Clinical trials: Near-Infrared Spectroscopy
Epilepsy
Analysis of Lateralization of Language in Epileptic Children by Near-infrared Spectroscopy (NIRS)
Recent data published by various laboratories as well as our preliminary data tend to prove that near-infrared spectroscopy can be used to determine the lateralization of language as part of the preoperative assessment for…
- Trial name
- LANGLAT (NCT02799108)
- Testing
- NIRS, fMRI
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Patent Ductus Arteriosus
Brain, Gut and Kidney Blood Flow During Medical Closure of PDA
The purpose of this study is to determine how the medications which are used to close the patent ductus arteriosus (PDA) in preterm infants affect brain, kidney and gut blood flow when compared to infants that are not treated…
- Trial name
- NCT00554307
- Testing
- INVOS Cerebral/Somatic oximeter
- Where
- United States
- Sponsor
- University of Louisville
Tramatic Brain Injury
Evaluating Near-infrared Spectroscopy Devices for Monitoring Traumatic Brain Injury
This project seeks to evaluate the capabilities of new Near Infrared Spectroscopy (NIRS) devices, which use light to measure brain activity, for monitoring how the brain and body react after a serious head injury (TBI)…
- Trial name
- NIRS in TBI (NCT07106216)
- Volunteers
- 10 people
- Sponsor
- University of Cambridge
ADHD
A Novel fNIRS Neurofeedback Intervention for Enhancement of Working Memory in Attention Deficit Hyperactivity Disorder (ADHD)
The proposed study is to test and validate a novel intervention that integrates computerized cognitive training with real-time neuromonitoring and neurofeedback to enhance working memory by probing the individualized neural…
- Trial name
- NCT04002167
- Testing
- Neurofeedback, Cognitive training
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Stanford University
Stroke, Cognitive Decline
Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients: an FNIRS Study
This is an fNIRS study performed to investigate Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients.
- Trial name
- NCT06703320
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dingqun Bai
Sarcopenia
Effects of Shanyu Pill in Older Adults With Sarcopenia
Sarcopenia is an age-related condition characterized by progressive loss of muscle mass, muscle strength, and physical function. It may also be associated with impaired cognitive function.
- Trial name
- NCT05919368
- Testing
- Shanyu pill
- Where
- 3 sites in China
- Volunteers
- 192 people
- Sponsor
- Fujian University of Traditional Chinese Medicine
Tourette Syndrome in Children
Study on the Mechanism of Pei Tu Ning Feng Tang in Alleviating Tourette Syndrome Via Functional Near-Infrared Spectroscopy (fNIRS) and the DA-MAPK-BDNF Pathway
Tourette Syndrome (TS) children were administered Pei Tu Ning Feng Tang treatment. The differences in gut microbiota composition, peripheral blood stress hormones, oxidative stress markers, cytokines, neurotransmitters, and hair…
- Trial name
- NCT07417371
- Testing
- Tourette Syndrome (TS) children were administered Pei Tu Ning Feng Tang treatment.
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Dongdong Qin
SCD
Exploring Near Infrared Spectroscopy (NIRS) Technologies for Assessment of Muscle Physiology, Tissue Oxygenation, and Blood Flow in Patients With Sickle Cell Disease (SCD)
Sickle cell disease (SCD) is an inherited disorder of the blood. SCD can injure the smallest blood vessels, which can cause pain and damage organs all over the body.
- Trial name
- NCT05604547
- Testing
- Non-Invasive Infrared Spectroscopy
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Healthy
Effects of Acute Intake of Flavanols on Cerebral Oxygenation and Cognition in Young Male Adults
The study evaluates the impact of one acute dose of cocoa flavanols on brain oxygenation during a hypercapnia challenge, as well as impact on cognitive performance in young healthy males.
- Trial name
- NCT04374409
- Testing
- High-flavanol cocoa powder, Low-flavanol cocoa powder
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Diabetes
UTLight-transcranial Doppler Assessment of Regional Cerebral Autoregulation
Cerebral autoregulation (CA) is a complex mechanism that serves the essential and vital purpose of controlling cerebral blood flow and metabolism. A stable and optimal brain blood flow is imperative for normal brain function.
