Clinical trials: Natural Orifice Surgery
Malnutrition
Prospective Evaluation of NOTES (Natural Orifice Translumenal Endoscopic Surgery) PEG "Rescue"
The purpose of this study is to determine: 1. Utility of urgent upper endoscopy in setting of dislodges (percutaneous endoscopic gastrostomy) PEG tube. 2.
- Trial name
- PEGRescue (NCT01119040)
- Testing
- Natural Orifice Translumenal Endoscopic Surgery
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Cholecystitis
Natural Orifice Transgastric Endoscopic Surgical Removal of the Gallbladder
Hypothesis: Natural orifice transgastric cholecystectomy with laparoscopic assist will be feasible and have comparable complication rates as standard lap cholecystectomy. Patient benefits will include less pain and scaring.
- Trial name
- NOTESchole (NCT01174069)
- Testing
- NOTES assisted laparoscopic cholecystectomy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Oregon Clinic
Colon Cancer, Natural Orifice Transluminal Endoscopic Surgery
Feasibility and Safety of Hybrid Transvaginal Natural Orifice Transluminal Endoscopic Surgery for Colon Cancer
This study aims to evaluate the safety and efficacy of radical colectomy with hybrid transvaginal natural orifice transluminal endoscopic surgery (hvNOTES).
- Trial name
- NCT04048421
- Testing
- hvNOTES radical colectomy
- Where
- 6 sites in China
- Volunteers
- 55 people
- Sponsor
- Renmin Hospital of Wuhan University
Colorectal Neoplasms, Incisional Hernia
AP-NOSES: A Prospective Multicentre Registry of Natural Orifice Specimen Extraction in Minimally Invasive Colorectal Surgery
Natural orifice specimen extraction (NOSE) is a minimally invasive colorectal surgical technique in which the surgical specimen is removed through a natural orifice, including transanal or transvaginal routes, thereby avoiding an…
- Trial name
- AP-NOSES (NCT07615036)
- Testing
- Natural Orifice Specimen Extraction, Transabdominal Specimen Extraction
- Where
- Singapore
- Volunteers
- 800 people
- Sponsor
- Singapore General Hospital
Natural Orifice Specimen Extraction Surgery, Robotic Surgery
A Prospective Single-center Randomized Controlled Trial of Robotic Surgery With Transrectal Resection Specimens (NOSES-IV) and Traditional Assisted Robotic Surgery for the Treatment of High Rectal and Sigmoid Colon Cancer
This study aimed to compare the short-term efficacy of robotic radical resection of high rectal cancer and sigmoid colon cancer (NOSES-IV) with transrectal resection specimens and traditional robotic surgery in the treatment of…
- Conditions
- Natural Orifice Specimen Extraction Surgery, Robotic Surgery, Short-term Outcomes
- Trial name
- NCT06906952
- Testing
- robotic natural orifice specimen extraction surgery, robotic transabdominal specimen extraction surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanchang University
Minimal Invasive Surgery, Colon Surgery
The Anorectal Function and QoL of Patients Receiving Transrectal NOSE Via Rigid TAMIS Platform in Minimal Invasive Colon Surgery
The primary objective of this study is to prospectively determine and precisely estimate the incidence of Internal Anal Sphincter (IAS) Injury at 12 months following colectomy with Transrectal NOSE.
- Trial name
- NCT07653607
- Testing
- Pre-op and post-op anorectal function and quality of life evaluation
- Volunteers
- 57 people
- Sponsor
- Chang Gung Memorial Hospital
Pancreatic Pseudocyst
Natural Orifice Translumenal Endoscopic Surgery (NOTES) Cystgastrostomy for the Treatment of Pancreatic Pseudocysts
Natural Orifice Translumenal Endoscopic Surgery (NOTES) describes a new field of investigational surgery which uses the endoscope as the primary operative tool.
- Trial name
- NCT00541593
- Testing
- Pancreatic Pseudocystgastrostomy
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center
Gynecologic Surgery
TUbal LIgation Per Differents Endoscopic Routes and Sexuality (TULIPES)
The goal of this clinical trial is compare the quality of sexual life at 6 months after tubal ligation, depending on whether it was performed by abdominal laparoscopy or by vNOTES, on the basis of a non-inferiority hypothesis.
- Trial name
- TULIPES (NCT05910385)
- Testing
- laparoscopy, vnotes
- Where
- 2 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Clermont-Ferrand
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Pelvic Organ Prolapse
VNOTES Approach in Mesh Free Sacrocolpopexy: A Functional and Anatomic Evaluation
This study aims to evaluate the effectiveness of mesh-free sacrocolpopexy performed using the VNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery) technique in the surgical treatment of pelvic organ prolapse.
- Trial name
- vnotes (NCT07114029)
- Testing
- Mesh-free Sacrocolpopexy via VNOTES
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Abdominal Adhesions
Natural Orifice Transgastric Endoscopic (NOTES) Transgastric Diagnostic Peritoneoscopy With Laparoscopic Assistance
The study will document being able to successfully perform transgastric diagnostic peritoneoscopy (laparoscopic visualization) using a small collection of study surgical tools.
