Clinical trials: Neck Disease, Head and Neck Cancer
Esophageal Neoplasms
Study Comparing Radiochemotherapy With Folfox 4 Regimen or 5FU-Cisplatin in Patients With Inoperable Esophageal Cancer
The primary objectives of this study are to assess the feasibility (completion of full treatment) in both arms and to assess endoscopic complete response rate in both arms.
- Trial name
- NCT00160030
- Testing
- FOLFOX 4, 5-FU / Cisplatin
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Sanofi
Head and Neck Carcinoma
Effects of Human Papillomavirus Diagnosis on Relationships of Patients With Head and Neck Cancer
This trial studies the effects of human papillomavirus diagnosis on the relationships of patients with head and neck cancer. Determining the effects of human papillomavirus diagnosis on relationships may determine whether human…
- Trial name
- NCT04666428
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Thomas Jefferson University
Esophageal Cancer, Recurrence
Predicting Early Tumor Recurrence in Patients With Esophageal Squamous Cell Carcinoma
The prognosis of patients with esophageal squamous cell carcinoma (ESCC) who develop post-operative early tumor recurrence is often relatively poor.
- Conditions
- Esophageal Cancer, Recurrence, DNA Methylation
- Trial name
- NCT06476067
- Testing
- Surgery
- Where
- 2 sites in Japan
- Volunteers
- 150 people
- Sponsor
- City of Hope Medical Center
Healthy, Head and Neck Cancer
Rehabilitation Assessment and Progress Tracking System Based on Video Images for Dysphagic Patients
The current cervical range of motion (CROM) and tongue movement measurement methods are not reliable between observers, which is not practical in real-world usage.
- Trial name
- NCT05141539
- Testing
- Rehabilitation assessment software, VFSS and FOIS
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Cancer, Thyroid Cancer
Pharmaceutical Management in Targeted Radioligand Therapy
Targeted Radionuclide Therapy (TRT) is a treatment modality used in nuclear medicine to target cancer cells while preserving surrounding healthy tissues.
- Conditions
- Cancer, Thyroid Cancer, Metastatic Prostate Cancer, Neuroendocrine Tumor Carcinoid
- Trial name
- PharmTRT (NCT07389512)
- Where
- 3 sites in France
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
Nasopharyngeal Carcinoma
Reduced-dose Radiotherapy for Low-risk Stage III Patients With Nasopharyngeal Carcinoma
To study the 2-year PFS (progression-free survival) of patients with stage III nasopharyngeal carcinoma of pretreatment EBV DNA<4000 copy/ml treated with induction chemotherapy followed by two different doses of…
- Trial name
- NCT03668730
- Testing
- Intensity-modulated radiation therapy, Paclitaxel liposome, Cisplatin
- Where
- China
- Volunteers
- 215 people
- Sponsor
- Sun Yat-sen University
Esophageal Cancer
Dose Escalated Adaptive RadioTherapy in Definitive Chemo-radiotherapy for Esophageal Cancer
In Denmark, 1000 new cases of esophageal and gastro-esophageal junction cancer occur every year. Surgery is the primary treatment for patients with localized disease who are considered medically and technically operable.
- Trial name
- DART (NCT04086901)
- Testing
- Radiotherapy dose escalation
- Where
- 3 sites in Denmark
- Volunteers
- 3 people
- Sponsor
- University of Aarhus
Head and Neck Cancer
Impact of Applying a Bandage Skin Hydrogel on the Pains of the Head and Neck in Patients With Cancer of Head and Neck Treated With Radiotherapy
The investigators hope to get by reduced and delayed acute radiodermatitis following the application of dressings to skin hydrogel Hydrosorb®, a reduction in head and neck pains and improved quality of life of patients with head…
- Trial name
- IPAC (NCT01520701)
- Testing
- bandage skin Hydrotac®, Ialuset®
- Where
- 7 sites in France
- Volunteers
- 130 people
- Sponsor
- Centre Francois Baclesse
Laryngeal Carcinoma
The Relationship Between The Differential Expression Of FosB Protein In Laryngeal Cancer Tissues And Clinical Prognosis
To determine whether there is statisstical difference in FosB (FBJ murine osteosarcoma viral oncogene homolog B) protein expression between laryngeal cancer tissue and adjacent tissue through immunohistochemistry methods.
- Trial name
- NCT06836765
- Testing
- the expression negative in laryngeal cancer tissue, the expression positive in laryngeal cancer tissue
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yang ji
Head and Neck Cancer, Dysphagia
Assessment of (Chemo)RT-related Dysphagia in HNC Patients Based on Cough-related Acoustic Features
To develop this objective and easily implementable assessment method of coughing based on acoustic features of voluntary and reflex coughs, there is a primary need in identifying and comparing acoustic cough features in healthy…
- Trial name
- NCT05865756
- Testing
- Acoustic cough features analysis
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Jules Bordet Institute
Carcinoma, Non-Small-Cell Lung, Ovarian Neoplasms
A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2
This clinical trial is studying advanced or metastatic solid tumors. Once a solid tumor has grown very large in one spot or has spread to other places in the body, it is called advanced or metastatic cancer.
