Clinical trials: Natural History
Immune Disorders
NIAID Clinical Center Genomics Opportunity Protocol
Background: There are many types of immune disorders. These range from rare immune deficiencies to allergies to autoimmune disease like rheumatoid arthritis. Genes are the instructions our body uses to work and develop.
- Trial name
- NCT02417766
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Schizophrenia, Parkinson's Disease
PET Scanning in Parkinson s Disease
This is an in vivo positron emission tomography (PET) study of regional cerebral dopamine and blood flow in normal volunteers, persons with Parkinson s disease (both familial and sporadic), and those with schizophrenia spectrum…
- Trial name
- NCT00024622
- Testing
- O-15 Water, 18F-Fluoro-L-dopa
- Where
- United States
- Volunteers
- 502 people
- Sponsor
- National Institute of Mental Health (NIMH)
Autism, Cerebral Palsy
Near-infrared Spectroscopy and Electroencephalography to Assess Cortical Activation During Motor Tasks in Infants and Toddlers With and Without Cerebral Palsy
Background: New ways to study the brain as people move include near-infrared spectroscopy (NIRS) and electroencephalography (EEG).
- Trial name
- NCT03434080
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Intraventricular Hemorrhage, Intracerebral Hemorrhage
The Natural History of Procalcitonin in Hemorrhagic Stroke
Approximately 12% of strokes in the United States are hemorrhagic.1 Hemorrhagic stroke can lead to multiple complications including fever that is not infectious.
- Trial name
- NCT01498705
- Testing
- Procalcitonin level
- Where
- United States
- Sponsor
- CAMC Health System
Colon Cancer, Breast Cancer
Where Culture Meets Genetics: Exploring Latinas Causal Attributions of Breast and Colon Cancer and Models of Disease Inheritance
Background: Culture can affect the way a person thinks about illness. This can affect how they seek help for illness. It can also affect how they choose a treatment and follow it.
- Trial name
- NCT02767986
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Healthy Volunteers, Substance Use Disorders
Characterization of Phenotypic and Genotypic Regressors for Imaging
The influence of genes on addictive and neuropsychiatric disorders is complex, especially given that multiple genes likely influence certain behaviors that are correlated with addiction.
- Trial name
- NCT01148381
- Where
- United States
- Volunteers
- 847 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Peripheral Neuropathy, Neuro-Degenerative Disease
A Prospective Natural History and Outcome Measure Discovery Study of Charcot-Marie-Tooth Disease, Type 4J
This is a multicenter, longitudinal, prospective observational natural history study of subjects with a molecularly confirmed diagnosis of CMT4J.
- Conditions
- Peripheral Neuropathy, Neuro-Degenerative Disease, Neuromuscular Diseases
- Trial name
- CMT4J (NCT06151600)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Elpida Therapeutics SPC
COVID-19
An Observational Study of Neurologic Function After COVID-19 Infection
Background: COVID-19 is an infection caused by a coronavirus. It can affect different parts of the body. For most people, it causes fevers or trouble breathing. Some people can have symptoms long after they recover.
- Trial name
- NCT04564287
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tumor Induced Osteomalcia, Osteomalacia
A Natural History Study of Bone and Mineral Disorders
This study has four objectives: 1) to provide investigators the opportunity to study bone specimens from patients with various skeletal diseases; 2) to treat patients with skeletal diseases at the NIH; 3) to expose NIH trainees…
- Conditions
- Tumor Induced Osteomalcia, Osteomalacia, Familial Tumoral Calcinosis
- Trial name
- NCT00024804
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Chronic Obstructive Pulmonary Disease (COPD), Smoking
The Natural History of Gene Expression in the Lung Cells of Non-Smokers, Smokers and Ex-Smokers in Health and Disease
Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD, commonly known as chronic bronchitis and emphysema).