- Trial name
- NOTES (NCT00962650)
- Testing
- Transgastric diagnostic peritoneoscopy with laparoscopic assistance
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Ethicon Endo-Surgery
Rectal Cancer, Robotic Surgery
Robotic Natural Orifice Specimen Extraction Surgery Versus Robotic Transabdominal Specimen Extraction Surgery for Early-Stage Rectal Cancer
A retrospective cohort study, conducted nationwide（China） and across multiple centers, aimed to compare the surgical quality and short-term outcomes of R-NOSES （robotic natural orifice specimen extraction surgery）with R-TSES…
- Conditions
- Rectal Cancer, Robotic Surgery, Natural Orifice Specimen Extraction Surgery
- Trial name
- NCT06405308
- Testing
- R-NOSES group, R-TSES group
- Where
- 8 sites in China
- Volunteers
- 636 people
- Sponsor
- Taiyuan Li
Cholelithiasis
Laparoscopic Cholecystectomy vs Hybrid Natural Orifice Translumenal Surgery
The purpose of the study is to determine the feasibility of cholecystectomy made by a transvaginal approach with a NOTES procedure (natural orifice translumenal endoscopic surgery).
- Trial name
- NCT00835250
- Testing
- Transvaginal hybrid NOTES cholecystectomy, Cholecystectomy
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Son Llatzer
Tubal Sterilization
Vaginal Natural Orifice Trans-luminal Endoscopic Surgery Salpingectomy for Tubal Sterilization: Clinical Outcomes and Learning Curve Analysis
The evolution from classical open surgery to laparoscopic surgery has led to a significant reduction of morbidity and mortality.
- Trial name
- NCT05581654
- Testing
- Salpingectomy
- Where
- 4 sites in Belgium
- Volunteers
- 240 people
- Sponsor
- Jani Jacques
Colorectal Cancer
Safety Study of Totally Laparoscopic Resection With Natural Orifice Specimen Extraction (NOSE) for Rectosigmoid Cancer
The purpose of this study is to compare the safety and efficacy of laparoscopic resection with natural orifice specimen extraction versus conventional laparoscopic surgery for sigmoid colon or rectal cancer.
- Trial name
- NCT02635503
- Testing
- transrectal specimen extraction, Conventional laparoscopic surgery
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Sterility, Female
Patient-centered Outcomes After Permanent Female Sterilization Procedure(POPS Trial)
The purpose of this study is to compare and capture key elements of the patient experience, quality of recovery, preferences and satisfaction after laparoscopic salpingectomy done via 3 different routes.
- Trial name
- POPS (NCT05518175)
- Testing
- Traditional laparoscopy, Single site laparoscopy, V-Notes surgery
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- The University of Texas Health Science Center, Houston
Colon Cancer
The Role of Natural Orifice Specimen Extraction Surgery (NOSES) in Treating Right-sided Colon Cancer
The purpose of this study is to investigate the short-term and long-term outcomes between natural orifice specimen extraction surgery (NOSES) and totally laparoscopic right hemicolectomy (TLRH).
- Trial name
- NCT06753968
- Testing
- Laparoscopic Right Hemicolectomy With Transrectal/transvaginal Specimen Extraction (NOSES), Totally laparoscopic right hemicolectomy (TLRH)
- Where
- China
- Volunteers
- 349 people
- Sponsor
- National Cancer Center, China
Pelvic Organ Prolapse
Laparoscopic Sacropexy and Vaginal Natural Orifice Transluminal Endoscopic Surgery Shull Suspension Comparison Trial
This is a prospective, randomized multicenter study whose objective is to compare two surgical techniques routinely used at our center for the correction of pelvic organ prolapse (laparoscopic cervicosacropexis versus…
- Trial name
- V-PULSE (NCT05856201)
- Testing
- Laparoscopic cervicosacropexy, Shull technique via V-NOTES
- Volunteers
- 90 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Uterine Fibroids, Hysterectomy
Predictors of Success and Failure of v-NOTES Hysterectomy for Large and Very Large Uteri
Uterine fibroids are the most common benign tumors in women of reproductive age and are a major indication for hysterectomy. This retrospective, single-center observational study aims to identify factors associated with the…
- Conditions
- Uterine Fibroids, Hysterectomy, Vaginal Natural Orifice Transluminal Endoscopic Surgery (v-NOTES)
- Trial name
- PRE v-NOTES (NCT07895953)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Appendicitis, Cholelithiasis
Minimally Invasive Surgery: Using Natural Orifice Translumenal Endoscopic Surgery (NOTES)
This is an observational study of pain and outcomes from patients undergoing transgastric NOTES removal of their appendix or gallbladder.
- Trial name
- NOTES (NCT00531219)
- Testing
- Transgastric Appendectomy, Transgastric Cholecystectomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego