Clinical trials: Neck Cancer
Nasopharyngeal Carcinoma (NPC)
Individualized Neck Cervical Irradiation Prophylaxis Trial of NPC
Based on the pattern of nasopharyngeal carcinoma cervical lymph node metastasis, which typically follows a sequential downward spread with rare skip metastases and a tendency for ipsilateral neck involvement, and in accordance…
- Trial name
- INCIPT-NPC (NCT07303023)
- Testing
- Individualized Neck Irradiation, Standard Neck Irradiation
- Where
- 6 sites in China
- Volunteers
- 462 people, healthy volunteers welcome
- Sponsor
- Fudan University
Advanced Solid Tumors, Undifferentiated Pleomorphic Sarcoma
ABBV-085, an Antibody Drug Conjugate, in Subjects With Advanced Solid Tumors
This is an open-label dose escalation study designed to evaluate the safety and pharmacokinetics of ABBV-085 and determine the recommended Phase 2 dose (as monotherapy or in combination with standard therapies) in subjects with…
- Conditions
- Advanced Solid Tumors, Undifferentiated Pleomorphic Sarcoma, Squamous Cell Carcinoma of the Head and Neck, Carcinoma of the Breast
- Trial name
- NCT02565758
- Testing
- ABBV-085
- Where
- 20 sites in United States, France and 1 more
- Volunteers
- 85 people
- Sponsor
- AbbVie
Cervical Cancer
Effect of HPV Vaccination on Women Aged 25 Years
The purposes of this study are to evaluate the effectiveness of vaccination in 25-year old women at the time of their first access to cervical cancer screening, to understand the impact of vaccination on screening activity; to…
- Trial name
- NCT02296255
- Testing
- Cervarix®, GlaxoSmithKline
- Where
- Italy
- Volunteers
- 832 people
- Sponsor
- Cancer Prevention and Research Institute, Italy
Squamous Cell Carcinoma of the Head and Neck
Phase 2 Study of Imprime PGG & Pembrolizumab in Subjects With Adv SCCHN Who Failed Pembro Monotherapy or Experiencing SD
Objective: To determine the Overall Response Rate (ORR) to Imprime PGG + pembrolizumab in subjects with advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN) Safety: To characterize the safety of Imprime PGG +…
- Trial name
- NCT03246685
- Testing
- Imprime PGG, Pembrolizumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- HiberCell, Inc.
Lung Cancer, Esophageal Cancer
Perspectives of Receiving Open Versus Minimally Invasive Surgery
This study will examine the perspectives of patients' undergoing surgery for lung or esophageal cancer. It will examine both pre-op and post-op patient perspectives and opinions regarding pain and surgical complications.
- Trial name
- PROMIS (NCT01807390)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
Nasopharyngeal Neoplasms, Carcinoma
Docetaxel in Combination With Cisplatin-5-fluorouracil for the Induction Treatment of Nasopharyngeal Carcinoma in Children and Adolescents
The primary objective is to estimate the Complete Response rate of docetaxel to the combination of cisplatin-5-fluorouracil (TCF) compared to cisplatin-5-fluorouracil (CF) in the Induction treatment of Nasopharyngeal Carcinoma…
- Trial name
- NCT00565448
- Testing
- docetaxel, cisplatin, 5-fluorouracil
- Where
- 26 sites in Algeria, Brazil and 12 more
- Volunteers
- 75 people
- Sponsor
- Sanofi
Thyroid Cancer, Differentiated Thyroid Cancer
F-18 Tetrafluoroborate PET/CT in Differentiated Thyroid Cancer
In patients who have undergone surgery for differentiated thyroid cancer and who demonstrate elevated serum Tg and/or ATg levels during follow-up after radioactive iodine therapy, lesion detection is performed using neck…
- Trial name
- NISDETECT (NCT07436455)
- Testing
- F-18-Tetrafluoroborate PET/CT
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara University
Cervical Cancer, Endometrial Cancer
CerviPrep for Applying Topical Gemcitabine to the Cervix in Treating Patients With Primary Endometrial, Cervical, or Ovarian Epithelial Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Cervical Cancer, Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT00610740
- Testing
- topical gemcitabine hydrochloride, therapeutic conventional surgery
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Fear, Anxiety
The Effect of 360° Virtual Reality Movies on Fear and Anxiety
To assess the effect of web-based 360° Virtual Reality movies on fear and anxiety, The investigators would like to assess the patient-perceived level of fear and anxiety quantitatively, making use of several questionnaires.
