Clinical trials: Nebulization
Pulmonary Arterial Hypertension
Safety, Tolerability, & Pharmacokinetics Study of Single & Multiple Inhaled Doses of Imatinib Inhalation Solution
This is a randomised, double-blind, placebo-controlled, dose escalation study to evaluate the safety, tolerability, and PK of single and multiple inhaled doses of imatinib inhalation solution (AER-901) in healthy adult…
- Trial name
- NCT04903730
- Testing
- AER-901 Solution for Nebulization
- Where
- Australia
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Aerami Therapeutics
Ventilator-Associated Pneumonia (VAP)
Colistin Methanesulfonate Sodium Inhalation for Prophylaxis of Ventilator-Associated Pneumonia (CIVAP): A Prospective, Multicentre, Double-Blind, Randomized, Placebo-Controlled Trial
Previous studies have identified Acinetobacter baumannii (AB), Pseudomonas aeruginosa (PA), and Klebsiella pneumoniae (KP) as the predominant pathogens responsible for ventilator-associated pneumonia (VAP).
- Trial name
- CIVAP (NCT06834971)
- Testing
- Colistimethate sodium (CMS)
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Qilu Hospital of Shandong University
Laparoscopic Cholecystectomy
Intraperitoneal Ropivacaine Nebulization for Pain Control After Laparoscopic Surgery
The purpose of this study is to assess if intraperitoneal nebulization of Ropivacaine 50 mg, 100 mg or 150 mg may prevent the use of morphine during the first day after laparoscopic cholecystectomy.
- Trial name
- NCT01143025
- Testing
- Ropivacaine 50 mg, Ropivacaine 100 mg, Ropivacaine 150 mg
- Where
- Italy
- Volunteers
- 165 people
- Sponsor
- San Gerardo Hospital
COPD Exacerbation
Evaluation of the Efficacy of Different Nebulization Techniques
COPD is the 3rd most common cause of death in the world, and the most common places of admission in our country with exacerbation of COPD are emergency services.
- Trial name
- NCT05507060
- Testing
- Vibrating MESH nebulizer (Aerogen Ultra), Jet nebulizers (Philips Respironics)
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Acute Bronchiolitis Due to Respiratory Syncytial Virus
Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis
The goal of this clinical trial is to compare the efficacy of hypertonic saline nebulization with adrenaline nebulization in the treatment of acute bronchiolitis in children.
- Trial name
- children (NCT06267118)
- Testing
- Hypertonic Saline Solution, 1 Ml, Adrenaline
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Combined Military Hospital, Pakistan
Respiratory Failure
Effectiveness of Routine Nebulization of Mucolytics and Bronchodilators During Mechanical Ventilation
The purpose of this multi-center randomized controlled non-inferiority trial is to determine the effect of a strategy using routine nebulisation of mucolytics and bronchodilators (four times daily) as compared to a strategy using…
- Trial name
- Nebulae (NCT02159196)
- Testing
- acetylcysteine and salbutamol, acetylcysteine, salbutamol
- Where
- 7 sites in Netherlands
- Volunteers
- 950 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Procedural Sedation
Dexmedetomidine and Midazolam Nebulization as Sedation During Cesarean Delivery in Pre-eclampsia
Null hypothesis: There is no difference between the effects of nebulization of dexmedetomidine and midazolam as procedural sedation during cesarean delivery under spinal Anesthesia in pre-eclamptic parturients Alternative…
- Trial name
- NCT04873596
- Testing
- Nebulized dexmedetomidine, Nebulized midazolam
- Where
- Egypt
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Asthma
Safety, Tolerability, and Pharmacokinetics After a Single Dose of Orally Inhaled DNAzyme Solution for Nebulisation in Male Patients With Asthma
Asthma is a chronic inflammatory bronchial disorder with three distinct components: airway hyper-responsiveness (respiratory hypersensitivity), airway inflammation, and intermittent airway obstruction.
- Trial name
- NCT01577953
- Testing
- SB010
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Sterna Biologicals GmbH & Co. KG
Pneumonia, Ventilator-Associated
Tobramycin Nebulization to Prevent Multidrug-Resistant Ventilator-Associated Pneumonia
The TOP-MDRVAP trial will test whether inhaled tobramycin can safely prevent pneumonia caused by multidrug-resistant bacteria in adults who need a breathing machine. Tobramycin is an antibiotic.