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Smoking, Smoking Cessation, Chronic Bronchitis
- Trial name
- NCT00974064
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Undiagnosed Disease, Healthy Volunteer (Adult With Typically Developing Child)
Inherited Diseases, Caregiving, and Social Networks
Approximately 66 million informal caregivers care for someone who is ill, disabled, or aged. These caregivers experience significant distress associated with caregiving, which may be particularly salient in the context of…
- Conditions
- Undiagnosed Disease, Healthy Volunteer (Adult With Typically Developing Child), Inherited Neurodegenerative Disorders, Inherited Metabolic Disorders (Inborn Errors of Metabolism)
- Trial name
- NCT01498263
- Where
- 2 sites in United States
- Volunteers
- 682 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Genetic Syndrome
NGLY1 Deficiency: A Prospective Natural History Study
NGLY1 deficiency is a rare genetic disorder that is characterized by: global developmental delay and/or intellectual disability, hypo- or alacrima, transient elevation of transaminases, and a hyperkinetic movement disorder.
- Trial name
- NCT03834987
- Testing
- Neurodevelopmental Assessment
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Stanford University
IBMPFD
Natural History Study of Patients With VCP-related Disease
A natural history study to understand the expected progression of disease in patients with confirmed mutations in the VCP gene over 1 year.
- Trial name
- NCT04823143
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Nationwide Children's Hospital
Centronuclear Myopathy
Natural History Study of Patients With Centronuclear Myopathies
This is a prospective, longitudinal study of the natural disease course intended to recruit approximately 60 patients with centronuclear myopathies (CNM) in Europe and the United States.
- Trial name
- NatHis-CNM (NCT04977648)
- Sponsor
- Dynacure
LGMD2I
Natural History Study of Patients With Limb-Girdle Muscular Dystrophy 2I
Prospective, longitudinal, interventional, single-group, multicenter natural history study to better know the LGMD2I disease physiopathology. The duration of participation for each patient will be up to 24 months.
- Trial name
- NCT03842878
- Where
- 3 sites in Denmark, France and 1 more
- Volunteers
- 52 people
- Sponsor
- Genethon
Sjogren's Syndrome, Salivary Gland
The Pathogenesis and Natural History of Sjogren's Disease
Background: -Sjogren s Disease (formerly: Sjogrens Syndrome, Sj(SqrRoot)(Delta)gren s syndrome) is a disease that affects about 1-4 million Americans. It is more common in women.
- Conditions
- Sjogren's Syndrome, Salivary Gland, Pathogenesis
- Trial name
- NCT01425892
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Cellular Immunotherapy, Adoptive, Genetic Therapy
Long-Term Follow up of Patients Undergoing Hematopoietic Stem Cell Transplantation, Cellular Therapy, or Gene Therapy
Background: People who have had an allogeneic hematopoietic stem cell transplant (HCT), cellular therapy (CT), or gene therapy (GT) have bone marrow or an immune system that is damaged.
- Conditions
- Cellular Immunotherapy, Adoptive, Genetic Therapy, Tissue Donors, Hematopoietic Stem Cell Transplantation
- Trial name
- NCT03000244
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Acute Lung Injury, Acute Respiratory Distress Syndrome
Acute Lung Injury in Children: Epidemiology and Natural History. PEDIATRIC ALIEN.
The investigators propose to perform a one-year prospective audit of all Acute lung injury (ALI)and cute respiratory distress syndrome (ARDS) pediatric patients managed in several ICUs in Spain.
- Trial name
- ALIEN (NCT01131598)
- Where
- Spain
- Volunteers
- 1 people
- Sponsor
- Hospital de Cruces
Hepatitis C, Chronic
Impact of the Sustained Viral Response of Chronic Hepatitis c After Treatment With Direct Action Antivirals
The purpose of this study is to evaluate the evolution of liver injury with fibrosis data obtained using non-invasive serological markers in patients who achieved SVR after treatment with direct-acting antivirals.
- Trial name
- Hepatitis (NCT05062408)
- Where
- Spain
- Volunteers
- 321 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Observational Study
The Natural History of Sialidosis Type I
Sialidosis type 1 is an autosomal recessive disorder caused by bialleic NEU1 gene mutations. Patients with sialidosis type I present variable neurological and eye dysfunction and the progression rate is variable.
- Trial name
- NCT06316752
- Testing
- Observational study
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
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