- Conditions
- Fear, Anxiety, Breast Cancer, Lung Cancer
- Trial name
- ENGAGE (NCT06199050)
- Testing
- Questionnaire: SPIRIT, Questionnaire: HADS, Questionnaire: QSC-R23
- Where
- Netherlands
- Volunteers
- 292 people
- Sponsor
- Maastricht Radiation Oncology
Head and Neck Cancer
Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION)
The purpose of this study is to demonstrate the superior efficacy of Xevinapant (Debio 1143) versus placebo when added to radiotherapy in the treatment of high-risk participants with resected locally advanced squamous cell…
- Trial name
- NCT05386550
- Testing
- Xevinapant, IMRT
- Where
- 206 sites in United States, Argentina and 24 more
- Volunteers
- 166 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Tongue Squamous Cell Carcinoma, Mixed Reality
Resection and Defect Repair of Oral Cancer Aided by Mixed Reality Technology
The objective of this exploratory clinical trial is to apply Unreal Engine 5 (UE5)-based Mixed Reality (MR) technology to achieve real-time stereoscopic visualization of surgical planning, personalized free flap harvest and…
- Conditions
- Tongue Squamous Cell Carcinoma, Mixed Reality, Virtual Surgical Planning, Free Flap
- Trial name
- NCT07466810
- Testing
- Unreal Engine 5 (UE5)-based Mixed Reality (MR) Technology-assisted Resection of Oral Cancer and Defect Reconstruction, Virtual Surgical Guide Technology-assisted Resection of Oral Cancer and Defect Reconstruction
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Head and Neck Paraganglioma
Head and Neck Paragangliomas: A 16-year Experience of a University Hospital in Turkey
The aim of the study is to examine the head and neck paraganglioma cases treated in Pamukkale University hospital between 2007-2023 and improve our understanding of these cases and contribute to the knowledge surrounding head and…
- Trial name
- NCT05942482
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Pamukkale University
Thyroid Cancer, Thyroid Cancer, Papillary
Intraoperative Neuromuscular Monitoring and Its Impact on Pre- and Postoperative Acoustic Outcomes in Thyroid Surgery
This study examines the impact of intraoperative recurrent laryngeal nerve monitoring signal changes on the postoperative voice quality of thyroid surgery patients.
- Trial name
- NCT06254859
- Testing
- Traditional thyroid surgery.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fujian Medical University
Cervical Cancer Metastatic, Cervical Cancer Recurrent
A Non-interventional Registration Study of Monotherapy or Combination Regimens Based on Camrelizumab or Famitinib for the Treatment of Cervical Cancer
This trial is a national multicenter, open-label, non-interventional study to observe and evaluate the safety and efficacy of monotherapy or combination regimens based on camrelizumab or famitinib in patients with cervical…
- Trial name
- NCT07266350
- Testing
- Camrelizumab, Famitinib
- Volunteers
- 1,300 people
- Sponsor
- Qi Zhou
Xerostomia Following Radiotherapy, Xerostomia Following in Neck or Head After Cancer Surgery
Does Craniosacraltherapy Combined With Exercises That Focuses om Respiration and Posture in the Upper Body Have an Effect on Xerostomia and Other Late Sequelae on People Who Has Been Suffering From Cancer in Mouth and Throat?
The current study aims to assess the efficacy of manual treatment with craniosacral therapy of fascial tissue in throat, neck, cranial and mouth region, on radiation and/or surgery-induced salivary gland hypofunction and…
- Conditions
- Xerostomia Following Radiotherapy, Xerostomia Following in Neck or Head After Cancer Surgery, Other Late Sequelae Following Radiotherapy and Cancer Surgery in Neck or Head
- Trial name
- NCT05882890
- Testing
- Craniosacral Therapy, Exercices Targeting Upper Posture and Respiration
- Where
- 2 sites in Denmark
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cathrine Rahbek
Head and Neck Cancer
EVEREST-HN 1: EVolution of a patiEnt-REported Symptom-based Risk Stratification sySTem
Can a patient-reported symptom-based risk stratification system improve the suspected head and neck cancer (HNC) pathway? Our methodology includes six interlinked work packages to deliver our aim, with EVEREST-HN 1 encompassing…
- Trial name
- NCT05909020
- Testing
- No intervention.
- Where
- 4 sites in United Kingdom
- Volunteers
- 165 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Cervical Cancer
A Clinical Study of PD-L1 Antibody ZKAB001（Drug Code） in Recurrent or Metastatic Cervical Cancer
This is a Phase 1, open-label, dose-escalation, and multidose study, aiming to investigate the safety, tolerability and pharmacokinetics(PK) of ZKAB001 (a fully human monoclonal antibody targeting the Programmed Death - Ligand 1…
- Trial name
- NCT03676959
- Testing
- ZKAB001 5mg/kg, ZKAB001 10mg/kg, ZKAB001 15mg/kg
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Lee's Pharmaceutical Limited
CIN2/3 Recurrence
Prognostic Value of Human Papillomavirus (HPV) Detection in Cervical Intra-epithelial Neoplasia (CIN) Recurrence After Conization
CIN2/3 have been increased for many years and mainly concern women aged 25-29 years. They are subsequent to a persistent HPV infection and are classically treated by conization.
- Trial name
- SUIVICOL (NCT01543048)
- Testing
- Study Follow-Up
- Where
- 4 sites in France
- Volunteers
- 106 people
- Sponsor
- University Hospital, Bordeaux
Cervical Cancer, Ovarian Cancer
Etoposide in Treating Patients With Advanced Ovarian or Cervical Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of etoposide in treating patients who have refractory…
- Trial name
- NCT00002478
- Testing
- etoposide
- Where
- 47 sites in United States
- Sponsor
- Gynecologic Oncology Group
Nasopharyngeal Carcinoma
Prognostic Utility of the Imaging and Biological Signatures in Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) differs from other head and neck malignancies terms of its epidemiology, pathology, and treatment outcome. Although NPC is a radiosensitive tumor, distant recurrence remains a clinical challenge.
- Trial name
- NCT04417985
- Testing
- 18F-FDG PET/CT, MRI
- Volunteers
- 112 people
- Sponsor
- Chang Gung Memorial Hospital
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