- Trial name
- UTLight (NCT02178787)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Procedural Sedation, Hypoxemia
HFNO Versus Face Mask for Cerebral Oxygenation During Procedural Sedation
This prospective randomized controlled trial aims to compare the effects of high-flow nasal oxygen (HFNO) and conventional face mask oxygen therapy on cerebral oxygenation during procedural sedation performed outside the…
- Conditions
- Procedural Sedation, Hypoxemia, Cerebral Oxygenation, SEDLine
- Trial name
- NCT07718295
- Testing
- High-Flow Nasal Oxygen (HFNO), Conventional Face Mask Oxygen
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Firat University
Anesthesia
Peri-operative NIRS Monitoring In Infants
The purpose of this research study is to examine the effects of routine anesthesia on infant brain oxygen levels. The investigators do not know how anesthesia effects blood flow in the brain of infants during surgery.
- Trial name
- NCT02442141
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Children's Hospital of Philadelphia
Dementia, Neurocognitive Disorders
Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme
This research aims to evaluate the effect of cognitive stimulation (CS) on the functioning of the prefrontal cortex (PFC), seeking an analysis of both cerebral hemodynamics in neuroplasticity and aspects related to the initiation…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT04693611
- Testing
- Individual cognitive stimulation therapy (iCST), Functional near-infrared spectroscopy (fNIRS)
- Where
- Portugal
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
Cerebral Oxygen Desaturation, Post-operative Delirium
Cerebral Oxygenation in Total Hip Arthroplasty Patients
We plan to investigate the relationship between hypotensive epidural anesthesia for hip arthroplasty and cerebral oxygen saturation.
- Trial name
- THANIRS (NCT02325154)
- Testing
- Cerebral Oximeter
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Spinal Muscular Atrophy
Mechanisms and Treatment of Exercise Intolerance and Persistent Fatigue in Spinal Muscular Atrophy
This study will focus on the pathophysiological underpinnings of reduced exercise capacity and fatigue in ambulatory patients with spinal muscular atrophy (SMA).
- Trial name
- NCT05518773
- Testing
- Observational
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Columbia University
Amphetamine Use Disorders, Amphetamine Use Disorder
Effects of Repetitive Transcranial Magnetic Stimulations in Patients With Amphetamine Use Disorders
Amphetamine Use Disorder (AUD) is a major public health issue in Taiwan, where it is the most commonly abused illegal drug. There are currently no effective approved medications to treat it, which makes finding new treatment…
- Conditions
- Amphetamine Use Disorders, Amphetamine Use Disorder, Amphetamine Dependence, Amphetamine Abuse
- Trial name
- NCT06960265
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- TsaoTun Psychiatric Center, Department of Health, Taiwan
Brain Death, Coma
Online Noninvasive Assessment of Human Brain Death and Deep Coma by Near-infrared Spectroscopy
This study aims to assess brain death and deep coma with the self-made near infrared spectroscopy (NIRS) instrument. The investigators used the noninvasive method to monitor the Δ[HbO2] (the concentration changes in…
- Trial name
- NCT04623294
- Testing
- Oxygen supply of high-low-high procedure, Oxygen supply of low-high-low procedure
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Blood Glucose
Study of GLUCUBE Performance, a Non-invasive System for Monitoring Blood Glucose Levels Based on Near Infrared Spectroscopy (NIRS) Technology.
This study is a prospective, single center, non-interventional, open label clinical investigation. The primary objective of the study is to evaluate the performance of GLUCUBE system compared to the standard glucometer in the…
- Trial name
- NCT04935957
- Testing
- GLUCUBE device
- Where
- Spain
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- iGluco
Pneumoperitoneum
Effects of Hemodynamic Changes Caused by Different Pneumoperitoneum Pressure Ranges (10-12 mmHg and 13- 15 mmHg ) on Cerebral Oxygenation (With a Non-invasive Technique, Near Infrared Spectroscopy (NIRS) ) in Laparoscopic Cholecystectomy
The negative effects of pneumoperitoneum used in laparoscopic cholecystectomy on cerebral metabolism, intracranial pressure, cardiovascular (blood pressure, heart rate, venous return) and respiratory system are known.
- Trial name
- NCT04309318
- Testing
- Low pneumoperitoneum (10-12 mmHg) pressure range group, High pneumoperitoneum (13-15 mmHg) pressure range group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Karadeniz Technical University
Stroke, Dysphagia
Effect of Theta Burst Transcranial Magnetic Stimulation on Patients with Dysphagia After Stroke
The purpose of this study was to observe the effect of Theta burst transcranial magnetic stimulation (TBS) on swallowing function in patients with dysphagia after stroke (PSD).
- Conditions
- Stroke, Dysphagia, Functional Near- Infrared Spectroscopy, Transcranial Magnetic Stimulation
- Trial name
- NCT06471309
- Testing
- Theta burst transcranial magnetic stimulation
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Zhang Xiaohui