Clinical trials: Neck Cancer
EGFR Positive Solid Tumors
A Phase 1 Study of IMGN289 in Adult Patients With EGFR-positive Solid Tumors
This is a Phase 1, first-in-human study to determine the recommended dose of IMGN289 in adult patients with advanced EGFR-positive tumors.
- Trial name
- NCT01963715
- Testing
- IMGN289
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- ImmunoGen, Inc.
Esophageal Cancer
Photodynamic Therapy Using HPPH in Treating Patients With Obstructive Esophageal Tumors
RATIONALE: Photodynamic therapy uses light and drugs that make tumor cells more sensitive to light to kill tumor cells. Photosensitizing drugs such as HPPH are absorbed by tumor cells and, when exposed to light, become active and…
- Trial name
- NCT00060268
- Testing
- HPPH
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Roswell Park Cancer Institute
Head and Neck Cancer
Bortezomib and Docetaxel in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
RATIONALE: Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It may also stop the growth of tumor cells by blocking blood flow to the tumor.
- Trial name
- NCT00425750
- Testing
- bortezomib, docetaxel, laboratory biomarker analysis
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Thyroid Nodule
Mini-flap BABA (Bilateral Axillo-breast Approach) Robotic Thyroidectomy is Safe
In this study, a randomized controlled study was conducted between two groups of 40 recipients of conventional flap during BABA robotic-thyroidectomy and 40 recipients of Mini-flap method during BABA robotic-thyroidectomy.
- Trial name
- NCT05216718
- Testing
- Mini-flap, Conventional flap
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Inje University
Radiotherapy-induced Oral Mucositis
Traditional Chinese Medicine Preparation Alleviates Radiotherapy-induced Oral Mucositis in Head and Neck Cancer Patients.
Evaluate the effectiveness and safety of traditional Chinese medicine compound in improving radiotherapy-induced oral mucositis in patients with head and neck malignant tumors.
- Trial name
- NCT07339774
- Testing
- Zishui Daohuo oral liquid combined with Kujiu mouthwash, Radiotherapy
- Where
- China
- Volunteers
- 128 people
- Sponsor
- West China Hospital
Head and Neck Squamous Cell Carcinoma, Radiotherapy
Pirfenidone as a Radiosensitizer in the Treatment of Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with a 5-year survival rate of less than 50%. Radiotherapy is an important measure to control tumor recurrence.
- Conditions
- Head and Neck Squamous Cell Carcinoma, Radiotherapy, Radiosensitizer, Pirfenidone
- Trial name
- NCT06142318
- Testing
- Pirfenidone
- Where
- 5 sites in China
- Volunteers
- 66 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Esophageal Squamous Cell Carcinoma
Afatinib in Previously Treated ESCC With EGFR Overexpression or EGFR Amplification (ESCC-A01)
This is a phase 2 trial investigating the effect and safety of afatinib in previously treated recurrent or metastasic esophageal squamous cell carcinoma with EGFR overexpression or EGFR amplification.
- Trial name
- NCT03940976
- Testing
- Afatinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University
Infections, Papillomavirus
Gynaecological Follow-up of a Subset of 580299/008 (NCT00122681) Study Subjects
This study is designed to provide up to four years of annual oncogenic HPV DNA testing and cervical cytology examination for NCT00122681 study subjects who displayed normal cervical cytology but tested positive for oncogenic HPV…
- Trial name
- NCT00937950
- Testing
- Gynaecological follow-up
- Where
- 83 sites in United States, Australia and 11 more
- Volunteers
- 2,022 people
- Sponsor
- GlaxoSmithKline
Esophageal Squamous Cell Carcinoma
Chidamide Plus Camrelizumab as Second-line Therapy for Advanced ESCC Treated With PD-1 Blockade
The purpose of this study is to observe and evaluate the efficacy and safety of chidamide plus camrelizumab as second-line therapy for advanced esophageal squamous cell carcinoma treated with PD-1 blockade
- Trial name
- NCT04984018
- Testing
- chidamide + camrelizumab
- Volunteers
- 73 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Solid Tumors
Cardiac Safety Assessment Study of Picoplatin in Solid Tumors
The purpose of this study is to investigate what effects, if any, picoplatin has on the heart rhythm.
- Trial name
- NCT00710697
- Testing
- Picoplatin
- Where
- 7 sites in United States
- Volunteers
- 40 people
- Sponsor
- Poniard Pharmaceuticals
Esophageal Cancer
MR/PET in the Evaluation of Patients With Esophageal Cancer
In this prospective study, we will recruit newly diagnosed esophageal cancer patients and perform MR/PET before and after chemoradiation therapy.
