Clinical trials: Natural Orifice Endoscopic Surgery
Enlarged Uterus, Adenomyosis
Comparing the Efficacy of TU-LESS and vNOTES for Hysterectomy of Enlarged Uterus
Enlarged uterus is frequently encountered in clinical practice, and its incidence due to conditions such as adenomyosis, uterine fibroids, and other gynecological disorders has steadily increased over the years statistically.
- Conditions
- Enlarged Uterus, Adenomyosis, Uterine Fibroids (UF)
- Trial name
- NCT06663553
- Testing
- TU-LESS, vNOTES
- Where
- China
- Volunteers
- 210 people
- Sponsor
- West China Second University Hospital
Regional Anesthesia Morbidity
V-notes Hysterectomy With Regional Anesthesia
Transluminal endoscopic surgery performed through the natural opening via the vagina is a more comfortable, scarless and less complicated method for patients.
- Trial name
- NCT06528886
- Testing
- hysterectomy by V-NOTES
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 17 people
- Sponsor
- Sanliurfa Education and Research Hospital
Rectal Neoplasms, Rectal Cancer Patients
Optimization and Standardization of Single-Port Robotic Transanal Minimally Invasive Surgery for Rectal Tumor Excision
Title Case Summary: "This study evaluates the safety, feasibility, and short-term clinical outcomes of a new surgical approach called Single-Port (SP) Robotic Transanal Minimally Invasive Surgery (SPR TAMIS) for treating rectal…
- Conditions
- Rectal Neoplasms, Rectal Cancer Patients, Rectal Benign Lesions
- Trial name
- NCT07522294
- Testing
- da Vinci SP Surgical System
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Jeng-Fu You
Appendectomy, Laparoscopic, Endoscopy
Transrectal NOTES Appendectomy - Feasibility Study
Natural orifice translumenal endoscopic surgery (NOTES) has revolutionized the concept of minimally invasive surgery. NOTES is currently performed through transgastric or transvaginal approaches.
- Trial name
- NCT01189916
- Testing
- Endoscopically assisted Appendectomy Surgery
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Northwestern University
Uterine Diseases
Hysterectomy by Transabdominal Laparoscopy or NOTES
Objective: To randomly compare hysterectomy by vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) versus laparoscopy uterus in women with benign gynecological pathology.
- Trial name
- HALON (NCT02631837)
- Testing
- vNOTES hysterectomy, LSC hysterectomy
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Imelda Hospital, Bonheiden
Gynecologic Disease, Inflammation
Inflammatory Markers in Natural Orifice Hysterectomies
The authors aimed to detect inflammatory marker changes in two natural orifice hysterectomies: single-port laparoscopic hysterectomy (SLH) and vaginal hysterectomy (VH).
- Trial name
- NCT04221308
- Testing
- Single port laparoscopic systems
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Derince Training and Research Hospital
Hysterectomy, Natural Orifice Transluminal Endoscopic Surgery
Vaginal NOTES Hysterectomy Versus Vaginal Hysterectomy
Rationale: Natural orifice transluminal endoscopic surgery (NOTES) is a minimal invasive technique using the natural body orifices like stomach, oesophagus, bladder, rectum and vagina to access the human body for surgery.
- Conditions
- Hysterectomy, Natural Orifice Transluminal Endoscopic Surgery, Vaginal Hysterectomy
- Trial name
- VANH (NCT04886791)
- Testing
- Vaginal NOTES hysterectomy, Vaginal hysterectomy
- Where
- 2 sites in Netherlands
- Volunteers
- 124 people
- Sponsor
- Zuyderland Medisch Centrum
Malnutrition
Prospective Evaluation of NOTES (Natural Orifice Translumenal Endoscopic Surgery) PEG "Rescue"
The purpose of this study is to determine: 1. Utility of urgent upper endoscopy in setting of dislodges (percutaneous endoscopic gastrostomy) PEG tube. 2.
- Trial name
- PEGRescue (NCT01119040)
- Testing
- Natural Orifice Translumenal Endoscopic Surgery
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Cholecystitis
Natural Orifice Transgastric Endoscopic Surgical Removal of the Gallbladder
Hypothesis: Natural orifice transgastric cholecystectomy with laparoscopic assist will be feasible and have comparable complication rates as standard lap cholecystectomy. Patient benefits will include less pain and scaring.
- Trial name
- NOTESchole (NCT01174069)
- Testing
- NOTES assisted laparoscopic cholecystectomy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Oregon Clinic
Colon Cancer, Natural Orifice Transluminal Endoscopic Surgery
Feasibility and Safety of Hybrid Transvaginal Natural Orifice Transluminal Endoscopic Surgery for Colon Cancer
This study aims to evaluate the safety and efficacy of radical colectomy with hybrid transvaginal natural orifice transluminal endoscopic surgery (hvNOTES).
