Clinical trials: Necrosis Pancreas
Pancreatic Necrosis, Necrosis Pancreas
Endoscopic Necrosectomy Versus Step-up Endoscopic Intervention
This trial is to compare clinical outcomes between patients undergoing immediate endoscopic necrosectomy compared to step-up endoscopic interventions in patients undergoing endoscopic therapy for infected necrotizing pancreatitis.
- Trial name
- DESTIN (NCT04113499)
- Testing
- Direct Endoscopic Intervention, Step-up Endoscopic Intervention
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- AdventHealth
Acute Pancreatitis
Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis
Around 20 per cent of patients with acute pancreatitis develop pancreatic or peripancreatic necrosis with or without peripancreatic collection.
- Trial name
- NCT01977118
- Testing
- streptokinase, Saline irrigation
- Where
- India
- Volunteers
- 28 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pancreatic Necrosis
Study of a Lumen- Apposing, Covered, Self-Expanding Metal Stent (Axios™) Versus Multiple Double Pigtail Stents
The present study aims to compare the clinical efficacy and cost effectiveness of the AXIOS™ stent versus the "conventional" approach using double pigtail plastic stents in the treatment of patients with walled-off pancreatic…
- Trial name
- NCT02673541
- Testing
- AXIOS™ stent, Double Pigtail Stents
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Acute Pancreatitis (AP)
Endoscopic Pancreatic Duct Stent Placement Versus Conventional Approach in the Treatment of Early Phase Acute Pancreatitis
The planned multicenter randomized study is aimed to assess the efficacy and safety of endoscopic pancreatic duct stenting in adult patients with acute pancreatitis.
- Trial name
- NCT07093996
- Testing
- Endoscopic pancreatic duct stent placement, Conventional treatment of acute pancreatitis in early phase
- Where
- 7 sites in China, Russia
- Volunteers
- 200 people
- Sponsor
- Almazov National Medical Research Centre
Acute Pancreatitis
DEciphering CIrculating SIgnatures Of Infected Pancreatic Necrosis
The purpose of the study is to identify novel blood-based biomarkers for prediction and diagnosis of infected pancreatic necrosis (IPN) in patients with necrotizing pancreatitis (NP).
- Trial name
- NCT06899087
- Testing
- not interventional
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Acute Necrotizing Pancreatitis, Walled Off Necrosis
Plastic Stents vs. NAGI Bi-flanged Metal Stent for Endoscopic Ultrasound Guided Drainage of Walled-off Necrosis
Introduction: Walled off necrosis (WON) is defined as a well circumscribed pancreatic and/or peri pancreatic necrosis containing a variable amount of necrotic tissue.
- Trial name
- NCT04479228
- Testing
- Endosonography guided transmural drainage
- Volunteers
- 80 people
- Sponsor
- Asian Institute of Gastroenterology, India
Acute Pancreatitis With Uninfected Necrosis, Unspecified
Hemoperfusion Efferon СT for the Treatment of Patients With Acute Pancreatitis
Mortality from severe acute pancreatitis reaches 42%. The prognosis of acute pancreatitis is associated with the development of acute inflammatory response syndrome (SIRS) and multiple organ failure (MOF).
- Trial name
- NCT05695001
- Testing
- Efferon CT
- Where
- Russia
- Volunteers
- 34 people
- Sponsor
- Efferon JSC
Pancreas Necrosis, Pancreatic Collection
EUS-guided Transmural Drainage of Walled-off Pancreatic Necrosis: Plastic vs Metallic Protesis.
Randomized multicenter study comparing plastic stents and self-expanding metallic stents in the eus-guided transmural drainage of walled-off pancreatic necrosis.
- Trial name
- PROMETHEUS (NCT03100578)
- Testing
- WOPN TRANSMURAL DRAINAGE: PLASTIC STENT, WOPN TRANSMURAL DRAINAGE: METALLIC STENT
- Where
- 8 sites in Spain
- Volunteers
- 99 people
- Sponsor
- Hospital Universitari de Bellvitge
Sepsis, Septic Shock
Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients
NUROPI is a single-centre, prospective, non-interventional study in the Intensive Care Unit (ICU) of Erasme Hospital (Hôpital Universitaire de Bruxelles, Brussels, Belgium).
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest (CA), Pancreatitis
- Trial name
- NuROPI (NCT07184593)
- Testing
- Plasma H3.1 nucleosome measurement
- Volunteers
- 1,000 people
- Sponsor
- Erasme University Hospital
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Pancreatic Fluid Collection, Walled-off Necrosis
Immediate Necrosectomy vs. Step-up Approach for Walled-off Necrosis
Walled-off necrosis (WON) is a pancreatic fluid collection, which contains necrotic tissue after four weeks of the onset of acute pancreatitis.
- Conditions
- Pancreatic Fluid Collection, Walled-off Necrosis, Pancreatitis, Acute Necrotizing, Pancreatic Pseudocyst
- Trial name
- WONDER-01 (NCT05451901)
- Testing
- Immediate necrosectomy, Step-up approach
- Where
- 21 sites in Japan
- Volunteers
- 70 people
- Sponsor
- Tokyo University
Acute Pancreatitis, Necrotizing Pancreatitis
Timing of Transmural Stent Removal in Necrotizing Pancreatitis
Although metal stents have been widely used in the endoscopic step-up approach for necrotizing pancreatitis, the exact timing of transmural stent removal has not been well studied.
