Clinical trials: Necrosis
Myocardial Infarction
GLP-1 on Non-ST-Segment Elevation Myocardial Infarction
The investigators planned to evaluate the effects of liraglutide on left ventricular function in patients with non-ST-segment elevation myocardial infarction (NSTEMI).
- Trial name
- NCT02577848
- Testing
- GLP-1
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chinese PLA General Hospital
Hyper-Immunoglobulin E. Syndrome (HEIS), Chronic Granulomatous Disease (CGD)
Skin Immunity Sample Collection Involving Blisters and Biopsies
Background: The way the body heals and protects itself from getting sick is called the immune response. Some people with weak immune systems get sick often or get rashes and skin infections.
- Trial name
- NCT03921515
- Testing
- Blister induction, Skin Biopsies
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
MI Related Malignant Ventricular Arrhythmia
Effect of Radiofrequency Ablation in Patients With Ventricular Arrhythmia Undergoing CABG
Patients with myocardial infarction related potential malignant ventricular arrhythmia have high risk of sudden death. The aim of this clinical trial is evaluating therapeutic efficacy of unipolar or bipolar radiofrequency…
- Trial name
- RACAVA (NCT02991170)
- Testing
- unipolar or bipolar radiofrequency ablation+CABG, CABG
- Where
- 3 sites in China
- Volunteers
- 180 people
- Sponsor
- Beijing Anzhen Hospital
Cardiovascular Diseases, Coronary Arteriosclerosis
Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)
To determine if supplements of vitamin C, vitamin E, beta-carotene, and B-vitamins (a combination of folic acid, vitamins B6 and B12) reduce risk of major cardiovascular events in high risk women with a prior history of…
- Conditions
- Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease, Heart Diseases
- Trial name
- WAFACS (NCT00000541)
- Testing
- dietary supplements, vitamin C, vitamin E
- Sponsor
- Brigham and Women's Hospital
Pain Postoperative
Foraminal Enlargement and Postoperative Pain.
The purpose of this study is to determine whether enlarging the apical foramen causes postoperative pain in teeth with necrotic pulp and apical periodontitis.
- Trial name
- NCT02770053
- Testing
- Foraminal enlargement
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Isparta Military Hospital
Elevated LDL-C and High Cholesterol
A Study of STX-1150 in Participants With Elevated Low-Density Lipoprotein Cholesterol (LDL-C)
STX-1150 is an investigational therapy designed to lower LDL-C by silencing a gene called PCSK9 in the liver. STX-1150 does not edit or permanently change the gene.
- Trial name
- STX-1150-01 (NCT07428473)
- Testing
- STX-1150
- Where
- 3 sites in Australia, New Zealand
- Volunteers
- 64 people
- Sponsor
- Monash University
Atrial Fibrillation
Pre Procedural Biomarkers Might Predict Recurrent Atrial Fibrillation After Catheter Ablation
Evaluation of the predictive value of serum levels of adipocytokines and primary phase reactant for recurrent atrial fibrillation (RAF) after catheter ablation in 26 patients had persistent and 91 patients had paroxysmal AF.
- Trial name
- NCT05114772
- Testing
- Measuring Serum bio-markers
- Where
- Egypt
- Volunteers
- 117 people
- Sponsor
- Tanta University
Myocardial Infarction (MI), Acute Coronary Syndromes (ACS)
A Clinical Trial to Demonstrate the Efficacy of Cangrelor
The primary objective of this study is to demonstrate that the efficacy of cangrelor is superior, or at least non-inferior, to that of clopidogrel in subjects requiring PCI.
- Trial name
- PCI (NCT00305162)
- Testing
- Cangrelor (P2Y12 inhibitor), clopidogrel (oral P2Y12 inhibitor)
- Where
- United States
- Volunteers
- 8,882 people
- Sponsor
- The Medicines Company
ST-elevation Myocardial Infarction, Non ST-elevation Myocardial Infarction
Impact of Initial Diagnosis on Mortality for Patients Hospitalised With Acute Myocardial Infarction
The aim of the study is to investigate the impact of an initial non-specific / non-cardiac diagnosis on mortality among patients hospitalised with acute myocardial infarction.
- Trial name
- NCT02600962
- Volunteers
- 564,412 people
- Sponsor
- University of Leeds
Brain Edema, Craniocerebral Trauma
A Comparison Between Two Techniques for Performing Decompressive Craniectomy
The purpose of this study is to compare two surgical techniques for a neurosurgical procedure used to treat cerebral edema (decompressive craniectomy): with watertight duraplasty vs.
- Conditions
- Brain Edema, Craniocerebral Trauma, Infarction, Middle Cerebral Artery
- Trial name
- NCT02594137
- Testing
- Without watertight duraplasty
- Volunteers
- 58 people
- Sponsor
- Hospital of the Restoration, Recife
Ischemic Stroke
DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval
The study will be a multicentre, prospective, randomized, open label, blinded endpoint (PROBE) phase 3 trial (2 arm with 1:1 randomization) in ischemic stroke patients within 4.5 hours of stroke onset.
