Clinical trials: Natural Orifice Surgery
Machine Learning, Surgery
Establishment of a Feasibility Model for NOSE Surgery Based on Machine Learning
The goal of this observational study is to test in patients with resectable rectosigmoid cancers. The main question it aims to answer is establishment of a feasibility model for predicting natural orifice specimen extraction…
- Conditions
- Machine Learning, Surgery, Rectosigmoid Cancer, Natural Orifice Specimen Extraction Surgery
- Trial name
- NCT05797064
- Testing
- Natural Orifice Specimen Extraction Surgery
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colorectal Neoplasms, Urologic Neoplasms
A Novel Robotic System for Single Port and Natural Orifice Transluminal Endoscopic Surgery
This is a prospective, single center, multispecialty study that aimed to evaluate the clinical feasibility and safety of single port surgery and NOTES (mainly transanal and transoral surgery) using a novel single port robotic…
- Conditions
- Colorectal Neoplasms, Urologic Neoplasms, Urologic Diseases, Nasopharyngeal Neoplasms
- Trial name
- NCT03010813
- Testing
- Robotic single port surgery and NOTES
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Chinese University of Hong Kong
Cholecystolithiasis, Surgery
The Effect of Transvaginal vs. Conventional Laparoscopic Cholecystectomy on the Postoperative Course
Uncomplicated laparoscopic cholecystectomy will in most patients result in moderate to severe pain until the first postoperative day. This will subside during the second and third postoperative day [1].
- Conditions
- Cholecystolithiasis, Surgery, Pain
- Trial name
- TRAVAKOL (NCT01552421)
- Testing
- TV NOTES cholecystectomy
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Laparoscopy-assisted Surgery, Total Laparoscopic Surgery With no Incision (Natural Orifice Transluminal Endoscopic Surgery, NOSES)
The Comparison Between Traditional Laparoscopy-assisted Surgery and NOSES in Radical Resection of Colorectal Cancer
This study is to compare the short-term and long-term outcomes of traditional laparoscopy-assisted surgery and total laparoscopic surgery with no incision (natural orifice transluminal endoscopic surgery, NOSES) for colorectal…
- Trial name
- NCT03470142
- Testing
- traditional laparoscopy-assisted surgery, total laparoscopic surgery with no incision (natural orifice transluminal endoscopic surgery, NOSES)
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Dong Yang
Hysterectomy, Vaginal
Hysterectomy by Transvaginal Natural Orifice Transluminal Endoscopic Surgery Versus or Laparoscopic Hysterectomy
In France, there are approximately 62,000 hysterectomies per year, 70% of which are benign. It is the most frequent surgical procedure in gynecology.
- Trial name
- vNOTESHC (NCT05884658)
- Testing
- vNOTES : natural vaginal orifice transluminal endoscopic system for hysterectomies, laparoscopic hysterectomy
- Where
- 6 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cholecystectomy, Laparoscopic, Endoscopy
NOTES-Assisted Laparoscopic Cholecystectomy Surgery
Refinements in laparoscopic surgery, coupled with advancements in therapeutic flexible endoscopy, have set the stage for surgery to move to even less invasive techniques to treat conditions in the GI tract and peritoneal cavity.
- Trial name
- TAS-NOTES (NCT00848146)
- Testing
- Endoscopically assisted Laparoscopic Cholecystectomy Surgery
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Northwestern University
Rectal Cancer, Surgery
Natural Orifice Specimen Extraction in Low Rectal Cancer Surgery
This study aims to compare the postoperative outcomes of low rectal cancer patients who underwent surgery with Natural Orifice Specimen Extraction (NOSE) versus traditional Pfannenstiel extraction.
- Trial name
- NOSES (NCT06326892)
- Testing
- Natural Orifice Specimen Extraction (NOSE), Traditional specimen extraction
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Istituto Clinico Humanitas
Colon Cancer
Transvaginal NOSES Versus Conventional Laparoscopic Surgery for Right Hemicolectomy
It is controversial that totally laparoscopic right hemicolectomy with transvaginal natural orifice specimen extraction (NOSES VIIIA) can provide non-inferior oncological outcomes compared to conventional laparoscopic surgery…
- Trial name
- NCT05495048
- Testing
- NOSES VIIIA, laparoscopic surgery with mini-laparotomy
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Pelvic Organ Prolapse
Evaluation of the Results of Lateral Suspension Surgeries Performed With the V-NOTES (Vaginal-Natural Orifice Transluminal Endoscopic Surgery) Technique
It was aimed to evaluate the quality of life and sexual function of patients by Pre- and postoperative POP-Q (Pelvic Organ Prolapse Quantification) staging and PISQ-12 (Pelvic Organ Prolapse/Urinary Incontinence Sexual…
- Trial name
- NCT05066737
- Testing
- lateral suspension via V-NOTES surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Natural Orifice Specimen Extraction Surgery, Middle Rectal Cancer
Robotic Natural Orifice Specimen Extraction Surgery Compared to Robotic Assisted Surgery for Median Rectal Cancer
The purpose of this study is to evaluate the short-term outcomes of roboric natural orifice specimen extraction surgery (NOSES-II) compared to conventional assisted robotic surgery in the treatment of median rectal cancer.
