Clinical trials: Negative Surgical Margins
Smoking, Lung Cancer
Centralized Lung Cancer EARly Detection Among Smokers (CLEAR Study)
This trial studies how well a centralized care strategy works in improving the quality of smoking cessation and shared decision making among patients who smoke and are considering lung cancer screening.
- Trial name
- NCT04200534
- Testing
- Best Practice, Nicotine Patch, Quality-of-Life Assessment
- Where
- 3 sites in United States
- Volunteers
- 358 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Rotation of Tooth
Clinical Trial to Compare Clear Aligners' Auxiliaries on Rotational Accuracy
This randomized clinical trial aims to assess the effectiveness of optimized attachments, IPR and a combination of the two techniques on the rotational accuracy of canines with clear aligners
- Trial name
- NCT06418984
- Testing
- auxiliary
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Florida
Malocclusion
Impact of Clear Aligners and Metal Brackets on Nutritional Status
This study aims to investigate the effect of clear aligners and traditional brackets on the nutritional status of orthodontic patients.
- Trial name
- NCT05936463
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marmara University
Tooth Discoloration, Tooth Sensitivity
At-home Bleaching Using Clear Retainers
The aim of this project is to clinically evaluate patient satisfaction, whitening efficacy, tooth sensitivity, and gingival irritation during at-home whitening with 10% carbamide peroxide using an Essix-type retainer or a Vivera…
- Conditions
- Tooth Discoloration, Tooth Sensitivity, Gingivitis, Satisfaction, Patient
- Trial name
- NCT05835453
- Testing
- Whitening
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Conventional Clear Bottle, Opaque Weighted Bottle
Influence of Bottle-Type on Infant Feeding Behaviors
The objective of the proposed research is to conduct a within-subject, experimental study that will describe mothers' feeding practices during typical bottle-feeding conditions and will examine whether removal of visual cues…
- Trial name
- OBS (NCT02111694)
- Testing
- Bottle Type
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Drexel University
Maxillary Lateral Incisor Malocclusion
Effect of Clear Aligner Attachment Design on Extrusion of Maxillary Lateral Incisors
The purpose of this research is to test which of four clear aligner attachment types is more efficient in extruding (erupting) maxillary lateral incisors vertically into correct position during orthodontic treatment.
- Trial name
- NCT04968353
- Testing
- Incisally-beveled attachment, Gingivally-beveled attachment, Optimized attachment
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Kidney Cancer, Renal Cell Carcinoma
An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy
The purpose of this study is to understand the metabolism of cancers involving the kidney, including renal cell carcinomas and urothelial cell carcinomas, and how kidney cancers use different types of fuel to support tumor…
- Conditions
- Kidney Cancer, Renal Cell Carcinoma, Clear Cell Carcinoma, Urothelial Carcinoma
- Trial name
- NCT04623502
- Testing
- 13C-Glucose, 13C-Acetate, 13C-Lactate
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Monitor Acne Lessions Count Reduction as Result of Usinfg the Device
Clinical and Usability Study to Determine Safety and Efficacy of the Clear Device for Acne Treatment
This is a clinical research study to determine the ability of the Clear device to treat mild to moderate inflammatory acne, and to determine if the average person is able to use the device properly according to the labeling as…
- Trial name
- NCT01678482
- Testing
- light based device for treatment of acne
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Home Skinovations Ltd.
Orthodontic Pain (D013850), Orthodontic Patient Experience
Comparison of Different Debonding Techniques of Clear Aligner Attachments
The goal of this clinical trial is to compare two different methods for removing clear aligner attachments from tooth surfaces and to evaluate the pain levels and removal times associated with each method.
- Conditions
- Orthodontic Pain (D013850), Orthodontic Patient Experience, Orthodontic Aligners, Orthodontic
- Trial name
- NCT07259642
- Testing
- Adhesive removal plier followed by tungsten carbide bur, Tungsten carbide bur
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Malocclusion
Effect of VPro5 Therapy on Clear Aligner Therapy
The investigators hypothesize that brief, daily application of HFA will increase the efficiency of clear aligner treatment by altering PDL metabolism without increasing pain or discomfort.