- Trial name
- NCT03494920
- Testing
- Direct endovascular clot retrieval, Bridging thrombolysis followed by ECR
- Where
- 33 sites in Australia, China and 2 more
- Volunteers
- 295 people
- Sponsor
- Neuroscience Trials Australia
Rheumatoid Arthritis
Comparative Study of Janus Kinase (JAK) Inhibitors Vs Tumor Necrosis Factor (TNF) Inhibitors in Rheumatoid Arthritis
Rheumatoid arthritis is a systemic autoimmune disease characterized by inflammatory synovitis and progressive joint destruction, which are associated with severe disability and increased mortality.
- Trial name
- NCT05567380
- Testing
- Observation
- Volunteers
- 150 people
- Sponsor
- Sohag University
ST-Elevation Myocardial Infarction (STEMI)
Reducing Slow/No-Reflow With Prophylactic High-Dose Intracoronary Adenosine Protocol in ST-Elevation Myocardial Infarction The REFLOW AMI Trial
The REFLOW AMI Trial aims to determine whether prophylactic high-dose intracoronary adenosine reduces slow-flow or no-reflow (SNR) in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous…
- Trial name
- REFLOW AMI (NCT07898696)
- Testing
- Adenosine, Standard Treatment only
- Where
- 2 sites in Pakistan
- Volunteers
- 660 people
- Sponsor
- Prof Muzaffar Ali Zahidi
Diabetes Mellitus, Non-insulin Dependent, Cardiovascular Diseases
Heavy Metals, Obesity and Cardiovascular Risk - Ancillary to Look AHEAD
To evaluate the relationship of baseline toenail chromium concentrations to weight loss, as well as the interaction between heavy metals and the beneficial effects of weight loss.
- Conditions
- Diabetes Mellitus, Non-insulin Dependent, Cardiovascular Diseases, Obesity, Myocardial Infarction
- Trial name
- NCT00031213
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myocardial Infarction, Acute, Anxiety State
Effectiveness of Multimedia Exposure in Patients Transferred to Hospital Suffering From Acute Myocardial Infarction
Randomised clinical trial, single-center, blinded assessment, controlled with standard practice with two-group parallel design. Eligible patients are those assisted and transferred suffering from ST-Elevation myocardial…
- Conditions
- Myocardial Infarction, Acute, Anxiety State, Emergencies
- Trial name
- NCT04560023
- Testing
- Exposition to multimedia content
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- University of Cadiz
Cardiogenic Shock
The Effects of oXiris in Cardiogenic Shock Requiring VA-ECMO
Cardiogenic shock (CS) defines a state of systemic hypo-perfusion leading to end-organ dysfunction related to cardiac pump failure and with mortality rates in the range of 27-50% according to recent reviews.
- Trial name
- CLEAN ECMO (NCT05642273)
- Testing
- oXiris membrane, Blood tests
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Depression After Video-assisted Thoracoscopic Surgery
TAES Alleviate Post-VATS Depression
Depression can significantly affect postoperative rehabilitation quality and increase the mortality of patients who receive video-assisted thoracoscopic surgery (VATS).
- Trial name
- TAES (NCT06718231)
- Testing
- Transcutaneous electrical acupoint stimulation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fuling Central Hospital of Chongqing City
STEMI - ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease
In-hospital Versus After-discharge Complete Revascularization
Patients with STEMI and multivessel disease in whom the culprit lesion has been successfully revascularized during prmimary PCI, will be randomized to in-hospital or after-discharge complete revascularization.
- Trial name
- REVIVA-ST (NCT04743154)
- Testing
- In-hospital nonculprit-lesions percutaneous coronary intervention (PCI), After-discharge nonculprit-lesions percutaneous coronary intervention (PCI)
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Hospital General Universitario de Valencia
Cardiogenic Shock, Cardiac Arrest
Outcomes of Patients With Venoarterial Extracorporeal Membrane Oxygenation
Venoarterial extracorporeal membrane oxygenation (VA ECMO)-also referred to as extracorporeal life support-is a form of temporary mechanical circulatory support and simultaneous extracorporeal gas exchange.
- Trial name
- NCT04039594
- Testing
- VA ECMO
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Anzhen Hospital
Non-inflammatory Degenerative Joint Disease, Osteoarthritis
BC Study of G7 Cup and Compatible Femoral Stems
A prospective , observational, multi-centre, cohort study of the G7™ Acetabular System used with compatible femoral stems in patients with degenerative disease of the hip. The study will be enrolled onto Beyond Compliance.
- Conditions
- Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis
- Trial name
- NCT03456622
- Where
- United Kingdom
- Volunteers
- 230 people
- Sponsor
- Zimmer Biomet