Clinical trials: Near-Infrared Spectroscopy
Fracture of Hip
Hemodynamic Monitoring and Resuscitation in Hip Fractures
Background: Fracture of the hip is a potentially fatal event in an elderly, frail, highly comorbid patient group suffering from dehydration and hypovolemia, and it carries a risk that equals major trauma in young patients in…
- Trial name
- NCT03401138
- Testing
- Preoperative Stroke Volume(SV)-guided fluid optimization
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Hvidovre University Hospital
Premature Infants, Near-infrared Spectroscopy
Cerebral Oxygenation to Guide Medical Interventions in Extremely Preterm Infants
Regional tissue oxygenation (rStO2) can be monitored by near-infrared spectroscopy. The investigators planned a SafeBoosC phase II trial to test if a reduction of the burden of hyper- and hypoxia can be accomplished during the…
- Conditions
- Premature Infants, Near-infrared Spectroscopy, Oximetry
- Trial name
- SafeBoosC-p (NCT01530360)
- Testing
- cerebral oximeter
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Gorm Greisen
Anemia of Prematurity (AOP)
Combining Restrictive Guidelines and a NIRS SCORE to Decrease RBC Transfusions
The primary aim of this study is to determine the mean number of red blood cell (RBC) transfusions received by preterm infants cared for using restrictive Hgb guidelines in combination with splanchnic to cerebral oxygenation…
- Trial name
- NCT02535208
- Testing
- Restrictive transfusions based on SCOR assessment, Liberal transfusions
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Patent Ductus Arteriosus
Patent Ductus Arteriosus and Splanchnic Oxygenation at First Feed
Patent ductus arteriosus (PDA) is common in preterm infants. In the presence of a large PDA, significant systemic to pulmonary shunting occurs, which may results in pulmonary hyperperfusion and systemic hypoperfusion.
- Trial name
- NCT03723889
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Depression
Neurophysiological RCT of Qigong in Elderly With Depression
Summary of Project: Elderly depression is a common mood disorder and the individuals will have persistent low mood and self-absorption that adversely affect their quality of life.
- Trial name
- NCT05000788
- Testing
- Qigong, Exercise
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Plaque
Adverse Plaque Characteristics in CCTA and TVC Imaging
The present study is intended to assess the vulnerability of plaques seen on CCTA by means of TVC Imaging System and to make comparisons between plaques with adverse plaque characteristics and ones without adverse plaque…
- Trial name
- CITRUS (NCT02350959)
- Testing
- Atorvastatin
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- National Health Insurance Service Ilsan Hospital
Multiple Sclerosis, Gait Disorders, Neurologic
Walking and Thinking - Brain Activity During Complex Walking in People With Multiple Sclerosis
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills.
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Neuro-Degenerative Disease, Aging
- Trial name
- NCT05787704
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 41 people
- Sponsor
- Karolinska Institutet
Craniocerebral Injuries, Head Injuries
Defining the Operating Characteristics of NIRS in the Diagnosis of Pediatric Traumatic Intracranial Hemorrhage
In this study, investigators look at a different type of technology that might help to avoid having to perform CT scans in certain patients suspected of having a head injury.
- Conditions
- Craniocerebral Injuries, Head Injuries, Head Injury, Minor, Head Trauma
- Trial name
- NCT03905031
- Testing
- InfraScanner 2000
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Dayton Children's Hospital
Traumatic Brain Injury, Post-concussion Syndrome
Measure of Cerebrovascular Dysfunction After TBI With fNIRS
The goal of this project is to determine if it is possible to assess Cerebrovascular Reactivity (CVR) to hypercapnia with functional Near Infrared Spectroscopy (fNIRS).
- Trial name
- NCT01789164
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Surgical Complications From General Anesthesia, Cerebral Ischemia
Measurement of the Cerebral Saturation for Assessment of Safety of Epidural Anaesthesia During Abdominal Surgery
Subsequent and non-randomised patients, adult patients qualified for major abdominal surgeries were enrolled
- Conditions
- Surgical Complications From General Anesthesia, Cerebral Ischemia, Anesthesia; Reaction
- Trial name
- NCT03161275
- Where
- Poland
- Volunteers
- 101 people
- Sponsor
- Jagiellonian University
Coronary Artery Disease
Evaluation of CTCA in Assessing Plaque Pathology and Physiology
Computed tomographic coronary angiography (CTCA) has been recently introduced to non-invasively evaluate coronary artery pathology.