- Conditions
- Natural Orifice Specimen Extraction Surgery, Middle Rectal Cancer, Robotic, Short-term Outcomes
- Trial name
- NCT06454201
- Testing
- robotic natural orifice specimen extraction surgery, robotic transabdominal specimen extraction surgery
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Nanchang University
Rectal Cancer Patients, Rectal Cancer Surgery
Postoperative Outcomes of Single-stapled Anastomosis Combined With Transanal Natural Orifice Specimen Extraction
Natural Orifice Specimen Extraction (NOSE) eliminates the need for additional abdominal incisions in minimally invasive colorectal procedures, potentially reducing the risk of wound complications and postoperative pain.
- Trial name
- NOSE (NCT07358247)
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Istituto Clinico Humanitas
Appendicitis, Cholelithiasis
Minimally Invasive Surgery: Using Natural Orfices
This is an observational study of pain and outcomes from females undergoing transvaginal NOTES removal of their appendix or gallbladder.
- Conditions
- Appendicitis, Cholelithiasis, Gallstones
- Trial name
- NOTES (NCT00530998)
- Testing
- Transvaginal Appendectomy, Transvaginal Cholecystectomy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Surgery, Gynecologic Disease
Study Evaluating the Success Rate of Outpatient Management of the Total Benign Hysterectomy by Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) Compared to Each of the Two Laparoscopic Routes (Conventional and Robot-assisted).
Benign total hysterectomy is one of the most commonly performed gynecological surgery. Conventionally performed by a classical surgical approach, it is now provided routinely and for several years by laparoscopy and more recently…
- Trial name
- HYSTERAMBU (NCT06471049)
- Testing
- Benign Hysterectomy
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Elsan
Rectal Neoplasms, Robotic Surgery
Robotic Transanal Specimen Extraction Surgery Versus Robotic Transabdominal Incision Specimen Extraction Surgery for Patients With Rectal Cancer: A Multicenter Randomized Controlled Trial
This prospective, multicenter, randomized, open-label study aims to evaluate the perioperative safety and feasibility of specimen extraction through anus regarding robotic radical excision of rectal cancer.
- Conditions
- Rectal Neoplasms, Robotic Surgery, Natural Orifice Specimen Extraction Surgery
- Trial name
- NCT05468944
- Testing
- Transanal specimen extraction robotic surgery, Transabdominal specimen extraction robotic surgery
- Where
- 12 sites in China
- Volunteers
- 556 people
- Sponsor
- Taiyuan Li
Obese, Surgery
Does BMI Influence Pain Follow vNOTE Surgery
Overweight and obesity are increasing dramatically worldwide and contribute substantially to the burden of morbidity and mortality.
- Conditions
- Obese, Surgery, Pain, Postoperative
- Trial name
- BMIVNOTES (NCT05230407)
- Testing
- Visual analog scale (VAS) assesment of pain
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Diverticulitis, Surgical Site Infection
Surgical Site Infection Outcomes in Natural Orifice Intracorporeal Anastomosis and Extraction (NICE) Procedure - The NICE Trial
The goal of this observational study is to learn if a new surgical technique, called the NICE procedure, is as safe as standard methods for treating benign left-sided colon and rectal diseases in adults.
- Conditions
- Diverticulitis, Surgical Site Infection, Surgical Site Infections, Colorectal Surgery
- Trial name
- NCT06957236
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Methodist Hospital Research Institute
Urologic Neoplasms
Transvaginal Versus Transabdominal Extraction of Laparoscopically-excised Kidney Specimen
The aim of this study is to evaluate the outcomes of transvaginal natural orifice specimen extraction (NOSE) in patients who are planning multiport laparoscopic surgery for resection of kidney.
- Trial name
- NCT05135520
- Testing
- Transvaginal natural orifice specimen extraction (NOSE), Transabdominal specimen extraction
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Gastrointestinal Surgery, Natural Orifice Surgery
IMTN Study- International Prospective Multicenter Trial on Clinical NOTES
Objectives: Since 2007, natural orifice surgery evolved from theory and animal research to clinical applications, but is still limited in the literature to small casuistic reports.
- Trial name
- IMTN (NCT00995735)
- Testing
- Cholecystectomy, Appendectomy
- Where
- Brazil
- Volunteers
- 1,000 people
- Sponsor
- IMTN NOTES Research Group
Achalasia, Dysphagia
Efficacy & Safety of Submucosal Endoscopic Myotomy With Mucosal Flap (SEMF) in the Treatment of Patients With Achalasia
The purpose of this study is to learn about the safety and usefulness of a procedure called endoscopic submucosal myotomy, which is a new technique in the treatment of achalasia.
- Trial name
- NCT01438398
- Testing
- Submucosal endoscopic myotomy with mucosal flap technique, Submucosal Endoscopic Mucosal Flap (SEMF) technique
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Winthrop University Hospital
Myoma
Multi-center Prospective Study on E-NOTES for Myomectomy With Traction of Multidirectional Sutures
Primary objectives : To investigate technical feasibility and postoperative morbidity after E-NOTES for Myomectomy with Traction of Multidirectional Sutures Secondary objectives : To investigate postoperative pain after E-NOTES…
- Trial name
- E-NOTES (NCT01829022)
- Testing
- E-NOTES
- Where
- 2 sites in South Korea
- Volunteers
- 35 people
- Sponsor
- National Cancer Center, Korea