- Trial name
- NCT03240770
- Testing
- VPro5 device, Deviation from Standard Tray Wear Time (14 Days)
- Where
- 4 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mani Alikhani
Anterior Functional Shift
White Spot Lesions Development in Mixed Dentition Patients
36 patient will be divided into two equal groups. one for removable inclined plane while the other will be treated using clear aligner appliances.
- Trial name
- WSL (NCT06798870)
- Testing
- removable appliances
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Crowding of Anterior Mandibular Teeth
Shape Memory Orthodontic Aligners
Innovative recent materials are trying to achieve the most of orthodontic movements using the least number of aligner, also trying to reduce the manufacturing steps combined by enhancing the accuracy of each aligner.
- Trial name
- NCT07431333
- Testing
- shape memory clear aligners
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Maxillary Prognathism
En-mass Retraction by KILBON Versus CAT Appliances
en-mass retraction by lingual retractor versus clear alighner therapy
- Trial name
- NCT06366737
- Testing
- KILBON Appliance, CAT appliance
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Orthodontic Tooth Movement
Clinical Trial to Assess the Efficacy of Reducing the Aligners' Wear Protocol
The hypothesis of this project is that replacing the current 7-day wear protocol with a 3-day wear protocol, while integrating less tooth movement per aligner (reduce the amount of activation per aligner) may produce more…
- Trial name
- NCT05905224
- Testing
- Invisalign 7-day wear protocol, Invisalign 3-day wear protocol
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Florida
Fasting
Recommended Clear Fluid Intake Volume at 2 Hours Prior to Esophagogastroduodenoscopy for Adult Patients
Research in developing patient fasting guidelines was developed years ago. On a physiological basis, patients with a longer fasting time may have less residual gastric content and lower risk of pulmonary aspiration.
- Trial name
- NCT04501393
- Testing
- Clear liquid intake
- Where
- Thailand
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Malocclusion, Misaligned Teeth
Optimizing Orthodontic Appliances Efficiency With Remote Dental Monitoring and Artificial Intelligence Algorithms
The decision on aligner changing is based on orthodontists' personal experience and common knowledge that an approximated time span for the aligner have exhausted its biological efficacy.
- Trial name
- NCT05573308
- Testing
- Clear Aligners with Dental Monitoring, Clear Aligners
- Where
- 4 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Mandibular Dental Crowding
Effects of Micro-osteoperforations on Lower Anterior Crowding Using Clear Aligners
this randomized controlled trial is designed to compare between clear aligner therapy in alleviating mandibular anterior crowding alone versus with micro-osteoperforations
- Trial name
- NCT07169968
- Testing
- clear aligners group, micro-osteoperforations group
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Healthy Participants
Gastric Volume Estimation by Ultrasonography After Glucose Loaded Clear Fluid Ingestion in Fasted Adult
Introduction; Pre operative gastric ultrasonography is a newly developed tool used to evaluate gastric content and volume in assessing perioperative aspiration risk and guide anaesthetic management.
- Trial name
- NCT04478435
- Testing
- glucose loaded clear fluid
- Where
- Malaysia
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Melasma
Combination Topical Cysteamine and Fractional 1927nm Low-Powered Diode Laser for Treatment of Facial Melasma
The primary objective of our study is to determine the efficacy of combined topical cysteamine cream with a 1927 diode non-ablative laser (Clear + Brilliant Permea®; Solta Medical, Inc.), compared to topical cysteamine (Cyspera)…
- Trial name
- NCT05656833
- Testing
- Fractional 1927nm Low-Powered Diode Laser, Topical Cysteamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- UnionDerm
Colorectal Cancer
Clear Liquid vs Liberalized Diet in Preparation for Colonoscopy
Colorectal cancer is the third most common cancer diagnosed in both men and women in the United States. The death rate from this disease, however, has been decreasing over the last 20 years.
- Trial name
- NCT02621658
- Testing
- Clear Liquid Diet, Full Liquid Diet
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- San Antonio Military Medical Center