- Trial name
- NCT03556644
- Testing
- CTCA imaging
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Brain Injuries, Infant, Premature
SafeBoosC - a Phase II Trial
Background 25,000 infants are born extremely preterm every year in Europe. This group of infants carries a high risk of death and subsequent cerebral impairment for the infant, especially in the first 72 hours of life.
- Trial name
- SafeBoosC (NCT01590316)
- Testing
- Cerebral NIRS oximetry
- Where
- Denmark
- Volunteers
- 165 people
- Sponsor
- Gorm Greisen
Stroke, Cerebral Oxygenation
Multi-channel Time-resolved Functional Near Infrared Spectroscopy for Prevention of Perioperative Brain Injury
Covert stroke occurs in one out of fourteen patients during or shortly after surgery, and may result in long-term disability. Fortunately, stroke that occurs during non-cardiac surgery is most commonly caused by inadequate blood…
- Trial name
- NCT05752981
- Testing
- multichannel time-resolved (tr) functional near infrared spectroscopy (fNIRS) (tr-fNIRS)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Myofacial Pain, Pelvic Pain
Measuring Pelvic Floor Muscle Fitness Before and After Treatment
This study is being done to better understand and improve treatment for myofascial pelvic pain, a common cause of long-lasting pelvic pain in women.
- Conditions
- Myofacial Pain, Pelvic Pain, Myofascial Pelvic Pain, Chronic Pelvic Pain
- Trial name
- NCT07605598
- Testing
- Near Infrared Imaging
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Primary Progressive Aphasia(PPA)
Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia
This is a monocenter randomized controlled clinical trial with cross-over arm - assessor blinded. The aims is investigating the effects of the speech language therapy (SLT) alone vs SLT + non-invasive brain stimulation (STIM)…
- Trial name
- NCT06921265
- Testing
- Training with Speech Language Therapy, Standard rTMS, Targeted rTMS
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Coronary Atherosclerosis, Endothelial Dysfunction
Assessment of Coronary Plaque Composition
The investigators' hypothesis is that local activation of the endogenous Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays an integral role in early atherosclerosis, and contributes to the mechanism of coronary endothelial…
- Conditions
- Coronary Atherosclerosis, Endothelial Dysfunction, Coronary Small Vessel Disease
- Trial name
- NCT01581632
- Testing
- LipiScan/LipiScan IVUS
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic
Near Infrared Spectroscopy
Cerebral Oximetry in Newborns - Comparing INVOS 5100 and FORE-SIGHT Cerebral Oximeters
Regional tissue oxygenation (rStO2) can be monitored by near infrared spectroscopy. The commercial devices FORE-SIGHT (CASMED) and INVOS (COVIDIEN) will be used simultaneously to test for their relative sensitivity for low oxygen…
- Trial name
- NCT01665287
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Myocardial Infarction
A Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, in People With a Heart Attack
The study is testing the effect of ziltivekimab on reducing plaque in the blood vessels of the heart, specifically aiming to manage or reduce atherosclerotic plaque.
- Trial name
- ZEPHYR (NCT07301034)
- Testing
- Ziltivekimab
- Where
- 20 sites in Austria, Denmark and 4 more
- Volunteers
- 332 people
- Sponsor
- Novo Nordisk A/S
Cerebral Blood Flow, Cerebral Perfusion Pressure
Continous Assessment of Cerebral Autoregulation With Near-infrared Spectroscopy
Cerebral autoregulation can be explained by a tight coupling between oxygen supply and demand of the brain, and is essential to maintain a constant cerebral blood flow (CBF) in the context of changes in cerebral perfusion…
- Trial name
- NCT02959008
- Testing
- measure TOI and BP
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yu Liyun
Cardiac Arrest
Vienna Near-Infrared Spectroscopy in Cardiac Arrest Study (VINIRSCA)
Measurement of Near-Infrared Spectroscopy (NIRS) during and after out-of-hospital cardiac arrest (OHCA) in the city of Vienna and the tertiary university hospital of the Medical University of Vienna, Austria.
- Trial name
- VINIRSCA (NCT04778488)
- Testing
- Near-Infrared-Spectroscopy (NIRS)
- Where
- Austria
- Volunteers
- 110 people
- Sponsor
- Medical University of Vienna