Clinical trials: Nebulization
Bronchiectasis, Airway Clearance Impairment
Is a Single Daily Session Combining HS + Physio Sufficient to Obtain Long-term Clinical Benefits in Bronchiectasis?
The present study will aim to find out whether a home treatment in people with bronchiectasis consisting of a single daily session to facilitate expectoration (combining nebulization of hypertonic saline (HS) at 6% followed by…
- Trial name
- NCT04905992
- Testing
- Hypertonic saline at 6%, Airway clearance techniques (oscillating positive expiratory pressure therapy)
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Clínico Universitario Lozano Blesa
Pressor Response
Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients
Dexmedetomidine nebulization in sever preeclamptic patients
- Trial name
- NCT07164326
- Testing
- Dexmedetomidine, Saline
- Volunteers
- 100 people
- Sponsor
- Assiut University
COPD (Chronic Obstructive Pulmonary Disease)
Phase 1 PK Study of AERO-007, an Inhaled LABA+LAMA Combination for Nebulization Delivery in COPD Patients
This is a phase 1, single-dose, 2-period crossover study in healthy volunteers to compare the systemic pharmacokinetic (PK) profile of inhaled AERO-002 versus inhaled active comparator product.
- Trial name
- NCT07802730
- Testing
- AERO-002 (60 mcg), Glycopyrrolate (18 mcg)
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AeroRx Therapeutics Inc.
Cystic Fibrosis
Tobramycin Inhalation Solution Administered by eFlow Rapid Nebulizer: Scintigraphy Study
This study assesses the aerosol delivery characteristics (measured by in vivo lung deposition, nebulization time, serum tobramycin concentrations, and pharmacokinetic parameters) and safety of tobramycin inhalation solution…
- Trial name
- NCT00399945
- Testing
- Tobramycin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Novartis
Cystic Fibrosis, Methicillin-resistant Staphylococcus Aureus
Pharmacokinetics of Vancomycin for Inhalation in Cystic Fibrosis
The purpose of this study is to determine the pharmacokinetics and safety of inhaled vancomycin in patients with cystic fibrosis.
- Trial name
- NCT01509339
- Testing
- Vancomycin
- Where
- United States
- Sponsor
- Case Western Reserve University
HFMD
Clinical Trial of Pegylated Interferon α-2b Via Nebulization for Treatment of Hand, Foot, and Mouth Disease .
This is a multicenter clinical trial investigating the safety and efficacy of inhaled Peginterferon α-2b at different doses, in combination with supportive care, for the treatment of patients with hand, foot, and mouth disease…
- Trial name
- NCT07008755
- Testing
- Peginterferon α-2b injection
- Where
- 5 sites in China
- Volunteers
- 90 people
- Sponsor
- Zhengzhou Children's Hospital, China
Anesthesia Complication, Anesthesia Intubation Complication
Magnesium Sulfate in Surgical Stress Attenuation Postoperative Sore Throat and Stress Response Induced Tracheal Intubation
Magnesium sulfate has many mechanisms of action for attenuating the stress response as inhibition of catecholamine releasing from the adrenal medulla, keeping the plasma concentration of epinephrine at a fixed level, decreasing…
- Trial name
- Magnesium (NCT06091631)
- Testing
- Magnesium sulfate vaporization
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
COPD
Phase 1/Phase 2a Study of AERO-007 Inhalation Solution, a Nebulized LABA/LAMA Combination for Maintenance Treatment of COPD
This is a phase 1/phase 2a, single dose, crossover study conducted in two parts. Part 1: Phase 1, open-label, 4-period crossover study in 8 healthy subjects to determine the optimal dose of AERO-001 and AERO-002, the active…
- Trial name
- NCT06841640
- Testing
- AERO-001, AERO-002, AERO-007
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AeroRx Therapeutics Inc.
COPD (Chronic Obstructive Pulmonary Disease), Non-invasive Ventilation
Effects of Vibrating Mesh Nebulisation in Patients With COPD During Non-invasive Ventilation (VMN-NIV)
Assessment of the effects of vibrating mesh nebulisation versus jet nebulisation on the electrical activity of the muscles involved in breathing (neural respiratory drive), breathing mechanics (respiratory impedance measured by…
- Trial name
- VMN-NIV (NCT06884228)
- Testing
- Vibrating mesh nebulisation, Jet nebuliser
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Laparoscopic Cholecystectomy
Local Anesthetic Nebulization and Instillation for Pain Control After Laparoscopic Surgery
Studies evaluating intraperitoneal local anesthetic instillation for pain relief after laparoscopic procedures have provided conflicting results.