- Trial name
- NCT02547610
- Testing
- The imaging biomarkers determined by MR-PET
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Cervical Neoplasia
Spectroscopic Evaluation of Cervical Neoplasia
The overall objective of this study is to evaluate whether fluorescence and reflectance spectroscopy can improve the ability to detect the presence of premalignant lesions on the cervix.
- Trial name
- NCT00766701
- Testing
- Procedure: Spectroscopy and Digital Imaging
- Where
- 7 sites in United States
- Volunteers
- 1,599 people
- Sponsor
- Guided Therapeutics
Endometrial Neoplasms, Ovarian Cancer
COM701 in Combination With BMS-986207 and Nivolumab in Subjects With Advanced Solid Tumors.
This is a phase 1/2 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary antitumor activity of COM701 in combination with BMS-986207 and nivolumab in patients with…
- Conditions
- Endometrial Neoplasms, Ovarian Cancer, Solid Tumor, Head and Neck Cancer
- Trial name
- NCT04570839
- Testing
- COM701 in combination with BMS-986207 and nivolumab.
- Where
- 9 sites in United States
- Volunteers
- 48 people
- Sponsor
- Compugen Ltd
Nasopharyngeal Carcinoma
Patients With Stage III-IVa Nasopharyngeal Carcinoma With or Without a Mobile Medical Platform Full-course Nutritional Intervention
To study the difference in the proportion of patients with nasopharyngeal carcinoma who lost more than 10% of their body weight within 1 month after radiotherapy and chemotherapy using the mobile platform for whole-process…
- Trial name
- NCT05834712
- Testing
- mobile platform or not mobile platform
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Sun Yat-sen University
Lymphedema of Leg, Cancer of Cervix
High Intensity Interval Training (HIIT) for Patients With Cancer-related Lymphedema in the Lower Limbs
The aim of the study is to explore the feasibility and safety of High Intensity Interval Training on a stationary bike for patients with lymphedema in the lower limbs and the role of compression garments during exercise.
- Conditions
- Lymphedema of Leg, Cancer of Cervix, Cancer, Ovarian, Cancer, Endometrial
- Trial name
- NCT03653819
- Testing
- First exercise session + compression, First exercise session - compression
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Herlev and Gentofte Hospital
Esophageal Cancer
Gefitinib, Cisplatin, Irinotecan, and Radiation Therapy Before Surgery in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer That Can Be Removed By Surgery
RATIONALE: Gefitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin and irinotecan, work in different ways to stop the growth of tumor…
- Trial name
- NCT00290719
- Testing
- cisplatin, gefitinib, irinotecan hydrochloride
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Francisco
Head and Neck Cancer
Pre-habilitation of Patients With Head and Neck Cancer
The purpose of this study is to explore whether early initiated physical exercise concurrent with a swallowing and mouth opening exercise program will have a positive effect on swallowing function and other quality of life…
- Trial name
- SYNK (NCT02385929)
- Testing
- Swallowing therapy & resistance training
- Where
- 2 sites in Denmark
- Volunteers
- 240 people
- Sponsor
- Irene Wessel
Squamous Cell Carcinoma of the Oral Cavity
Contribution of Residual Tumour DNA Testing on the Surgical Bed
The aim of this study is to evaluate the interest of residual tumour DNA research in the operating bed after squamous cell carcinoma excision.
- Trial name
- MARGINS (NCT05934929)
- Testing
- Circulating tumor DNA detection
- Where
- 2 sites in France
- Volunteers
- 31 people
- Sponsor
- Centre Henri Becquerel
Sensory Perceptual Characteristics, User Acceptability of Gel Delivery System
Perception & Acceptability of a Cervical Cancer Prevention Prebiotic Device
PreBioGyn will be compared to market leading vaginal pH buffering gels using established forearm test methods associated with vaginal lubricity sensation in 42 women.
- Trial name
- NCT04841629
- Testing
- PreBioGyn Gel, Trimosan Gel, RepHresh Gel
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Glyciome, LLC
Head and Neck Cancer
Goal Directed Fluid Therapy in Free Flap Reconstructive Surgery
Wide excision of head and neck cancer with microsurgical free flap's reconstruction (FFR) results to a high cancer cure rate and a good functional recovery.
- Trial name
- NCT01129037
- Testing
- Goal directed fluid management based on continuous monitoring of stroke volume
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- University Health Network, Toronto
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