- Trial name
- TOP-MDRVAP (NCT07856355)
- Testing
- Tobramycin inhalation solution
- Where
- China
- Volunteers
- 574 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Asthma
Study to Assess the Efficacy of Ipratropium Bromide Associated With High Dose Salbutamol by Repeated Nebulisation Versus Repeat Nebulisation of Salbutamol Alone, in Acute Asthmatic Attacks in Young Children
To determine whether addition of ipratropium bromide to salbutamol nebulisations produces significantly greater bronchodilation in young children presenting to an emergency department with an acute attack of asthma
- Trial name
- NCT02235428
- Testing
- Ipratropium bromide, Salbutamol
- Volunteers
- 3 people
- Sponsor
- Boehringer Ingelheim
Pneumonia, Bacterial, Extracorporeal Membrane Oxygenation
" Study of the Benefit of Nebulized Amikacin in the Treatment of Gram-negative Bacillus Pneumonia Acquired During Mechanical Ventilation in Patients Receiving Extracorporeal Membrane Veno-arterial Oxygenation "
Pneumonia are the most frequent infectious complication in patients on Extracorporeal Membrane Oxygenation Veno-arterial (ECMO-VA), with a treatment failure rate of around 40%, even though antibiotic therapy is tailored to the…
- Trial name
- NAVAP-ECMO (NCT06602557)
- Testing
- Amikacin, Standard of care
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fear is a Common Psychological Response Undergoing Medical Procedures,Act From Uncertainty, Anticipation of Pain, Loss of Control, Previous Negative Experiences
(Effect of Toy Nebulizer Versus Distraction Cards on Children's Fear and Parental Satisfaction During Nebulization Therapy: A Comparative Study
Goal To compare the effectiveness of a toy nebulizer versus distraction cards in reducing fear among children during nebulization therapy while improving parental satisfaction.
- Trial name
- NCT07417839
- Testing
- distraction card, Nebuliser toy
- Where
- Iraq
- Volunteers
- 120 people
- Sponsor
- University of Baghdad
Chronic Obstructive Pulmonary Disease
Evaluation of the Effectiveness of the Nebulization Bronchodilators Under High Nasal Flow Humidified
The principal objective is to show noninferiority of nebulized salbutamol through the high flow nasal system moistened AIRVO ™ 2 in terms of reversibility of airflow obstruction compared to nebulization by the usual method (spray…
- Trial name
- AirvoNEB (NCT02812979)
- Testing
- Airvo2 with Aerogen Solo, Mask, arm control Airvo2 without nebulization of salbutamol
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Tours
NEBULIZATION, Children
Video Games and Mask Painting on During Nebulizer Application in Children
The clinical features of respiratory system diseases seen in childhood are generally moderate and improve in a short time. Respiratory system diseases are divided into two as upper respiratory system diseases and lower…
- Trial name
- NCT06755918
- Testing
- Control, Video game, Mask painting
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Semra Kose
Pressor Response
Lignocaine Nebulization for Attenuation of Intubation Stress Response
To study the effect of lignocaine nebulization on attenuation of the pressor response during induction and emergence of anesthesia in patients with severe pre-eclampsia
- Trial name
- NCT04441073
- Testing
- Lignocaine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
COPD Exacerbation, COPD
Borg Score Outcomes in Respiratory Compromised Acute Exacerbating Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Treatment Via Vibrating Mesh Nebuliser Versus Jet Nebuliser in the Emergency Department
The purpose of this study is to compare clinical outcomes in patients with acute COPD treated with a vibrating mesh nebuliser (VMN) versus a current standard jet nebuliser (JN), in the Emergency Department (ED).
- Trial name
- BRAVE (NCT04181073)
- Testing
- Jet Nebuliser, Vibrating Mesh Nebuliser
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- NHS Greater Clyde and Glasgow
Healthy Volunteers, Aerosol Therapy
Inhaled Dose Analysis Using a Breath Actuated Nebulizer in Healthy Subjects
The goal of this crossover study is to compare urine drug concentrations using a continuous vibrating mesh nebulizer versus a breath-actuated vibrating mesh nebulizer in healthy volunteers.
- Conditions
- Healthy Volunteers, Aerosol Therapy, Inhaled Drug Dose, Pharmacogenomic Drug Interaction
- Trial name
- NCT06157515
- Testing
- Breath-actuated vibrating mesh nebulizer, Continuous vibrating mesh nebulizer
- Where
- Taiwan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Pulmonary Hypertension, Mitral Regurgitation
Effect of Brief Nebulization of Milrinone on Pulmonary Arterial Pressure Before Cardiopulmonary Bypass on Mitral Valve Surgery Patients
Our main hypothesis is that inhalation of milrinone can reduce the elevated pulmonary arterial pressure due to severe mitral valve regurgitation without compromising systemic hemodynamics.
- Trial name
- NCT01621971
- Testing
- inhaled milrinone, intravenous milrinone
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Konkuk University Medical Center
Sore Throat
Effect of Nebulized Magnesium Sulfate on Post-intubation Stress Response in Patients Undergoing Laparoscopic Cholecystectomy
This randomized controlled double blinded study will be carried out on 140 patients underwent elective fit laparoscopic cholecystectomy at El-Rajhi Assiut University Hospital. Inclusion criteria: 20-50 years old. Both sexes.
- Trial name
- NCT07123714
- Testing
- Nebulization of magnesium sulfate
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy Subjects
Lung Bioavailability With Continuous or Discontinuous Nebulization
To compare the continuous and sicontinuous delivery of drug with AKITA.
- Trial name
- NCT01913184
- Testing
- AKITA
- Where
- Belgium
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain