Clinical trials: Nebulization
Coronavirus
A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia
In December 2019, a novel coronavirus infectious disease characterized by acute respiratory impairment due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan city of Hubei province in China.
- Trial name
- NCT04276987
- Testing
- MSCs-derived exosomes
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Ruijin Hospital
SARS-CoV-2 Infection
Study to Evaluate the Efficacy of COVID19-0001-USR in Patients With Mild/or Moderate COVID-19 Infection in Outpatient
Determine the efficacy and safety of COVID19-0001-USR in the treatment of SARS-COV-2 infection in mild to moderate manifestations administered via nebulization/inhalation.
- Trial name
- COVID-19 (NCT04595136)
- Testing
- Drug COVID19-0001-USR, normal saline
- Where
- Colombia
- Volunteers
- 60 people
- Sponsor
- United Medical Specialties
Pneumonia
Nebulized Ceftazidime and Amikacin in Ventilator Associated Pneumonia
Pseudomonas aeruginosa is one of the major causative microorganisms of ventilator-associated pneumonia often resistant to antibiotics.
- Trial name
- NCT00786305
- Testing
- ceftazidime and amikacin
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Chronic Obstructive Pulmonary Disease, High-flow Nasal Cannula
High-flow Nasal Cannula Nebulization of Beta 2 Adrenergic Agonist During Acute Exacerbation of Chronic Obstructive Pulmonary Disease
High-flow nasal cannula is an oxygenation technique increasingly used for patients admitted for acute respiratory failure. Literature essentially concerns "de novo" acute hypoxemic failure and the interest of high-flow during…
- Trial name
- OPTINEB (NCT03449056)
- Testing
- salbutamol
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Poitiers University Hospital
Croup
Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup
Acute laryngotracheobronchitis, better known as croup, is one of the common respiratory complaints among children and the most common cause of airway obstruction in children aged six months to six years.
- Trial name
- NCT00938353
- Testing
- beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Cystic Fibrosis
A Single Arm 48-Week Follow-on Safety Study to a Core Study Comparing the Efficacy and Tolerability of Tobrineb®/Actitob®/Bramitob® Versus TOBI®
This is a 48-week extension study to CMA-0631-PR-0010 Core Study. Patients who have a positive culture for P. aeruginosa at visit 4 of the first 8-week core study period and/or if deemed appropriate by the Investigators will be…
- Trial name
- CT03Ext (NCT01111383)
- Testing
- tobramycin
- Where
- 20 sites in France, Poland and 1 more
- Volunteers
- 209 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Rhinosinusitis With Polyposis
Efficacy and Safety of Budesonide Inhalation Suspension for the Treatment of Chronic Rhinosinusitis With Polyposis.
Topical and systemic steroids constitute the first choice in medical treatment for nasal polyps. This study aimed to evaluate the efficacy and safety of a short course of budesonide inhalation suspension via transnasal…
- Trial name
- NCT03687515
- Testing
- budesonide, Prednisone
- Volunteers
- 91 people
- Sponsor
- Beijing Tongren Hospital
Sedation, Emergence Delirium
Nebulized Dexmedetomidine Combined With Ketamine Versus Nebulized Dexmedetomidine for Cleft Palate
To compare the efficacy of the pre-operative nebulization of a combination of dexmedetomidine and ketamine versus nebulization of dexmedetomidine alone for sedation and prevention of emergence delirium in children undergoing…
- Trial name
- NCT05821972
- Testing
- Nebulization of dexmedetomidine and ketamine, Nebulization of dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Neonatal Respiratory Failure
Normal Saline Nebulization on Prevention of Extubation Failure in Neonates
this study is about evaluating the effect of using normal saline nebulization in preventing re-intubation in extubated neonates , provided that the cause of intubation is mainly due to respiratory cause
- Trial name
- NCT05194761
- Testing
- Normal saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Inhalation Injury, Burn Injury
Trial of Nebulized Heparin Versus Placebo for Inhalation Trauma
The purpose of this international multi-center double-blind randomized placebo-controlled trial is to determine the effect of nebulized heparin, compared to placebo, on the number of ventilator-free days at day 28, in burn…
- Trial name
- Hepburn (NCT01773083)
- Testing
- unfractionated heparin
- Where
- 8 sites in Australia, Belgium and 1 more
- Volunteers
- 13 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Nasal Polyps
Effects and Safety of Budesonide Inhalation Suspension Via Transnasal Nebulization in Nasal Polyps
This randomized, double-blind, placebo-controlled clinical trial enrolled subjects with eosinophilic CRSwNP. Subjects were randomized to receive either budesonide inhalation suspension or placebo for 14 days.