- Trial name
- NCT04048421
- Testing
- hvNOTES radical colectomy
- Where
- 6 sites in China
- Volunteers
- 55 people
- Sponsor
- Renmin Hospital of Wuhan University
Pancreatic Pseudocyst
Natural Orifice Translumenal Endoscopic Surgery (NOTES) Cystgastrostomy for the Treatment of Pancreatic Pseudocysts
Natural Orifice Translumenal Endoscopic Surgery (NOTES) describes a new field of investigational surgery which uses the endoscope as the primary operative tool.
- Trial name
- NCT00541593
- Testing
- Pancreatic Pseudocystgastrostomy
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center
Gynecologic Surgery
TUbal LIgation Per Differents Endoscopic Routes and Sexuality (TULIPES)
The goal of this clinical trial is compare the quality of sexual life at 6 months after tubal ligation, depending on whether it was performed by abdominal laparoscopy or by vNOTES, on the basis of a non-inferiority hypothesis.
- Trial name
- TULIPES (NCT05910385)
- Testing
- laparoscopy, vnotes
- Where
- 2 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Clermont-Ferrand
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Pelvic Organ Prolapse
VNOTES Approach in Mesh Free Sacrocolpopexy: A Functional and Anatomic Evaluation
This study aims to evaluate the effectiveness of mesh-free sacrocolpopexy performed using the VNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery) technique in the surgical treatment of pelvic organ prolapse.
- Trial name
- vnotes (NCT07114029)
- Testing
- Mesh-free Sacrocolpopexy via VNOTES
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Abdominal Adhesions
Natural Orifice Transgastric Endoscopic (NOTES) Transgastric Diagnostic Peritoneoscopy With Laparoscopic Assistance
The study will document being able to successfully perform transgastric diagnostic peritoneoscopy (laparoscopic visualization) using a small collection of study surgical tools.
- Trial name
- NOTES (NCT00962650)
- Testing
- Transgastric diagnostic peritoneoscopy with laparoscopic assistance
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Ethicon Endo-Surgery
Cholelithiasis
Laparoscopic Cholecystectomy vs Hybrid Natural Orifice Translumenal Surgery
The purpose of the study is to determine the feasibility of cholecystectomy made by a transvaginal approach with a NOTES procedure (natural orifice translumenal endoscopic surgery).
- Trial name
- NCT00835250
- Testing
- Transvaginal hybrid NOTES cholecystectomy, Cholecystectomy
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Son Llatzer
Tubal Sterilization
Vaginal Natural Orifice Trans-luminal Endoscopic Surgery Salpingectomy for Tubal Sterilization: Clinical Outcomes and Learning Curve Analysis
The evolution from classical open surgery to laparoscopic surgery has led to a significant reduction of morbidity and mortality.
- Trial name
- NCT05581654
- Testing
- Salpingectomy
- Where
- 4 sites in Belgium
- Volunteers
- 240 people
- Sponsor
- Jani Jacques
Sterility, Female
Patient-centered Outcomes After Permanent Female Sterilization Procedure(POPS Trial)
The purpose of this study is to compare and capture key elements of the patient experience, quality of recovery, preferences and satisfaction after laparoscopic salpingectomy done via 3 different routes.
- Trial name
- POPS (NCT05518175)
- Testing
- Traditional laparoscopy, Single site laparoscopy, V-Notes surgery
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pelvic Organ Prolapse
Laparoscopic Sacropexy and Vaginal Natural Orifice Transluminal Endoscopic Surgery Shull Suspension Comparison Trial
This is a prospective, randomized multicenter study whose objective is to compare two surgical techniques routinely used at our center for the correction of pelvic organ prolapse (laparoscopic cervicosacropexis versus…
- Trial name
- V-PULSE (NCT05856201)
- Testing
- Laparoscopic cervicosacropexy, Shull technique via V-NOTES
- Volunteers
- 90 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Uterine Fibroids, Hysterectomy
Predictors of Success and Failure of v-NOTES Hysterectomy for Large and Very Large Uteri
Uterine fibroids are the most common benign tumors in women of reproductive age and are a major indication for hysterectomy. This retrospective, single-center observational study aims to identify factors associated with the…
- Conditions
- Uterine Fibroids, Hysterectomy, Vaginal Natural Orifice Transluminal Endoscopic Surgery (v-NOTES)
- Trial name
- PRE v-NOTES (NCT07895953)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France