- Conditions
- Acute Pancreatitis, Necrotizing Pancreatitis, Walled-Off Necrosis
- Trial name
- TTSRNP (NCT04963868)
- Testing
- Stent removed by the novel strategy, Stent removed by the conventional strategy
- Where
- China
- Volunteers
- 156 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Pancreatic Walled-off Necrosis
The Effect of Proton Pump Inhibitors(PPIs) on Endoscopic Treatment of Walled-off Necrosis (WON)
In this multicenter, randomized controlled trial, patients with pancreatic walled-off necrosis (WON) based on inclusion and exclusion criteria will be randomly assigned in a 1:1 ratio to either receive intravenous infusion or…
- Trial name
- NCT07488299
- Testing
- Proton Pump Inhibitors
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Qilu Hospital of Shandong University
ENDOSCOPIC ULTRASONOGRAPHY
COMPARISON OF OUTCOMES OF BI-FLANGED METAL STENT ALONE VERSUS BI-FLANGED METAL STENT WITH CO-AXIAL PLASTIC STENT FOR DRAINAGE OF WALLED-OFF PANCREATIC NECROSIS - A PROSPECTIVE RANDOMISED CONTROLLED STUDY.
Endoscopic ultrasound guided drainage of WON with metal stent is the mainstay of WON management. But there are few complications related to BFMS , like bleeding due to vessel erosion, stent clogging , stent migration .
- Trial name
- BFMSP (NCT05632900)
- Testing
- Endoscopic ultrasound guided drainage of walled off pancreatic necrosis
- Where
- India
- Volunteers
- 76 people
- Sponsor
- Asian Institute of Gastroenterology, India
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Cardiac Structure and Function in Patients with Cystic Fibrosis
In a prospective observational cohort study (n = 100), the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and cystic fibrosis genotype and severity and determine whether these…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis, Pulmonary, Cystic Fibrosis of Pancreas
- Trial name
- NCT06084468
- Where
- 2 sites in Denmark
- Volunteers
- 104 people
- Sponsor
- Herlev and Gentofte Hospital
Acute Necrotizing Pancreatitis
Effectiveness of Endorotor PED® System Versus Conventional Endoscopic Techniques for the Management of Walled-off Pancreatic Necrosis in Acute Necrotizing Pancreatitis: Randomized Single-blinded Controlled Superiority Trial and Cost-utility Analysis
This is a national single-blinded prospective multicenter randomized (1:1) controlled trial, with two parallel arms, using a PROBE methodology, including patients with complicated acute necrotizing pancreatitis who require DEN of…
- Trial name
- ROTONEC (NCT07253350)
- Testing
- Endorotor Group, Conventional group
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Acute Pancreatitis, Pancreatic Necrosis
Percutaneous Continuous Irrigation Combined With Transgastric Necrosectomy usingLAMS in Treatment of SAP
Severe acute pancreatitis (SAP) is the most severe form of acute pancreatitis (AP) and Infection of pancreatic necrosis (IPN) have shown to be one of the decisive factors defining the severity of illness.
- Trial name
- PCISLAMS (NCT05508828)
- Testing
- Percutaneous Continuous Irrigation assisted Vacuum Drainage Combined With Transgastric Necrosectomy
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Chinese Medical Association
Acute Pancreatitis, Pancreatic Fluid Collection
Management and Outcomes of Local Complications of Acute Pancreatitis and Postoperative Pancreatic Fistula
This multicenter prospective observational registry will evaluate the clinical characteristics and treatment outcomes of adults with local complications of acute pancreatitis or postoperative pancreatic fistula.
- Conditions
- Acute Pancreatitis, Pancreatic Fluid Collection, Postoperative Pancreatic Fistula
- Trial name
- WONDERFUL (NCT07862088)
- Testing
- Routine Clinical Management of Local Complications
- Where
- 12 sites in Japan
- Volunteers
- 5,000 people
- Sponsor
- Tokyo University
Walled Off Pancreatic Necrosis (WON)
Rad Predictors for WON
This is a retrospective chart review study examining 1) demographic data such as age, sex, etiology of pancreatitis 2) clinical data including radiological characteristics of walled off pancreatic necrosis, walled off necrosis…
- Trial name
- NCT03801070
- Testing
- endoscopic drainage of walled off pancreatic necrosis
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Washington University School of Medicine
Acute Pancreatitis, Pancreatic Pseudocyst
Registry of Patients Undergoing Endoscopic Management of Pancreatic Fluid Collections
Acute pancreatitis is one of the most common gastrointestinal disorders requiring hospitalization worldwide. Pancreatic fluid collections can occur as a consequence of acute and chronic pancreatitis and can result in significant…
- Conditions
- Acute Pancreatitis, Pancreatic Pseudocyst, Pancreatic Necrosis
- Trial name
- NCT06179459
- Testing
- Endoscopic management of pancreatic fluid collections
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Orlando Health, Inc.