- Trial name
- NCT02024659
- Testing
- budesonide
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Beijing Tongren Hospital
Asthma Exacerbation, Emergency Department
Continuous Versus Intermittent Nebulization Therapy in Acute Asthma Exacerbation at Emergency Department
The goal of this clinical is to compare treatment outcomes between continuous nebulization and intermittent therapy in the management of acute exacerbation of asthma in the emergency department(ED).
- Conditions
- Asthma Exacerbation, Emergency Department, Nebulization
- Trial name
- NCT06291740
- Testing
- continuous nebulization, Intermittent nebulization
- Volunteers
- 40 people
- Sponsor
- Thammasat University
Long-term Tracheostomy Ventilated Patients
Effects of Vibrating Mesh Nebulisation in Patients on Long-term Tracheostomy Ventilation: a Pilot Randomised Crossover Trial
Assessment of the effects of vibrating mesh nebulisation versus jet nebulisation on respiratory function in patients with long-term tracheostomy ventilation: evaluating neural respiratory drive, breathing mechanics, cardiac…
- Trial name
- EVOLVE (NCT06834581)
- Testing
- Vibrating mesh nebuliser, Jet nebuliser
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
COVID-19, INTERFERON
Treatment of COVID-19 by Nebulization of Inteferon Beta 1b Efficiency and Safety Study
COVID-19 is causing a serious viral pandemic in terms of health and social impact. To date, no treatment has yet demonstrated Strong efficacy in treating the infectious disease (COVID-19).
- Conditions
- COVID-19, INTERFERON, NEBULIZATION
- Trial name
- COV-NI (NCT04469491)
- Testing
- inhaled type I interferon, WFI water nebulization
- Where
- 7 sites in France
- Volunteers
- 74 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection
CaspoNEB: Efficacy and Safety of Caspofungin Aerosols for the Curative Treatment of Pneumocystis Pneumonia
To assess the efficacy of administrating daily caspofungin aerosols versus placebo for seven days, in adjunction of conventional systemic antifungal therapy during curative treatment of Pneumocystis pneumonia, on the clinical…
- Conditions
- Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection, Pneumocystis Infections
- Trial name
- CaspoNEB (NCT06892951)
- Testing
- Caspofungin Acetate 50 MG, Physiologic saline
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Hemoptysis
TXA Nebulization for the Treatment of Hemoptysis
Hemoptysis is a common presentation in medical emergency. Prompt medical therapy, bronchoscopic and endovascular procedures remains the cornerstone of management for both diagnostic as well as therapeutic purpose in hemoptysis.
- Trial name
- TXA-NEB (NCT05648656)
- Testing
- TXA Nebulization, 0.9% NS Nebulization
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Anaesthesia, Rhinitis
A Comparison Between Co-phenylcaine Nasal Spray and Nasal Nebulization Prior to Rigid Nasoendoscopic Examination
Co-phenylcaine is a widely available nasal spray commonly used by otorhinolaryngologists for the purpose of decongestion and local anesthetic prior to a nasoendoscopic or nasopharyngolaryngoscopy.
- Trial name
- NCT03380715
- Testing
- Nasal nebulisation into the right nostril, Nasal Spray into the right nostril
- Where
- 2 sites in Malaysia
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Pain, Postoperative
Clinical Trial of the Use of Intraperitoneal Local Anaesthetic
Patients undergoing keyhole gall bladder removal will be divided into 3 groups, one control, one will have local anaesthetic and the third will have normal saline nebulised into their abdomen before closure of the wounds to…
- Trial name
- NCT00180687
- Testing
- Nebulised Bupivacaine intraperitoneally, Normal Saline, Injected Bupivacaine intraperitoneally
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Acute Respiratory Distress Syndrome, Severe Acute Respiratory Syndrome
Streptokinase Versus Unfractionated Heparin Nebulization in Severe ARDS
Background: Intra-alveolar clotting and alveolar collapse in ARDS is due to alveolar capillaries epithelial and leakage. Subsequently, collapse induces hypoxemia that is resistant to recruitment (RM).
- Trial name
- NCT03465085
- Testing
- Unfractionated heparin, Streptokinase
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
CHİLD
The Effects of Finger Painting During Nebulization Therapy on Fear and Anxiety Levels in Children
Aim: This study was conducted to evaluate the effects of finger-painting intervention administered during nebulization therapy on the fear and anxiety levels of children.
- Trial name
- NCT07885527
- Testing
- the finger-painting
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Firat University