visual Motor Coordination
Background: The relation between eye movement and brain function is a subject of interest to the National Eye Institute. By comparing eye movement in healthy volunteers to research conducted on patients who have difficulty moving…
- Trial name
- NCT00568243
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Chronic Kidney Disease
Evolution of Bone Histomorphometry and Vascular Calcification Before and After Renal Transplantation
A study of the natural history of bone and mineral disease (BMD) in patients with end-stage renal disease before and after kidney transplantation
- Trial name
- NCT01886950
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lymphangiomatosis, Lymphedema
Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders
Background: Lymphatics are a type of vessel, similar to arteries and veins. Lymphatic disorders happen when these vessels don t work properly.
- Conditions
- Lymphangiomatosis, Lymphedema, Lymphangiectasia, Pulmonary Lymphangiectasia
- Trial name
- NCT02156115
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Traumatic Brain Injury
Long-term Clinical Correlates of Traumatic Brain Injury
Background: Traumatic brain injury may have a range of effects, from severe and permanent disability to more subtle functional and cognitive deficits that often go undetected during initial treatment.
- Trial name
- NCT01132898
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
AMN, AMN Gene Mutation
Study of Disease Progression in Adults With Inherited Forms of Spastic Paraplegia
The course of AMN-related disabilities over time is poorly or incompletely understood due to a limited number of patients and lack of treatments.
- Conditions
- AMN, AMN Gene Mutation, X-ALD
- Trial name
- CYGNET (NCT05008874)
- Testing
- Natural History Observation
- Where
- 6 sites in United States, Germany and 1 more
- Volunteers
- 65 people
- Sponsor
- SwanBio Therapeutics, Inc.
Clinical Characteristics, Natural History
Rajaie Cardiomyopathy and Myocarditis Registry
The prevalence of patients with cardiomyopathies who referred to Rajaei Cardiovascular medical and research center is remarkable, and also the mission of this center is to achieve center of excellence in the field of…
- Conditions
- Clinical Characteristics, Natural History, Long-term Outcomes, Current Therapeutic Approaches
- Trial name
- NCT04304118
- Where
- Iran
- Volunteers
- 6,000 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.