- Conditions
- Carcinoma, Non-Small-Cell Lung, Ovarian Neoplasms, Endometrial Neoplasms, Head and Neck Neoplasms
- Trial name
- NCT06003231
- Testing
- disitamab vedotin
- Where
- 96 sites in United States, Australia and 5 more
- Volunteers
- 120 people
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
Differentiated Thyroid Cancer, Thyroid Cancer
Thyroid Hormone Replacement After Radio Iodine: Value and Efficacy
This study will be a multicentre prospective cohort study on TH-substitution after thyroid hormone withdrawal preceding radioiodine treatment.
- Conditions
- Differentiated Thyroid Cancer, Thyroid Cancer, Levothyroxine, Liothyronine
- Trial name
- THRIVE (NCT06647602)
- Testing
- Euthyrox (levothyroxine), Cytomel (liothyronine)
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- University Medical Center Groningen
Head and Neck Cancer
Docetaxel and S-1 Followed By Radiation Therapy and Low-Dose Cisplatin in Treating Patients With Stage III or Stage IV Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, S-1, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00625937
- Testing
- cisplatin, docetaxel, tegafur-gimeracil-oteracil potassium
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Yonsei University
Advanced Solid Tumor, Metastatic Solid Tumor
A Phase I Study of WM-S1-030 in Patients With Advanced Solid Tumors
This study evaluates the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of WM-S1-030 in patients with advanced solid tumors.
- Conditions
- Advanced Solid Tumor, Metastatic Solid Tumor, Colorectal Cancer, Lung Cancer
- Trial name
- NCT04801095
- Testing
- WM-S1-030
- Where
- 6 sites in Australia, South Korea
- Volunteers
- 100 people
- Sponsor
- Wellmarker Bio
Esophagus Cancer
Evaluation of Full-field Coherence Tomography for ex Vivo Staging and Assessment of Superficial Esophageal Squamous Carcinoma: a Pilot Study
New tools are needed to 1) diagnose and 2) stage early esophageal squamous cell carcinoma (SCC) in order to improve outcomes of this frequent and lethal cancer.
- Trial name
- OESOCiTy (NCT03467529)
- Testing
- Non interventional study
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Head and Neck Cancer
Quality-Of-Life Assessment in Patients With Head and Neck Cancer Treated With Radiation Therapy
RATIONALE: Gathering information over time about patients' quality-of-life and satisfaction with care may help doctors plan the best treatment and help patients live more comfortably.
- Trial name
- NCT01210872
- Testing
- questionnaire administration, quality-of-life assessment, standard follow-up care
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Georges Francois Leclerc
Oral Mucositis
Safety and Efficacy of ALD518 for Reducing Oral Mucositis in Head and Neck Cancer Subjects
The purpose of this study is to evaluate the safety and efficacy of ALD518 in modifying the course of oral mucositis in subjects with head and neck cancer receiving concomitant chemotherapy and radiotherapy
- Trial name
- NCT01403064
- Testing
- ALD518, 0.9% saline
- Where
- 31 sites in United States, Australia and 4 more
- Volunteers
- 76 people
- Sponsor
- CSL Behring
Gastroesophageal Adenocarcinoma
RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial
Esophageal and gastroesophageal junction cancers are serious diseases with limited cure rates, even when patients receive chemotherapy and surgery. New ways to improve treatment are urgently needed.
- Trial name
- RESTAGE (NCT07625930)
- Testing
- FLOT (Fluorouracil+Leucovorin+Oxaliplatin+Docetaxel), Simvastatin, Durvalumab
- Where
- Canada
- Volunteers
- 184 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Oral Cavity Squamous Cell Carcinoma
Study Comparing Limited and Extensive Neck Surgery in Oral Cancer Patients With Neck Spread
Oral cavity squamous cell carcinoma (OCSCC) frequently metastasizes to cervical lymph nodes, and the extent of neck dissection remains an area of ongoing debate in patients with clinically node-positive (cN1) disease.
- Trial name
- ExtentN1 (NCT07717307)
- Testing
- Selective Neck Dissection (Levels I-IV), Modified Neck Dissection (Levels I-V)
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Kolhapur Cancer Centre - Cancer Centers of America
Esophageal Cancer
Bispectral Index Throughout Esophageal Cancer Operation
The investigators try to conduct a study to assess the impact of changing patients' lateral decubitus position on BIS readings during esophageal cancer operation.
- Trial name
- NCT03397745
- Testing
- BIS
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Samsung Medical Center
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