- Trial name
- NCT01248819
- Testing
- Ropivacaine 60 mg, Ropivacaine 100 mg
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- San Gerardo Hospital
Snoring, Mouth Breathing
Comparison of Nebulized Budesonide and Intranasal Budesonide Spray in Children With Adenotonsillar Hypertrophy
Budesonide is one of the most common drugs uesd in children with adenotonsillar hypertrophy. This study aim to evaluate the efficacy of a short course of budesonide inhalation suspension via transnasal nebulization in children…
- Trial name
- NCT05325489
- Testing
- Nebulized Budesonide, Intranasal Budesonide Spray
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Xiangya Hospital of Central South University
Allergic Asthma
Effects of AER 001 Administered by Nebulization on Antigen Challenge in Atopic Asthmatics
This is a single centre, double-blind, randomised, parallel group, repeated dose asthmatic subjects. Subjects will receive AER 001 (60 mgs) or placebo twice daily for 28 days.
- Trial name
- NCT00535431
- Testing
- AER 001
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Aerovance, Inc.
Nebulization, Hypertonic Saline
Effect of Nebulized and Intravenous Hypertonic Saline 3% on the Management of Patients With Acute Respiratory Distress Syndrome
The aim of our study is to compare between the effect of nebulized and intravenous injection of hypertonic saline 3% on the outcome of patients with acute respiratory distress syndrome.
- Conditions
- Nebulization, Hypertonic Saline, Acute Respiratory Distress Syndrome
- Trial name
- NCT06226402
- Testing
- Hypertonic saline 3% nebulizer, Intravenous hypertonic saline 3%
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Tanta University
COVID-19 Acute Respiratory Distress Syndrome
Safety and Efficacy of Inhaled XW001 For Hospitalized COVID-19 Patients Requiring Oxygen Therapy
This is a multiregional, randomized, double-blind, placebo-controlled Phase 2 study in patients with confirmed symptomatic COVID-19, designed to evaluate the safety, tolerability, efficacy, and PK of XW001 (IL-29 analog)…
- Trial name
- NCT05083117
- Testing
- XW001
- Where
- 2 sites in Argentina, Peru
- Sponsor
- Sciwind Biosciences APAC CO Pty. Ltd.
Nebulization, Spray-as-You-Go
Nebulization Versus Spray-as-You-Go Airway Topical Anesthesia Using Dexmedetomidine and Lidocaine Mixture During Awake Flexible Fiberoptic Intubation in Temporomandibular Ankylosis
The aim of this study is to compare the efficacy of airway topical anesthesia with nebulization to the spray-as-you-go technique using dexmedetomidine and lidocaine mixture to achieve upper airway anesthesia in TMJ ankylosis…
- Conditions
- Nebulization, Spray-as-You-Go, Dexmedetomidine, Lidocaine
- Trial name
- NCT06088875
- Testing
- Nebulization, Spray-as-you-go
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Anesthesia
Airway Nerve Block Versus Nebulization by Lignocaine During Diagnostic Flexible Bronchoscopy Under Moderate Sedation.
To compare the effectiveness of nebulization versus airway nerve block technique to achieve upper airway anesthesia for diagnostic fiberoptic bronchoscopy under moderate sedation.
- Trial name
- NCT04806438
- Testing
- Group A, Group B
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Healthy
Safety and Tolerability of Autologous Non-hematopoietic Peripheral Blood Stem Cells Therapy in Healthy Adult Volunteers.
SANTANA Study is a phase 1, prospective, monocentric, open-label clinical trial involving healthy adult volunteers, with the objective to evaluate the safety and tolerability of the compressor nebulization of autologous…
- Trial name
- SANTANA (NCT04645485)
- Testing
- Nebulization of autologous non-hematopoietic peripheral blood stem cells (NHPBSC).
- Where
- United Arab Emirates
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Abu Dhabi Stem Cells Center
Anesthesia
Ketamine Versus Lidocaine Nebulization for Awake Fiberoptic Intubation
This randomized double-blinded study is performed to compare ketamine versus lidocaine for nebulization for awake nasal fiberoptic intubation as regard efficacy and side effects.
- Trial name
- NCT03414879
- Testing
- Ketamine, Lidocaine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Acute Asthma
Magnesium Nebulization Utilization in Management of Pediatric Asthma
Acute asthma is the most common cause of pediatric hospitalizations. While the investigators know that repeat inhalations of ß2 agonists and ipratropium with early oral steroids substantially reduce hospitalizations, many…
- Trial name
- MAGNUMPA (NCT01429415)
- Testing
- Magnesium Sulfate Sandoz, Sodium Chloride , USP PPC
- Where
- 7 sites in Canada
- Volunteers
- 818 people
- Sponsor
- The Hospital for Sick Children
Chronic Obstructive Pulmonary Disease (COPD), Type 2 Respiratory Failure
Effectiveness of Bronchodilator Nebulization With and Without Noninvasive Ventilation in COPD
The study aim to evaluate effectiveness of two bronchodilator nebulization strategies in patients with acute decompensated type 2 respiratory failure due to acute exacerbation of chronic obstructive pulmonary disease..
- Trial name
- NCT03481543
- Testing
- In-line nebulization through NIV mask, Off-NIV nebulization
- Where
- Singapore
- Volunteers
- 11 people
- Sponsor
- National University Health System, Singapore