Clinical trials: Necator Americanus Infection
Necator Americanus Infection
Immunisation, Treatment and Controlled Human Hookworm Infection
24 healthy volunteers will be immunized with three times 50 L3 larvae or placebo followed by treatment with albendazol and subsequently challenged with twice 50 L3 larvae.
- Trial name
- ITCHHI (NCT03702530)
- Testing
- 3x 50 L3 larvae immunisation with albendazole treatment, 2x 50 L3 larvae infection
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Necator Americanus Infection
Repeated Controlled Human Hookworm Infection
Twenty-four healthy hookworm-naive volunteers will be exposed to 50 L3 Necator americanus larvae for a maximum of three times.
- Trial name
- ReCHHI1 (NCT03257072)
- Testing
- 50 Necator americanus L3 larvae, 100 Necator americanus L3 larvae, 150 Necator americanus L3 larvae
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Meta Roestenberg
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults
Hookworms digest hemoglobin from erythrocytes for use as an energy source via a proteolytic cascade that begins with the aspartic protease, APR-1.
- Trial name
- NCT01717950
- Testing
- Na-APR-1 (M74)/Alhydrogel®, Gluco-Pyranosylphospho-Lipid A Aqueous Formulation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity Study of Na-GST-1 With or Without CpG
Na-GST-1 is a protein expressed during the adult stage of the hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT02143518
- Testing
- Na-GST-1/Alhydrogel®, CpG 10104
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of Co-Administered Hookworm Vaccine Candidates Na-GST-1 and Na-APR-1 in Gabonese Adults
Na-GST-1 and Na-APR-1 are proteins expressed during the adult stage of the Necator americanus hookworm life cycle that are thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT02126462
- Testing
- Na-APR-1 (M74)/Alhydrogel®, Na-GST-1/Alhydrogel®, Hepatitis B vaccine
- Where
- Gabon
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Testing, Performance
Validation of INSPiRED Innovative Smart Diagnostic Devices for the Detection of Parasites Infections.
Malaria, schistosomiasis and ancylostomiasis are three parasitic diseases which affect hundreds of millions of people and are an important cause of global mortality and morbidity.
- Conditions
- Testing, Performance, Specificity, Sensitivity
- Trial name
- INSPiRED-WP3 (NCT04505046)
- Where
- Gabon
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche Médicale de Lambaréné
Hookworm Infection, Hookworm Disease
Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults
Na-GST-1 is a protein expressed during the adult stage of the Necator americanus hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT03373214
- Testing
- Na-GST-1, CPG 10104
- Where
- Gabon
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Necator Americanus Infection
Immune Responses in the Skin After Hookworm Infection
Five healthy volunteers will be repeatedly exposed to L3 Necator americanus larvae after which two skin biopsies will be taken. Three of the volunteers will be treated two weeks after each infection after which the study will end…
- Trial name
- HiBiSki (NCT06478498)
- Testing
- Necator americanus L3 larvae
- Where
- Netherlands
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Ascaris Lumbricoides Infection, Necator Americanus Infection
Cement flooRs AnD chiLd hEalth (CRADLE)
This randomized trial in rural Bangladesh will measure whether installing concrete floors in households with soil floors reduces child enteric infection.
- Conditions
- Ascaris Lumbricoides Infection, Necator Americanus Infection, Trichuris Trichiura; Infection, Diarrhea
- Trial name
- NCT05372068
- Testing
- Concrete household floor
- Where
- Bangladesh
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Stanford University
Necator Americanus Infection
Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center
Four healthy hookworm-naive volunteers will be exposed to 50 L3 Necator americanus larvae once and will retain infection for up to 2 years.
- Trial name
- CHHIL (NCT03126552)
- Testing
- Necator americanus L3 larvae
- Where
- Netherlands
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Celiac Disease
Hookworm Therapy for Coeliac Disease
This trial is a Phase 1b multicentre, multinational, randomized, double-blind with single-blind arm and open label extension phase, placebo controlled, clinical trial evaluating the safety and predictability of an escalating…
- Trial name
- NainCeD-3 (NCT02754609)
- Testing
- Gluten micro-challenge, Inadvertent gluten challenge, Moderate gluten challenge
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- James Cook University, Queensland, Australia
Hookworm
Study to Test Whether Shoes Protect Children Against Hookworm Infection on Pemba Island, Zanzibar
Small association studies have hypothesised that shoes protect against hookworm infection. The purpose of this pragmatic study was determine, under field conditions, whether school-age children on Pemba Island, Zanzibar, would…
- Trial name
- SKIP (NCT01869127)
- Testing
- Shoes
- Where
- Tanzania
- Volunteers
- 1,056 people, healthy volunteers welcome
- Sponsor
- Bird, Christopher
Intestinal Helminthiasis, Diarrhea
The Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in Vietnamese School Children
Cheap and effective drugs called 'anthelmintics' are routinely administered to children in developing countries to eliminate infections by parasitic helminths.
- Trial name
- NCT02597556
- Testing
- Albendazole
- Where
- Vietnam
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Hookworm Infection
Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae
An experimental hookworm infection model is being developed to provide early proof-of-concept that a hookworm vaccine targeting the blood-feeding pathway of adult hookworms is feasible and efficacious.
- Trial name
- NCT01940757
- Testing
- Necator americanus Hookworm Larvae
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hookworm Disease, Hookworm Infection
Study of Co-administered Na-APR-1 (M74) and Na-GST-1 in Gabonese Children
Double blind, randomized, controlled, dose-escalation Phase 1 clinical trial in hookworm-exposed children aged 6 to 10 years living in the area of Lambaréné, Gabon.
- Trial name
- NCT02839161
- Testing
- Na-GST-1/Alhydrogel, Na-APR-1 (M74)/Alhydrogel, Hepatitis B Vaccine
- Where
- Gabon
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine